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Volumn 32, Issue 2, 2018, Pages 213-222

Do the SGLT-2 Inhibitors Offer More than Hypoglycemic Activity?

Author keywords

Cardiac magnetic resonance; Cardiovascular diseases; Empagliflozin; Heart failure; SGLT 2 receptor inhibitors; Type 2 diabetes mellitus

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; INSULIN; KETONE BODY; METFORMIN; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN; SULFONYLUREA DERIVATIVE; BIOLOGICAL MARKER;

EID: 85045736351     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-018-6786-x     Document Type: Review
Times cited : (43)

References (61)
  • 3
    • 85015871607 scopus 로고    scopus 로고
    • Management of type 2 diabetes in 2017
    • PID: 28249081
    • Reusch JEB, Manson JE. Management of type 2 diabetes in 2017. JAMA. 2017;317:1015–6.
    • (2017) JAMA , vol.317 , pp. 1015-1016
    • Reusch, J.E.B.1    Manson, J.E.2
  • 4
    • 33845338724 scopus 로고    scopus 로고
    • Projections of global mortality and burden of disease from 2002 to 2030
    • Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3:2011–30.
    • (2006) PLoS Med , vol.3 , pp. 2011-2030
    • Mathers, C.D.1    Loncar, D.2
  • 5
    • 85016923678 scopus 로고    scopus 로고
    • New oral hypoglycemic agents and cardiovascular risk. Crossing the metabolic border
    • PID: 27687335
    • Dalama B, Mesa J. New oral hypoglycemic agents and cardiovascular risk. Crossing the metabolic border. Rev Esp Cardiol. 2016;69(11):1088–97.
    • (2016) Rev Esp Cardiol , vol.69 , Issue.11 , pp. 1088-1097
    • Dalama, B.1    Mesa, J.2
  • 6
    • 64649104158 scopus 로고    scopus 로고
    • From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus
    • PID: 19336687
    • Defronzo RA. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58:773–95.
    • (2009) Diabetes , vol.58 , pp. 773-795
    • Defronzo, R.A.1
  • 7
    • 84886689057 scopus 로고    scopus 로고
    • Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes
    • PID: 23882037
    • DeFronzo RA, Eldor R, Abdul-Ghani M. Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes. Diabetes Care. 2013;36:S127–38.
    • (2013) Diabetes Care , vol.36 , pp. S127-S138
    • DeFronzo, R.A.1    Eldor, R.2    Abdul-Ghani, M.3
  • 8
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837–53.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 9
    • 0034628425 scopus 로고    scopus 로고
    • Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N Engl J Med. 2000;342:381–9.
    • (2000) N Engl J Med , vol.342 , pp. 381-389
  • 10
    • 85016021198 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibition: cardioprotection by treating diabetes-a translational viewpoint explaining its potential salutary effects
    • PID: 27533948
    • de Leeuw AE, de Boer RA. Sodium-glucose cotransporter 2 inhibition: cardioprotection by treating diabetes-a translational viewpoint explaining its potential salutary effects. Eur Heart J Cardiovasc Pharmacother. 2016;2(4):244–55.
    • (2016) Eur Heart J Cardiovasc Pharmacother , vol.2 , Issue.4 , pp. 244-255
    • de Leeuw, A.E.1    de Boer, R.A.2
  • 11
    • 84938559248 scopus 로고    scopus 로고
    • Delay in treatment intensification increases the risk of cardiovascular events in patients with type 2 diabetes
    • PID: 26249018
    • Paul SK, Klein K, Thorsted BL, Wolden ML, Khunti K. Delay in treatment intensification increases the risk of cardiovascular events in patients with type 2 diabetes. Cardiovasc Diabetol. 2015;14:100.
    • (2015) Cardiovasc Diabetol , vol.14
    • Paul, S.K.1    Klein, K.2    Thorsted, B.L.3    Wolden, M.L.4    Khunti, K.5
  • 12
    • 53749091595 scopus 로고    scopus 로고
    • Long-term follow-up of intensive glucose control in type 2 diabetes
    • PID: 18784091
    • Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HAW. Long-term follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359(15):1565–76.
