Identification of antiplatelet and acetylcholinesterase inhibitory constituents in betel nut

Journal of Chinese Integrative Medicine

Volumn 9, Issue 6, 2011, Pages 619-625

  Ghayur, Muhammad Nabeel ^a,b   Kazim, Syed Faraz ^a   Rasheed, Huma ^c   Khalid, Asaad ^c,d   Jumani, Maliha Iqbal ^a   Choudhary, Muhammad Iqbal ^c   Gilani, Anwarul Hassan ^a  

^a AGA KHAN UNIVERSITY   (Pakistan)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF KARACHI   (Pakistan)

^d National Center for Research Sudan   (Sudan)

Author keywords

Areca catechu; Catechin; Cholinesterase inhibitors; Plant extracts; Platelet aggregation inhibitors; Tannic acid

Indexed keywords

ADENOSINE DIPHOSPHATE; ADRENALIN; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; ARECA CATECHU EXTRACT; ARECAIDINE; ARECOLINE; CALCIUM ION; CATECHIN; CHOLINESTERASE INHIBITOR; DIOSGENIN; GALLIC ACID; IONOPHORE; PLANT EXTRACT; TANNIN; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG; ACETYLCHOLINESTERASE;

ARTICLE; BETEL NUT; DRUG ACTIVITY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG POTENCY; ENZYME ACTIVITY; HUMAN; IC 50; IN VITRO STUDY; THROMBOCYTE AGGREGATION; ARECA; DRUG EFFECTS; METABOLISM; THROMBOCYTE RICH PLASMA;

ACETYLCHOLINESTERASE; ARECA; CHOLINESTERASE INHIBITORS; HUMANS; PLANT EXTRACTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET-RICH PLASMA;

EID: 85047687912     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20110607     Document Type: Article

References (46)

