메뉴 건너뛰기




Volumn 110, Issue , 2018, Pages 44-51

Dissecting whole-genome sequencing-based online tools for predicting resistance in Mycobacterium tuberculosis: can we use them for clinical decision guidance?

Author keywords

Multidrug resistant tuberculosis; Mykrobe predictor; PhyResSE; TB profiler; TGS TB; Whole genome sequencing

Indexed keywords

ANTIBIOTIC RESISTANCE; ARTICLE; BIOINFORMATICS; CLINICAL DECISION MAKING; COMPARATIVE STUDY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; HUMAN; MAJOR CLINICAL STUDY; MULTIDRUG RESISTANT TUBERCULOSIS; MUTAGENESIS; MYCOBACTERIUM TUBERCULOSIS; ONLINE SYSTEM; PRIORITY JOURNAL; PROMOTER REGION; SENSITIVITY AND SPECIFICITY; WHOLE GENOME SEQUENCING; BIOLOGY; COMPUTER SIMULATION; DRUG EFFECT; GENETICS; GENOTYPE; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MULTIDRUG RESISTANCE; PHENOTYPE; PREDICTIVE VALUE; PROCEDURES;

EID: 85044567113     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2018.03.009     Document Type: Article
Times cited : (34)

References (54)
  • 1
    • 84893257773 scopus 로고    scopus 로고
    • Global tuberculosis report
    • World Health Organization, Global tuberculosis report., 2017.
    • (2017)
    • World Health Organization1
  • 3
    • 84872381586 scopus 로고    scopus 로고
    • Global tuberculosis report
    • World Health Organization, Global tuberculosis report., 2015.
    • (2015)
    • World Health Organization1
  • 4
    • 84869238310 scopus 로고    scopus 로고
    • Incubation time of mycobacterial cultures: how long is long enough to issue a final negative report to the clinician?
    • Pfyffer, G.E., Wittwer, F., Incubation time of mycobacterial cultures: how long is long enough to issue a final negative report to the clinician?. J Clin Microbiol, 50, 2012, 12.
    • (2012) J Clin Microbiol , vol.50 , pp. 12
    • Pfyffer, G.E.1    Wittwer, F.2
  • 5
    • 84913525614 scopus 로고    scopus 로고
    • Companion handbook to the WHO guidelines for the programmatic management of drug-resistant tuberculosis
    • (WHO/HTM/TB/2014.11)
    • World Health Organization, Companion handbook to the WHO guidelines for the programmatic management of drug-resistant tuberculosis. 2014 (WHO/HTM/TB/2014.11).
    • (2014)
    • World Health Organization1
  • 6
    • 77956497725 scopus 로고    scopus 로고
    • Rapid molecular detection of tuberculosis and rifampin resistance
    • Boehme, C.C., Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med 11 (2010), 1005–1015.
    • (2010) N Engl J Med , vol.11 , pp. 1005-1015
    • Boehme, C.C.1
  • 7
    • 85047114781 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis and whole-genome sequencing: how close are we to unleash its full potential?
    • Satta, G., Lipman, M., Smith, G., Arnold, C., Kon, O.M., McHugh, T.D., Mycobacterium tuberculosis and whole-genome sequencing: how close are we to unleash its full potential?. Clin Microbiol Infect, 10, 2017, 1016.
    • (2017) Clin Microbiol Infect , vol.10 , pp. 1016
    • Satta, G.1    Lipman, M.2    Smith, G.3    Arnold, C.4    Kon, O.M.5    McHugh, T.D.6
  • 8
    • 85005954418 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis and whole genome sequencing: a practical guide and online tools available for the clinical microbiologist
    • Satta, G., Atzeni, A., McHugh, T.D., Mycobacterium tuberculosis and whole genome sequencing: a practical guide and online tools available for the clinical microbiologist. Clin Microbiol Infect 23 (2017), 69–72.
    • (2017) Clin Microbiol Infect , vol.23 , pp. 69-72
    • Satta, G.1    Atzeni, A.2    McHugh, T.D.3
  • 9
    • 84992199734 scopus 로고    scopus 로고
    • Bioinformatics tools and databases for whole genome sequence analysis of Mycobacterium tuberculosis
    • Faksri, K., Tan, J.H., Chaiprasert, A., Teo, Y.Y., Ong, R.T., Bioinformatics tools and databases for whole genome sequence analysis of Mycobacterium tuberculosis. Infect Genet Evol 45 (2016), 359–368.
