Interferon-τ (IFNτ) regulation of IFN-stimulated gene expression in cell lines lacking specific IFN-signaling components

Endocrinology

Volumn 142, Issue 5, 2001, Pages 1786-1794

  Stewart, M David ^a   Johnson, Greg A ^a   Bazer, Fuller W ^a   Spencer, Thomas E ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; GAMMA INTERFERON; OXYTOCIN RECEPTOR; STAT1 PROTEIN; STAT2 PROTEIN; TRANSCRIPTION FACTOR; 2',5' OLIGOADENYLATE SYNTHETASE; DNA BINDING PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 9; INTERFERON STIMULATED GENE FACTOR 3; ISGF3G PROTEIN, HUMAN; PLACENTA PROTEIN; STAT1 PROTEIN, HUMAN; STAT2 PROTEIN, HUMAN; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TROPHOBLAST PROTEIN 1;

ANIMAL CELL; ARTICLE; ENDOMETRIUM; GENE MUTATION; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

2',5'-OLIGOADENYLATE SYNTHETASE; CELL LINE; DNA-BINDING PROTEINS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE I; INTERFERON-STIMULATED GENE FACTOR 3; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; PHOSPHORYLATION; PREGNANCY PROTEINS; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 85047686621     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.5.8138     Document Type: Article

References (48)

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2. Antiproliferative activity of a pregnancy recognition hormone, ovine trophoblast protein-1
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4. Immunomodulating functions of recombinant ovine interferon τ, potential for therapy in multiple sclerosis and autoimmune disorders
5. IFN-τ exhibits potent suppression of human papillomavirus E6/E7 oncoprotein expression
6. Molecular cloning of ovine and bovine type I interferon receptor subunits from uteri, and endometrial expression of messenger ribonucleic acid for ovine receptors during the estrous cycle and pregnancy
7. τ-interferon: Pregnancy recognition signal in ruminants
8. Endocrinology of the transition from recurring estrous cycles to establishment of pregnancy in subprimate mammals
9. Ovine interferon τ suppresses transcription of the estrogen receptor and oxytocin receptor genes in the ovine endometrium
10. Expression of interferon regulatory factors one and two in the ovine endometrium: Effects of pregnancy and ovine interferon τ
11. Development and characterization of immortalized ovine endometrial epithelial cell lines
12. Interferon-τ activates multiple signal transducers and activators of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells
13. A low molecular weight endometrial secretory protein which is increased by ovine trophoblast protein-1 is a β2-microglobulin-like protein
14. Expression of the interferon τ inducible ubiquitin cross-reactive protein in the ovine uterus
15. Interferon-τ and progesterone regulate ubiquitin cross-reactive protein expression in the ovine uterus
16. Effects of the estrous cycle and early pregnancy on uterine expression of Mx protein in sheep (Ovis aries)
17. Stimulation of 2′,5′-oligoadenylate synthetase activity in sheep endometrium during pregnancy, by intrauterine infusion of ovine trophoblast protien-1, and by intramuscular administration of recombinant bovine interferon-αI1
18. Effects of the estrous cycle, pregnancy and interferon r on 2′,5′-oligoadenylate synthetase expression in the ovine uterus
19. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFNα and IFNγ and is likely to autoregulate the p91 gene
20. Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes
21. Transcriptional induction of the p69 isoform of 2′,5′-oligoadenylate synthetase by interferon-β and interferon-γ, involves three regulatory elements and interferon-stimulated gene factor 3
22. Complementation of a mutant cell line: Central role of the 91 kDa of ISGF3 in the interferon-α and -γ, signal transduction pathways
23. Role of STAT2 in the α interferon signaling pathway
24. Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
25. High yield expression and secretion of ovine pregnancy recognition hormone interferon-τ by Picha pastoris
26. Four different forms of interferon-induced 2′-5′ oligo(A) synthetase identified by immunoblotting in human cells
27. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ
28. Induction of expression of interferon-stimulated gene factor-3 (ISGF-3) proteins by interferons
29. Identification of genes differentially regulated by interferon α,β, or γ using oligonucleotide arrays
30. Interferons, double-stranded RNA, and RNA degredation. Isolation and characterization of homogenous human (2′-5′)(a)n synthetase
31. Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies
32. Characterization of 69- and 100-kDa forms of 2-SA-synthetase from interferon-treated human cells
33. Expansion and molecular evolution of the interferon-induced 2′-5′ oligoadenylate synthetase gene family
34. Preparation and characterizafion of polyclonal antibodies specific for the 69 and 100 k-dalton forms of human 2-5A synthetase
35. Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon
36. Isoforms p69 and p100 of 2′,5′-oligoadenylate synthetase induced differentially by interferons in vivo and in vitro
37. The 100-kDa 2′,5′-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2′p5′A molecules is composed of three homologous domains
38. The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-α signals
39. Activation of transcription by IFNγ: Tyrosine phosphorylation of a 91-kD DNA binding protein
40. A single phosphotyrosine residue of Stat91 required for gene activation by interferon
41. How cells respond to interferons
42. How Stat1 mediates constitutive gene expression: A complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene
43. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
44. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotryosyl peptide interactions
45. Preassociation of STAT1 with STAT2 and STAT3 in separate signaling complexes prior to cytokine stimulation
46. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
47. p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons
48. Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3