Flt3-ligand-mobilized peripheral blood, but not Flt3-ligand-expanded bone marrow, facilitating cells promote establishment of chimerism and tolerance

Stem Cells

Volumn 24, Issue 4, 2006, Pages 936-948

  Huang, Yiming ^a   Kucia, Magda ^a   Rezzoug, Francine ^a   Ratajczak, Janina ^a   Tanner, Michael K ^a   Ratajczak, Mariusz Z ^a   Schanie, Carrie L ^a   Xu, Hong ^a   Fugier Vivier, Isabelle ^a   Ildstad, Suzanne T ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

CXCR4; Facilitating cells; Mobilization; Stromal cell derived factor 1; Tolerance

Indexed keywords

ATAXIN 1; CHEMOKINE RECEPTOR CXCR4; FLT3 LIGAND; PADGEM PROTEIN; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1; VASCULAR CELL ADHESION MOLECULE 1; ALPHA CHEMOKINE; FLT3 LIGAND PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; RECOMBINANT PROTEIN;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; BONE MARROW; CELL FUNCTION; CHIMERA; CONTROLLED STUDY; DOWN REGULATION; EX VIVO STUDY; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PROTEIN EXPRESSION; RECIPIENT; SUPERNATANT; UPREGULATION; ALLOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; BLOOD CELL; BONE MARROW CELL; C3H MOUSE; C57BL MOUSE; CLONOGENIC ASSAY; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; GENETICS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION;

ANIMALS; BLOOD CELLS; BONE MARROW CELLS; CHEMOKINES, CXC; CHIMERA; COLONY-FORMING UNITS ASSAY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; IMMUNE TOLERANCE; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; P-SELECTIN; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; RECEPTORS, CXCR4; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSPLANTATION, HOMOLOGOUS;

EID: 85047697093     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.SC-05-0395     Document Type: Article

References (54)