    • (2008) N Engl J Med , vol.359 , Issue.15 , pp. 1565-1576
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3    Matthews, D.R.4    Neil, H.A.W.5
  • 13
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in type 2 diabetes
    • Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein H, Miller M, Byington R, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358(24):2545–59.
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2545-2559
    • Gerstein, H.1    Miller, M.2    Byington, R.3
  • 14
    • 84964703072 scopus 로고    scopus 로고
    • Evaluating the cardiovascular safety of new medications for type 2 diabetes: time to reassess?
    • PID: 27208377, May
    • Smith RJ, Goldfine AB, Hiatt WR. Evaluating the cardiovascular safety of new medications for type 2 diabetes: time to reassess? Diabetes Care. 2016 May;39(5):738–42.
    • (2016) Diabetes Care , vol.39 , Issue.5 , pp. 738-742
    • Smith, R.J.1    Goldfine, A.B.2    Hiatt, W.R.3
  • 15
    • 84873733300 scopus 로고    scopus 로고
    • Metformin: an old but still the best treatment for type 2 diabetes
    • PID: 23415113
    • Rojas LB, Gomes MB. Metformin: an old but still the best treatment for type 2 diabetes. Diabetol Metab Syndr. 2013;5(1):6.
    • (2013) Diabetol Metab Syndr , vol.5 , Issue.1 , pp. 6
    • Rojas, L.B.1    Gomes, M.B.2
  • 16
    • 85009168575 scopus 로고    scopus 로고
    • 8. Pharmacologic approaches to glycemic treatment
    • Stoll BJ, et al. 8. Pharmacologic approaches to glycemic treatment. Diabetes Care. 2017;40:S64–74.
    • (2017) Diabetes Care , vol.40 , pp. S64-S74
    • Stoll, B.J.1
  • 17
    • 84996565592 scopus 로고    scopus 로고
    • Strategies for diabetes management: using newer oral combination therapies early in the disease
    • PID: 27796904
    • Zonszein J, Groop PH. Strategies for diabetes management: using newer oral combination therapies early in the disease. Diabetes Ther. 2016;7(4):621–39.
    • (2016) Diabetes Ther , vol.7 , Issue.4 , pp. 621-639
    • Zonszein, J.1    Groop, P.H.2
  • 18
    • 84976260652 scopus 로고    scopus 로고
    • Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus
    • PID: 27339889, Oct
    • Tahrani AA, Barnett AH, Bailey CJ. Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus. Nat Rev Endocrinol. 2016 Oct;12(10):566–92.
    • (2016) Nat Rev Endocrinol , vol.12 , Issue.10 , pp. 566-592
    • Tahrani, A.A.1    Barnett, A.H.2    Bailey, C.J.3
  • 19
    • 84987618026 scopus 로고    scopus 로고
    • Management of type 2 diabetes: the current situation and key opportunities to improve care in the UK
    • PID: 27491724
    • Bain SC, Feher M, Russell-Jones D, Khunti K. Management of type 2 diabetes: the current situation and key opportunities to improve care in the UK. Diabetes Obes Metab. 2016;18(12):1157–66.
    • (2016) Diabetes Obes Metab , vol.18 , Issue.12 , pp. 1157-1166
    • Bain, S.C.1    Feher, M.2    Russell-Jones, D.3    Khunti, K.4
  • 20
    • 77955285732 scopus 로고    scopus 로고
    • Rosiglitazone revisited: Un updated meta-analysis of risk for myocardial infarction and cardiovascular mortality
    • Nissen SE, Wolski K. Rosiglitazone revisited: un updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch Intern Med 2010;170914:1191–1201.