    • (2016) Infect Genet Evol , vol.45 , pp. 359-368
    • Faksri, K.1    Tan, J.H.2    Chaiprasert, A.3    Teo, Y.Y.4    Ong, R.T.5
  • 10
    • 85038818750 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools
    • Schleusener, V., Köser, C.U., Beckert, P., Niemann, S., Feuerriegel, S., Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools. Sci Rep, 7, 2017, 46327.
    • (2017) Sci Rep , vol.7 , pp. 46327
    • Schleusener, V.1    Köser, C.U.2    Beckert, P.3    Niemann, S.4    Feuerriegel, S.5
  • 11
    • 84961629633 scopus 로고    scopus 로고
    • Whole genome sequencing of Mycobacterium tuberculosis for detection of recent transmission and tracing outbreaks: a systematic review
    • Nikolayevskyy, V., Kranzer, K., Niemann, S., Drobniewski, F., Whole genome sequencing of Mycobacterium tuberculosis for detection of recent transmission and tracing outbreaks: a systematic review. Tuberculosis 98 (2016), 77–85.
    • (2016) Tuberculosis , vol.98 , pp. 77-85
    • Nikolayevskyy, V.1    Kranzer, K.2    Niemann, S.3    Drobniewski, F.4
  • 12
    • 85017180920 scopus 로고    scopus 로고
    • Expert opinion on whole genome sequencing for public health surveillance
    • ECDC Stockholm
    • European Centre for Disease Prevention and Control, Expert opinion on whole genome sequencing for public health surveillance. 2016, ECDC, Stockholm.
    • (2016)
    • European Centre for Disease Prevention and Control1
  • 13
    • 73949101816 scopus 로고    scopus 로고
    • Mechanisms of drug resistance in Mycobacterium tuberculosis
    • Zhang, Y., Yew, W.W., Mechanisms of drug resistance in Mycobacterium tuberculosis. Int J Tubercul Lung Dis 13 (2009), 1320–1330.
    • (2009) Int J Tubercul Lung Dis , vol.13 , pp. 1320-1330
    • Zhang, Y.1    Yew, W.W.2
  • 15
    • 85040763196 scopus 로고    scopus 로고
    • Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
    • [Epub ahead of print]
    • Coll, F., Phelan, J., Hill-Cawthorne, G.A., Nair, M.B., Mallard, K., Ali, S., Abdallah, A.M., et al. Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis. Nat Genet, 2018, 10.1038/s41588-017-0029-0 [Epub ahead of print].
    • (2018) Nat Genet
    • Coll, F.1    Phelan, J.2    Hill-Cawthorne, G.A.3    Nair, M.B.4    Mallard, K.5    Ali, S.6    Abdallah, A.M.7
  • 16
    • 85009773526 scopus 로고    scopus 로고
    • Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance
    • Manson, A.L., Cohen, K.A., Abeel, T., Desjardins, C.A., Armstrong, D.T., Barry, C.E., et al. Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance. Nat Genet 49:3 (2017), 395–402, 10.1038/ng.3767.
    • (2017) Nat Genet , vol.49 , Issue.3 , pp. 395-402
    • Manson, A.L.1    Cohen, K.A.2    Abeel, T.3    Desjardins, C.A.4    Armstrong, D.T.5    Barry, C.E.6
  • 18
    • 84942192606 scopus 로고    scopus 로고
    • Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study
    • Walker, T.M., Kohl, T.A., Omar, S.V., Hedge, J., Del Ojo Elias, C., Bradley, P., et al. Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study. Lancet Infect Dis 15:10 (2015), 1193–1202.
    • (2015) Lancet Infect Dis , vol.15 , Issue.10 , pp. 1193-1202
    • Walker, T.M.1    Kohl, T.A.2    Omar, S.V.3    Hedge, J.4    Del Ojo Elias, C.5    Bradley, P.6
  • 20
    • 85044569682 scopus 로고    scopus 로고
    • PhyResSE: a web tool delineating Mycobacterium tuberculosis antibiotic resistance and lineage from whole-genome sequencing data
    • Feuerriegel, S., Schleusenerc, V., Beckerta, P., Kohla, T.A., Miotto, P., Cirillo, D.M., et al. PhyResSE: a web tool delineating Mycobacterium tuberculosis antibiotic resistance and lineage from whole-genome sequencing data. JCM, 6, 2015, 53.
