τ-Interferon: Pregnancy recognition signal in ruminants

Experimental Biology and Medicine

Volumn 213, Issue 3, 1996, Pages 215-229

  Spencer, Thomas E ^a,b   Ott, Troy L ^a   Bazer, Fuller W ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; OXYTOCIN; OXYTOCIN RECEPTOR; PROGESTERONE RECEPTOR; PROSTAGLANDIN F2 ALPHA; TAU INTERFERON;

BOVIDS; ENDOMETRIUM; ESTRUS CYCLE; GENE EXPRESSION; LUTEOLYSIS; NONHUMAN; PREGNANCY; REVIEW; SHEEP;

ANIMALS; CORPUS LUTEUM; ESTRUS; FEMALE; INTERFERON TYPE I; PREGNANCY; PREGNANCY PROTEINS; RECEPTORS, OXYTOCIN; RECEPTORS, STEROID; SHEEP;

BOVIDAE; OVIS; OVIS ARIES;

EID: 0030450063     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (110)

1. Hansel W, Convey EM. Physiology of the estrous cycle. J Anim Sci 57(Suppl):404-424, 1983.
2. 2α throughout the estrous cycle. J Endocrinol 69:275-286, 1976.
3. Moor RM, Rowson LEA. Influence of the embryo and uterus on luteal function in the sheep. Nature 201:522-523, 1964.
4. Wiltbank JN, Casida LE. Alteration of ovarian activity by hysterectomy. J Anim Sci 15:134-140, 1956.
5. 2α from the ovine uterus during luteolysis and its abrogation in early pregnancy. Anim Reprod Sci 7:31-55, 1984.
6. McCracken JA, Carlson JC, Glew ME, Goding JR, Baird DT, Green K, Samuelson B. Prostaglandin F-2 alpha identified as a luteolytic hormone in sheep. Nature 238:129-134, 1972.
7. Staples LD, Whylie PA. Contribution of the utero-ovarian lymphatic network to the control of corpus luteum function in the ewe. In: Lindsay DR, Pearce DT, Eds. Reproduction in Sheep, Cambridge: Cambridge University Press, pp 122-124, 1984.
8. Heap RB, Fleet IR, Hamon M. Prostaglandin F-2 alpha is transferred from the uterus to the ovary in sheep by lymphatic and blood vascular pathways. J Reprod Fertil 74:645-656, 1985.
9. Scaramuzzi RJ, Baird DT. The oestrus cycle after active immunization against prostaglandin F-2 alpha. J Reprod Fertil 46:39-47, 1976.
10. Fairclough RJ, Smith JF, McGowan LT. Prolongation of the oestrus cycle in cows and ewes after passive immunization with PGF antibodies. J Reprod Fertil 62:213-219, 1981.
11. Niswender GD, Nett TM. Corpus luteum and its control in infraprimate species. In: Knobil E, Neill JD, Eds. The Physiology of Reproduction. New York: Raven Press, pp 781-816, 1994.
12. Wiltbank MC, Diskin MG, Niswender GD. Differential actions of second messenger systems in the corpus luteum. J Reprod Fertil 43:65-75, 1991.
13. McGuire WJ, Hawkins DE, Niswender GD. Activation of protein kinase (PK)-C inhibits progesterone production in vivo. Biol Reprod 46(Suppl 1):84, 1991.
14. Wiltbank MC, Knickerbocker JJ, Niswender GD. Regulation of the corpus luteum by protein kinase C. I. Phosphorylation activity and steroidogenic action in large and small ovine luteal cells. Biol Reprod 40:1194-1200, 1989.
15. 2α. Dom Anim Endocrinol 7:229-238, 1990.
16. 4 isomerase (3β-HSD) in the ovine corpus luteum. Biol Reprod 48:1185-1190, 1993.
17. Boshier DP, Fairclough RJ, Holloway H. Assessment of sheep blastocyst effects on neutral lipids in the uterine caruncular epithelium. J Reprod Fertil 79:569-573, 1987.
