Expression and assembly of largest foreign protein in chloroplasts: oral delivery of human FVIII made in lettuce chloroplasts robustly suppresses inhibitor formation in haemophilia A mice

Plant Biotechnology Journal

Volumn 16, Issue 6, 2018, Pages 1148-1160

  Kwon, Kwang Chul ^a   Sherman, Alexandra ^b   Chang, Wan Jung ^a   Kamesh, Aditya ^a   Biswas, Moanaro ^b   Herzog, Roland W ^b   Daniell, Henry ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

antibody suppression; bioencapsulation; human blood clotting factor; oral delivery

Indexed keywords

BLOOD CLOTTING FACTOR 8; CHOLERA TOXIN; F8 PROTEIN, HUMAN; FUSION PROTEIN;

ANIMAL; BIOSYNTHESIS; CHLOROPLAST; DRUG EFFECT; ESCHERICHIA COLI; GENETICS; HEMOPHILIA A; IMMUNOLOGICAL TOLERANCE; LETTUCE; METABOLISM; MOUSE; PRECLINICAL STUDY;

ANIMALS; CHLOROPLASTS; CHOLERA TOXIN; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI; FACTOR VIII; HEMOPHILIA A; IMMUNE TOLERANCE; LETTUCE; MICE; RECOMBINANT FUSION PROTEINS;

EID: 85048003754     PISSN: 14677644     EISSN: 14677652     Source Type: Journal    
DOI: 10.1111/pbi.12859     Document Type: Article

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