    • (2010) Arch Intern Med , pp. 1191-1201
    • Nissen, S.E.1    Wolski, K.2
  • 21
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): A randomised controlled trial
    • Dormandy JA, Charbonnel B, Eckland DJ, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005;366:1279-89.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3
  • 22
    • 0242332284 scopus 로고    scopus 로고
    • Use of thiazolidinediones and risk of heart failure in people with type 2 diabetes: a retrospective cohort study
    • PID: 14578227
    • Delea TE, Edelsberg JS, Hagiwara M, Oster G, Philips LS. Use of thiazolidinediones and risk of heart failure in people with type 2 diabetes: a retrospective cohort study. Diabetes Care. 2003;26(11):2983–9.
    • (2003) Diabetes Care , vol.26 , Issue.11 , pp. 2983-2989
    • Delea, T.E.1    Edelsberg, J.S.2    Hagiwara, M.3    Oster, G.4    Philips, L.S.5
  • 23
    • 85019611136 scopus 로고    scopus 로고
    • Novel diabetes drugs and the cardiovascular specialist
    • PID: 28545639
    • Sattar N, Petrie MC, Zinman B, Januzzi JL. Novel diabetes drugs and the cardiovascular specialist. J Am Coll Cardiol. 2017;69(21):2646–56.
    • (2017) J Am Coll Cardiol , vol.69 , Issue.21 , pp. 2646-2656
    • Sattar, N.1    Petrie, M.C.2    Zinman, B.3    Januzzi, J.L.4
  • 24
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a posiion statement of the american diabetes association and the european association for the study of diabetes
    • PID: 25538310
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a posiion statement of the american diabetes association and the european association for the study of diabetes. Diabetes Care. 2015;38(1):140–9.
    • (2015) Diabetes Care , vol.38 , Issue.1 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 25
    • 84890568491 scopus 로고    scopus 로고
    • Efficacy and safety of dipeptidyl peptidase-4 inhibitors and metformin as initial combination therapy and as monotherapy in patients with type 2 diabetes mellitus: a meta-analysis
    • PID: 23803146
    • Wu D, Li L, Liu C. Efficacy and safety of dipeptidyl peptidase-4 inhibitors and metformin as initial combination therapy and as monotherapy in patients with type 2 diabetes mellitus: a meta-analysis. Diabetes Obes Metab. 2014;16(1):30–7.
    • (2014) Diabetes Obes Metab , vol.16 , Issue.1 , pp. 30-37
    • Wu, D.1    Li, L.2    Liu, C.3
  • 26
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013;369:1317-26.
    • (2013) N Engl J Med , vol.369 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 29
    • 84904007147 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and cardiovascular outcomes: meta-analysis of randomized clinical
    • PID: 24750644
    • Wu S, Hopper I, Skiba M, Krum H. Dipeptidyl peptidase-4 inhibitors and cardiovascular outcomes: meta-analysis of randomized clinical. Cardiovasc Ther. 2014;32(4):147–58.
    • (2014) Cardiovasc Ther , vol.32 , Issue.4 , pp. 147-158
    • Wu, S.1    Hopper, I.2    Skiba, M.3    Krum, H.4
  • 31
    • 84864270406 scopus 로고    scopus 로고
    • Basal insulin and cardiovascular and other outcomes in dysglycemia
    • The ORIGIN Trial Investigators. Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med. 2012;367(4):319–28.
    • (2012) N Engl J Med , vol.367 , Issue.4 , pp. 319-328
  • 34
    • 85024835007 scopus 로고    scopus 로고
    • SGTL2 inhibitors and amputations in the US FDA Adverse Event Reporting System
    • PID: 28733172
    • Fadini GP, Avogaro A. SGTL2 inhibitors and amputations in the US FDA Adverse Event Reporting System. Lancet Diabetes Endocrinol. 2017;5(9):680–1.
    • (2017) Lancet Diabetes Endocrinol , vol.5 , Issue.9 , pp. 680-681
    • Fadini, G.P.1    Avogaro, A.2
  • 35
    • 84959871979 scopus 로고    scopus 로고
    • Review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists
    • PID: 26511102
    • Madsbad S. Review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists. Diabetes Obes Metab. 2016;18(4):317–32.
    • (2016) Diabetes Obes Metab , vol.18 , Issue.4 , pp. 317-332
    • Madsbad, S.1
  • 38
    • 85030448557 scopus 로고    scopus 로고
    • Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes
    • PID: 28910237
    • Holman RR, Bethel MA, Mentz RJ, et al. Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2017;377(13):1228–39.