18. Eggleston DL, Wilken C, Van Kirk EA, Slaughter RG, Ji TH, Murdoch WJ. Progesterone induces expression of endometrial messenger RNA encoding for cyclooxygenase (sheep). Prostaglandins 39:675-383, 1990.
19. Morgan GL, Geisert RD, McCann JP, Bazer FW, Ott TL, Mirando MA, Stewart M. Failure of luteolysis and extension of the interoestrous interval in sheep treated with the progesterone antagonist mifepristone (RU 486). J Reprod Fertil 98:451-457, 1993.
20. 2α in ruminants. Biol Reprod 45:655-663, 1991.
21. Silivia WJ, Raw RE. Regulation of pulsatile secretion of prostaglandin F2 alpha from the ovine uterus by ovarian steroids. J Reprod Fertil 98:341-347, 1993.
22. Salamonsen LA. Local regulators and establishment of pregnancy: A review. Reprod Fertil Dev 4:125-134, 1992.
23. Bazer FW. Mediators of maternal recognition of pregnancy in mammals. Proc Soc Exp Biol Med 199:373-384, 1992.
24. Bazer FW, Spencer TE, Ott TL, Johnson HM. Cytokines and pregancy recognition. In: Hunt JS, Ed. Immunobiology of Reproduction. New York: Springer-Verlag, pp 37-56, 1994.
25. Flint APF, Leat WMF, Sheldrick EL, Stewart HJ. Stimulation of phosphoinositide hydrolysis by oxytocin and the mechanism by which oxytocin controls prostaglandin synthesis in the ovine endometrium. Biochem J 237:797-805, 1986.
26. Wathes DC, Denning Kendall PA. Control of the synthesis and secretion of ovarian oxytocin in ruminants. J Reprod Fertil 45(Suppl):39-52, 1992.
27. 2α concentrations in the utero-ovarian vein of preganat and nonpregnant sheep. Endrocinology 119:2590-2597, 1986.
28. Jones DSC, Flint APF. Oxytocin-neurophysin mRNA in the corpus luteum of the sheep during the oestrus cycle and in pregnancy. J Endocrinol 111(Suppl 1):140, 1986.
29. Rhodes L, Nathanielsz. PW. Myometrial activity and plasma progesterone and oxytocin concentrations in cycling and early pregnant ewes. Biol Reprod 42:834-841, 1990.
30. Wathes DC, Lamming GE. The oxytocin receptor, luteolysis and the maintenance of pregnancy. J Reprod Fertil 49(Suppl): 53-67, 1995.
31. 2α during luteal regression and early pregnancy in sheep. Reprod Fertil Devel 4:321-328, 1992.
32. Wathes DC, Hamon M. Localization of oestradiol, progesterone and oxytocin receptors in the uterus during the oestrus cycle and early pregnancy of the ewe. J Endocrinology 138:479-491, 1993.
33. Spencer TE, Bazer FW. Temporal and spatial alterations in uterine estrogen receptor and progesterone receptor gene expression during the estrous cycle and early pregnancy in the ewe. Biol Reprod 53:1527-1543, 1995.
34. Stevenson KR, Riley PR, Stewart HJ, Flint APF, Wathes DC. Localization of oxytocin receptor mRNA in the ovine uterus during the oestrus cycle and early pregnancy. J Mol Endocrinol 12:93-105, 1994.
35. Sheldrick EL, Flint APF. Endrocine control of uterine oxytocin receptors in the ewe. J Endocrinol 106:249-258, 1985.
36. Ayad VJ, Matthews EL, Wathes DC, Parkinson TJ, Wild ML. Autoradiographical localization of oxytocin receptors in the endometrium during the oestrus cycle of the ewe. J Endocrinol 130:199-206, 1991.
37. Wallace JM, Morgan PJ, Helliwell R, Aitken RP, Cheyne M, Williams LM. Characterization and autoradiographical localization of oxytocin receptors within the ovine endometrium in relations to post-partum corpus luteum function. J Endocrinol 128:253-260, 1991.
