Wortmannin inhibits platelet aggregation produced by interaction of γ-aminobutyric acid and the calcium ionophore, a23187

Research Communications in Molecular Pathology and Pharmacology

Volumn 109, Issue 1-2, 2001, Pages 87-94

  Saeed, S A ^a   Connor, J D ^a   Rasheed, H ^a   Gilani, A H ^a   Lodhi, S ^a   Ali, S S ^a   Rashid, S ^a   Khan, E ^a   Shah, B H ^a  

^a AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BACLOFEN; BENZODIAZEPINE DERIVATIVE; CALCIMYCIN; CALCIUM IONOPHORE; DIAZEPAM; DILTIAZEM; FLUNITRAZEPAM; MUSCIMOL; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; VERAPAMIL; WORTMANNIN;

ARTICLE; DRUG EFFECT; DRUG INHIBITION; DRUG POTENTIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION INHIBITION; TIGHT JUNCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; CALCIMYCIN; DRUG SYNERGISM; ENZYME INHIBITORS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION;

EID: 0034946473     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Inositol trisphosphate and calcium signalling
2. GABA-B Receptor Pharmacology
3. Calcium signaling in platelets and other cells
4. Abnormal peripheral benzodiazepine receptor density associated with generalized social phobia
5. Binding of benzodiazepines to blood platelets from various species
6. GABAergic mechanisms in blood cells: Their possible role
7. Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes
8. Regulation of phosphatidylinositide 3-kinase, a potential signaling enzyme in platelets
9. Role of phosphatidylinositol 3-kinase in platelet aggregation
10. Synergistic interaction of a calcium ionophore, A23187, and dopamine in human platelet aggregation
11. Synergistic actions of platelet activating factor and 5-HT in platelet aggregation: Effect of 5-HT blockers and anti-asthma drugs
12. Synergistic actions of 5-HT and arachidonic acid in platelet aggregation: Effect of 5-HT blockers
13. Phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits 5-hydroxytryptamine-mediated potentiation of platelet aggregation induced by epinephrine
14. Synergistic interaction of adrenaline and histamine in human platelet aggregation is mediated through activation of phospholipase C, MAP kinase and cyclooxygenase pathways
15. ++ signalling pathways
16. Changes in platelets and renal benzodiazepine binding in spontaneously hypertensive rats
17. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
18. Effects of increasing doses of vigabatrin on platelet γ-aminobutyric acid-transaminase and brain γ-aminobutyric acid in rats
19. +)-dependent tyrosine phosphorylation
20. Properties of (3H) diazepam binding sites on rat blood platelets
21. Insights into the structure and function of GABA-benzodiazepine receptors: Ion channels and psychiatry