Slug (SNAI2) expression in oral SCC cells results in altered cell-cell adhesion and increased motility

Cell Adhesion and Migration

Volumn 5, Issue 4, 2011, Pages

  Katafiasz, Dawn ^a   Smith, Lynette M ^b   Wahl III, James K ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Cadherin; Cell motility; Cell cell adhesion; Microarray; Slug (SNAI2)

Indexed keywords

CADHERIN; TRANSCRIPTION FACTOR SLUG; ZINC FINGER PROTEIN; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR; TUMOR MARKER;

ARTICLE; CANCER CELL CULTURE; CANCER RECURRENCE; CELL ADHESION; CELL JUNCTION; CELL MOTILITY; CONTROLLED STUDY; DESMOSOME; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE OVEREXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MOUTH CARCINOMA; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; CELL MOTION; DNA MICROARRAY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HEAD AND NECK TUMOR; METABOLISM; PATHOLOGY; RETROVIRUS; TUMOR CELL LINE;

GASTROPODA;

CARCINOMA, SQUAMOUS CELL; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; DESMOSOMES; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HEAD AND NECK NEOPLASMS; HUMANS; MICROSCOPY, FLUORESCENCE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RETROVIRIDAE; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR MARKERS, BIOLOGICAL;

EID: 85046979989     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.5.4.17040     Document Type: Article

References (41)

