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Volumn 68, Issue 2, 2018, Pages 763-772

Noninvasive, Quantitative Assessment of Liver Fat by MRI-PDFF as an Endpoint in NASH Trials

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

EID: 85047244319     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.29797     Document Type: Review
Times cited : (333)

References (64)
  • 2
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55:2005–2023
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5    Cusi, K.6
  • 3
    • 84976479130 scopus 로고    scopus 로고
    • Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes
    • Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73–84
    • (2016) Hepatology , vol.64 , pp. 73-84
    • Younossi, Z.M.1    Koenig, A.B.2    Abdelatif, D.3    Fazel, Y.4    Henry, L.5    Wymer, M.6
  • 4
    • 84924938800 scopus 로고    scopus 로고
    • Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies
    • Singh S, Allen AM, Wang Z, Prokop LJ, Murad MH, Loomba R. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol. 2015;13:643–654
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 643-654
    • Singh, S.1    Allen, A.M.2    Wang, Z.3    Prokop, L.J.4    Murad, M.H.5    Loomba, R.6
  • 5
    • 84923893879 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States
    • Wong RJ, Aguilar M, Cheung R, Perumpail RB, Harrison SA, Younossi ZM, et al. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology. 2015;148:547–555
    • (2015) Gastroenterology , vol.148 , pp. 547-555
    • Wong, R.J.1    Aguilar, M.2    Cheung, R.3    Perumpail, R.B.4    Harrison, S.A.5    Younossi, Z.M.6
  • 6
    • 84988462353 scopus 로고    scopus 로고
    • Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease
    • Rotman Y, Sanyal AJ. Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease. Gut. 2017; 66:180–190
    • (2017) Gut , vol.66 , pp. 180-190
    • Rotman, Y.1    Sanyal, A.J.2
  • 9
    • 84900011091 scopus 로고    scopus 로고
    • Spatial distribution of MRI-Determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease
    • Bonekamp S, Tang A, Mashhood A, Wolfson T, Changchien C, Middleton MS, et al. Spatial distribution of MRI-Determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease. J Magn Reson Imaging. 2014;39:1525–1532
    • (2014) J Magn Reson Imaging , vol.39 , pp. 1525-1532
    • Bonekamp, S.1    Tang, A.2    Mashhood, A.3    Wolfson, T.4    Changchien, C.5    Middleton, M.S.6
  • 11
    • 84888298670 scopus 로고    scopus 로고
    • Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials
    • Noureddin M, Lam J, Peterson MR, Middleton M, Hamilton G, Le TA, et al. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013;58:1930–1940
    • (2013) Hepatology , vol.58 , pp. 1930-1940
    • Noureddin, M.1    Lam, J.2    Peterson, M.R.3    Middleton, M.4    Hamilton, G.5    Le, T.A.6
  • 12
    • 84898434442 scopus 로고    scopus 로고
    • Inter-examination precision of magnitude-based MRI for estimation of segmental hepatic proton density fat fraction in obese subjects
    • Negrete LM, Middleton MS, Clark L, Wolfson T, Gamst AC, Lam J, et al. Inter-examination precision of magnitude-based MRI for estimation of segmental hepatic proton density fat fraction in obese subjects. J Magn Reson Imaging. 2014;39:1265–1271
    • (2014) J Magn Reson Imaging , vol.39 , pp. 1265-1271
    • Negrete, L.M.1    Middleton, M.S.2    Clark, L.3    Wolfson, T.4    Gamst, A.C.5    Lam, J.6
  • 14
    • 80053011699 scopus 로고    scopus 로고
    • Reproducibility of MRI-determined proton density fat fraction across two different MR scanner platforms
    • Kang GH, Cruite I, Shiehmorteza M, Wolfson T, Gamst AC, Hamilton G, et al. Reproducibility of MRI-determined proton density fat fraction across two different MR scanner platforms. J Magn Reson Imaging. 2011;34:928–934