38. Spencer TE, Bazer FW. Interferon tau suppresses transcription of the estrogen receptor and oxytocin receptor genes in ovine endometrium. Endocrinology 137:1144-1147, 1996.
39. 2α release in ewes. J Reprod Fertil 100:469-475, 1994.
40. 2α release by progesterone and oestradiol in ewes. J Reprod Fertil 100:143-150, 1994.
41. Homanics GE, Silvia WJ. Effects of progesterone and estradiol-17β on uterine secretion of prostaglandin F-2α in response to oxytocin in ovariectomized ewes. Biol Reprod 38:804-811, 1988.
42. Leavitt WW, Okulicz WC, McCracken JA, Schramm WW, Robidoux WF Jr. Rapid recovery of nuclear estrogen receptor and oxytocin receptor in the ovine uterus following progesterone withdrawal. J Steroid Biochem 222:687-691, 1985.
43. Spencer TE, Becker WC, George P, Mirando MA, Ogle TF, Bazer FW. Ovine Interferon-τ regulates expression of endometrial receptors for estrogen and oxytocin, but not progesterone. Biol Reprod 53:732-745, 1995.
44. Vallet JL, Lamming GE, Batten M. Control of endometrial oxytocin receptor and uterine response to oxytocin by progesterone and oestradiol in the ewe. J Reprod Fertil 10:625-634, 1990.
45. 2α after withdrawal of exogenous progesterone. J Reprod Fertil 95:885-893, 1992.
46. Spencer TE, Becker WC, George P, Mirando MA, Ogle TF, Bazer FW. Ovine interferon-tau (IFN-τ) inhibits estrogen receptor up-regulation and estrogen-induced luteolysis in cyclic ewes. Endocrinology 136:4932-4944, 1995.
47. Hixon JE, Flint APF. Effects of luteolytic dose of oestradiol benzoate on uterine oxytocin receptor concentrations, phosphoinositide turnover and prostaglandin F-2α secretion in sheep. J Reprod Fertil 78:457-467, 1987.
48. Bouvier C, Lagace G, Collu R. G protein modulation by estrogens. Mol Cell Endocrinol 79:65-73, 1991.
49. Huslig RL, Fogwell RL, Smith WL. The proslaglandin forming cyclooxygenase of ovine uterus: Relationship to luteal function. Biol Reprod 21:589-600, 1979.
50. Flint APF, Sheldrick EL. Ovarian oxytocin and maternal recognition of pregnancy. J Reprod Fertil 76:831-839, 1986.
51. 2α during luteolysis in the ewe. Biol Reprod 45:395-403, 1991.
52. Matthews EL, Ayad VJ, Wathes DC. The effect of oestradiol-17B on oxytocin receptor concentrations in the reproductive tract of the anestrous ewe. J Reprod Fertil abstract series 8, No. 81.
53. Hazzard TM, Stormshak F. Reduction in uterine oxytocin receptors during chronic estrogen treatment of the ewe. Biol Reprod 52(Suppl 1):201, 1995.
54. Flint APF, Sheldrick EL. Continuous infusion of oxytocin prevents induction of uterine oxytocin receptor and blocks luteal regression in cyclic ewes. J Reprod Fertil 75:623-631, 1985.
55. Flint APF, Sheldrick EL. Endocrine control of uterine oxytocin receptors in the ewe. J Endocrinol 106:249-258, 1985.
56. Ayad VJ, Parkinson TJ, Matthews EL, Wild ML. Effects of pregnancy and systemic or intrauterine oxytocin infusion on the distribution of endometrial oxytocin receptors in the ewe: An autoradiographic study. J Endocrinology 137:423-431, 1993.
57. Sheldrick EL, Flick-Smith HC. Effect of ovarian hormones on oxytocin receptor concentrations in explants of uterus from ovariectomized ewes. J Reprod Fertil 97:241-245, 1993.
