메뉴 건너뛰기




Volumn 11, Issue 1, 2018, Pages

Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer

Author keywords

Chromosome 10; Genomic instability; Prostate cancer; PTEN; TCGA

Indexed keywords

ANEUPLOIDY; ANGIOGENESIS; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER RECURRENCE; CELL ADHESION; CELL METABOLISM; CELL STRUCTURE; CHROMOSOME 10; COHORT ANALYSIS; COMPUTER ANALYSIS; COPY NUMBER VARIATION; GENE CLUSTER; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC VARIATION; GENOMIC INSTABILITY; GLEASON SCORE; HUMAN; HUMAN TISSUE; MALE; METASTASIS; PRIORITY JOURNAL; PROSTATE CANCER; PTEN GENE; SEGMENTAL DUPLICATION; SOMATIC COPY NUMBER VARIATION; TRANSCRIPTOMICS; TUMOR SUPPRESSOR GENE;

EID: 85042588570     PISSN: None     EISSN: 17558166     Source Type: Journal    
DOI: 10.1186/s13039-017-0348-y     Document Type: Article
Times cited : (18)

References (56)
  • 2
    • 33645231294 scopus 로고    scopus 로고
    • The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion
    • Verhagen P, van Duijn P, Hermans K, Looijenga L, van Gurp R, Stoop H, et al. The PTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletion. J Pathol. 2006;208:699-707
    • (2006) J Pathol , vol.208 , pp. 699-707
    • Verhagen, P.1    Van Duijn, P.2    Hermans, K.3    Looijenga, L.4    Van Gurp, R.5    Stoop, H.6
  • 3
    • 84925295476 scopus 로고    scopus 로고
    • PTEN loss in biopsy tissue predicts poor clinical outcomes in prostate cancer
    • Mithal P, Allott E, Gerber L, Reid J, Welbourn W, Tikishvili E, et al. PTEN loss in biopsy tissue predicts poor clinical outcomes in prostate cancer. Int J Urol. 2014;21:1209-14
    • (2014) Int J Urol , vol.21 , pp. 1209-1214
    • Mithal, P.1    Allott, E.2    Gerber, L.3    Reid, J.4    Welbourn, W.5    Tikishvili, E.6
  • 4
    • 84932195056 scopus 로고    scopus 로고
    • A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer
    • Troyer DA, Jamaspishvili T, Wei W, Feng Z, Good J, Hawley S, et al. A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer. Prostate. 2015;75:1206-15
    • (2015) Prostate , vol.75 , pp. 1206-1215
    • Troyer, D.A.1    Jamaspishvili, T.2    Wei, W.3    Feng, Z.4    Good, J.5    Hawley, S.6
  • 5
    • 84957655735 scopus 로고    scopus 로고
    • In prostate cancer needle biopsies, detections of PTEN loss by fluorescence in situ hybridization (FISH) and by immunohistochemistry (IHC) are concordant and show consistent association with upgrading
    • Picanco-Albuquerque CG, Morais CL, Carvalho FLF, Peskoe SB, Hicks JL, Ludkovski O, et al. In prostate cancer needle biopsies, detections of PTEN loss by fluorescence in situ hybridization (FISH) and by immunohistochemistry (IHC) are concordant and show consistent association with upgrading. Virchows Arch. 2016;468:607-17
    • (2016) Virchows Arch , vol.468 , pp. 607-617
    • Picanco-Albuquerque, C.G.1    Morais, C.L.2    Carvalho, F.L.F.3    Peskoe, S.B.4    Hicks, J.L.5    Ludkovski, O.6
  • 8
    • 85029063787 scopus 로고    scopus 로고
    • PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation
    • Hou S-Q, Ouyang M, Brandmaier A, Hao H, Shen WH. PTEN In the maintenance of genome integrity: from DNA replication to chromosome segregation. BioEssays. 2017;39:1700082
    • (2017) BioEssays , vol.39 , pp. 1700082
    • Hou, S.-Q.1    Ouyang, M.2    Brandmaier, A.3    Hao, H.4    Shen, W.H.5
  • 9
    • 84919684630 scopus 로고    scopus 로고
