A role for MAP kinase in the antitumor activity of a nucleoside analog

Cancer Gene Therapy

Volumn 9, Issue 1, 2002, Pages 37-43

  Whartenby, Katharine A ^a   Darnowski, James W ^a   Freeman, Scott M ^b,c   Calabresi, Paul ^a  

^a BROWN UNIVERSITY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c ONYX PHARMACEUTICALS   (United States)

Author keywords

Ganciclovir; Gene therapy; Herpes simplex virus thymidine kinase; MAP kinase; Nucleoside analogs

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; DNA; DNA POLYMERASE; GANCICLOVIR; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NUCLEOSIDE DERIVATIVE; THYMIDINE KINASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA SYNTHESIS; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; GENE THERAPY; HERPES SIMPLEX VIRUS 1; PHOSPHORYLATION; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; BLOTTING, WESTERN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; COLONY-FORMING UNITS ASSAY; CYTIDINE DEAMINASE; DNA, NEOPLASM; DNA-DIRECTED DNA POLYMERASE; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; GANCICLOVIR; HERPESVIRUS 1, HUMAN; HUMANS; IMIDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASES; NAD; POLY(ADP-RIBOSE) POLYMERASES; PYRIDINES; THYMIDINE KINASE; TUMOR CELLS, CULTURED;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 85047699341     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700406     Document Type: Article

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