58. Ott TL, Zhou Y, Mirando MA, Stevens C, Harney JP, Ogle TF, Bazer FW. Changes in progesterone and oestrogen receptor mRNA and protein during maternal recognition of pregnancy and luteolysis in ewes. J Mol Endocrinol 10:171-183, 1993.
59. Koligian KB, Stormshak F. Nuclear and cytoplasmic estrogen receptors in ovine endometrium during the estrous cycle. Endocrinology 101:524-533, 1977.
60. Miller BG, Murphy L, Stone GM. Hormone receptor levels and hormone, RNA and protein metabolism in the genital tract during the estrous cycle of the ewe. J Endocrinol 73:91-98, 1977.
61. Zelinski MB. Hirota NA, Keenan EJ, Stormshak FJ. Influence of exogenous estradiol-17β on endometrial progesterone and estrogen receptors during the luteal phase of the ovine estrous cycle. Biol Reprod 23:743-751, 1980.
62. Zelinski MB, Noel P, Weber DW, Stormshak F. Characterization of cytoplasmic progesterone receptors in the bovine endometrium during proestrus and diestrus. J Anim Sci 55:376-383, 1982.
63. Ing NH, Fleming JGW, Newton GR, Bazer FW. Estrogen up-regulates expression of its receptor gene in sheep endometrium. Biol Reprod 50(Suppl 1):118, 1994.
64. Evans RW, Leavitt WW. Progesterone inhibition of uterine nuclear estrogen receptor: Dependence on RNA and protein synthesis. Proc Nat Acad Sci USA 77:5856-5860, 1980.
65. Cherny RA, Salamonsen LA, Findlay JK. Immunocytochemical localization of oestrogen receptors in the endometrium of the ewe. Reprod Fertil Dev 3:321-331, 1991.
66. Moor RM, Rowson LEA. Local maintenance of the corpus luteum in sheep with embryos transferred to various isolated portions of the uterus. J Reprod Fertil 12:539-550, 1966.
67. Moor RM, Rowson LEA. The corpus luteum of the sheep: Effect of the removal of embryos on luteal function. J Endocrinol 34:497-502, 1966.
68. Moor RM, Rowson LEA, Hay MF, Caldwell BV. The corpus luteum of the sheep: Effect of the conceptus on luteal function at several stages during pregnancy. J Endocrinol 43:301-307, 1969.
69. Casida LE, Warwick EJ. The necessity of the corpus luteum for maintenance of pregnancy in the ewe. J Anim Sci 4:34-38, 1945.
70. Denamur R, Martinet J. Effets of de l'ovariectomie chez la brebis pendant la gestation. C. R. Seanc Soc Biol 149:2105-2107, 1955.
71. Rowson LEA, Moor RM. The influence of embryonic tissue homogenate infused into the uterus on the life-span of the corpus luteum in the sheep. J Reprod Fertil 13:511-516, 1967.
72. Martal J, LaCroix MC, Lordes C, Saunier M, Winterberger-Torres S. Trophoblastin, an antiluteolytic protein present in early pregnancy in sheep. J Reprod Fertil 56:63-73, 1979.
73. Roberts RM, Cross JC, Leaman DW. Interferons as hormones of pregnancy. Endocr Rev 13:432-152, 1992.
74. Ashworth CJ, Bazer FW. Changes in ovine conceptus and endometrial function following synchronous embryo transfer and administration of progesterone. Biol Reprod 40:425-433, 1989.
75. Hansen TR, Imakawa K, Polites HG, Marotti KR, Anthony RV, Roberts RM. Interferon RNA of embryonic origin is expressed transiently during early pregnancy in the ewe. J Biol Chem 263:12801-12804, 1988.
76. Stewart HJ, McCann SHE, Northrop AJ, Lamming GE, Flint APF. Sheep antiluteolytic interferon: cDNA sequence and analysis of mRNA levels. J Mol Endocrinol 2:101-109, 1989.
77. Guillomot M, Michel C, Gaye P, Charlier N, Trojan J, Martal J. Cellular localization of an embryonic interferon, ovine trophoblastin, and its mRNA in sheep embryos during early pregnancy. Biol Cell 68:205-211, 1990.
