Dangers and Long-Term Outcomes in Metabolically Healthy Obesity: The Impact of the Missing Fitness Component ∗

Journal of the American College of Cardiology

Volumn 71, Issue 17, 2018, Pages 1866-1868

  Deedwania, Prakash ^a   Lavie, Carl J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

cardiometabolic; cardiovascular disease; fitness; metabolic syndrome; obesity; physical activity

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT;

ADVERSE OUTCOME; BODY WEIGHT GAIN; CARDIOMETABOLIC RISK; CARDIORESPIRATORY FITNESS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RISK; DIABETES MELLITUS; DIET RESTRICTION; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; DYSLIPIDEMIA; EDITORIAL; GLYCEMIC CONTROL; HIGH RISK PATIENT; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; METABOLIC PARAMETERS; METABOLIC SYNDROME X; METABOLICALLY HEALTHY OBESITY; OBESITY; PHYSICAL ACTIVITY; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; PUBLIC HEALTH PROBLEM; RISK REDUCTION; METABOLICALLY BENIGN OBESITY; RISK FACTOR;

CARDIOVASCULAR DISEASES; HUMANS; METABOLIC SYNDROME; OBESITY; OBESITY, METABOLICALLY BENIGN; RISK FACTORS;

EID: 85045457231     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2018.02.057     Document Type: Editorial

References (18)

1. Hales, C.M., Carroll, M.D., Fryer, C.D., Ogden, C.L., Prevalence of obesity among adults and youths: United States, 2015-2016. NCHS data brief, no 288. 2017, National Center for Health Statistics, Hyattsville, MD.
2. Lavie, C.J., De Schutter, A., Parto, P., et al. Obesity and prevalence of cardiovascular diseases and prognosis—the obesity paradox updated. Prog Cardiovasc Dis 58 (2016), 537–547.
3. Lavie, C.J., Pandey, A., Lau, D.H., Alpert, M.A., Sanders, P., Obesity and atrial fibrillation prevalence, pathogenesis, and prognosis: effects of weight loss and exercise. J Am Coll Cardiol 70 (2017), 2022–2035.
4. Ortega, F.B., Lavie, C.J., Blair, S.N., Obesity and cardiovascular disease. Circ Res 118 (2016), 1752–1770.
5. Bell, J.A., Hamer, M., Batty, G.D., Singh-Manoux, A., Sabia, S., Kivimäki, M., Incidence of metabolic risk factors among healthy obese adults: 20-year follow-up. J Am Coll Cardiol 66 (2015), 871–873.
6. Caleyachetty, R., Thomas, N., Toulis, K.A., et al. Metabolically healthy obese and incident cardiovascular disease events among 3.5 million men and women. J Am Coll Cardiol 70 (2017), 1429–1437.
7. Mørkedal, B., Vatten, L.J., Romundstad, P.R., Laugsand, L.E., Janszky, I., Risk of myocardial infarction and heart failure among metabolically healthy but obese individuals: HUNT (Nord-Trøndelag Health Study), Norway. J Am Coll Cardiol 63 (2014), 1071–1078.
8. Lavie, C.J., Schutter, De, Milani, R.V., Healthy obese versus unhealthy lean: the obesity paradox. Nat Rev Endocrinol 11 (2015), 55–62.
9. Mongraw-Chaffin, M., Foster, M.C., Anderson, C.A.M., et al. Metabolically healthy obesity, transition to metabolic syndrome, and cardiovascular risk. J Am Coll Cardiol 71 (2018), 1857–1865.
10. Lavie, C.J., Milani, R.V., Cardiac rehabilitation and exercise training programs in metabolic syndrome and diabetes. J Cardiopulm Rehabil 25 (2005), 59–66.
11. Srikanth, S., Deedwania, P., Management of dyslipidemia in patients with hypertension, diabetes, and metabolic syndrome. Curr Hypertens Rep, 18, 2016, 76.
12. Ortega, F.B., Cadenas-Sanchez, C., Sui, X., Blair, S.N., Lavie, C.J., Role of fitness in the metabolically healthy but obese phenotype: a review and update. Prog Cardiovasc Dis 58 (2015), 76–86.
13. Lavie, C.J., Ortega, F.B., Kokkinos, P., Impact of physical activity and fitness in metabolically healthy obesity. J Am Coll Cardiol 71 (2018), 812–813.
14. Oktay, A.A., Lavie, C.J., Kokkinos, P.F., Parto, P., Pandey, A., Ventura, H.O., The interaction of cardiorespiratory fitness with obesity and the obesity paradox in cardiovascular disease. Prog Cardiovasc Dis 60 (2017), 30–44.
15. Kennedy, A.B., Lavie, C.J., Blair, S.N., Fitness or fatness: which is more important?. JAMA 319 (2018), 231–232.
16. Lavie, C.J., Sharma, A., Alpert, M.A., et al. Update on obesity and obesity paradox in heart failure. Prog Cardiovasc Dis 58 (2016), 393–400.
17. Roberson, L.L., Aneni, E.C., Maziak, W., et al. Beyond BMI: the “metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality–a systematic review. BMC Public Health, 14, 2014, 14.
18. Bennett, D.A., Du, H., Clarke, R., et al. Association of physical activity with risk of major cardiovascular diseases in Chinese men and women. JAMA Cardiol 2 (2017), 1349–1358.