    • (2011) J Magn Reson Imaging , vol.34 , pp. 928-934
    • Kang, G.H.1    Cruite, I.2    Shiehmorteza, M.3    Wolfson, T.4    Gamst, A.C.5    Hamilton, G.6
  • 15
    • 80052996528 scopus 로고    scopus 로고
    • Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy
    • Reeder SB, Cruite I, Hamilton G, Sirlin CB. Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging. 2011;34:729–749
    • (2011) J Magn Reson Imaging , vol.34 , pp. 729-749
    • Reeder, S.B.1    Cruite, I.2    Hamilton, G.3    Sirlin, C.B.4
  • 16
    • 34547934476 scopus 로고    scopus 로고
    • Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise
    • Liu CY, McKenzie CA, Yu H, Brittain JH, Reeder SB. Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise. Magn Reson Med. 2007;58:354–364
    • (2007) Magn Reson Med , vol.58 , pp. 354-364
    • Liu, C.Y.1    McKenzie, C.A.2    Yu, H.3    Brittain, J.H.4    Reeder, S.B.5
  • 18
    • 55749085613 scopus 로고    scopus 로고
    • Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling
    • Yu H, Shimakawa A, McKenzie CA, Brodsky E, Brittain JH, Reeder SB. Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling. Magn Reson Med. 2008;60:1122–1134
    • (2008) Magn Reson Med , vol.60 , pp. 1122-1134
    • Yu, H.1    Shimakawa, A.2    McKenzie, C.A.3    Brodsky, E.4    Brittain, J.H.5    Reeder, S.B.6
  • 20
    • 84955690545 scopus 로고    scopus 로고
    • In vivo breath-hold (1) H MRS simultaneous estimation of liver proton density fat fraction, and T1 and T2 of water and fat, with a multi-TR, multi-TE sequence
    • Hamilton G, Middleton MS, Hooker JC, Haufe WM, Forbang NI, Allison MA, et al. In vivo breath-hold (1) H MRS simultaneous estimation of liver proton density fat fraction, and T1 and T2 of water and fat, with a multi-TR, multi-TE sequence. J Magn Reson Imaging. 2015;42:1538–1543
    • (2015) J Magn Reson Imaging , vol.42 , pp. 1538-1543
    • Hamilton, G.1    Middleton, M.S.2    Hooker, J.C.3    Haufe, W.M.4    Forbang, N.I.5    Allison, M.A.6
  • 21
    • 79959539203 scopus 로고    scopus 로고
    • Combination of complex-based and magnitude-based multiecho water-fat separation for accurate quantification of fat-fraction
    • Yu H, Shimakawa A, Hines CD, McKenzie CA, Hamilton G, Sirlin CB, et al. Combination of complex-based and magnitude-based multiecho water-fat separation for accurate quantification of fat-fraction. Magn Reson Med. 2011;66:199–206
    • (2011) Magn Reson Med , vol.66 , pp. 199-206
    • Yu, H.1    Shimakawa, A.2    Hines, C.D.3    McKenzie, C.A.4    Hamilton, G.5    Sirlin, C.B.6
  • 22
    • 84857361190 scopus 로고    scopus 로고
    • Addressing phase errors in fat-water imaging using a mixed magnitude/complex fitting method
    • Hernando D, Hines CD, Yu H, Reeder SB. Addressing phase errors in fat-water imaging using a mixed magnitude/complex fitting method. Magn Reson Med. 2012;67:638–644
    • (2012) Magn Reson Med , vol.67 , pp. 638-644
    • Hernando, D.1    Hines, C.D.2    Yu, H.3    Reeder, S.B.4
  • 23
    • 84867834721 scopus 로고    scopus 로고
    • Proton density fat-fraction: a standardized MR-based biomarker of tissue fat concentration
    • Reeder SB, Hu HH, Sirlin CB. Proton density fat-fraction: a standardized MR-based biomarker of tissue fat concentration. J Magn Reson Imaging. 2012;36:1011–1014
    • (2012) J Magn Reson Imaging , vol.36 , pp. 1011-1014
    • Reeder, S.B.1    Hu, H.H.2    Sirlin, C.B.3
  • 24
    • 84945180317 scopus 로고    scopus 로고
    • Quantitative magnetic resonance imaging of hepatic steatosis: validation in ex vivo human livers
    • Bannas P, Kramer H, Hernando D, Agni R, Cunningham AM, Mandal R, et al. Quantitative magnetic resonance imaging of hepatic steatosis: validation in ex vivo human livers. Hepatology. 2015;62:1444–1455
