Effects of exercise on markers of oxidative stress: An Ancillary analysis of the Alberta Physical Activity and Breast Cancer Prevention Trial

BMJ Open Sport and Exercise Medicine

Volumn 2, Issue 1, 2016, Pages

  Friedenreich, Christine M ^a,b   Pialoux, Vincent ^c   Wang, Qinggang ^a   Shaw, Eileen ^a   Brenner, Darren R ^a,b   Waltz, Xavier ^d   Conroy, Shannon M ^e   Johnson, Rhys ^a   Woolcott, Christy G ^f   Poulin, Marc J ^d   Courneya, Kerry S ^g  

^a ALBERTA HEALTH SERVICES   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c Univ Lyon University Jean Monnet Saint Etienne   (France)

^d UNIVERSITY OF CALGARY   (Canada)

^e CANCER PREVENTION INSTITUTE OF CALIFORNIA   (United States)

^f DALHOUSIE UNIVERSITY   (Canada)

^g UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Antioxidants; Cancer; Exercise physiology; Randomised controlled trial

Indexed keywords

EID: 85044128198     PISSN: 20557647     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmjsem-2016-000171     Document Type: Article

References (72)

1. Canadian Cancer Society's Advisory Committee on Cancer Statistics. Canadian Cancer Statistics 2015. Toronto, ON: Canadian Cancer Society, 2015.
2. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
3. Holford TR, Cronin KA, Mariotto AB, et al. Changing patterns in breast cancer incidence trends. J Natl Cancer Inst Monogr 2006: 19-25.
4. Neilson HK, Friedenreich CM, Brockton NT, et al. Physical activity and postmenopausal breast cancer: proposed biologic mechanisms and areas for future research. Cancer Epidemiol Biomarkers Prev 2009; 18: 11-27.
5. Foster-Schubert KE, Alfano CM, Duggan CR, et al. Effect of diet and exercise, alone or combined, on weight and body composition in overweight-To-obese postmenopausal women. Obesity (Silver Spring) 2012; 20: 1628-38.
6. Friedenreich CM, Woolcott CG, McTiernan A, et al. Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J Clin Oncol 2010; 28: 1458-66.
7. McTiernan A, Tworoger SS, Ulrich CM, et al. Effect of exercise on serum estrogens in postmenopausal women: A 12-month randomized clinical trial. Cancer Res 2004; 64: 2923-8.
8. Monninkhof EM, Velthuis MJ, Peeters PH, et al. Effect of exercise on postmenopausal sex hormone levels and role of body fat: A randomized controlled trial. J Clin Oncol 2009; 27: 4492-9.
9. Friedenreich CM, MacLaughlin S, Neilson HK, et al. Study Design and Methods for the Breast Cancer and Exercise Trial in Alberta (BETA). BMC Cancer 2014; 14: 919.
10. Campbell PT, Campbell KL, Wener MH, et al. A yearlong exercise intervention decreases CRP among obese postmenopausal women. Med Sci Sports Exerc 2009; 41: 1533-9.
11. Friedenreich CM, Neilson HK, Woolcott CG, et al. Inflammatory marker changes in a year-long randomized exercise intervention trial among postmenopausal women. Cancer Prev Res 2012; 5: 98-108.
12. Frank LL, Sorensen BE, Yasui Y, et al. Effects of exercise on metabolic risk variables in overweight postmenopausal women: A randomized clinical trial. Obes Res 2005; 13: 615-25.
13. Nourazarian AR, Kangari P, Salmaninejad A. Roles of oxidative stress in the development and progression of breast cancer. Asian Pac J Cancer Prev 2014; 15: 4745-51.
14. Kruk J. Overweight, obesity, oxidative stress and the risk of breast cancer. Asian Pac J Cancer Prev 2014; 15: 9579-86.
15. Toyokuni S, Okamoto K, Yodoi J, et al. Persistent oxidative stress in cancer. FEBS Lett 1995; 358: 1-3.
16. Radak Z, Marton O, Nagy E, et al. The complex role of physical exercise and reactive oxygen species on brain. J Sport Health Sci 2013; 2: 87-93.
17. Behrend L, Henderson G, Zwacka RM. Reactive oxygen species in oncogenic transformation. Biochem Soc Trans 2003; 31: 1441-4.
18. Semenza GL. HIF-1: using two hands to flip the angiogenic switch. Cancer Metastasis Rev 2000; 19: 59-65.
19. Goodman M, Bostick RM, Dash C, et al. A summary measure of pro-And anti-oxidant exposures and risk of incident, sporadic, colorectal adenomas. Cancer Causes Control 2008; 19: 1051-64.
20. Klaunig JE, Kamendulis LM. The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 2004; 44: 239-67.
21. Leaf DA, Kleinman MT, Hamilton M, et al. The exercise-induced oxidative stress paradox: The effects of physical exercise training. Am J Med Sci 1999; 317: 295-300.