    • (2015) JCM , vol.6 , pp. 53
    • Feuerriegel, S.1    Schleusenerc, V.2    Beckerta, P.3    Kohla, T.A.4    Miotto, P.5    Cirillo, D.M.6
  • 21
    • 84958967008 scopus 로고    scopus 로고
    • TGS-TB: total genotyping solution for Mycobacterium tuberculosis using short-read whole-genome sequencing
    • Sekizuka, T., Yamashita, A., Murase, Y., Iwamoto, T., Mitarai, S., Kato, S., Kuroda, M., TGS-TB: total genotyping solution for Mycobacterium tuberculosis using short-read whole-genome sequencing. PLoS One, 10(11), 2015, e0142951.
    • (2015) PLoS One , vol.10 , Issue.11 , pp. e0142951
    • Sekizuka, T.1    Yamashita, A.2    Murase, Y.3    Iwamoto, T.4    Mitarai, S.5    Kato, S.6    Kuroda, M.7
  • 22
    • 84952009484 scopus 로고    scopus 로고
    • Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis
    • Bradley, P., Gordon, N.C., Walker, T.M., Dunn, L., Heys, S., Huang, B., et al. Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis. Nature communication, 6, 2015, 10063.
    • (2015) Nature communication , vol.6 , pp. 10063
    • Bradley, P.1    Gordon, N.C.2    Walker, T.M.3    Dunn, L.4    Heys, S.5    Huang, B.6
  • 23
    • 84945587445 scopus 로고    scopus 로고
    • Mechanisms of drug resistance in Mycobacterium tuberculosis: update
    • Zhang, Y., Yew, W.W., Mechanisms of drug resistance in Mycobacterium tuberculosis: update. Int J Tubercul Lung Dis 19:11 (2015), 1276–1289.
    • (2015) Int J Tubercul Lung Dis , vol.19 , Issue.11 , pp. 1276-1289
    • Zhang, Y.1    Yew, W.W.2
  • 24
    • 84963623732 scopus 로고    scopus 로고
    • External quality assessment for tuberculosis diagnosis and drug resistance in the European union: a five year multicentre implementation study
    • Nikolayevskyy, V., Hillemann, D., Richter, E., Ahmed, N., van der Werf, M.J., Kodmon, C., et al. External quality assessment for tuberculosis diagnosis and drug resistance in the European union: a five year multicentre implementation study. PLoS One, 11(4), 2016, e0152926.
    • (2016) PLoS One , vol.11 , Issue.4 , pp. e0152926
    • Nikolayevskyy, V.1    Hillemann, D.2    Richter, E.3    Ahmed, N.4    van der Werf, M.J.5    Kodmon, C.6
  • 25
    • 84941652872 scopus 로고    scopus 로고
    • A global perspective on pyrazinamide resistance: systematic review and meta-analysis
    • Whitfield, M.G., Soeters, H.M., Warren, R.M., York, T., Sampson, S.L., Streicher, E.M., et al. A global perspective on pyrazinamide resistance: systematic review and meta-analysis. PLoS One, 10(7), 2015, e0133869.
    • (2015) PLoS One , vol.10 , Issue.7 , pp. e0133869
    • Whitfield, M.G.1    Soeters, H.M.2    Warren, R.M.3    York, T.4    Sampson, S.L.5    Streicher, E.M.6
  • 26
    • 85027864391 scopus 로고    scopus 로고
    • Whole genome sequencing of clinical strains of Mycobacetrium tuberculosis from Mumbai, India: a potential tool for determining drug-resistance and strain lineage
    • Chatterjee, A., Nilgiriwala, Saranath, D., Rodrigues, C., Mistry, N., Whole genome sequencing of clinical strains of Mycobacetrium tuberculosis from Mumbai, India: a potential tool for determining drug-resistance and strain lineage. Tuberculosis 107 (2017), 63–72.
    • (2017) Tuberculosis , vol.107 , pp. 63-72
    • Chatterjee, A.1    Nilgiriwala2    Saranath, D.3    Rodrigues, C.4    Mistry, N.5
  • 27
    • 85006757655 scopus 로고    scopus 로고
    • The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs
    • Phelan, J., O´Sullivan, D., Machado, D., Ramos, J., Whale, A., O´Grady, J., et al. The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs. Genome Med, 8, 2016, 132.