    • (2015) Hepatology , vol.62 , pp. 1444-1455
    • Bannas, P.1    Kramer, H.2    Hernando, D.3    Agni, R.4    Cunningham, A.M.5    Mandal, R.6
  • 25
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–1321
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 26
    • 70350462793 scopus 로고    scopus 로고
    • T1 independent, T2* corrected MRI with accurate spectral modeling for quantification of fat: validation in a fat-water-SPIO phantom
    • Hines CD, Yu H, Shimakawa A, McKenzie CA, Brittain JH, Reeder SB. T1 independent, T2* corrected MRI with accurate spectral modeling for quantification of fat: validation in a fat-water-SPIO phantom. J Magn Reson Imaging. 2009;30:1215–1222
    • (2009) J Magn Reson Imaging , vol.30 , pp. 1215-1222
    • Hines, C.D.1    Yu, H.2    Shimakawa, A.3    McKenzie, C.A.4    Brittain, J.H.5    Reeder, S.B.6
  • 27
    • 84963623324 scopus 로고    scopus 로고
    • Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom
    • Hernando D, Sharma SD, Aliyari Ghasabeh M, Alvis BD, Arora SS, Hamilton G, et al. Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom. Magn Reson Med. 2017;77:1516–1524
    • (2017) Magn Reson Med , vol.77 , pp. 1516-1524
    • Hernando, D.1    Sharma, S.D.2    Aliyari Ghasabeh, M.3    Alvis, B.D.4    Arora, S.S.5    Hamilton, G.6
  • 29
    • 84858735166 scopus 로고    scopus 로고
    • Validation of MRI biomarkers of hepatic steatosis in the presence of iron overload in the ob/ob mouse
    • Hines CD, Agni R, Roen C, Rowland I, Hernando D, Bultman E, et al. Validation of MRI biomarkers of hepatic steatosis in the presence of iron overload in the ob/ob mouse. J Magn Reson Imaging. 2012;35:844–851
    • (2012) J Magn Reson Imaging , vol.35 , pp. 844-851
    • Hines, C.D.1    Agni, R.2    Roen, C.3    Rowland, I.4    Hernando, D.5    Bultman, E.6
  • 30
    • 84939255323 scopus 로고    scopus 로고
    • Reproducibility of MR-based liver fat quantification across field strength: Same-day comparison between 1.5T and 3T in obese subjects
    • Artz NS, Haufe WM, Hooker CA, Hamilton G, Wolfson T, Campos GM, et al. Reproducibility of MR-based liver fat quantification across field strength: Same-day comparison between 1.5T and 3T in obese subjects. J Magn Reson Imaging. 2015;42:811–817
    • (2015) J Magn Reson Imaging , vol.42 , pp. 811-817
    • Artz, N.S.1    Haufe, W.M.2    Hooker, C.A.3    Hamilton, G.4    Wolfson, T.5    Campos, G.M.6
  • 31
    • 84928540723 scopus 로고    scopus 로고
    • Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach: prospective validation against MR spectroscopy
    • Bashir MR, Zhong X, Nickel MD, Fananapazir G, Kannengiesser SA, Kiefer B, et al. Quantification of hepatic steatosis with a multistep adaptive fitting MRI approach: prospective validation against MR spectroscopy. AJR Am J Roentgenol. 2015;204:297–306
    • (2015) AJR Am J Roentgenol , vol.204 , pp. 297-306
    • Bashir, M.R.1    Zhong, X.2    Nickel, M.D.3    Fananapazir, G.4    Kannengiesser, S.A.5    Kiefer, B.6
  • 32
    • 84969801284 scopus 로고    scopus 로고
    • Sitagliptin vs. placebo for non-alcoholic fatty liver disease: a randomized controlled trial
    • Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R, et al. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: a randomized controlled trial. J Hepatol. 2016;65:369–376
    • (2016) J Hepatol , vol.65 , pp. 369-376
    • Cui, J.1    Philo, L.2    Nguyen, P.3    Hofflich, H.4    Hernandez, C.5    Bettencourt, R.6
  • 33
    • 79952291566 scopus 로고    scopus 로고
    • Quantification of hepatic steatosis with T1-independent, T2-corrected MR imaging with spectral modeling of fat: blinded comparison with MR spectroscopy