    • (2017) N Engl J Med , vol.377 , Issue.13 , pp. 1228-1239
    • Holman, R.R.1    Bethel, M.A.2    Mentz, R.J.3
  • 40
    • 85044600598 scopus 로고    scopus 로고
    • Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis
    • PID: 29221659
    • Bethel M, Patel RA, Merrill P, et al. Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis. Lancet Diabetes Endocrinol. 2018;6(2):105–13.
    • (2018) Lancet Diabetes Endocrinol , vol.6 , Issue.2 , pp. 105-113
    • Bethel, M.1    Patel, R.A.2    Merrill, P.3
  • 41
    • 84864283226 scopus 로고    scopus 로고
    • SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects
    • Ferrannini E, Solini A. SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects. Nat Rev Endocrinol 2012;8:495-502.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 495-502
    • Ferrannini, E.1    Solini, A.2
  • 42
    • 35348891586 scopus 로고    scopus 로고
    • Regulatory mechanisms of Na+/glucose cotransporters in renal proximal tubule cells
    • Lee YJ, Han HJ. Regulatory mechanisms of Na+/glucose cotransporters in renal proximal tubule cells. Kidney Int Suppl. 2007;106:S27–35.
    • (2007) Kidney Int Suppl , vol.106 , pp. S27-S35
    • Lee, Y.J.1    Han, H.J.2
  • 43
    • 85019723974 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2017 a bridged for primary care providers
    • American Diabetes Association. Standards of medical care in diabetes-2017 a bridged for primary care providers. Clin Diabetes. 2017;35(1):5–26.
    • (2017) Clin Diabetes , vol.35 , Issue.1 , pp. 5-26
  • 45
    • 84935010322 scopus 로고    scopus 로고
    • SGLT2 inhibitors: The latest “New kids on the block”!
    • PID: 25715412
    • Cefalu WT, Riddle MC. SGLT2 inhibitors: The latest “New kids on the block”! Diabetes Care. 2015;38(3):352–4.
    • (2015) Diabetes Care , vol.38 , Issue.3 , pp. 352-354
    • Cefalu, W.T.1    Riddle, M.C.2
  • 46
    • 77953930901 scopus 로고    scopus 로고
    • Importance of HDL cholesterol in atherothrombosis: How did we get here? Where are we going?
    • Badimon JJ, Santos-Gallego CG, Badimon L. [Importance of HDL cholesterol in atherothrombosis: how did we get here? Where are we going?]. Rev Esp Cardiol 2010;63 Suppl 2:20–35.
    • (2010) Rev Esp Cardiol , vol.63 , pp. 20-35
    • Badimon, J.J.1    Santos-Gallego, C.G.2    Badimon, L.3
  • 47
    • 84941636048 scopus 로고    scopus 로고
    • HDL: Quality or quantity?
    • Santos-Gallego CG. HDL: Quality or quantity? Atherosclerosis 2015;243(1):121–3.
    • (2015) Atherosclerosis , vol.243 , Issue.1 , pp. 121-123
    • Santos-Gallego, C.G.1
  • 48
    • 84941677540 scopus 로고    scopus 로고
    • Dysfunction: Is the Answer in the Sphinx's Riddle?
    • Badimon JJ, Santos-Gallego CG. HDL Dysfunction: Is the Answer in the Sphinx's Riddle? J Am Coll Cardiol 2015;66(13):1486–8.
