Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 during Endosomal Maturation

Nucleic Acid Therapeutics

Volumn 28, Issue 2, 2018, Pages 86-96

  Miller, Colton M ^a   Wan, W Brad ^b   Seth, Punit P ^b   Harris, Edward N ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

antisense oligonucleotide; ASO; endosome escape; endosome maturation; Stabilin

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; EARLY ENDOSOME ANTIGEN 1; HYALURONIC ACID BINDING PROTEIN; PROTEIN RAB 5C; RAB PROTEIN; RAB7 PROTEIN; STABILIN RECEPTOR; UNCLASSIFIED DRUG; DOCOSAHEXAENOIC ACID; HOMING RECEPTOR; LONG UNTRANSLATED RNA; MALAT1 LONG NON-CODING RNA, HUMAN; NERVE CELL ADHESION MOLECULE; OLIGONUCLEOTIDE PHOSPHOROTHIOATE; RAB5C PROTEIN, HUMAN; STAB1 PROTEIN, HUMAN; VESICULAR TRANSPORT PROTEIN;

ARTICLE; CELL MATURATION; CELL MIGRATION; ENDOSOME; ENDOTHELIUM CELL; INTERNALIZATION; LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; SPLEEN; DRUG EFFECT; ENDOCYTOSIS; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; SYNTHESIS;

CELL ADHESION MOLECULES, NEURONAL; DOCOSAHEXAENOIC ACIDS; ENDOCYTOSIS; ENDOSOMES; HEK293 CELLS; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; RAB GTP-BINDING PROTEINS; RAB5 GTP-BINDING PROTEINS; RECEPTORS, LYMPHOCYTE HOMING; RNA, LONG NONCODING; VESICULAR TRANSPORT PROTEINS;

EID: 85045123970     PISSN: 21593337     EISSN: 21593345     Source Type: Journal    
DOI: 10.1089/nat.2017.0694     Document Type: Article

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