    • Meisamy S, Hines CD, Hamilton G, Sirlin CB, McKenzie CA, Yu H, et al. Quantification of hepatic steatosis with T1-independent, T2-corrected MR imaging with spectral modeling of fat: blinded comparison with MR spectroscopy. Radiology. 2011;258:767–775
    • (2011) Radiology , vol.258 , pp. 767-775
    • Meisamy, S.1    Hines, C.D.2    Hamilton, G.3    Sirlin, C.B.4    McKenzie, C.A.5    Yu, H.6
  • 34
    • 84892727549 scopus 로고    scopus 로고
    • Effect of flip angle on the accuracy and repeatability of hepatic proton density fat fraction estimation by complex data-based, T1-independent, T2*-corrected, spectrum-modeled MRI
    • Johnson BL, Schroeder ME, Wolfson T, Gamst AC, Hamilton G, Shiehmorteza M, et al. Effect of flip angle on the accuracy and repeatability of hepatic proton density fat fraction estimation by complex data-based, T1-independent, T2*-corrected, spectrum-modeled MRI. J Magn Reson Imaging. 2014;39:440–447
    • (2014) J Magn Reson Imaging , vol.39 , pp. 440-447
    • Johnson, B.L.1    Schroeder, M.E.2    Wolfson, T.3    Gamst, A.C.4    Hamilton, G.5    Shiehmorteza, M.6
  • 35
    • 84947488966 scopus 로고    scopus 로고
    • Hepatic fat quantification using the proton density fat fraction (PDFF): utility of free-drawn-PDFF with a large coverage area
    • Kim KY, Song JS, Kannengiesser S, Han YM. Hepatic fat quantification using the proton density fat fraction (PDFF): utility of free-drawn-PDFF with a large coverage area. Radiol Med. 2015;120:1083–1093
    • (2015) Radiol Med , vol.120 , pp. 1083-1093
    • Kim, K.Y.1    Song, J.S.2    Kannengiesser, S.3    Han, Y.M.4
  • 36
  • 37
    • 84865569519 scopus 로고    scopus 로고
    • Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial
    • Le TA, Chen J, Changchien C, Peterson MR, Kono Y, Patton H, et al. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology. 2012;56:922–932
    • (2012) Hepatology , vol.56 , pp. 922-932
    • Le, T.A.1    Chen, J.2    Changchien, C.3    Peterson, M.R.4    Kono, Y.5    Patton, H.6
  • 38
    • 84894228448 scopus 로고    scopus 로고
    • Effect of echo-sampling strategy on the accuracy of out-of-phase and in-phase multiecho gradient-echo MRI hepatic fat fraction estimation
    • Levin YS, Yokoo T, Wolfson T, Gamst AC, Collins J, Achmad EA, et al. Effect of echo-sampling strategy on the accuracy of out-of-phase and in-phase multiecho gradient-echo MRI hepatic fat fraction estimation. J Magn Reson Imaging. 2014;39:567–575
    • (2014) J Magn Reson Imaging , vol.39 , pp. 567-575
    • Levin, Y.S.1    Yokoo, T.2    Wolfson, T.3    Gamst, A.C.4    Collins, J.5    Achmad, E.A.6
  • 40
  • 41
    • 84941316225 scopus 로고    scopus 로고
    • Proton density fat-fraction is an accurate biomarker of hepatic steatosis in adolescent girls and young women
    • Rehm JL, Wolfgram PM, Hernando D, Eickhoff JC, Allen DB, Reeder SB. Proton density fat-fraction is an accurate biomarker of hepatic steatosis in adolescent girls and young women. Eur Radiol. 2015;25:2921–2930
    • (2015) Eur Radiol , vol.25 , pp. 2921-2930
    • Rehm, J.L.1    Wolfgram, P.M.2    Hernando, D.3    Eickhoff, J.C.4    Allen, D.B.5    Reeder, S.B.6
  • 42
    • 84946482679 scopus 로고    scopus 로고
    • Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults
    • Tyagi A, Yeganeh O, Levin Y, Hooker JC, Hamilton GC, Wolfson T, et al. Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults. Abdom Imaging. 2015;40:3070–3077
    • (2015) Abdom Imaging , vol.40 , pp. 3070-3077
    • Tyagi, A.1    Yeganeh, O.2    Levin, Y.3    Hooker, J.C.4    Hamilton, G.C.5    Wolfson, T.6
  • 43
    • 84945449135 scopus 로고    scopus 로고
    • Accuracy of multiecho magnitude-based MRI (M-MRI) for estimation of hepatic proton density fat fraction (PDFF) in children