    • Recurrent copy number alterations in prostate cancer: An in silico meta-analysis of publicly available genomic data
    • Williams JL, Greer PA, Squire JA. Recurrent copy number alterations in prostate cancer: an in silico meta-analysis of publicly available genomic data. Cancer Genet Elsevier Inc. 2014;207:474-88
    • (2014) Cancer Genet Elsevier Inc , vol.207 , pp. 474-488
    • Williams, J.L.1    Greer, P.A.2    Squire, J.A.3
  • 10
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 12
    • 83055176408 scopus 로고    scopus 로고
    • PTEN genomic deletions that characterize aggressive prostate cancer originate close to segmental duplications
    • Yoshimoto M, Ludkovski O, Degrace D, Williams JL, Evans A, Sircar K, et al. PTEN genomic deletions that characterize aggressive prostate cancer originate close to segmental duplications. Genes Chromosom Cancer. 2012; 51:149-60
    • (2012) Genes Chromosom Cancer , vol.51 , pp. 149-160
    • Yoshimoto, M.1    Ludkovski, O.2    Degrace, D.3    Williams, J.L.4    Evans, A.5    Sircar, K.6
  • 15
    • 84857688369 scopus 로고    scopus 로고
    • Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats
    • Stankiewicz P, Kulkarni S, Dharmadhikari AV, Sampath S, Bhatt SS, Shaikh TH, et al. Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats. Hum Mutat. 2012;33:165-79
    • (2012) Hum Mutat , vol.33 , pp. 165-179
    • Stankiewicz, P.1    Kulkarni, S.2    Dharmadhikari, A.V.3    Sampath, S.4    Bhatt, S.S.5    Shaikh, T.H.6
  • 17
    • 84971492722 scopus 로고    scopus 로고
    • When genome maintenance goes badly awry
    • Kass EM, Moynahan ME, Jasin M. When genome maintenance goes badly awry. Mol Cell. 2016;62:777-87
    • (2016) Mol Cell , vol.62 , pp. 777-787
    • Kass, E.M.1    Moynahan, M.E.2    Jasin, M.3
  • 20
    • 34548299547 scopus 로고    scopus 로고
    • FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome
    • Yoshimoto M, Cunha IW, Coudry RA, Fonseca FP, Torres CH, Soares FA, et al. FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome. Br J Cancer. 2007;97:678-85
    • (2007) Br J Cancer , vol.97 , pp. 678-685
    • Yoshimoto, M.1    Cunha, I.W.2    Coudry, R.A.3    Fonseca, F.P.4    Ch, T.5    Soares, F.A.6
  • 21
    • 84869884237 scopus 로고    scopus 로고
    • Genomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity
    • Choucair K, Ejdelman J, Brimo F, Aprikian A, Chevalier S, Lapointe JPTEN. Genomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity. BMC Cancer. 2012;12: 543-51
    • (2012) BMC Cancer , vol.12 , pp. 543-551
    • Choucair, K.1    Ejdelman, J.2    Brimo, F.3    Aprikian, A.4    Chevalier, S.5    Jpten, L.6
  • 22
    • 84956632580 scopus 로고    scopus 로고
    • Integrated analysis of the genomic instability of PTEN in clinically insignificant and significant prostate cancer
    • Murphy SJ, Karnes RJ, Kosari F, Castellar BERP, Kipp BR, Johnson SH, et al. Integrated analysis of the genomic instability of PTEN in clinically insignificant and significant prostate cancer. Mod Pathol. 2016;29:143-56
    • (2016) Mod Pathol , vol.29 , pp. 143-156
    • Murphy, S.J.1    Karnes, R.J.2    Kosari, F.3    Berp, C.4    Kipp, B.R.5    Johnson, S.H.6
  • 25
    • 84968538157 scopus 로고    scopus 로고
    • Analytic validation of a clinical-grade PTEN immunohistochemistry assay in prostate cancer by comparison with PTEN FISH
    • Lotan TL, Wei W, Ludkovski O, Morais CL, Guedes LB, Jamaspishvili T, et al. Analytic validation of a clinical-grade PTEN immunohistochemistry assay in prostate cancer by comparison with PTEN FISH. Mod Pathol. 2016;29:904-14