    • (2016) Genome Med , vol.8 , pp. 132
    • Phelan, J.1    O´Sullivan, D.2    Machado, D.3    Ramos, J.4    Whale, A.5    O´Grady, J.6
  • 28
    • 84969930909 scopus 로고    scopus 로고
    • Legionella pneumophila strain associated with the first evidence of person-to-person transmission of Legionnaires’ disease: a unique mosaic genetic backbone
    • Borges, V., Nunes, A., Sampaio, D.A., Vieira, L., Machado, J., Simões, M.J., et al. Legionella pneumophila strain associated with the first evidence of person-to-person transmission of Legionnaires’ disease: a unique mosaic genetic backbone. Sci Rep, 6, 2016, 26261.
    • (2016) Sci Rep , vol.6 , pp. 26261
    • Borges, V.1    Nunes, A.2    Sampaio, D.A.3    Vieira, L.4    Machado, J.5    Simões, M.J.6
  • 29
    • 85043462793 scopus 로고    scopus 로고
    • A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis
    • Miotto, P., Tessema, B., Tagliani, E., Chindelevitch, L., Starks, A.M., Emerson, C., et al. A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis. Eur Respir J, 50, 2017, 1701354 https://doi.org/10.1183/13993003.01354-2017.
    • (2017) Eur Respir J , vol.50 , pp. 1701354
    • Miotto, P.1    Tessema, B.2    Tagliani, E.3    Chindelevitch, L.4    Starks, A.M.5    Emerson, C.6
  • 30
    • 84898471871 scopus 로고    scopus 로고
    • Phylogenetic polymorphisms in antibiotic resistance genes of the Mycobacterium tuberculosis complex
    • Feuerriegel, S., Köser, C.U., Niemann, S., Phylogenetic polymorphisms in antibiotic resistance genes of the Mycobacterium tuberculosis complex. J Antimicrob Chemother 69:5 (2014), 1205–1210.
    • (2014) J Antimicrob Chemother , vol.69 , Issue.5 , pp. 1205-1210
    • Feuerriegel, S.1    Köser, C.U.2    Niemann, S.3
  • 32
    • 79955539272 scopus 로고    scopus 로고
    • Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis
    • Campbell, P.J., Morlock, G.P., Sikes, R.D., Dalton, T.L., Metchock, B., Starks, A.M., et al. Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis. Antimicrob Agents Chemother 55:5 (2011), 2032–2041.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.5 , pp. 2032-2041
    • Campbell, P.J.1    Morlock, G.P.2    Sikes, R.D.3    Dalton, T.L.4    Metchock, B.5    Starks, A.M.6
  • 33
    • 77954184916 scopus 로고    scopus 로고
    • embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation
    • Plinke, C., Cox, H.S., Zarkua, N., Karimovich, H.A., Braker, K., Diel, R., et al. embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation. J Antimicrob Chemother 65:7 (2010), 1359–1367.
    • (2010) J Antimicrob Chemother , vol.65 , Issue.7 , pp. 1359-1367
    • Plinke, C.1    Cox, H.S.2    Zarkua, N.3    Karimovich, H.A.4    Braker, K.5    Diel, R.6
  • 35
    • 85008613637 scopus 로고    scopus 로고
    • The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee
    • Ellington, M.J., Ekelund, O., Aarestrup, F.M., Canton, R., Doumith, M., Cet al, Giske, The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee. Clin Microbiol Infect 23:1 (2017), 2–22, 10.1016/j.cmi.2016.11.012.
    • (2017) Clin Microbiol Infect , vol.23 , Issue.1 , pp. 2-22
    • Ellington, M.J.1    Ekelund, O.2    Aarestrup, F.M.3    Canton, R.4    Doumith, M.5    Cet al, G.6
  • 36
    • 53649111744 scopus 로고    scopus 로고
    • Pyrazinamide resistance among South African multidrug-resistant Mycobacterium tuberculosis isolates
    • Mphahlele, M., Syre, H., Valvatne, H., Stavrum, R., Mannsåker, T., Muthivhi, T., et al. Pyrazinamide resistance among South African multidrug-resistant Mycobacterium tuberculosis isolates. J Clin Microbiol 46 (2008), 3459–3464.