    • Zand KA, Shah A, Heba E, Wolfson T, Hamilton G, Lam J, et al. Accuracy of multiecho magnitude-based MRI (M-MRI) for estimation of hepatic proton density fat fraction (PDFF) in children. J Magn Reson Imaging. 2015;42:1223–1232
    • (2015) J Magn Reson Imaging , vol.42 , pp. 1223-1232
    • Zand, K.A.1    Shah, A.2    Heba, E.3    Wolfson, T.4    Hamilton, G.5    Lam, J.6
  • 44
    • 84876907610 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis
    • Tang A, Tan J, Sun M, Hamilton G, Bydder M, Wolfson T, et al. Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis. Radiology. 2013;267:422–431
    • (2013) Radiology , vol.267 , pp. 422-431
    • Tang, A.1    Tan, J.2    Sun, M.3    Hamilton, G.4    Bydder, M.5    Wolfson, T.6
  • 45
    • 84878274416 scopus 로고    scopus 로고
    • Hepatic steatosis: quantification by proton density fat fraction with MR imaging versus liver biopsy
    • Idilman IS, Aniktar H, Idilman R, Kabacam G, Savas B, Elhan A, et al. Hepatic steatosis: quantification by proton density fat fraction with MR imaging versus liver biopsy. Radiology. 2013;267:767–775
    • (2013) Radiology , vol.267 , pp. 767-775
    • Idilman, I.S.1    Aniktar, H.2    Idilman, R.3    Kabacam, G.4    Savas, B.5    Elhan, A.6
  • 46
    • 85027925485 scopus 로고    scopus 로고
    • Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease—MRI accurately quantifies hepatic steatosis in NAFLD
    • Permutt Z, Le TA, Peterson MR, Seki E, Brenner DA, Sirlin C, et al. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease—MRI accurately quantifies hepatic steatosis in NAFLD. Aliment Pharmacol Ther. 2012;36:22–29
    • (2012) Aliment Pharmacol Ther , vol.36 , pp. 22-29
    • Permutt, Z.1    Le, T.A.2    Peterson, M.R.3    Seki, E.4    Brenner, D.A.5    Sirlin, C.6
  • 47
    • 84995360076 scopus 로고    scopus 로고
    • MRI and MRE for non-invasive quantitative assessment of hepatic steatosis and fibrosis in NAFLD and NASH: clinical trials to clinical practice
    • Dulai PS, Sirlin CB, Loomba R. MRI and MRE for non-invasive quantitative assessment of hepatic steatosis and fibrosis in NAFLD and NASH: clinical trials to clinical practice. J Hepatol. 2016;65:1006–1016
    • (2016) J Hepatol , vol.65 , pp. 1006-1016
    • Dulai, P.S.1    Sirlin, C.B.2    Loomba, R.3
  • 48
    • 85028090816 scopus 로고    scopus 로고
    • Agreement between magnetic resonance imaging proton density fat fraction measurements and pathologist-assigned steatosis grades of liver biopsies from adults with nonalcoholic steatohepatitis
    • Middleton MS, Heba ER, Hooker CA, Bashir MR, Fowler KJ, Sandrasegaran K, et al. Agreement between magnetic resonance imaging proton density fat fraction measurements and pathologist-assigned steatosis grades of liver biopsies from adults with nonalcoholic steatohepatitis. Gastroenterology. 2017;153:753–761
    • (2017) Gastroenterology , vol.153 , pp. 753-761
    • Middleton, M.S.1    Heba, E.R.2    Hooker, C.A.3    Bashir, M.R.4    Fowler, K.J.5    Sandrasegaran, K.6
  • 49
    • 84925339397 scopus 로고    scopus 로고
    • Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial)
    • Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, et al. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology. 2015;61:1239–1250
    • (2015) Hepatology , vol.61 , pp. 1239-1250
    • Loomba, R.1    Sirlin, C.B.2    Ang, B.3    Bettencourt, R.4    Jain, R.5    Salotti, J.6
  • 50
    • 64949095273 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T
    • Yokoo T, Bydder M, Hamilton G, Middleton MS, Gamst AC, Wolfson T, et al. Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T. Radiology. 2009;251:67–76
    • (2009) Radiology , vol.251 , pp. 67-76
    • Yokoo, T.1    Bydder, M.2    Hamilton, G.3    Middleton, M.S.4    Gamst, A.C.5    Wolfson, T.6
  • 51
    • 84896918649 scopus 로고    scopus 로고