22. Melikoglu MA, Kaldirimci M, Katkat D, et al. The effect of regular long term training on antioxidant enzymatic activities. J Sports Med Phys Fitness 2008; 48: 388-90.
23. Pialoux V, Brown AD, Leigh R, et al. Effect of cardiorespiratory fitness on vascular regulation and oxidative stress in postmenopausal women. Hypertension 2009; 54: 1014-20.
24. Campbell PT, Gross MD, Potter JD, et al. Effect of exercise on oxidative stress: A 12-month randomized, controlled trial. Med Sci Sports Exerc 2010; 42: 1448-53.
25. Radak Z, Chung HY, Goto S. Systemic adaptation to oxidative challenge induced by regular exercise. Free Radic Biol Med 2008; 44: 153-9.
26. Ambrosone CB. Oxidants and antioxidants in breast cancer. Antioxid Redox Signal 2000; 2: 903-17.
27. Ji LL. Exercise and oxidative stress: role of the cellular antioxidant systems. Exerc Sport Sci Rev 1995; 23: 135-66.
28. Soares JP, Silva AM, Oliveira MM, et al. Effects of combined physical exercise training on DNA damage and repair capacity: role of oxidative stress changes. Age (Dordr) 2015; 37: 9799.
29. Loft S, Møller P, Cooke MS, et al. Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker? Eur J Nutr 2008; 47(Suppl 2): 19-28.
30. Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2009; 27: 120-39.
31. Rossner P Jr, Gammon MD, Terry MB, et al. Relationship between urinary 15-F2t-isoprostane and 8-oxodeoxyguanosine levels and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2006; 15: 639-44.
32. Chiou CC, Chang PY, Chan EC, et al. Urinary 8-hydroxydeoxyguanosine and its analogs as DNA marker of oxidative stress: development of an ELISA and measurement in both bladder and prostate cancers. Clin Chim Acta 2003; 334: 87-94.
33. Chirico EN, Martin C, Faës C, et al. Exercise training blunts oxidative stress in sickle cell trait carriers. J Appl Physiol (1985) 2012; 112: 1445-53.
34. Johansson LH, Borg LA. A spectrophotometric method for determination of catalase activity in small tissue samples. Anal Biochem 1988; 174: 331-6.
35. Beauchamp C, Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 1971; 44: 276-87.
36. Oberley L, Spitz D. Nitroblue tetrazolium. Handbook of methods for oxygen radical research. Boca Raton: CDC Press, 1985.
37. Warburton DE, Katzmarzyk PT, Rhodes RE, et al. Evidenceinformed physical activity guidelines for Canadian adults. Can J Public Health 2007; 98(Suppl 2): S16-68.
38. Kraemer HC, Wilson GT, Fairburn CG, et al. Mediators and moderators of treatment effects in randomized clinical trials. Arch Gen Psychiatry 2002; 59: 877-83.
39. Bouzid MA, Hammouda O, Matran R, et al. Influence of physical fitness on antioxidant activity and malondialdehyde level in healthy older adults. Appl Physiol Nutr Metab 2015; 40: 582-9.
40. Farinha JB, De Carvalho NR, Steckling FM, et al. An active lifestyle induces positive antioxidant enzyme modulation in peripheral blood mononuclear cells of overweight/obese postmenopausal women. Life Sci 2015; 121: 152-7.
41. Fraile-Bermúdez AB, Kortajarena M, Zarrazquin I, et al. Relationship between physical activity and markers of oxidative stress in independent community-living elderly individuals. Exp Gerontol 2015; 70: 26-31.
42. Rowinski R, Kozakiewicz M, Ked? ziora-Kornatowska K, et al. Markers of oxidative stress and erythrocyte antioxidant enzyme activity in older men and women with differing physical activity. Exp Gerontol 2013; 48: 1141-6.
43. Shanely RA, Nieman DC, Henson DA, et al. Inflammation and oxidative stress are lower in physically fit and active adults. Scand J Med Sci Sports 2013; 23: 215-23.
44. Cardoso AM, Bagatini MD, Roth MA, et al. Acute effects of resistance exercise and intermittent intense aerobic exercise on blood cell count and oxidative stress in trained middle-Aged women. Braz J Med Biol Res 2012; 45: 1172-82.
45. Takahashi M, Miyashita M, Kawanishi N, et al. Low-volume exercise training attenuates oxidative stress and neutrophils activation in older adults. Eur J Appl Physiol 2013; 113: 1117-26.
46. Palasuwan A, Suksom D, Margaritis I, et al. Effects of tai chi training on antioxidant capacity in pre-And postmenopausal women. J Ageing Res 2011; 2011: 234696.
47. Devries MC, Hamadeh MJ, Glover AW, et al. Endurance training without weight loss lowers systemic, but not muscle, oxidative stress with no effect on inflammation in lean and obese women. Free Radic Biol Med 2008; 45: 503-11.