    • (2016) Mod Pathol , vol.29 , pp. 904-914
    • Lotan, T.L.1    Wei, W.2    Ludkovski, O.3    Morais, C.L.4    Guedes, L.B.5    Jamaspishvili, T.6
  • 26
    • 84879690468 scopus 로고    scopus 로고
    • Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer
    • Cuzick J, Yang ZH, Fisher G, Tikishvili E, Stone S, Lanchbury JS, et al. Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer. Br J Cancer. 2013;108:2582-9
    • (2013) Br J Cancer , vol.108 , pp. 2582-2589
    • Cuzick, J.1    Zh, Y.2    Fisher, G.3    Tikishvili, E.4    Stone, S.5    Lanchbury, J.S.6
  • 27
    • 84944441319 scopus 로고    scopus 로고
    • Genetic variation and the de novo assembly of human genomes
    • Chaisson MJP, Wilson RK, Eichler EE. Genetic variation and the de novo assembly of human genomes. Nat Rev Genet. 2015;16:627-40
    • (2015) Nat Rev Genet , vol.16 , pp. 627-640
    • Chaisson, M.J.P.1    Wilson, R.K.2    Eichler, E.E.3
  • 29
    • 84885158978 scopus 로고    scopus 로고
    • The cancer biology of whole-chromosome instability
    • Duijf PHG, Benezra R. The cancer biology of whole-chromosome instability. Oncogene. 2013;32:4727-36
    • (2013) Oncogene , vol.32 , pp. 4727-4736
    • Duijf, P.H.G.1    Benezra, R.2
  • 30
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear PTEN in maintaining chromosomal integrity
    • Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell. 2007;128:157-70
    • (2007) Cell , vol.128 , pp. 157-170
    • Shen, W.H.1    Balajee, A.S.2    Wang, J.3    Wu, H.4    Eng, C.5    Pandolfi, P.P.6
  • 32
    • 84960540174 scopus 로고    scopus 로고
    • DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer
    • Kurfurstova D, Bartkova J, Vrtel R, Mickova A, Burdova A, Majera D, et al. DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer. Mol Oncol. 2016;10:879-94
    • (2016) Mol Oncol , vol.10 , pp. 879-894
    • Kurfurstova, D.1    Bartkova, J.2    Vrtel, R.3    Mickova, A.4    Burdova, A.5    Majera, D.6
  • 33
    • 84887992179 scopus 로고    scopus 로고
    • Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome
    • Davoli T, AW X, Mengwasser KE, Sack LM, Yoon JC, Park PJ, et al. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 2013;155:948-62
    • (2013) Cell , vol.155 , pp. 948-962
    • Davoli, T.1    Aw2    Mengwasser, K.E.3    Sack, L.M.4    Yoon, J.C.5    Park, P.J.6
  • 34
    • 84863541457 scopus 로고    scopus 로고
    • Recurrent hemizygous deletions in cancers may optimize proliferative potential
    • Solimini NL, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, et al. Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science. 2012;337:104-9
    • (2012) Science , vol.337 , pp. 104-109
    • Solimini, N.L.1    Xu, Q.2    Ch, M.3    Liang, A.C.4    Schlabach, M.R.5    Luo, J.6
  • 35
    • 84895926621 scopus 로고    scopus 로고
    • PTEN C-terminal deletion causes genomic instability and tumor development
    • Sun Z, Huang C, He J, Lamb KL, Kang X, Gu T, et al. PTEN C-terminal deletion causes genomic instability and tumor development. Cell Rep. 2014;6:844-54
    • (2014) Cell Rep , vol.6 , pp. 844-854
    • Sun, Z.1    Huang, C.2    He, J.3    Lamb, K.L.4    Kang, X.5    Gu, T.6
  • 37
    • 85016157905 scopus 로고    scopus 로고
    • Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer
    • Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, et al. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer. Nature. 2017; 542:484-8
