The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

Cell

Volumn 173, Issue 5, 2018, Pages 1244-1253.e10

  Mompeán, Miguel ^a,e   Li, Wenbo ^a,f   Li, Jixi ^b,c   Laage, Ségolène ^a,g   Siemer, Ansgar B ^a,h   Bozkurt, Gunes ^c,d   Wu, Hao ^c,d   McDermott, Ann E ^a  

^a Columbia University ^*  (United States)

^b FUDAN UNIVERSITY   (China)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g Adocia   (France)

^h UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

functional amyloid; hetero amyloid; NMR structure; RHIM; RIPK1; RIPK3; signaling complex; solid state NMR; SSNMR; X ray crystallography

Indexed keywords

AMYLOID; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN KINASE 1; RECEPTOR INTERACTING PROTEIN KINASE 3; UNCLASSIFIED DRUG; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, HUMAN; RIPK3 PROTEIN, HUMAN;

APLYSIA CALIFORNICA; ARTICLE; BETA SHEET; CONTROLLED STUDY; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SOLID STATE NUCLEAR MAGNETIC RESONANCE; VALIDATION PROCESS; AMINO ACID SEQUENCE; CHEMISTRY; METABOLISM; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; AMYLOID; CRYSTALLOGRAPHY, X-RAY; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SEQUENCE ALIGNMENT;

EID: 85045427291     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2018.03.032     Document Type: Article

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