1. De Craene B, van Roy F, Berx G. Unraveling signalling cascades for the Snail family of transcription factors. Cell Signal 2005; 17:535-547 (Pubitemid 40430957)
2. Shirley SH, Hudson LG, He J, Kusewitt DF. The skinny on Slug. Mol Carcinog 2010; 49:851-861
3. Barrallo-Gimeno A, Nieto MA. Evolutionary history of the Snail/Scratch superfamily. Trends Genet 2009; 25:248-252
4. Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 2002; 3:155-166
5. Parent AE, Newkirk KM, Kusewitt DF. Slug (Snai2) expression during skin and hair follicle development. J Invest Dermatol 2010; 130:1737-1739
6. Murray SA, Oram KF, Gridley T. Multiple functions of Snail family genes during palate development in mice. Development 2007; 134:1789-1797 (Pubitemid 46796575)
7. Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007; 7:415-428 (Pubitemid 46809165)
8. Singh A, Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010; 29:4741-4751
9. Brandl M, Seidler B, Haller F, Adamski J, Schmid RM, Saur D, et al. IKK(alpha) controls canonical TGF(ss)- SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells. J Cell Sci 2010; 123:4231-4239
10. Barrallo-Gimeno A, Nieto MA. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 2005; 132:3151-3161 (Pubitemid 41167144)
11. Ginos MA, Page GP, Michalowicz BS, Patel KJ, Volker SE, Pambuccian SE, et al. Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res 2004; 64:55-63. (Pubitemid 38114082)
12. Baker SR. An in vivo model for squamous cell carcinoma of the head and neck. Laryngoscope 1985; 95:43-56. (Pubitemid 15153043)
13. Sobolik-Delmaire T, Katafiasz D, Keim SA, Mahoney MG, Wahl JK, 3rd. Decreased plakophilin-1 expression promotes increased motility in head and neck squamous cell carcinoma cells. Cell Commun Adhes 2007; 14:99-109.
14. Vernon AE, LaBonne C. Tumor metastasis: a new twist on epithelial-mesenchymal transitions. Curr Biol 2004; 14:719-721
15. Wang SP, Wang WL, Chang YL, Wu CT, Chao YC, Kao SH, et al. p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. Nat Cell Biol 2009; 11:694-704.
16. Maeda M, Johnson E, Mandal SH, Lawson KR, Keim SA, Svoboda RA, et al. Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn). Oncogene 2006; 25:4595-4604 (Pubitemid 44175118)
17. Sobolik-Delmaire T, Katafiasz D, Keim SA, Mahoney MG, Wahl JK, 3rd. Decreased plakophilin-1 expression promotes increased motility in head and neck squamous cell carcinoma cells. Cell Commun Adhes 2007; 14:99-109. (Pubitemid 47209086)
18. Savagner P, Yamada KM, Thiery JP. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelialmesenchymal transition. J Cell Biol 1997; 137:1403-1419 (Pubitemid 27265951)
19. Yanagisawa M, Huveldt D, Kreinest P, Lohse CM, Cheville JC, Parker AS, et al. A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion and predicts metastatic disease. J Biol Chem 2008; 283:18344-18354
20. Kusewitt DF, Choi C, Newkirk KM, Leroy P, Li Y, Chavez MG, et al. Slug/Snai2 is a downstream mediator of epidermal growth factor receptor-stimulated reepithelialization. J Invest Dermatol 2009; 129:491-495
21. Thiery JP, Chopin D. Epithelial cell plasticity in development and tumor progression. Cancer Metastasis Rev 1999; 18:31-42. (Pubitemid 29411090)
22. Bair EL, Massey CP, Tran NL, Borchers AH, Heimark RL, Cress AE, et al. Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts. Exp Cell Res 2001; 270:259-267 (Pubitemid 33030164)
23. Jaggi M, Wheelock MJ, Johnson KR. Differential displacement of classical cadherins by VE-cadherin. Cell Commun Adhes 2002; 9:103-115 (Pubitemid 36032978)
24. Bolos V, Peinado H, Perez-Moreno MA, Fraga MF, Esteller M, Cano A. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 2003; 116:499-511. (Pubitemid 36231290)
25. Mo YY, Reynolds AB. Identification of murine p120 isoforms and heterogeneous expression of p120cas isoforms in human tumor cell lines. Cancer Res 1996; 56:2633-2640
26. Keirsebilck A, Bonne S, Staes K, van Hengel J, Nollet F, Reynolds A, et al. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. Genomics 1998; 50:129-146 (Pubitemid 28303508)
27. Warzecha CC, Sato TK, Nabet B, Hogenesch JB, Carstens RP. ESRP1 and ESRP2 are epithelial cell-typespecific regulators of FGFR2 splicing. Mol Cell 2009; 33:591-601.
28. Prunier C, Howe PH. Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). J Biol Chem 2005; 280:17540-17548 (Pubitemid 41389228)
29. Peinado H, Del Carmen Iglesias-de la Cruz M, Olmeda D, Csiszar K, Fong KS, Vega S, et al. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J 2005; 24:3446-3458 (Pubitemid 41486782)
30. Wilanowski T, Caddy J, Ting SB, Hislop NR, Cerruti L, Auden A, et al. Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J 2008; 27:886-897 (Pubitemid 351417170)
31. Ireton RC, Davis MA, van Hengel J, Mariner DJ, Barnes K, Thoreson MA, et al. A novel role for p120 catenin in E-cadherin function. J Cell Biol 2002; 159:465-476 (Pubitemid 35332833)
32. Islam S, Carey TE, Wolf GT, Wheelock MJ, Johnson KR. Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion. J Cell Biol 1996; 135:1643-1654 (Pubitemid 26427658)
33. Sacco PA, McGranahan TM, Wheelock MJ, Johnson KR. Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem 1995; 270:20201-20206
34. Wahl JK, 3rd. Generation of monoclonal antibodies specific for desmoglein family members. Hybrid Hybridomics 2002; 21:37-44.
35. Wahl JK, Sacco PA, McGranahan-Sadler TM, Sauppe LM, Wheelock MJ, Johnson KR. Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains. J Cell Sci 1996; 109:1143-1154 (Pubitemid 26168265)
36. Johnson KR, Lewis JE, Li D, Wahl J, Soler AP, Knudsen KA, et al. P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res 1993; 207:252-260 (Pubitemid 23246796)
37. Narayana N, Gist J, Smith T, Tylka D, Trogdon G, Wahl JK. Desmosomal component expression in normal, dysplastic and oral squamous cell carcinoma. Dermatol Res Pract 2010; 2010:649731.
38. Sobolik-Delmaire T, Reddy R, Pashaj A, Roberts BJ, Wahl JKI. Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA. J Invest Dermatol 2010; 130:2638-2646
39. Nieman MT, Prudoff RS, Johnson KR, Wheelock MJ. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 1999; 147:631-644
40. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 2003; 31:15.
41. Klipper-Aurbach Y, Wasserman M, Braunspiegel- Weintrob N, Borstein D, Peleg S, Assa S, et al. Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus. Med Hypotheses 1995; 45:486-490