The antiproliferative and antiviral activities of IFN-τ variants in human cells

Journal of Interferon and Cytokine Research

Volumn 17, Issue 12, 1997, Pages 769-779

  Alexenko, Andrei P ^a   Leaman, Douglas W ^b   Li, Junzhi ^c   Roberts, R Michael ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; TAU INTERFERON;

ANTIVIRAL ACTIVITY; ARTICLE; CATTLE; DAUDI CELL; DRUG EFFECT; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; SHEEP; TROPHOBLAST; VIRUS INHIBITION;

BOS TAURUS; BOVINAE; OVIS; OVIS ARIES; VESICULAR STOMATITIS VIRUS;

EID: 0031456603     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1997.17.769     Document Type: Article

References (42)

1. ROBERTS, R.M., LIU, L., and ALEXENKO, A. (1997). New and atypical families of type I interferons in mammals: comparative functions, structures, and evolutionary relationships. Prog. Nucleic Acid Res. Mol. Biol. 56, 287-325.
2. LEAMAN, D.W., and ROBERTS, R.M. (1992). Genes for the trophoblast interferons in sheep, goat, and musk ox and distribution of related genes among mammals. J. Interferon Res. 12, 1-11.
3. ROBERTS, R.M., CROSS, J.C., and LEAMAN, D.W. (1992). Interferons as hormones of pregnancy. Endocrine Rev. 13, 432-452.
4. LEAMAN, D.W., CROSS, J.C., and ROBERTS, R.M. (1994). Multiple regulatory elements are required to direct trophoblast interferon gene expression in choriocarcinoma cells and trophectoderm. Mol. Endocrinol. 8, 456-468.
5. CROSS, J.C., and ROBERTS, R.M. (1991). Constitutive and trophoblast-specific expression of a class of bovine interferon genes. Proc. Natl. Acad. Sci. USA 88, 3817-3821.
6. LI, J., and ROBERTS, R.M. (1994). Interferon-tau and interferon-alpha interact with the same receptors in bovine endometrium: use of a readily iodinatable form of IFN-tau for binding studies. J. Biol. Chem. 269, 13544-13550.
7. DARNELL, I.E., KERR, I.M., and STARK, G.R. (1994). Jak-Stat pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421.
8. LEAMAN, D.W., LEUNG, S., LI, X., and STARK, G. (1996). Regulation of Stat-dependent pathways by growth factors and cytokines. FASEB J. 10, 1578-1588.
9. DECKER, T., LEW, D.J., and DARNELL, J.E. (1991). Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcriptions of the guanylate-binding protein gene. Mol. Cell. Biol. 11, 5147-55153.
10. SUBRAMANIAM, P.S., KHAN, S.A., PONTZER, C.H., and JOHNSON, H.M. (1995). Differential recognition of the type I interferon receptor by interferons τ and α is responsible for their disparate cytotoxicities. Proc. Natl. Acad. Sci. USA 92, 12270-12274.
11. UZÉ, G., LUTFALLA, G., and GRESSER, I. (1990). Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell 60, 225-234.
12. DEMAEYER, E., and DEMAEYER-GUIGNARD, J. (1988). Interferons and Other Regulatory Cytokines. New York: John Wiley.
13. NIWANO, Y., HANSEN, T.R., KAZEMI, M., MALATHY, P.V., JOHNSON, H.D., ROBERTS, R.M., and IMAKAWA, K. (1989). Suppression of T-lymphocyte blastogenesis by ovine trophoblast protein-1 and human interferon-alpha may be independent of interleukin-2 production. Am. J. Reprod. Immunol. 20, 21-26.
14. LI, J., and ROBERTS, R.M. (1994). Structure-function relationships in the interferon-tau (IFN-τ): changes in receptor binding and in antiviral and antiproliferative activities resulting from site-directed mutagenesis performed near the carboxyl terminus. J. Biol. Chem. 269, 24826-24833.
15. JOHNSON, H.M., BAZER, F.W., SZENTE, B.E., and JARPE, M.A. (1994). How interferons fight disease. Sci. Am. 68, 270-275.
16. PONTZER, C.H., BAZER, F.W., and JOHNSON, H.M. (1991). Antiproliferative activity of a pregnancy recognition hormone, ovine trophoblast protein-1. Cancer Res. 51, 5304-5307.
17. BAZER, F.W., and JOHNSON, H.M. (1991). Type I conceptus interferons: maternal recognition of pregnancy signals and potential therapeutic agents. Am. J. Reprod. Immunol. 26, 19-22.
18. SOOS, J.M., SUBRAMANIAM, P.S., HOBEIKA, A.C., SCHIFFENBAUER, J., and JOHNSON, H.M. (1995). The IFN pregnancy recognition hormone IFN-τ blocks both development and super-antigen reactivation of experimental allergic encephalomyelitis without associated toxicity. J. Immunol. 155, 2747-2753.
19. DEREUDDRE-BOSQUET, N., CLAYETTE, P., MARTIN, M., MABONDZO, A., FRETIER, P., GRAS, G., MARTAL, J., and DORMONT, D. (1996). Anti-HIV potential of a new interferon, interferon-tau (trophoblastin). J. Acq. Immun. Defic. Syndr. Hum. Retrovirol. 11, 241-246.
20. LI, J., ALEXENKO, A.P., and ROBERTS, R.M. (1995). A bifunctional vector suitable for both site-directed mutagenesis and recombinant expression of interferon-tau in Escherichia coli. Protein Express. Purif. 6, 401-407.