78. Nephew KP, McClure KE, Ott TL, Bazer FW, Pope WF. Relationship between variation in conceptus development and differences in estrous cycle duration in ewes. Biol Reprod 44:536-539, 1991.
79. Pontzer CH, Torres BA, Vallet JL, Bazer FW, Johnson JM. Antiviral activity of the pregnancy recognition hormone ovine trophoblast protein-one. Biochem Biophys Res Comm 152: 801, 1988.
80. Pontzer CH, Bazer FW, Johnson HM. Antiproliferative activity of a pregnancy recognition hormone, ovine trophoblast protein-1. Cancer Res 51:5304-5309, 1991.
81. Ott TL, Van Heeke G, Johnson HM, Bazer FW. Cloning and expression in Saccharomyces cerevisiae of a synthetic gene for the Type-I trophoblast interferon ovine trophoblast protein-1. J Interferon Res 11:357-364, 1991.
82. Newton GR, Vallet JL, Hansen PJ, Bazer FW. Inhibition of lymphocyte proliferation by ovine trophoblast protein-1 and a high molecular weight glycoprotein produced by the periimplantation sheep conceptus. Am J Reprod Immunol 19:99-107, 1989.
83. Fillion C, Chaoaut G, Reinaud P, Charpigny JC, Martal J. Immunoregulatory effects of ovine trophoblastin protein (oTP): All five isoforms suppress PHA-induced lymphocyte proliferation. J Reprod Immunol 19:237, 1991.
84. Tuo WT, Ott TL, Bazer FW. Natural killer cell activity of lymphocytes exposed to ovine, Type I, trophoblast interferon. Am J Reprod Immunol 29:26-34, 1993.
85. Bazer FW, Johnson HM. Type I conceptus interferons: maternal recognition of pregnancy signals and potential therapeutic agents. Am J Reprod Immunol 26:19-27, 1991.
86. Soos JM, Subramaniam PS, Hobeika AC, Schiffenbauer J, Johnson HM. The IFN pregnancy recognition hormone IFN-τ blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity. J Immunol 155:2747-2753, 1995.
87. Subramaniam PS, Khan SA, Pontzer CH, Johnson HM. Differential recognition of the type I Interferon receptor by interferons τ and α is responsible for their disparate cytotoxicities. Proc Nat Acad Sci USA 92:12270-12274, 1995.
88. Gutterman JU. Cytokine therapeutics: lessons from interferon α. Proc Nat Acad Sci USA 91:1998-1205, 1994.
89. Ott TL, Van Heeke G, Hotstetler CE, Schalue TK, Olmsted JJ, Johnson HM, Bazer FW. Intrauterine injection of recombinant ovine interferon-tau extends the interestrous interval in sheep. Theriogenology 40:757-769, 1993.
90. 2α of cows in response to recombinant interferon-tau. J Dairy Sci 78:1921-1931, 1995.
91. Ott TL, Newton GR. Intrauterine injection of recombinant ovine interferon τ (rolFNτ) block luteolysis and extends CL lifespan in goats. Biol Reprod 48(Suppl 1):173, 1993.
92. Thatcher WW, Meyer MD, Danet-Desnoyers G. Maternal recognition of pregnancy. J Reprod Fertil Suppl 49:15-28, 1995.
93. Mirando MA, Harney JP, Zhou Y, Ogle TF, Ott TL, Moffatt RJ, Bazer FW. Changes in progesterone and oestrogen receptor mRNA and protein and oxytocin receptors in endometrium of ewes after intrauterine injection of ovine trophoblast interferon. J Mol Endocrinol 10:185-192, 1993.
94. Spencer TE, Ing NH, Ott TL, Mayes JS, Becker WC, Watson GH, Mirando MA, Bazer FW. Intrauterine injection of ovine interferon-τ (IFN-τ) alters oestrogen receptor and oxytocin receptor expression in the endometrium of cyclic ewes. J Mol Endocrinol 15:203-220, 1995.
