Protective effect of tauroursodeoxycholic acid on the autophagy of nerve cells in rats with acute spinal cord injury

European Review for Medical and Pharmacological Sciences

Volumn 22, Issue 4, 2018, Pages 1133-1141

  Miao, L ^a   Dong, Y ^b   Zhou, F B ^b   Chang, Y L ^b   Suo, Z G ^b   Ding, H Q ^b  

^a Ningxia People's Hospital Yinchuan   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; Neuroprotection; Spinal cord injury; TUDCA

Indexed keywords

BECLIN 1; CASPASE 3; EOSIN; HEMATOXYLIN; MESSENGER RNA; TAUROURSODEOXYCHOLIC ACID; NEUROPROTECTIVE AGENT; TAUROCHENODEOXYCHOLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; ELECTRON MICROSCOPY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LOCOMOTION; LOW DRUG DOSE; MALE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD INJURY; TRANSMISSION ELECTRON MICROSCOPY; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; AUTOPHAGY; LOCOMOTION; MALE; NEURONS; NEUROPROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; TAUROCHENODEOXYCHOLIC ACID;

EID: 85042765223     PISSN: 11283602     EISSN: 22840729     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. HE FY, FENG WZ, ZHONG J, XU W, SHAO HY, ZHANG YR. Effects of propofol and dexmedetomidine anesthesia on Th1/Th2 of rat spinal cord injury. Eur Rev Med Pharmacol Sci 2017; 21: 1355-1361.
2. SUN BW, SHEN HM, LIU BC, FANG HL. Research on the effect and mechanism of the CXCR-4-overexpressing BMSCs combined with SDF-1α for the cure of acute SCI in rats. Eur Rev Med Pharmacol Sci 2017; 21: 167-174.
3. AHUJA CS, WILSON JR, NORI S, KOTTER MRN, DRUSCHEL C, CURT A, FEHLINGS MG. Traumatic spinal cord injury. Nat Rev Dis Primers 2017; 3: 17018.
4. GASPAR JM, MARTINS A, CRUZ R, RODRIGUES CM, AMBRÓSIO AF, SANTIAGO AR. Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose. Neuroscience 2013; 253: 380-388.
5. COLAK A, KELTEN B, SAǦMANLIGIL A, AKDEMIR O, KARAOǦLAN A, SAHAN E, CELIK O, BARUT S. Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats. J Clin Neurosci 2008; 15: 665-671.
6. DONG Y, MIAO L, HEI L, LIN L, DING H. Neuroprotective effects and impact on caspase-12 expression of tauroursodeoxycholic acid after acute spinal cord injury in rats. Int J Clin Exp Pathol 2015; 8: 15871-15878.
7. BURSCH W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ 2001; 8: 569-581.
8. XU YJ, YU C, LI F, FENG YZ, LIU Q, DONG QR, ZHENG ZG. Experimental comparison of apoptosis of neural cells between 3 different lesions of spinal cord in rats. Chinese Journal of Orthopaedic Trauma 2005; 7: 1059-1062.
9. KOIKE M, SHIBATA M, TADAKOSHI M, GOTOH K, KOMATSU M, WAGURI S, KAWAHARA N, KUIDA K, NAGATA S, KOMINAMI E, TANAKA K, UCHIYAMA Y. Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol 2008; 172: 454-469.
10. SALMINEN A, KAARNIRANTA K, KAUPPINEN A. Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany NY) 2012; 4: 166-175.
11. FURUYA T, KIM M, LIPINSKI M, LI J, KIM D, LU T, SHEN Y, RAMEH L, YANKNER B, TSAI LH, YUAN J. Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell 2010; 38: 500-511.
12. SCULL CM, TABAS I. Mechanisms of ER stress-induced apoptosis in atherosclerosis. Arterioscler Thromb Vasc Biol 2011; 31: 2792-2797.
13. YANG Z, KLIONSKY DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol 2010; 12: 814-822.
14. KELEKAR A. AUTOPHAGY. Ann NY Acad Sci 2005; 1066: 259-271.
15. LIANG XH, JACKSON S, SEAMAN M, BROWN K, KEMPKES B, HIBSHOOSH H, LEVINE B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402: 672-676.
16. RAVIKUMAR B, DUDEN R, Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet 2002; 11: 1107-1117.
17. GUTIERREZ MG, MASTER SS, SINGH SB, TAYLOR GA, COLOMBO MI, DERETIC V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004; 119: 753-766.
18. DEL ROSO A, VITTORINI S, CAVALLINI G, DONATI A, GORI Z, MASINI M, POLLERA M, BERGAMINI E. Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis. Exp Gerontol 2003; 38: 519-527.