    • (2008) J Clin Microbiol , vol.46 , pp. 3459-3464
    • Mphahlele, M.1    Syre, H.2    Valvatne, H.3    Stavrum, R.4    Mannsåker, T.5    Muthivhi, T.6
  • 37
    • 84954207692 scopus 로고    scopus 로고
    • Genome sequencing reveals novel deletions associated with secondary resistance to pyrazinamide in MDR Mycobacterium tuberculosis
    • Martinez, E., Holmes, N., Jelfs, P., Sintchenko, V., Genome sequencing reveals novel deletions associated with secondary resistance to pyrazinamide in MDR Mycobacterium tuberculosis. J Antimicrob Chemother 70 (2015), 2511–2514.
    • (2015) J Antimicrob Chemother , vol.70 , pp. 2511-2514
    • Martinez, E.1    Holmes, N.2    Jelfs, P.3    Sintchenko, V.4
  • 38
    • 0029943128 scopus 로고    scopus 로고
    • Molecular mechanisms of drug resistance in Mycobacterium tuberculosis
    • Blanchard, J.S., Molecular mechanisms of drug resistance in Mycobacterium tuberculosis. Annu Rev Biochem 65 (1996), 215–239.
    • (1996) Annu Rev Biochem , vol.65 , pp. 215-239
    • Blanchard, J.S.1
  • 39
    • 0015373050 scopus 로고
    • Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis
    • Takayama, K., Wang, L., David, H.L., Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis. Antimicrob Agents Chemother 2:1 (1972), 29–35.
    • (1972) Antimicrob Agents Chemother , vol.2 , Issue.1 , pp. 29-35
    • Takayama, K.1    Wang, L.2    David, H.L.3
  • 40
    • 0028156861 scopus 로고
    • inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
    • Banerjee, A., Dubnau, E., Quemard, A., Balasubramanian, V., Um, K.S., Wilson, T., et al. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 26 3:5144 (1994), 227–230.
    • (1994) Science , vol.26 3 , Issue.5144 , pp. 227-230
    • Banerjee, A.1    Dubnau, E.2    Quemard, A.3    Balasubramanian, V.4    Um, K.S.5    Wilson, T.6
  • 41
    • 18744398724 scopus 로고    scopus 로고
    • Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis
    • Larsen, M.H., Vilchèze, C., Kremer, L., Besra, G.S., Parsons, L., Salfinger, M., et al. Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis. Mol Microbiol 46:2 (2002), 453–466.
    • (2002) Mol Microbiol , vol.46 , Issue.2 , pp. 453-466
    • Larsen, M.H.1    Vilchèze, C.2    Kremer, L.3    Besra, G.S.4    Parsons, L.5    Salfinger, M.6
  • 42
    • 0034023994 scopus 로고    scopus 로고
    • Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea
    • Lee, H., Cho, S.N., Bang, H.E., Lee, J.H., Bai, G.H., Kim, S.J., Kim, J.D., Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea. Int J Tubercul Lung Dis 4:5 (2000), 441–447.
    • (2000) Int J Tubercul Lung Dis , vol.4 , Issue.5 , pp. 441-447
    • Lee, H.1    Cho, S.N.2    Bang, H.E.3    Lee, J.H.4    Bai, G.H.5    Kim, S.J.6    Kim, J.D.7
  • 44
    • 0029954860 scopus 로고    scopus 로고
    • Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus
    • Scorpio, A., Zhang, Y., Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat Med 2:6 (1996), 662–667.
    • (1996) Nat Med , vol.2 , Issue.6 , pp. 662-667
    • Scorpio, A.1    Zhang, Y.2
  • 45
    • 85035008667 scopus 로고    scopus 로고
    • Whole-transcriptome and -genome analysis of extensively drug-resistant Mycobacterium tuberculosis clinical isolates identifies downregulation of ethA as a mechanism of ethionamide resistance
    • de Welzen, L., Eldholm, V., Maharaj, K., Manson, A.L., Earl, A.M., Pym, A.S., Whole-transcriptome and -genome analysis of extensively drug-resistant Mycobacterium tuberculosis clinical isolates identifies downregulation of ethA as a mechanism of ethionamide resistance. Antimicrob Agents Chemother, 22(12), 2017, 61.