95. Ott TL, Mirando MA, Davis MA, Bazer FW. Effects of ovine conceptus secretory protein and progesterone on oxytocin-stimulated endometrial prostaglandin production and inositol phosphate turnover in ovariectomized ewes. J Reprod Fertil 95:19-29, 1992.
96. Spencer TE, Mirando MA, Mayes JS, Watson GH, Ott TL, Bazer FW. Effects of interferon-tau and progesterone on oestrogen-stimulated expression of receptors for oestrogen, progesterone and oxytocin in the endometrium of ovariectomized ewe. Reprod Fertil Devel 8:843-853, 1996.
97. Lamming GE, Wathes DC, Flint APF, Payne JH, Stevenson KR, Vallet JL. Local action of trophoblast interferons in suppression of the development of oxytocin and oestradiol receptors in ovine endometrium. J Reprod Fertil 105:165-175, 1995.
98. Matsuyama T, Grossman A, Mittrucker H-W, Siderovski DP, Kiefer F, Kawakami T, Richardson CD, Taniguchi T, Yoshinaga SK, Mak TW. Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Nucleic Acids Res 23:2127-2136, 1995.
99. Darnell JE Jr., Kerr IM, Stark GR. JAK-STAT pathways and transcriptional activation in response to IFNs and other extra-cellular signaling proteins. Science 264:1415-1421, 1994.
100. Ott TL, Wiley AA, SpencerTE, Bartol FF, Bazer FW. Uterine expression of interferon-induced Mx in cyclic and pregnant ewes. Biol Reprod 52(Suppl 1):143, 1995.
101. Cunha GR, Bigsby RM, Cooke PS, Sugimura Y. Stromal-epithelial interactions in adult organs. Cell Differentiation 17:137-148, 1985.
102. Eley RM, Thatcher WW, Bazer FW, Fields MJ. Steroid metabolism by the bovine uterine endometrium and conceptus. Biol Reprod 28:804-816, 1983.
103. Hung TT, Gibbons WE. Evaluation of androgen antagonism of estrogen effect by dihydrotestosterone. J Steroid Biochem 19:1513-1520, 1983.
104. Fuentes MA, Muldoon TG, Mahesh VB. Inhibitory effect of 5-alpha-dihydroprogesterone on nuclear estrogen receptor binding of the anterior pituitary and uterus in the rat. Neuroendocrinology 52:213-220, 1990.
105. Rubin JS, Bottaro DP, Chedid M, Miki T, Ron D, Cheon H-G, Taylor WG, Fortney E, Sakata H, Finch PW, LaRochelle WJ. Keratinocyte growth factor. Cell Biol Int 19:399-411, 1995.
106. Alarid ET, Rubin JS, Young P, Chedid M, Ron D, Aaronson SA, Cunha GR. Keratinocyte growth factor functions in epithelial induction during seminal vesicle development. Proc Nat Acad Sci USA 91:1074-1078, 1994.
107. Cantley LG, Barros EJ, Gandhi M, Rauchmann M, Nigam SK. Regulation of mitogenesis, motogenesis and tubulogenesis by hepatocyte growth factor in renal collecting duct cells. Am J Physiol 267:F271-F280, 1994.
108. Koji T, Chedid M, Rubin JS. Slayden OD, Csaky KG, Aaronson SA, Brenner RM. Progesterone-dependent expression of keratinocyte growth factor mRNA in stromal cells of the primate endometrium: Keratinocyte growth factor as a progestomedin. J Cell Biol 125:393-401, 1994.
109. Liu SH, Bartol FF, Tuo W, Spencer TE, Bazer FW. Expression of keratinocyte growth factor mRNA in porcine endometrium. Biol Reprod 52(Suppl 1):87, 1995.
110. Vallet JL, Bazer FW, Roberts RM. The effect of ovine trophoblast protein-one on endometrial protein secretion and cyclic nucleotides. Biol Reprod 37:1307-1316, 1987.