Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk

Science

Volumn 359, Issue 6383, 2018, Pages 1520-1523

  Zhang, De Liang ^a   Wu, Jian ^b   Shah, Binal N ^c   Greutélaers, Katja C ^d   Ghosh, Manik C ^a   Ollivierre, Hayden ^a   Su, Xin Zhuan ^b   Thuma, Philip E ^e   Bedu Addo, George ^f   Mockenhaupt, Frank P ^d   Gordeuk, Victor R ^c   Rouault, Tracey A ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e Malaria Research Trust   (Zambia)

^f KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

Author keywords

[No Author keywords available]

Indexed keywords

FERROPORTIN; GLUTAMINE; GLYCOPHORIN C; HEMOGLOBIN; HEPCIDIN; HISTIDINE; IRON; CATION TRANSPORT PROTEIN; METAL TRANSPORTING PROTEIN 1;

ANEMIA; CELL; HEMOGLOBIN; HEMOPARASITE; IRON; MALARIA; MUTATION; OXIDATIVE STRESS; RODENT;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOOXIDATION; BIOACCUMULATION; CELL DAMAGE; CONTROLLED STUDY; DISEASE SEVERITY; ERYTHROCYTE; ERYTHROID CELL; FEMALE; FPN GENE; GENE DELETION; GHANAIAN; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN CELL; INTRAVASCULAR HEMOLYSIS; IRON OVERLOAD; MAJOR CLINICAL STUDY; MALARIA; MALARIA CONTROL; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIMIPARA; PRIORITY JOURNAL; PROTEIN DEGRADATION; SUPPLEMENTATION; SURVIVAL RATE; AMINO ACID SUBSTITUTION; ANEMIA; ANIMAL; BLACK PERSON; BLOOD; CHILD; DRUG EFFECT; GENETIC SELECTION; GENETICS; HEMOLYSIS; KNOCKOUT MOUSE; MALE; METABOLISM; MUTATION; OXIDATIVE STRESS; RISK; ZAMBIA;

MUS;

AFRICAN CONTINENTAL ANCESTRY GROUP; AMINO ACID SUBSTITUTION; ANEMIA; ANIMALS; CATION TRANSPORT PROTEINS; CHILD; ERYTHROCYTES; FEMALE; HEMOLYSIS; HEPCIDINS; HUMANS; IRON; MALARIA; MALE; MICE; MICE, KNOCKOUT; MUTATION; OXIDATIVE STRESS; RISK; SELECTION, GENETIC; SEQUENCE DELETION; ZAMBIA;

EID: 85044621917     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aal2022     Document Type: Article

References (35)

1. A. F. Cowman, J. Healer, D. Marapana, K. Marsh, Cell 167, 610-624 (2016).
2. P. A. Sigala, J. R. Crowley, S. Hsieh, J. P. Henderson, D. E. Goldberg, J. Biol. Chem. 287, 37793-37807 (2012).
3. M. A. Clark, M. M. Goheen, C. Cerami, Front. Pharmacol. 5, 84 (2014).
4. P. F. Scholl, A. K. Tripathi, D. J. Sullivan, Curr. Top. Microbiol. Immunol. 295, 293-324 (2005).
5. A. M. Prentice, J. Nutr. 138, 2537-2541 (2008).
6. J. M. Rifkind, E. Nagababu, S. Ramasamy, L. B. Ravi, Redox Rep. 8, 234-237 (2003).
7. J. Umbreit, Am. J. Hematol. 82, 134-144 (2007).
8. T. Kanias, J. P. Acker, FEBS J. 277, 343-356 (2010).
9. S. Sazawal et al., Lancet 367, 133-143 (2006).
10. M. Gwamaka et al., Clin. Infect. Dis. 54, 1137-1144 (2012).
11. N. Spottiswoode, P. E. Duffy, H. Drakesmith, Front. Pharmacol. 5, 125 (2014).
12. D. L. Zhang, M. C. Ghosh, T. A. Rouault, Front. Pharmacol. 5, 124 (2014).
13. N. Wilkinson, K. Pantopoulos, Front. Pharmacol. 5, 176 (2014).
14. A. Donovan et al., Cell Metab. 1, 191-200 (2005).
15. H. Drakesmith, E. Nemeth, T. Ganz, Cell Metab. 22, 777-787 (2015).
16. S. Abboud, D. J. Haile, J. Biol. Chem. 275, 19906-19912 (2000).
17. E. Nemeth et al., Science 306, 2090-2093 (2004).
18. D. L. Zhang, R. M. Hughes, H. Ollivierre-Wilson, M. C. Ghosh, T. A. Rouault, Cell Metab. 9, 461-473 (2009).
19. D. L. Zhang et al., Blood 118, 2868-2877 (2011).
20. A. C. Heinrich, R. Pelanda, U. Klingmüller, Blood 104, 659-666 (2004).
21. E. N. Pesciotta et al., PLOS ONE 9, e85504 (2014).
22. D. Pospisilova et al., Haematologica 99, e118-e121 (2014).
23. Z. A. Jenkins et al., Pediatr. Hematol. Oncol. 24, 237-243 (2007).
24. R. Taniguchi et al., Nat. Commun. 6, 8545 (2015).
25. S. Aschemeyer et al., Blood 131, 899-910 (2018).
26. K. Schümann, N. W. Solomons, Food Nutr. Bull. 34, 349-356 (2013).
27. I. Kasvosve et al., Am. J. Clin. Nutr. 82, 1102-1106 (2005).
28. D. Albuquerque et al., Ann. Hum. Biol. 38, 378-381 (2011).
29. V. R. Gordeuk et al., Blood Cells Mol. Dis. 31, 299-304 (2003).
30. S. Nekhai et al., Haematologica 98, 455-463 (2013).
31. M. E. Molyneux, T. E. Taylor, J. J. Wirima, A. Borgstein, Q. J. Med. 71, 441-459 (1989).
32. P. E. Thuma et al., J. Infect. Dis. 203, 211-219 (2011).
33. M. Fried, F. Nosten, A. Brockman, B. J. Brabin, P. E. Duffy, Nature 395, 851-852 (1998).
34. M. A. Grundy, N.Gorman, P.R. Sinclair, M. J.Chorney, G. S. Gerhard, J. Biochem. Biophys. Methods 59, 195-200 (2004).
35. M. J. Murray, A. B. Murray, M. B. Murray, C. J. Murray, BMJ 2, 1113-1115 (1978).