    • (2017) Antimicrob Agents Chemother , vol.22 , Issue.12 , pp. 61
    • de Welzen, L.1    Eldholm, V.2    Maharaj, K.3    Manson, A.L.4    Earl, A.M.5    Pym, A.S.6
  • 46
    • 0345306174 scopus 로고    scopus 로고
    • ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates
    • Morlock, G.P., Metchock, B., Sikes, D., Crawford, J.T., Cooksey, R.C., ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother 47:12 (2003), 3799–3805.
    • (2003) Antimicrob Agents Chemother , vol.47 , Issue.12 , pp. 3799-3805
    • Morlock, G.P.1    Metchock, B.2    Sikes, D.3    Crawford, J.T.4    Cooksey, R.C.5
  • 48
    • 0034662963 scopus 로고    scopus 로고
    • Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis
    • DeBarber, A.E., Mdluli, K., Bosman, M., Bekker, L.G., Barry, C.E., Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. Proc Natl Acad Sci USA 97:17 (2000), 9677–9682.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.17 , pp. 9677-9682
    • DeBarber, A.E.1    Mdluli, K.2    Bosman, M.3    Bekker, L.G.4    Barry, C.E.5
  • 49
    • 49049119354 scopus 로고    scopus 로고
    • Biological and molecular characteristics of Mycobacterium tuberculosis clinical isolates with low-level resistance to isoniazid in Japan
    • Abe, C., Kobayashi, I., Mitarai, S., Wada, M., Kawabe, Y., Takashima, T., et al. Biological and molecular characteristics of Mycobacterium tuberculosis clinical isolates with low-level resistance to isoniazid in Japan. J Clin Microbiol 46:7 (2008), 2263–2268, 10.1128/JCM.00561-08.
    • (2008) J Clin Microbiol , vol.46 , Issue.7 , pp. 2263-2268
    • Abe, C.1    Kobayashi, I.2    Mitarai, S.3    Wada, M.4    Kawabe, Y.5    Takashima, T.6
  • 50
    • 84952979528 scopus 로고    scopus 로고
    • Rapid, comprehensive, and affordable mycobacterial diagnosis with whole genome sequencing: a prospective study
    • Pankhurst, L.J., Del Ojo Elias, C., Votintseva, A.A., Walker, T.M., Cole, K., Davies, J., et al. Rapid, comprehensive, and affordable mycobacterial diagnosis with whole genome sequencing: a prospective study. Lancet Respir Med 4 (2016), 49–58.
    • (2016) Lancet Respir Med , vol.4 , pp. 49-58
    • Pankhurst, L.J.1    Del Ojo Elias, C.2    Votintseva, A.A.3    Walker, T.M.4    Cole, K.5    Davies, J.6
  • 51
  • 52
    • 85044577100 scopus 로고    scopus 로고
    • England world leaders in the use of whole genome sequencing to diagnose TB
    • (Accessed 30 May 2017)
    • PHE, England world leaders in the use of whole genome sequencing to diagnose TB. https://www.gov.uk/government/news/england-world-leaders-in-the-use-of-whole-genome-sequencing-to-diagnose-tb, 2017. (Accessed 30 May 2017)
    • (2017)
    • PHE1
  • 53
    • 84874531408 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in Mycobacterium tuberculosis and the need for a curated database
    • Stucki, D., Gagneux, S., Single nucleotide polymorphisms in Mycobacterium tuberculosis and the need for a curated database. Tuberculosis 93:1 (2013), 30–39.
    • (2013) Tuberculosis , vol.93 , Issue.1 , pp. 30-39
    • Stucki, D.1    Gagneux, S.2
  • 54
    • 84983786096 scopus 로고    scopus 로고
    • Integration of published information into a resistance-associated mutation database for Mycobacterium tuberculosis
    • Salamon, H., Yamaguchi, K.D., Cirillo, D.M., Miotto, P., Schito, M., Posey, J., et al. Integration of published information into a resistance-associated mutation database for Mycobacterium tuberculosis. J Infect Dis 211:2 (2015), S50–S57.
    • (2015) J Infect Dis , vol.211 , Issue.2 , pp. S50-S57
    • Salamon, H.1    Yamaguchi, K.D.2    Cirillo, D.M.3    Miotto, P.4    Schito, M.5    Posey, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.