Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo

Cell Host and Microbe

Volumn 23, Issue 1, 2018, Pages 110-120.e7

  Yamada, Eri ^a   Nakaoka, Shinji ^b,c   Klein, Lukas ^d   Reith, Elisabeth ^d   Langer, Simon ^d   Hopfensperger, Kristina ^d   Iwami, Shingo ^c,e   Schreiber, Gideon ^f   Kirchhoff, Frank ^d   Koyanagi, Yoshio ^a   Sauter, Daniel ^d   Sato, Kei ^a,c  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY HOSPITAL ULM   (Germany)

^e KYUSHU UNIVERSITY   (Japan)

^f WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

HIV; humanized mouse; ISG; SIV; tetherin; type I interferon; Vpu

Indexed keywords

ACCESSORY VIRAL PROTEIN U; BONE MARROW STROMAL ANTIGEN 2; INTERFERON; MESSENGER RNA; TRANSCRIPTOME; UNCLASSIFIED DRUG; VIRAL PROTEIN; VIRUS RNA; BST2 PROTEIN, HUMAN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOCYTE ANTIGEN; VPU PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CONTROLLED STUDY; GAIN OF FUNCTION MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VIVO STUDY; MOUSE; MOUSE MODEL; NONHUMAN; OPEN READING FRAME; PANDEMIC; PRECURSOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T CELL DEPLETION; UPREGULATION; VIRUS LOAD; VIRUS MUTANT; VIRUS MUTATION; VIRUS REPLICATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEK293 CELL LINE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; JURKAT CELL LINE; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; VIROLOGY;

ANIMALS; ANTIGENS, CD; CELL LINE, TUMOR; GPI-LINKED PROTEINS; HEK293 CELLS; HIV INFECTIONS; HIV-1; HUMAN IMMUNODEFICIENCY VIRUS PROTEINS; HUMANS; INTERFERON TYPE I; JURKAT CELLS; MICE; MICE, INBRED NOD; NF-KAPPA B; VIRAL REGULATORY AND ACCESSORY PROTEINS; VIRUS REPLICATION;

EID: 85044783738     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2017.12.009     Document Type: Article

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