1. Chu NS. Effects of betel chewing on the central and autonomic nervous systems. J Biomed Sci. 2001; 8(3): 229-236.
2. Gilani AH, Ghayur MN. The betel nut chewing culture. In: Gottschalk-Batshkus CE, Green JC. Ethnotherapies in the cycle of life: fading, being and becoming. Munich: BOD-Books on Demand/Ethnomed Institut für Ethnomedizin e. V. 2005: 287-294. German.
3. Kusomoto IT, Nakabayashi T, Kida H, Miyashiro H, Hattori M, Namba T, Shimotohna K. Screening of various plant extracts used in ayurvedic medicine for inhibitory effects on human immunodeficiency virus type 1 (HIV-1) protease. Phytother Res. 1995; 9(3): 180-184.
4. Chempakam B. Hypoglycemic activity of arecoline in betel nut Areca catechu L. Indian J Exp Biol. 1993; 31 (5): 474-475.
5. Ohsugi M, Fan W, Hase K, Xiong Q, Tezuka Y, Komatsu K, Namba T, Saitoh T, Tazawa K, Kadota S. Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. J Ethnopharmacol. 1999; 67 (1): 111-119.
6. Iwamoto M, Matsuo T, Uchino K, Tonosaki Y, Fukuchi A. New 5'-nucleotidase inhibitors, NPF-86 I A, NPF-86 I B, NPF-86IIA, and NPF-86IIB from Areca catechu; Part II Anti-tumor effects. Planta Med. 1988; 54(5): 422-425.
7. Sullivan RJ, Allen JS, Otto C, Tiobech J, Nero K. Effects of chewing betel nut (Areca catechu) on the symptoms of people with schizophrenia in Palau, Micronesia. Br J Psychiatry. 2000; 177(2): 174-178.
8. Inokuchi J, Okabe H, Yamauchi T, Nagamatsu A, Nonaka G, Nishioka I. Antihypertensive substance in seeds of Areca catechu L. Life Sci. 1986; 38(15): 1375-1382.
9. Gilani AH, Ghayur MN, Saify ZS, Ahmed SP, Choudhary MI, Khalid A. Presence of cholinomimetic and acetylcholinesterase inhibitory constituents in betel nut. Life Sci. 2004; 75(20): 2377-2389.
10. Gilani AH, Ghayur MN, Houghton PJ, Jabeen Q, Kazim SF, Jumani MI, Saeed SA. Studies on the hypotensive, cardio-suppressant, vasodilator and antiplatelet activities of betel nut crude extract and its constituents. Int J Pharmacol. 2006; 2(1): 33-41.
11. Ghayur MN, Gilani AH. Cardio-selective inhibitory effect of the betel nut extract: possible explanation. Pharmazie. 2007; 62(1): 67-71.
12. Bhandare AM, Kshirsagar AD, Vyawahare NS, Hadambar AA, Thorve VS. Potential analgesic, antiinflammatory and antioxidant activities of hydroalcoholic extract of Areca catechu L. nut. Food Chem Toxicol. 2010; 48(12): 3412-3417.
13. Pithayanukul P, Nithitanakool S, Bavovada R. Hepatoprotective potential of extracts from seeds of Areca catechu and nutgalls of Quercus in fectoria. Molecules. 2009; 14(12): 4987-5000.
14. Moutasim KA, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF, Fortune F, Tilakaratne WM, Hart IR, Thomas GJ. Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. J Pathol. 2011; 223(3): 366-377.
15. Al-Swiahb JN, Chen CH, Chuang HC, Fang FM, Tasi HT, Chien CY. Clinical, pathological and molecular determinants in squamous cell carcinoma of the oral cavity. Future Oncol. 2010; 6(5): 837-850.
16. IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans, volume 37. Tobacco habits other than smoking; betel-quid and areca-nut chewing; and some related nitrosamines. Summaries of data reported and evaluations. Lyon: World Health Organization, International Agency for Research on Cancer. 1985.
17. IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans, volume 85. Betel-quid and areca-nut chewing and some areca-nut-derived nitrosamines. Summaries of data reported and evaluations. Lyon: World Health Organization, International Agency for Research on Cancer. 2004.
18. Sharan RN. Association of betel nut with carcinogenesis. Cancer J. 1996; 9(1): 13-19.
19. Warnakulasuriya S, Trivedy C, Peters TJ. Areca nut use: an independent risk factor for oral cancer. BMJ. 2002; 324(7341): 799-800.
20. Trivedy CR, Craig G, Warnakulasuriya S. The oral health consequences of chewing areca nut. Addict Biol. 2002; 7(1): 115-125.
21. Sharan RN, Choudhury Y. Betel nut and susceptibility to cancer. In: Sharan RN, Choudhury Y. Environmental factors, genes and the development of human cancers. New York: Springer. 2010: 401-428.
22. Bhat SJ, Blank MD, Balster RL, Nichter M, Nichter M. Areca nut dependence among chewers in a South Indian community who do not also use tobacco. Addiction. 2010; 105(7): 1303-1310.