21. NISWENDER, K.D., LI, J., POWELL, M.R., LOOS, K.R., ROBERTS, R.M., KEISSLER, D.H., and SMITH, M.F. (1997). Effects of variants of interferon-τ with mutations near the carboxyl terminus on luteal life span in sheep. Biol. Reprod. 56, 214-220.
22. KLEMANN, S.W., LI, J., IMAKAWA, K., CROSS, J.C., FRANCIS, H., and ROBERTS, R.M. (1990). The production, purification, and bioactivity of recombinant bovine trophoblast protein-1 (bovine trophoblast interferon). Mol. Endocrinol. 4, 1506-1514.
23. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
24. CORY, A.H., OWEN, T.C., BARLTROP, J.A., and CORY, J.G. (1991). Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun. 3, 207-212.
25. BRENNAN, G.L., and KRONENBERG, L.H. (1983). Automated bioassay of interferons in microtest plates. BioTechniques 1, 78-83.
26. SAS INSTITUTE (1995). In: JMP Statistics and Graphics Guide, version 3.1, SAS Institute, Inc., Cary, NC, pp. 139-174.
27. PORTER, A.C.G., CHERNAJOVSKI, Y., DALE, T.C., GILBERT, C.S., STARK, G.R., and KERR, I.M. (1988). Interferon response element of the human gene 6-16. EMBO J. 7, 85-92.
28. WILSON, K.C., and FINBLOOM, D.S. (1992). Interferon γ rapidly induces in human monocytes a DNA-binding factor, that recognizes the γ response region within the promoter of the gene for the high affinity Fcγ receptor. Proc. Natl. Acad. Sci. USA 89, 11964-11968.
29. LEAMAN, D.W., PISHARODY, S., FLICKINGER, T.W., COMMANE, M.A., SCHLESSINGER, R.J., KERR, I.M., LEVY, D.E., and STARK, G.R. (1996). Role of JAKs in activation of Stats and stimulation of c-fos gene expression by epidermal growth factor. Mol. Cell. Biol. 16, 369-375.
30. SENDA, T., SAITOH, S.I., MITSUI, Y., LI, J., and ROBERTS, R.M. (1995). A three-dimensional model of bovine interferon-τ. J. Interferon Cytokine Res. 15, 1053-1060.
31. SENDA, T., SAITOH, S.I., and MITSUI, Y. (1995). Refined crystal structure of recombinant murine interferon-β at 2.15 A resolution. J. Mol. Biol. 253, 187-207.
32. NISBET, I.T., BEILHARZ, M.W., HERTZOG, P.J., TYMMS, M.J., and LINNANE, A.W. (1985). Single amino acid substitutions at conserved residues of human interferon-α can effect antiviral specific activity. Biochem. Int. 11, 301-309.
33. WAINE, G.J., TYMMS, M.J., BRANDT, E.R., CHEETHAM, B.F., and LINNANE, A.W. (1992). Structure-function study of the region encompassing residues 26-40 of human interferon-α4: identification of residues important for antiviral and antiproliferative activities. J. Interferon Res. 12, 43-48.
34. FISH, E.N. (1992). Definition of receptor binding domains in interferon-alpha. J. Interferon Res. 12, 257-266.
35. MITSUI, Y., SENDA, T., SHIMAZU, T., MATSUDA, S., and UTSUMI, J. (1993). Structural, functional and evolutionary implications of three-dimensional crystal structure of murine interferon-β. Pharmacol. Ther. 58, 93-132.
36. CHEETHAM, B.F., McINNES, B., MANTAMADIOTIS, T., MURRAY, P.J., ALIN, P., BOURKE, P., LINNANE, A.W., and TYMMS, M.J. (1991). Structure-function studies of human interferons-α: enhanced activity on human and murine cells. Antiviral Res. 15, 27-40.
37. ACKRILL, A.M., FOSTER, G.R., LAXTON, C.D., FLAVELL, D.M., STARK, G.R., and KERR, I.M. (1991). Inhibition of the cellular response to interferons by products of adenovirus type 5E1A oncogene. Nucleic Acids Res. 19, 4387-4393.
38. BANDYOPADHYAY, S.K., DHANANJAYA, V.R., KALVAKOLANU, D.V., and SEN, G.C. (1990). Gene induction by interferons: functional complementation between trans-acting factors induced by alpha interferon and gamma interferon. Mol. Cell. Biol. 10, 5035-5063.
39. BANDYOPADHYAY, S.K., and SEN, G.C. (1992). Role of protein phosphorylation in activation or interferon-stimulated gene factors. J. Biol. Chem. 267, 6389-6396.
40. WEIHUA, X., KOLLA, V., and KALVAKOLANU, D.V. (1997). Interferon-γ induced transcription of the murine ISGF-γ(p48) gene is mediated by novel factors. Proc. Natl. Acad. Sci. USA 94, 103-108.
41. ZAV'YALOV, V.P., NAVOLOTSKAYA, E.V., VASILENKO, R.N., ABRAMOV, V.M., VOLODINA, E.Y., ROSLOVTSEVA, O.A., PRUSAKOV, A.N., and KAUROV, O.A. (1995). The sequence 130-137 of human interferon-α2 is involved in competition of interferon, prothymosin γ and cholera toxin B subunit for common receptors on human fibroblasts. Mol. Immunol. 32, 425-431.
42. HAELEWYN, J., MICHIELS, L., VERHAERT, P., HOYLAERTS, M.F., WITTERS, R., and DeLEY, M. (1997). Interaction of truncated human interferon γ variants with the interferon γ receptor: crucial importance of Arg-129. Biochem. J. 324, 591-595.