1. Kaufman CL, Colson YL, Wren SM et al. Phenotypic characterization of a novel bone-marrow derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 1994;84:2436-2446.
2. + bone marrow subpopulation that promotes allogeneic stem cell engraftment. Nat Med 2000;6:904-909.
3. - cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity 1999;11:579-590.
4. Grimes HL, Schanie CL, Huang Y et al. Graft facilitating cells are derived from hematopoietic stem cells and functionally require CD3, but are distinct from T lymphocytes. Exp Hematol 2004;32:946-954.
5. Fugier-Vivier I, Rezzoug F, Huang Y et al. Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment. J Exp Med 2005;201:373-383.
6. Rosnet O, Marchetto S, deLapeyriere O et al. Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene 1991;6:1641-1650.
7. Matthews W, Jordan CT, Wiegand GW et al. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 1991;65:1143-1152.
8. Hannum C, Culpepper J, Campbell D et al. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature 1994;368:643-648.
9. Antonysamy MA, Thomson AW. Flt3 ligand (FL) and its influence on immune reactivity. Cytokine 2000;12:87-100.
10. Broxmeyer HE, Lu L, Cooper S et al. Flt3 ligand stimulates/costimulates the growth of myeloid stem/progenitor cells. Exp Hematol 1995;23:1121-1129.
11. Gabbianelli M, Pelosi E, Montesoro E et al. Multi-level effects of flt3 ligand on human hematopoiesis: Expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors. Blood 1995;86:1661-1670.
12. + hematopoietic progenitor cells. Blood 1995;86:3413-3420.
13. +. Blood 1996;87:3563-3570.
14. Brasel K, McKenna HJ, Morrissey PJ et al. Hematologic effects of flt3 ligand in vivo in mice. Blood 1996;88:2004-2012.
15. Teshima T, Reddy P, Lowler KP et al. Flt3 ligand therapy for recipients of allogeneic bone marrow transplants expands host CD8 alpha(+) dendritic cells and reduces experimental acute graft-versus-host disease. Blood 2002;99:1825-1832.
16. McKenna HJ, Stocking KL, Miller RE et al. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood 2000;95:3489-3497.
17. Mackarehtschian K, Hardin JD, Moore KA et al. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 1995;3:147-161.
18. Neipp M, Zorina T, Domenick MA et al. Effect of FLT3 ligand and granulocyte colony-stimulating factor on expansion and mobilization of facilitating cells and hematopoietic stem cells in mice: Kinetics and repopulating potential. Blood 1998;92:3177-3188.
19. Mueller YM, Cramer DE, Huang Y et al. Hematopoietic stem cells from the marrow of mice treated with Flt3 ligand are significantly expanded but exhibit reduced engraftment potential. Transplantation 2002;73:1177-1185.
20. Huang Y, Rezzoug F, Chilton PM et al. Matching at the MHC Class I K locus is essential for long-term engraftment of purified hematopoietic stem cells: A role for host NK cells in regulating HSC engraftment. Blood 2004;104:873-880.
21. Xu H, Chilton PM, Huang Y et al. Production of donor T cells is critical for induction of donor-specific tolerance and maintenance of chimerism. J Immunol 2004;172:1463-1471.
22. Billingham ME. Pathology and etiology of chronic rejection of the heart. Clin Transplant 1994;8:289-292.
23. Reca R, Mastellos D, Majka M et al. Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1. Blood 2003;101:3784-3793.
24. Chilton PM, Rezzoug F, Ratajczak MZ et al. Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients. Blood 2004;105:2189-2197.
25. Arpinati M, Green CL, Heimfeld S et al. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood 2000;95:2484-2490.
26. Rossi M, Arpinati M, Rondelli D et al. Plasmacytoid dendritic cells: Do they have a role in immune responses after hematopoietic cell transplantation? Hum Immunol 2002;63:1194-1200.
27. Simmons PJ, Levesque JP, Zannettino AC. Adhesion molecules in haemopoiesis. Baillieres Clin Haematol 1997;10:485-505.
28. Verfaillie CM. Adhesion receptors as regulators of the hematopoietic process. Blood 1998;92:2609-2612.
29. Verfaillie C, Blakolmer K, McGlave P. Purified primitive human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma. J Exp Med 1990;172:509-520.
30. Frenette PS, Subbarao S, Mazo IB et al. Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc Natl Acad Sci U S A 1998;95:14423-14428.
31. Broxmeyer HE, Kim CH, Cooper SH et al. Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors. Ann NY Acad Sci 1999;872:142-162.
32. Ratajczak MZ, Reca R, Wysoczynski M et al. Transplantation studies in C3-deficient animals reveal a novel role of the third complement component (C3) in engraftment of bone marrow cells. Leukemia 2004;18:1482-1490.
33. Frimberger AE, Stering AI, Quesenberry PJ. An in vitro model of hematopoietic stem cell homing demonstrates rapid homing and maintenance of engraftable stem cells. Blood 2001;98:1012-1018.
34. Ratajczak J, Reca R, Kucia M et al. Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow. Blood 2004;103:2071-2078.
35. D'Amico A, Wu L. The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J Exp Med 2003;198:293-303.
36. Thomas J, Liu F, Link DC. Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Curr Opin Hematol 2002;9:183-189.
37. Brasel K, McKenna HJ, Charrier K et al. Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice. Blood 1997;90:3781-3788.
38. Chilton PM, Rezzoug F, Fugier-Vivier I et al. Flt3-ligand treatment prevents diabetes in NOD mice. Diabetes 2004;53:1995-2002.
39. Adolfsson J, Borge OJ, Bryder D et al. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 2001;15:659-669.
40. Moore MA. Cytokine and chemokine networks influencing stem cell proliferation, differentiation, and marrow homing. J Cell Biochem Suppl 2002;38:29-38.
41. Lapidot T, Petit I. Current understanding of stem cell mobilization: The roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol 2002;30:973-981.
42. Levesque JP, Liu F, Simmons PJ et al. Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood 2004;104:65-72.
43. Orschell-Traycoff CM, Hiatt K, Dagher RN et al. Homing and engraftment potential of Sca-1(+)lin(-) cells fractionated on the basis of adhesion molecule expression and position in cell cycle. Blood 2000;96:1380-1387.
44. Wright DE, Bowman EP, Wagers AJ et al. Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med 2002;195:1145-1154.
45. + stem/progenitor cells to bone marrow. Blood 2004;103:2981-2989.
46. Papayannopoulou T. Bone marrow homing: The players, the playfield, and their evolving roles. Curr Opin Hematol 2003;10:214-219.
47. Lapidot T, Kollet O. The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice. Leukemia 2002;16:1992-2003.
48. Peled A, Grabovsky V, Habler L et al. The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow. J Clin Invest 1999;104:1199-1211.
49. Fukuda S, Broxmeyer HE, Pelus LM. Flt3 ligand and the Flt3 receptor regulate hematopoietic cell migration by modulating the SDF-1alpha(CXCL12)/CXCR4 axis. Blood 2005;105:3117-3126.
50. Broxmeyer HE, Cooper S, Kohli L et al. Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo. J Immunol 2003;170:421-429.
51. Lataillade JJ, Clay D, Bourin P et al. Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: Evidence for an autocrine/paracrine mechanism. Blood 2002;99:1117-1129.
52. Wakkach A, Fournier N, Brun V et al. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 2003;18:605-617.
53. Makarenkova V, Chakrabarti AK, Liberatore JA et al. Dendritic cells and natural killer cells interact via multiple TNF family molecules. J Leukoc Biol 2005;77:408-413.
54. Colson YL, Christopher K, Glickman J et al. Absence of clinical GVHD and the in vivo induction of regulatory T cells following facilitating cell transplantation. Blood 2004;104:3829-3835.