Neuroprotective effects and impact on caspase-12 expression of tauroursodeoxycholic acid after acute spinal cord injury in rats

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 12, 2015, Pages 15871-15878

  Dong, Yi ^a   Miao, Lei ^a   Hei, Long ^a   Lin, Leilei ^a   Ding, Huiqiang ^a  

^a NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase 12; Neuroprotection; Spinal cord injury; Tauroursodeoxycholic acid

Indexed keywords

CASP12 PROTEIN, RAT; CASPASE 12; NEUROPROTECTIVE AGENT; TAUROCHENODEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID;

ACUTE DISEASE; ANIMAL; ANIMAL BEHAVIOR; CONVALESCENCE; DISEASE MODEL; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; SPINAL CORD; SPINAL CORD INJURIES; SPRAGUE DAWLEY RAT; TIME FACTOR; TUNEL ASSAY; WESTERN BLOTTING;

ACUTE DISEASE; ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CASPASE 12; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES; TAUROCHENODEOXYCHOLIC ACID; TIME FACTORS;

EID: 84963748799     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Emery E, Aldana P, Bunge MB, Puckett W, Srinivasan A, Keane RW, Bethea J, Levi AD. Apoptosis after traumatic human spinal cord injury. J Neurosurg 1998; 89: 911-920.
2. Kim EM, Shin EJ, Choi JH, Son HJ, Park IS, Joh TH, Hwang O. Matrix metalloproteinase-3 is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress. J Biol Chem 2010; 285: 16444-16452.
3. Peng P, Ma Q, Wang L, Zhang O, Han H, Liu X, Zhou Y, Zhao Y. Preconditioning with tauroursodeoxycholic acid protects against contrast-induced HK-2 cell apoptosis by inhibiting endoplasmic reticulum stress. Angiology 2015; 66: 941-9
4. Xie Q, Khaoustov VI, Chung CC, Sohn J, Krishnan B, Lewis DE, Yoffe B. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology 2002; 36: 592-601.
5. Vang S, Longley K, Steer C J, Low WC. The unexpected uses of urso-and tauroursodeoxycholic acid in the treatment of non-liver diseases. Glob Adv Health Med 2014; 3: 58-69.
6. Colak A, Kelten B, Sagmanligil A, Akdemir O, Karaoglan A, Sahan E, Celik O, Barut S. Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats. J Clin Neurosci 2008; 15: 665-671.
7. Rivlin AS, Tator CH. Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 1977; 47: 577-581.
8. Liu XZ, Xu XM, Hu R, Du C, Zhang SX, McDonald JW, Dong HX, Wu YJ, Fan GS, Jacquin MF, Hsu CY, Choi DW. Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci 1997; 17: 5395-5406.
9. Garbossa D, Fontanella M, Fronda C, Benevello C, Muraca G, Ducati A, Vercelli A. New strategies for repairing the injured spinal cord: the role of stem cells. Neurol Res 2006; 28: 500-504.
10. Okano H, Ogawa Y, Nakamura M, Kaneko S, Iwanami A, Toyama Y. Transplantation of neural stem cells into the spinal cord after injury. Semin Cell Dev Biol 2003; 14: 191-198.
11. Allen AR. Surgery for experimental lesions of spinal cord equivalent to crush injury of fracture dislocation of spinal column: a preliminary report. JAMA 1911; 57: 878-880.
12. Lan WB, Lin JH, Chen XW, Wu CY, Zhong GX, Zhang LQ, Lin WP, Liu WN, Li X, Lin JL. Overexpressing neuroglobin improves functional recovery by inhibiting neuronal apoptosis after spinal cord injury. Brain Res 2014; 1562: 100-108.
13. Lu PG, Feng H, Yuan SJ, Zhang RW, Li M, Hu R, Liu ZS, Yin J. Effect of preconditioning with hyperbaric oxygen on neural cell apoptosis after spinal cord injury in rats. J Neurosurg Sci 2013; 57: 253-258.
14. Liu G, Wang X, Shao G, Liu Q. Genetically modified Schwann cells producing glial cell linederived neurotrophic factor inhibit neuronal apoptosis in rat spinal cord injury. Mol Med Rep 2014; 9: 1305-1312.
15. Nalepa G, Rolfe M, Harper JW. Drug discovery in the ubiquitin-proteasome system. Nat Rev Drug Discov 2006; 5: 596-613.
16. Minamino T, Kitakaze M. ER stress in cardiovascular disease. J Mol Cell Cardio 2010; 48: 1105-1110.
17. Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic. reticulum stressinduced apoptosis. EMBO Rep 2006; 7: 880-885.
18. Scull CM, Tabas I. Mechanisms of ER stressinduced apoptosis in atherosclerosis. Arterioscler Thromb Vasc Biol 2011; 31: 2792-2797.
19. Kim EM, Hwang O. Role of matrix metalloproteinase-3 in neurodegeneration. J Neurochem 2011; 116: 22-232.
20. Stennicke HR, Salvesen GS. Properties of the caspases. Biochim Biophys Acta 1998; 1387: 17-31.
21. Gaspar JM, Martins A, Cruz R, Rodrigues CM, Ambrósio AF, Santiago AR. Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose. Neuroscience 2013; 253: 380-388.