23. Shrestha J, Shanbhag T, Shenoy S, Amuthan A, Prabhu K, Sharma S, Banerjee S, Kafle S. Antiovulatory and abortifacient effects of Areca catechu (betel nut) in female rats. Indian J Pharmacol. 2010; 42(5): 306-311.
24. Nadkarni KM. Dr. K. M. Nadkarni's Indian materia medica. Bombay: Popular Prakashan. 1976.
25. Lin SK, Chang YJ, Ryu SJ, Chu NS. Cerebral hemodynamic responses to betel chewing: a Doppler study. Clin Neuropharmacol. 2002; 25(5): 244-250.
26. Maiese K, Holloway HH, Larson DM, Soncrant TT. Effect of acute and chronic arecoline treatment on cerebral metabolism and blood flow in the conscious rat. Brain Res. 1994; 641(1): 65-75.
27. Shah BH, Rasheed H, Rahman IH, Shariff AH, Khan FL, Rahman HB, Hanif S, Saeed SA. Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine. Exp Mol Med. 2001; 33(4): 226-233.
28. Ghayur MN, Gilani AH, Rasheed H, Khan A, Iqbal Z, Ismail M, Saeed SA, Janssen LJ. Cardiovascular and airway relaxant activities of peony root extract. Can J Physiol Pharmacol. 2008; 86(11): 793-803.
29. Ellman GL, Courtney KD, Andres V Jr, Feather-Stone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961; 7: 88-95.
30. Jeng JH, Chen SY, Liao CH, Tung YY, Lin BR, Hahn LJ, Chang MC. Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. Free Radic Biol Med. 2002; 32(9): 860-871.
31. Ghayur MN, Gilani AH. Species differences in the prokinetic effects of ginger. Int J Food Sci Nutr. 2006; 57(1-2): 65-73.
32. Ghayur MN, Gilani AH, Houghton PJ. Species differences in the gut stimulatory effects of radish seeds. J Pharm Pharmacol. 2005; 57(11): 1493-1502.
33. Tazawa R, Green ED, Ohashi K, Wu KK, Wang LH. Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter. Arch Biochem Biophys. 1996; 334(2): 349-356.
34. Saeed SA, Connor JD, Rasheed H, Gilani AH, Lodhi S, Ali SS, Rashid S, Khan E, Shah BH. Wortmannin inhibits platelet aggregation produced by interaction of gamma-aminobutyric acid and the calcium tonophore, A23187. Res Commun Mol Pathol Pharmacol. 2001; 109(1-2): 87-94.
35. Kimura Y, Okuda H. Effects of cr and ß-adrenergic antagonist on epinephrine-induced aggregation and intracellular free calcium concentration in human platelets. Biochem Biophys Res Commun. 1994; 202 (2): 1069-1075.
36. Lages B, Weiss HJ. Enhanced increases in cytosolic Ca2+ in ADP-stimulated platelets from patients with d-storage pool deficiency-a possible indicator of interactions between granule-bound ADP and the membrane ADP receptor. Thromb Haemost. 1997; 77 (2): 376-382.
37. Gilani AH, Rahman AU. Trends in ethnopharmacology. J Ethnopharmacol. 2005; 100(1-2): 43-49.
38. Ghayur MN, Khan H, Gilani AH. Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid. Arch Pharm Res. 2007; 30(8): 970-975.
39. Guh JY, Chen HC, Tsai JF, Chuang LY. Betel-quid use is associated with heart disease in women. Am J Clin Nutr. 2007; 85(5): 1229-1235.
40. Lin WY, Chiu TY, Lee LT, Lin CC, Huang CY, Huang KC. Betel nut chewing is associated with increased risk of cardiovascular disease and all-cause mortality in Taiwanese men. Am J Clin Nutr. 2008; 87(5): 1204-1211.
41. Yen AM, Chen LS, Chiu YH, Boucher BJ, Chen TH. A prospective community-population-registry based cohort study of the association between betel-quid chewing and cardiovascular disease in men in Taiwan (KCIS no. 19). Am J Clin Nutr. 2008; 87(1): 70-78.
42. Bullock R. New drugs for Alzheimer's disease and other dementias. Br J Psychiatry. 2002; 180: 135-139.
43. Palmer AM. Pharmacotherapy for Alzheimer's disease: progress and prospects. Trends Pharmacol Sci. 2002; 23(9): 426 433.
44. Soncrant TT, Raffaele KC, Asthana S, Berardi A, Morris PP, Haxby JV. Memory improvement without toxicity during chronic, low dose intravenous arecoline in Alzheimer's disease. Psychopharmacology (Berl). 1993; 112(4): 421-427.
45. Rupniak NM, Steventon MJ, Field MJ, Jennings CA, Iversen SD. Comparison of the effects of four cholinomimetic agents on cognition in primates following disruption by scopolamine or by lists of objects. Psychopharmacology (Berl). 1989; 99(2): 189-195.
46. Shih YT, Chen PS, Wu CH, Tseng YT, Wu YC, Lo YC. Arecoline, a major alkaloid of the areca nut, causes neurotoxicity through enhancement of oxidative stress and suppression of the antioxidant protective system. Free Radic Biol Med. 2010; 49 (10): 1471-1479.