48. Schmitz KH, Warren M, Rundle AG, et al. Exercise effect on oxidative stress is independent of change in estrogen metabolism. Cancer Epidemiol Biomarkers Prev 2008; 17: 220-3.
49. Elosua R, Molina L, Fito M, et al. Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women. Atherosclerosis 2003; 167: 327-34.
50. Covas MI, Elosua R, Fitó M, et al. Relationship between physical activity and oxidative stress biomarkers in women. Med Sci Sports Exerc 2002; 34: 814-19.
51. Shin YA, Lee JH, Song W, et al. Exercise training improves the antioxidant enzyme activity with no changes of telomere length. Mech Ageing Dev 2008; 129: 254-60.
52. Rosado-Pérez J, Ortiz R, Santiago-Osorio E, et al. Effect of Tai Chi versus walking on oxidative stress in Mexican older adults. Oxid Med Cell Longev 2013; 2013: 298590.
53. Arikawa AY, Thomas W, Gross M, et al. Aerobic training reduces systemic oxidative stress in young women with elevated levels of F2-isoprostanes. Contemp Clin Trials 2013; 34: 212-17.
54. Smith DT, Carr LJ, Dorozynski C, et al. Internet-delivered lifestyle physical activity intervention: limited inflammation and antioxidant capacity efficacy in overweight adults. J Appl Physiol (1985) 2009; 106: 49-56.
55. Bartfay W, Bartfay E. A case-control study examining the effects of active versus sedentary lifestyles on measures of body iron burden and oxidative stress in postmenopausal women. Biol Res Nurs 2014; 16: 38-45.
56. Merino J, Ferré R, Girona J, et al. Even low physical activity levels improve vascular function in overweight and obese postmenopausal women. Menopause 2013; 20: 1036-42.
57. Karolkiewicz J, Michalak E, Pospieszna B, et al. Response of oxidative stress markers and antioxidant parameters to an 8-week aerobic physical activity program in healthy, postmenopausal women. Arch Gerontol Geriatr 2009; 49: e67-71.
58. Attipoe S, Park JY, Fenty N, et al. Oxidative stress levels are reduced in postmenopausal women with exercise training regardless of hormone replacement therapy status. J Women Ageing 2008; 20: 31-45.
59. Hernández R, Mahedero G, Caballero MJ, et al. Effects of physical exercise in pre-And postmenopausal women on lipid peroxidation and antioxidant systems. Endocr Res 1999; 25: 153-61.
60. Judge S, Leeuwenburgh C. Cardiac mitochondrial bioenergetics, oxidative stress, and ageing. Am J Physiol, Cell Physiol 2007; 292: C1983-92.
61. Castelao JE, Gago-Dominguez M. Risk factors for cardiovascular disease in women: relationship to lipid peroxidation and oxidative stress. Med Hypotheses 2008; 71: 39-44.
62. Gago-Dominguez M, Castelao JE, Pike MC, et al. Role of lipid peroxidation in the epidemiology and prevention of breast cancer. Cancer Epidemiol Biomarkers Prev 2005; 14: 2829-39.
63. Helmersson J, Basu S. F(2)-isoprostane and prostaglandin F(2 alpha) metabolite excretion rate and day to day variation in healthy humans. Prostaglandins Leukot Essent Fatty Acids 2001; 65: 99-102.
64. Sircar D, Subbaiah PV. Isoprostane measurement in plasma and urine by liquid chromatography-mass spectrometry with one-step sample preparation. Clin Chem 2007; 53: 251-8.
65. Finaud J, Lac G, Filaire E. Oxidative stress: relationship with exercise and training. Sports Med 2006; 36: 327-58.
66. Neubauer O, König D, Kern N, et al. No indications of persistent oxidative stress in response to an ironman triathlon. Med Sci Sports Exerc 2008; 40: 2119-28.
67. Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 2008; 88: 1243-76.
68. Powers SK, Ji LL, Leeuwenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: A brief review. Med Sci Sports Exerc 1999; 31: 987-97.
69. Friedenreich CM, Woolcott CG, McTiernan A, et al. Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: A randomized controlled trial. Int J Obes (Lond) 2011; 35: 427-35.
70. Keaney JF Jr, Larson MG, Vasan RS, et al. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol 2003; 23: 434-9.
71. Furukawa S, Fujita T, Shimabukuro M, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114: 1752-61.
72. Cottone S, Mulè G, Nardi E, et al. Relation of C reactive protein to oxidative stress and to endothelial activation in essential hypertension. Am J Hypertens 2006; 19: 313-8.