Characterization of a Cell-Culturing System for the Study of Contact-Independent Extracellular Vesicle Communication

Journal of Circulating Biomarkers

Volumn 5, Issue , 2016, Pages

  Revenfeld, Anne Louise Schacht ^a   Søndergaard, Evo Kristina Lindersson ^a   Stensballe, Allan ^b   Bæk, Rikke ^a   Jørgensen, Malene Møller ^a   Varming, Kim ^a  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b AALBORG UNIVERSITY   (Denmark)

Author keywords

Cell Communication; Contact independent; EV Array; Extracellular Vesicles; Phenotype; Transwell

Indexed keywords

EID: 85043652574     PISSN: None     EISSN: 18494544     Source Type: Journal    
DOI: 10.5772/62580     Document Type: Article

References (17)

1. Revenfeld AL, Baek R, Nielsen MH, Stensballe A, Varming K, Jorgensen M. Diagnostic and prognostic potential of extracellular vesicles in peripheral blood. Clin Ther. 2014 Jun 1;36(6):830–46
2. Andaloussi SEL, Mager I, Breakefield XO, Wood MJ. Extracellular vesicles: Biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013 May;12(5):347–57
3. Akers JC, Gonda D, Kim R, Carter BS, Chen CC. Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol. 2013 May;113(1):1–11
4. Hwang I, Shen X, Sprent J. Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: Distinct roles for CD54 and B7 molecules. Proc Natl Acad Sci USA. 2003 May 27;100(11):6670–5
5. Hoen EN Nolte-'t, Buschow SI, Anderton SM, Stoorvogel W, Wauben MH. Activated T cells recruit exosomes secreted by dendritic cells via LFA-1. Blood. 2009 Feb 26;113(9):1977–81
6. Mittelbrunn M, Gutierrez-Vazquez C, Villarroya-Beltri C, Gonzalez S, Sanchez-Cabo F, Gonzalez MA. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun. 2011;2:282
7. Ren Y, Yang J, Xie R, Gao L, Yang Y, Fan H. Exosomal-like vesicles with immune-modulatory features are present in human plasma and can induce CD4+ T-cell apoptosis in vitro. Transfusion. 2010 May;51(5):1002–11
8. Game DS, Rogers NJ, Lechler RI. Acquisition of HLA-DR and costimulatory molecules by T cells from allogeneic antigen presenting cells. Am J Transplant. 2005 Jul;5(7):1614–25
9. Hwang I, Sprent J. Role of the actin cytoskeleton in T cell absorption and internalization of ligands from APC. J Immunol. 2001 Apr 15;166(8):5099–107
10. Jorgensen MM, Baek R, Varming K. Potentials and capabilities of the Extracellular Vesicle (EV) Array. J Extracell Vesicles. 2015;4:26048
11. Jorgensen M, Baek R, Pedersen S, Soendergaard EK, Kristensen SR, Varming K. Extracellular Vesicle (EV) Array: Microarray capturing of exosomes and other extracellular vesicles for multiplexed phenotyping. J Extracell Vesicles. 2013;2:20920
12. Pegtel DM, Cosmopoulos K, Thorley-Lawson DA, van Eijndhoven MA, Hopmans ES, Lindenberg JL. Functional delivery of viral miRNAs via exosomes. Proc Natl Acad Sci USA. 2010 Apr 6;107(14):6328–33
13. Rechavi O, Erlich Y, Amram H, Flomenblit L, Karginov FV, Goldstein I. Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs. Genes Dev. 2009 Aug 15;23(16):1971–9
14. Findlay JW, Smith WC, Lee JW, Nordblom GD, Das I, DeSilva BS. Validation of immunoassays for bioanalysis: A pharmaceutical industry perspective. J Pharm Biomed Anal. 2000 Jan;21(6):1249–73
15. He M, Crow J, Roth M, Zeng Y, Godwin AK. Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology. Lab Chip. 2014 Oct 7;14(19):3773–80
16. Franquesa M, Hoogduijn MJ, Ripoll E, Luk F, Salih M, Betjes MG. Update on controls for isolation and quantification methodology of extracellular vesicles derived from adipose tissue mesenchymal stem cells. Front Immunol. 2014;5:525
17. Basu S, Bhattacharyya SN. Insulin-like growth factor-1 prevents miR-122 production in neighbouring cells to curtail its intercellular transfer to ensure proliferation of human hepatoma cells. Nucleic Acids Res. 2014 Jun;42(11):7170–85