    • Natural history of hepatic steatosis: observed outcomes for subsequent liver and cardiovascular complications
    • Pickhardt PJ, Hahn L, Munoz del Rio A, Park SH, Reeder SB, Said A. Natural history of hepatic steatosis: observed outcomes for subsequent liver and cardiovascular complications. AJR Am J Roentgenol. 2014;202:752–758
    • (2014) AJR Am J Roentgenol , vol.202 , pp. 752-758
    • Pickhardt, P.J.1    Hahn, L.2    Munoz del Rio, A.3    Park, S.H.4    Reeder, S.B.5    Said, A.6
  • 52
    • 84985991705 scopus 로고    scopus 로고
    • Macrovesicular steatosis in living related liver donors: correlation of biopsy findings with CT liver attenuation index and body mass index
    • Jehangir M, Nazir R, Jang A, Rana A, Rafique S, Dar FS. Macrovesicular steatosis in living related liver donors: correlation of biopsy findings with CT liver attenuation index and body mass index. Clin Transplant. 2016;30:1016–1020
    • (2016) Clin Transplant , vol.30 , pp. 1016-1020
    • Jehangir, M.1    Nazir, R.2    Jang, A.3    Rana, A.4    Rafique, S.5    Dar, F.S.6
  • 53
    • 85007372640 scopus 로고    scopus 로고
    • Accuracy of liver fat quantification with advanced CT, MRI, and ultrasound techniques: prospective comparison with MR spectroscopy
    • Kramer H, Pickhardt PJ, Kliewer MA, Hernando D, Chen GH, Zagzebski JA, et al. Accuracy of liver fat quantification with advanced CT, MRI, and ultrasound techniques: prospective comparison with MR spectroscopy. AJR Am J Roentgenol. 2017;208:92–100
    • (2017) AJR Am J Roentgenol , vol.208 , pp. 92-100
    • Kramer, H.1    Pickhardt, P.J.2    Kliewer, M.A.3    Hernando, D.4    Chen, G.H.5    Zagzebski, J.A.6
  • 54
    • 84921785945 scopus 로고    scopus 로고
    • Accuracy of MR imaging-estimated proton density fat fraction for classification of dichotomized histologic steatosis grades in nonalcoholic fatty liver disease
    • Tang A, Desai A, Hamilton G, Wolfson T, Gamst A, Lam J, et al. Accuracy of MR imaging-estimated proton density fat fraction for classification of dichotomized histologic steatosis grades in nonalcoholic fatty liver disease. Radiology. 2015;274:416–425
    • (2015) Radiology , vol.274 , pp. 416-425
    • Tang, A.1    Desai, A.2    Hamilton, G.3    Wolfson, T.4    Gamst, A.5    Lam, J.6
  • 55
    • 84931574623 scopus 로고    scopus 로고
    • Noninvasive diagnosis of nonalcoholic fatty liver disease and quantification of liver fat using a new quantitative ultrasound technique
    • Lin SC, Heba E, Wolfson T, Ang B, Gamst A, Han A, et al. Noninvasive diagnosis of nonalcoholic fatty liver disease and quantification of liver fat using a new quantitative ultrasound technique. Clin Gastroenterol Hepatol. 2015;13:1337–1345
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 1337-1345
    • Lin, S.C.1    Heba, E.2    Wolfson, T.3    Ang, B.4    Gamst, A.5    Han, A.6
  • 56
    • 77958154016 scopus 로고    scopus 로고
    • Controlled attenuation parameter (CAP): a novel VCTE guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: preliminary study and validation in a cohort of patients with chronic liver disease from various causes
    • Sasso M, Beaugrand M, de Ledinghen V, Douvin C, Marcellin P, Poupon R, et al. Controlled attenuation parameter (CAP): a novel VCTE guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: preliminary study and validation in a cohort of patients with chronic liver disease from various causes. Ultrasound Med Biol. 2010;36:1825–1835
    • (2010) Ultrasound Med Biol , vol.36 , pp. 1825-1835
    • Sasso, M.1    Beaugrand, M.2    de Ledinghen, V.3    Douvin, C.4    Marcellin, P.5    Poupon, R.6
  • 57
    • 84898640575 scopus 로고    scopus 로고
    • Non-invasive assessment of hepatic steatosis in patients with NAFLD using controlled attenuation parameter and 1H-MR spectroscopy