    • (2015) J am Coll Cardiol , vol.66 , Issue.13 , pp. 1486-1488
    • Badimon, J.J.1    Santos-Gallego, C.G.H.D.L.2
  • 51
    • 79955884728 scopus 로고    scopus 로고
    • Experimental models for the investigation of high-density lipoprotein-mediated cholesterol efflux
    • Santos-Gallego CG, Giannarelli C, Badimon JJ. Experimental models for the investigation of high-density lipoprotein-mediated cholesterol efflux. Curr Atheroscler Rep 2011;13(3):266–76
    • (2011) Curr Atheroscler Rep , vol.13 , Issue.3 , pp. 266-276
    • Santos-Gallego, C.G.1    Giannarelli, C.2    Badimon, J.J.3
  • 52
    • 85041180129 scopus 로고    scopus 로고
    • How does empagliflozin reduce cardiovascular mortality? Insights from a mediatin analysis of the EMPA-REG OUTCOME
    • PID: 29203583
    • Inzucchi SE, Zinman B, Fitchett D, et al. How does empagliflozin reduce cardiovascular mortality? Insights from a mediatin analysis of the EMPA-REG OUTCOME. Diabetes Care. 2018;41(2):356–63.
    • (2018) Diabetes Care , vol.41 , Issue.2 , pp. 356-363
    • Inzucchi, S.E.1    Zinman, B.2    Fitchett, D.3
  • 53
    • 0029008947 scopus 로고
    • Insulin, ketone bodies, and mitochondrial energy transduction
    • Sato K, Kashiwaya Y, Keon CA, et al. Insulin, ketone bodies, and mitochondrial energy transduction. FASEB J 1995;9:651–8.
    • (1995) FASEB J , vol.9 , pp. 651-658
    • Sato, K.1    Kashiwaya, Y.2    Keon, C.A.3
  • 54
    • 84975853831 scopus 로고    scopus 로고
    • CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis
    • Ferrannini E, Mark M, Mayoux E. CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis. Diabetes Care 2016;39:1108–14.
    • (2016) Diabetes Care , vol.39 , pp. 1108-1114
    • Ferrannini, E.1    Mark, M.2    Mayoux, E.3
  • 55
    • 84975840750 scopus 로고    scopus 로고
    • Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis
    • PID: 27289124
    • Mudaliar S, Alloju S, Henry RR. Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis. Diabetes Care. 2016;39(7):1115–22.
    • (2016) Diabetes Care , vol.39 , Issue.7 , pp. 1115-1122
    • Mudaliar, S.1    Alloju, S.2    Henry, R.R.3
  • 56
    • 85031915334 scopus 로고    scopus 로고
    • Activation and inhibition of sodium-hydrogen exchanger is a mechanism that links the pathophysiology and treatment of diabetes mellitus with that of heart failure
    • PID: 29038209
    • Packer M. Activation and inhibition of sodium-hydrogen exchanger is a mechanism that links the pathophysiology and treatment of diabetes mellitus with that of heart failure. Circulation. 2017;136(16):1548–59.
    • (2017) Circulation , vol.136 , Issue.16 , pp. 1548-1559
    • Packer, M.1
  • 57
    • 85032620814 scopus 로고    scopus 로고
    • Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure proposal of a novel mechanism of action
    • PID: 28768320
    • Packer M, Anker SD, Butler J, et al. Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure proposal of a novel mechanism of action. JAMA Cardiol. 2017;2(9):1025–9.
    • (2017) JAMA Cardiol , vol.2 , Issue.9 , pp. 1025-1029
    • Packer, M.1    Anker, S.D.2    Butler, J.3
  • 58
    • 85035777138 scopus 로고    scopus 로고
    • Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation
    • PID: 29197997
    • Uthman L, Baartscheer A, Bleijlevens B, et al. Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation. Diabetologia. 2018;61(3):722–6.
    • (2018) Diabetologia , vol.61 , Issue.3 , pp. 722-726
    • Uthman, L.1    Baartscheer, A.2    Bleijlevens, B.3
  • 59
    • 84991712516 scopus 로고    scopus 로고
    • Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of te cardiac Na+/H+ exchanger in rats and rabbits
    • PID: 27752710
    • Baartscheer A, Schumacher CA, Wüst RC, et al. Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of te cardiac Na+/H+ exchanger in rats and rabbits. Diabetologia. 2017;60(3):568–73.
    • (2017) Diabetologia , vol.60 , Issue.3 , pp. 568-573
    • Baartscheer, A.1    Schumacher, C.A.2    Wüst, R.C.3


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