Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

Journal of Experimental Medicine

Volumn 215, Issue 6, 2018, Pages 1571-1588

  Pardi, Norbert ^a   Hogan, Michael J ^a   Naradikian, Martin S ^b   Parkhouse, Kaela ^b   Cain, Derek W ^c   Jones, Letitia ^c   Moody, M Anthony ^c   Verkerke, Hans P ^d   Myles, Arpita ^b   Willis, Elinor ^b   LaBranche, Celia C ^e   Montefiori, David C ^e   Lobby, Jenna L ^f   Saunders, Kevin O ^c   Liao, Hua Xin ^c   Korber, Bette T ^g   Sutherland, Laura L ^c   Scearce, Richard M ^c   Hraber, Peter T ^g   Tombácz, István ^a   Muramatsu, Hiromi ^a   Ni, Houping ^a   Balikov, Daniel A ^a   Li, Charles ^a   Mui, Barbara L ^h   Tam, Ying K ^h   Krammer, Florian ⁱ   Karikó, Katalin ^j   Polacino, Patricia ^d   Eisenlohr, Laurence C ^f   Madden, Thomas D ^h   Hope, Michael J ^h   Lewis, Mark G ^k   Lee, Kelly K ^d   Hu, Shiu Lok ^d   Hensley, Scott E ^b   Cancro, Michael P ^b   Haynes, Barton F ^c   Weissman, Drew ^a   more..

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^g LOS ALAMOS NATIONAL LABORATORY   (United States)

^h Acuitas Therapeutics   (Canada)

ⁱ MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^j BIONTECH AG   (Germany)

^k BIOQUAL INC   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLYCOPROTEIN GP 120; INACTIVATED VIRUS VACCINE; INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 4; LIPID NANOPARTICLE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; M1 PSI MESSENGER RNA; MEMBRANE ANTIGEN; MESSENGER RNA; NANOCARRIER; NEUTRALIZING ANTIBODY; NUCLEOSIDE DERIVATIVE; RNA VACCINE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VIRUS ANTIGEN; VIRUS ENVELOPE PROTEIN; ANTIGEN; IMMUNOLOGICAL ADJUVANT; LIPID; NANOPARTICLE; NUCLEOSIDE; SUBUNIT VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY AFFINITY; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE SUBPOPULATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENCY; FEMALE; GERMINAL CENTER; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMORAL IMMUNITY; IMMUNE RESPONSE; INFLUENZA A (H1N1); INFLUENZA A VIRUS (A/PUERTO RICO/8/1934(H1N1)); MOUSE; NANOENCAPSULATION; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; PROTEIN SUBUNIT; RHESUS MONKEY; SINGLE DRUG DOSE; SPLEEN CELL; TFH CELL; VACCINATION; VACCINE IMMUNOGENICITY; VIRUS ENVELOPE; VIRUS NEUTRALIZATION; VIRUS PARTICLE; ZIKA VIRUS; ANIMAL; ANTIBODY PRODUCTION; CHEMISTRY; CYTOLOGY; HELPER CELL; IMMUNOLOGY; METABOLISM; TIME FACTOR;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODY FORMATION; ANTIGENS; B-LYMPHOCYTES; GERMINAL CENTER; LIPIDS; MACACA MULATTA; NANOPARTICLES; NUCLEOSIDES; PROTEIN SUBUNITS; RNA, MESSENGER; T-LYMPHOCYTES, HELPER-INDUCER; TIME FACTORS; VACCINATION; VACCINES, SUBUNIT;

EID: 85048139283     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20171450     Document Type: Article

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