    • (2017) Nature , vol.542 , pp. 484-488
    • Zhao, D.1    Lu, X.2    Wang, G.3    Lan, Z.4    Liao, W.5    Li, J.6
  • 38
    • 0026795845 scopus 로고
    • Expression of the cellular adhesion molecule E-Cadherin is reduced or absent in high-grade prostate cancer
    • Isaacs WB, Carter BS, Debruyne FMJ, Schalken JA. Expression of the cellular adhesion molecule E-Cadherin is reduced or absent in high-grade prostate cancer. Cancer Res. 1992;52:5104-9
    • (1992) Cancer Res , vol.52 , pp. 5104-5109
    • Isaacs, W.B.1    Carter, B.S.2    Debruyne, F.M.J.3    Schalken, J.A.4
  • 39
    • 84886059336 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway
    • Ni J, Cozzi P, Hao J, Beretov J, Chang L, Duan W, et al. Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway. Int J Biochem Cell Biol. 2013;45:2736-48
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 2736-2748
    • Ni, J.1    Cozzi, P.2    Hao, J.3    Beretov, J.4    Chang, L.5    Duan, W.6
  • 40
    • 84925664997 scopus 로고    scopus 로고
    • Integrins and cancer: Regulators of cancer stemness, metastasis, and drug resistance
    • Seguin L, Desgrosellier JS, Weis SM, Cheresh DA. Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance. Trends Cell Biol. 2015;25:234-40
    • (2015) Trends Cell Biol , vol.25 , pp. 234-240
    • Seguin, L.1    Desgrosellier, J.S.2    Weis, S.M.3    Cheresh, D.A.4
  • 41
    • 84899586492 scopus 로고    scopus 로고
    • Interleukin-17 promotes development of castration-resistant prostate cancer potentially through creating an immunotolerant and pro-angiogenic tumor microenvironment
    • Zhang Q, Liu S, Zhang Q, Xiong Z, Wang AR, Myers L, et al. Interleukin-17 promotes development of castration-resistant prostate cancer potentially through creating an immunotolerant and pro-angiogenic tumor microenvironment. Prostate. 2014;74:869-79
    • (2014) Prostate , vol.74 , pp. 869-879
    • Zhang, Q.1    Liu, S.2    Zhang, Q.3    Xiong, Z.4    Wang, A.R.5    Myers, L.6
  • 42
    • 84976867074 scopus 로고    scopus 로고
    • Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer
    • Martin PL, Yin J-J, Seng V, Casey O, Corey E, Morrissey C, et al. Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer. Oncogene. 2017; 36:525-33
    • (2017) Oncogene , vol.36 , pp. 525-533
    • Martin, P.L.1    Yin, J.-J.2    Seng, V.3    Casey, O.4    Corey, E.5    Morrissey, C.6
  • 43
    • 77955382651 scopus 로고    scopus 로고
    • Clinical outcomes and correlates of TP53 mutations and cancer
    • Robles AI, Harris CC. Clinical outcomes and correlates of TP53 mutations and cancer. Cold Spring Harb Perspect Biol. 2010;2:1-15
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , pp. 1-15
    • Robles, A.I.1    Harris, C.C.2
  • 46
    • 84870377034 scopus 로고    scopus 로고
    • A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas
    • Nikolaev SI, Sotiriou SK, Pateras IS, Santoni F, Sougioultzis S, Edgren H, et al. A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas. Cancer Res. 2012;72: 6279-89
    • (2012) Cancer Res , vol.72 , pp. 6279-6289
    • Nikolaev, S.I.1    Sotiriou, S.K.2    Pateras, I.S.3    Santoni, F.4    Sougioultzis, S.5    Edgren, H.6
  • 47
    • 83155184073 scopus 로고    scopus 로고
    • Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with cowden and cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations
    • Ngeow J, Mester J, Rybicki LA, Ni Y, Milas M, Eng C. Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with cowden and cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations. J Clin Endocrinol Metab. 2011;96:2063-71
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2063-2071
    • Ngeow, J.1    Mester, J.2    Rybicki, L.A.3    Ni, Y.4    Milas, M.5    Eng, C.6
  • 49
    • 79956199669 scopus 로고    scopus 로고
    • FAS Haploinsufficiency is a common disease mechanism in the human autoimmune Lymphoproliferative syndrome
    • Kuehn HS, Caminha I, Niemela JE, Rao VK, Davis J, Fleisher TA, et al. FAS Haploinsufficiency is a common disease mechanism in the human autoimmune Lymphoproliferative syndrome. J Immunol. 2011;186:6035-43
    • (2011) J Immunol , vol.186 , pp. 6035-6043
    • Kuehn, H.S.1    Caminha, I.2    Niemela, J.E.3    Rao, V.K.4    Davis, J.5    Fleisher, T.A.6
  • 50
    • 84907440621 scopus 로고    scopus 로고
    • Evidence for molecular differences in prostate cancer between african American and Caucasian men
    • Khani F, Mosquera JM, Park K, Blattner M, OReilly C, MacDonald TY, et al. Evidence for molecular differences in prostate cancer between african American and Caucasian men. Clin Cancer Res. 2014;20:4925-34
    • (2014) Clin Cancer Res , vol.20 , pp. 4925-4934
    • Khani, F.1    Mosquera, J.M.2    Park, K.3    Blattner, M.4    Oreilly, C.5    MacDonald, T.Y.6
  • 52
    • 84979788035 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of PTEN loss in African-American and European-American men undergoing radical prostatectomy
    • Tosoian JJ, Almutairi F, Morais CL, Glavaris S, Hicks J, Sundi D, et al. Prevalence and prognostic significance of PTEN loss in African-American and European-American men undergoing radical prostatectomy. Eur Urol. European association of. Urology. 2017;71:697-700
    • (2017) Eur Urol. European Association Of. Urology , vol.71 , pp. 697-700
    • Tosoian, J.J.1    Almutairi, F.2    Morais, C.L.3    Glavaris, S.4    Hicks, J.5    Sundi, D.6
  • 53
    • 77953704493 scopus 로고    scopus 로고
    • Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size
    • Shinawi M, Liu P, Kang SHL, Shen J, Belmont JW, Scott D, et al. Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size. J Med Genet. 2010;47:332-41
    • (2010) J Med Genet , vol.47 , pp. 332-341
    • Shinawi, M.1    Liu, P.2    Kang, S.H.L.3    Shen, J.4    Belmont, J.W.5    Scott, D.6
  • 54
    • 85042623052 scopus 로고    scopus 로고
    • The identification of microdeletion and reciprocal microduplication in 22q11.2 using high-resolution CMA technology
    • Leite AJC, Pinto IP, Da Cruz E, Cunha DM, Ribeiro CL, Da Silva CC, et al. The identification of microdeletion and reciprocal microduplication in 22q11.2 using high-resolution CMA technology. Biomed Res Int. 2016;2016:1-9
    • (2016) Biomed Res Int , vol.2016 , pp. 1-9
    • Leite, A.J.C.1    Pinto, I.P.2    Da Cruz, E.3    Cunha, D.M.4    Ribeiro, C.L.5    Da Silva, C.C.6
  • 56
    • 84873412457 scopus 로고    scopus 로고
    • MATH, A novel measure of intratumor genetic heterogeneity, is high in poor-outcome classes of head and neck squamous cell carcinoma
    • Mroz EA, Rocco JW. MATH, A novel measure of intratumor genetic heterogeneity, is high in poor-outcome classes of head and neck squamous cell carcinoma. Oral Oncol. 2013;49:211-5
    • (2013) Oral Oncol , vol.49 , pp. 211-215
    • Mroz, E.A.1    Rocco, J.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.