    • Karlas T, Petroff D, Garnov N, Bohm S, Tenckhoff H, Wittekind C, et al. Non-invasive assessment of hepatic steatosis in patients with NAFLD using controlled attenuation parameter and 1H-MR spectroscopy. PLoS One. 2014;9:e91987
    • (2014) PLoS One , vol.9
    • Karlas, T.1    Petroff, D.2    Garnov, N.3    Bohm, S.4    Tenckhoff, H.5    Wittekind, C.6
  • 58
    • 85042148368 scopus 로고    scopus 로고
    • Optimal threshold of controlled attenuation parameter with MRI-PDFF as the gold standard for the detection of hepatic steatosis
    • Caussy C, Alquiraish MH, Nguyen P, Hernandez C, Cepin S, Fortney LE, et al. Optimal threshold of controlled attenuation parameter with MRI-PDFF as the gold standard for the detection of hepatic steatosis. Hepatology. 2017;. https://doi.org/10.1002/hep.29639
    • (2017) Hepatology
    • Caussy, C.1    Alquiraish, M.H.2    Nguyen, P.3    Hernandez, C.4    Cepin, S.5    Fortney, L.E.6
  • 59
    • 84898827951 scopus 로고    scopus 로고
    • Controlled attenuation parameter (CAP) for the diagnosis of steatosis: a prospective study of 5323 examinations
    • de Ledinghen V, Vergniol J, Capdepont M, Chermak F, Hiriart JB, Cassinotto C, et al. Controlled attenuation parameter (CAP) for the diagnosis of steatosis: a prospective study of 5323 examinations. J Hepatol. 2014;60:1026–1031
    • (2014) J Hepatol , vol.60 , pp. 1026-1031
    • de Ledinghen, V.1    Vergniol, J.2    Capdepont, M.3    Chermak, F.4    Hiriart, J.B.5    Cassinotto, C.6
  • 60
    • 85010743428 scopus 로고    scopus 로고
    • Magnetic resonance elastography vs transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease
    • Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, et al. Magnetic resonance elastography vs transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease. Gastroenterology. 2017;152:598–607
    • (2017) Gastroenterology , vol.152 , pp. 598-607
    • Park, C.C.1    Nguyen, P.2    Hernandez, C.3    Bettencourt, R.4    Ramirez, K.5    Fortney, L.6
  • 61
    • 79953246982 scopus 로고    scopus 로고
    • T(1) independent, T(2) (*) corrected chemical shift based fat-water separation with multi-peak fat spectral modeling is an accurate and precise measure of hepatic steatosis
    • Hines CD, Frydrychowicz A, Hamilton G, Tudorascu DL, Vigen KK, Yu H, et al. T(1) independent, T(2) (*) corrected chemical shift based fat-water separation with multi-peak fat spectral modeling is an accurate and precise measure of hepatic steatosis. J Magn Reson Imaging. 2011;33:873–881
    • (2011) J Magn Reson Imaging , vol.33 , pp. 873-881
    • Hines, C.D.1    Frydrychowicz, A.2    Hamilton, G.3    Tudorascu, D.L.4    Vigen, K.K.5    Yu, H.6
  • 62
    • 84945492791 scopus 로고    scopus 로고
    • Interexamination repeatability and spatial heterogeneity of liver iron and fat quantification using MRI-based multistep adaptive fitting algorithm
    • Sofue K, Mileto A, Dale BM, Zhong X, Bashir MR. Interexamination repeatability and spatial heterogeneity of liver iron and fat quantification using MRI-based multistep adaptive fitting algorithm. J Magn Reson Imaging. 2015;42:1281–1290
    • (2015) J Magn Reson Imaging , vol.42 , pp. 1281-1290
    • Sofue, K.1    Mileto, A.2    Dale, B.M.3    Zhong, X.4    Bashir, M.R.5
  • 64
    • 84981267545 scopus 로고    scopus 로고
    • Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis
    • Patel J, Bettencourt R, Cui J, Salotti J, Hooker J, Bhatt A, et al. Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis. Therap Adv Gastroenterol. 2016;9:692–701
    • (2016) Therap Adv Gastroenterol , vol.9 , pp. 692-701
    • Patel, J.1    Bettencourt, R.2    Cui, J.3    Salotti, J.4    Hooker, J.5    Bhatt, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.