A Multicenter, Double-Blind, Phase III Clinical Trial to Evaluate the Efficacy and Safety of a Cell and Gene Therapy in Knee Osteoarthritis Patients

Human Gene Therapy Clinical Development

Volumn 29, Issue 1, 2018, Pages 48-59

  Kim, Myung Ku ^a   Ha, Chul Won ^b   In, Yong ^c   Cho, Sung Do ^d   Choi, Eui Sung ^e   Ha, Jeong Ku ^f   Lee, Ju Hong ^g   Yoo, Jae Doo ^h   Bin, Seong Il ⁱ   Choi, Choong Hyeok ^j   Kyung, Hee Soo ^k   Lee, Myung Chul ^l  

^a Inha University Hospital   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c The Catholic University of Korea College of Medicine   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

^e Chungbuk National University Hospital   (South Korea)

^f Inje University College of Medicine   (South Korea)

^g Chonbuk National University Medical School   (South Korea)

^h Ewha Womans University   (South Korea)

ⁱ University of Ulsan College of Medicine   (South Korea)

^j Hanyang University   (South Korea)

^k Kyungpook National University   (South Korea)

^l Seoul National University Hospital   (South Korea)

more..

Author keywords

gene therapy; osteoarthritis; Phase III; TissueGene C

Indexed keywords

BIOLOGICAL MARKER; C1M PROTEIN; C3M PROTEIN; CARBOXY TERMINAL TELOPEPTIDE; CARBOXY TERMINAL TELOPEPTIDE OF TYPE II COLLAGEN; CARTILAGE OLIGOMERIC MATRIX PROTEIN; PROCOLLAGEN; PROCOLLAGEN II AMINO TERMINAL PROPEPTIDE; PROTEIN; RETROVIRUS VECTOR; STROMELYSIN; TONOGENCHONCEL L; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; COLLAGEN TYPE 1;

ADULT; ARTHRALGIA; ARTICLE; ARTICULAR CARTILAGE; BLADDER CANCER; BRAIN HEMORRHAGE; CAROTID ARTERY OBSTRUCTION; CHONDROCYTE; CLAVICLE FRACTURE; CONGENITAL MALFORMATION; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DEATH; DISABILITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INTOXICATION; DRUG SAFETY; FACE FRACTURE; FEMALE; GASTROINTESTINAL DISEASE; GENE OVEREXPRESSION; HEADACHE; HUMAN; INJECTION SITE; INJECTION SITE EDEMA; INJECTION SITE PAIN; INJECTION SITE SWELLING; INJURY; JOINT SWELLING; KNEE FUNCTION; KNEE INJURY AND OSTEOARTHRITIS OUTCOME SCORE; KNEE MENISCUS RUPTURE; KNEE OSTEOARTHRITIS; KNEE PAIN; KNEE RADIOGRAPHY; LIMB FRACTURE; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; METABOLISM; MULTICENTER STUDY; MULTIPLE FRACTURE; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOLYSIS; PAIN SEVERITY; PERIPHERAL EDEMA; PHASE 3 CLINICAL TRIAL; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PRURITUS; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RECREATION; RHINOPHARYNGITIS; SALIVARY GLAND DISEASE; SIDE EFFECT; SKIN DISEASE; SPORT; SUBCUTANEOUS TISSUE; SUICIDE ATTEMPT; SYNOVIUM; UPPER LIMB; VIRAL GENE THERAPY; VISUAL ANALOG SCALE; WESTERN ONTARIO AND MCMASTER UNIVERSITIES OSTEOARTHRITIS INDEX; AGED; BLOOD; CARTILAGE; CLINICAL TRIAL; GENE THERAPY; GENETICS; MIDDLE AGED; PHYSIOLOGY; PROCEDURES; REGENERATION; URINE;

AGED; CARTILAGE; COLLAGEN TYPE I; DOUBLE-BLIND METHOD; FEMALE; GENETIC THERAPY; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; REGENERATION;

EID: 85045402130     PISSN: 23248637     EISSN: 23248645     Source Type: Journal    
DOI: 10.1089/humc.2017.249     Document Type: Article

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