메뉴 건너뛰기




Volumn 8, Issue 1, 2018, Pages 37-48

Genomic heterogeneity as a barrier to precision medicine in gastroesophageal adenocarcinoma

(57)  Pectasides, Eirini a,b   Stachler, Matthew D a,c   Derks, Sarah a,d   Liu, Yang a,e   Maron, Steven f   Islam, Mirazul a,e   Alpert, Lindsay f   Kwak, Heewon f   Kindler, Hedy f   Polite, Blase f   Sharma, Manish R f   Allen, Kenisha f   O’Day, Emily f   Lomnicki, Samantha f   Maranto, Melissa f   Kanteti, Rajani f   Fitzpatrick, Carrie f   Weber, Christopher f   Setia, Namrata f   Xiao, Shu Yuan f   more..


Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; OXALIPLATIN; TRASTUZUMAB;

EID: 85042565998     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-17-0395     Document Type: Article
Times cited : (251)

References (54)
  • 1
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
    • Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2014;136: E359–86.
    • (2014) Int J Cancer , vol.136 , pp. E359-E386
    • Ferlay, J.1    Soerjomataram, I.2    Dikshit, R.3    Eser, S.4    Mathers, C.5    Rebelo, M.6
  • 3
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239–46.
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3    Vergnenegre, A.4    Massuti, B.5    Felip, E.6
  • 5
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010;376:687–97.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3    Chung, H.C.4    Shen, L.5    Sawaki, A.6
  • 6
    • 84958818670 scopus 로고    scopus 로고
    • Lapatinib in combination with capecitabine plus oxaliplatin in human epidermal growth factor receptor 2-Positive advanced or metastatic gastric, esophageal, or gastroesophageal adenocarcinoma: TRIO-013/LOGiC- A randomized phase III trial
    • Hecht JR, Bang Y-J, Qin SK, Chung HC, Xu JM, Park JO, et al. Lapatinib in combination with capecitabine plus oxaliplatin in human epidermal growth factor receptor 2-Positive advanced or metastatic gastric, esophageal, or gastroesophageal adenocarcinoma: TRIO-013/LOGiC- A randomized phase III trial. J Clin Oncol 2016;34: 443–51.
    • (2016) J Clin Oncol , vol.34 , pp. 443-451
    • Hecht, J.R.1    Bang, Y.-J.2    Qin, S.K.3    Chung, H.C.4    Xu, J.M.5    Park, J.O.6
  • 7
    • 84940608924 scopus 로고    scopus 로고
    • METGastric: A phase III study of onartuzumab plus mFOLFOX6 in patients with metastatic HER2-negative (HER2-) and MET-positive (MET+) adenocarcinoma of the stomach or gastroesophageal junction (GEC)
    • Shah MA, Bang Y-J, Lordick F, Tabernero J, Chen M, Hack SP, et al. METGastric: a phase III study of onartuzumab plus mFOLFOX6 in patients with metastatic HER2-negative (HER2-) and MET-positive (MET+) adenocarcinoma of the stomach or gastroesophageal junction (GEC). ASCO Meeting Abstracts 2015;33:4012.
    • (2015) ASCO Meeting Abstracts , vol.33 , pp. 4012
    • Shah, M.A.1    Bang, Y.-J.2    Lordick, F.3    Tabernero, J.4    Chen, M.5    Hack, S.P.6
  • 8
    • 85029894816 scopus 로고    scopus 로고
    • Rilotumumab plus epirubicin, cisplatin, and capecitabine as first-line therapy in advanced MET-positive gastric or gastro-oesophageal junction cancer (RILOMET-1): A randomised, double-blind, placebo-controlled, phase 3 trial
    • Sep 25
    • Catenacci DVT, Tebbutt NC, Davidenko I, Murad AM, Al-Batran SE, Ilson DH, et al. Rilotumumab plus epirubicin, cisplatin, and capecitabine as first-line therapy in advanced MET-positive gastric or gastro-oesophageal junction cancer (RILOMET-1): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol 2017 Sep 25. pii: S1470-2045(17)30566–1.
    • (2017) Lancet Oncol
    • Catenacci, D.V.T.1    Tebbutt, N.C.2    Davidenko, I.3    Murad, A.M.4    Al-Batran, S.E.5    Ilson, D.H.6
  • 9
    • 84940585870 scopus 로고    scopus 로고
    • A randomized, open-label phase II study of AZD4547 (AZD) versus paclitaxel (P) in previously treated patients with advanced gastric cancer (AGC) with fibroblast growth factor receptor 2 (FGFR2) polysomy or gene amplification (amp): SHINE study
    • Bang Y-J, Van Cutsem E, Mansoor W, Petty RD, Chao Y, Cunningham D, et al. A randomized, open-label phase II study of AZD4547 (AZD) versus paclitaxel (P) in previously treated patients with advanced gastric cancer (AGC) with fibroblast growth factor receptor 2 (FGFR2) polysomy or gene amplification (amp): SHINE study. ASCO Meeting Abstracts 2015;33:4014.
    • (2015) ASCO Meeting Abstracts , vol.33 , pp. 4014
    • Bang, Y.-J.1    Van Cutsem, E.2    Mansoor, W.3    Petty, R.D.4    Chao, Y.5    Cunningham, D.6
  • 10
    • 84876951761 scopus 로고    scopus 로고
    • Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): A randomised, open-label phase 3 trial
    • Lordick F, Kang Y-K, Chung H-C, Salman P, Oh SC, Bodoky G, et al. Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial. Lancet Oncol 2013;14:490–9.
    • (2013) Lancet Oncol , vol.14 , pp. 490-499
    • Lordick, F.1    Kang, Y.-K.2    Chung, H.-C.3    Salman, P.4    Oh, S.C.5    Bodoky, G.6
  • 11
    • 84876992498 scopus 로고    scopus 로고
    • Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): A randomised, open-label phase 3 trial
    • Waddell T, Chau I, Cunningham D, Gonzalez D, Okines AFC, Frances A, et al. Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial. Lancet Oncol 2013;14:481–9.
    • (2013) Lancet Oncol , vol.14 , pp. 481-489
    • Waddell, T.1    Chau, I.2    Cunningham, D.3    Gonzalez, D.4    Okines, A.F.C.5    Frances, A.6
  • 12
    • 80051612067 scopus 로고    scopus 로고
    • Heterogeneous distribution of EGFR mutations is extremely rare in lung adenocarcinoma
    • Yatabe Y, Matsuo K, Mitsudomi T. Heterogeneous distribution of EGFR mutations is extremely rare in lung adenocarcinoma. J Clin Oncol 2011;29:2972–7.
    • (2011) J Clin Oncol , vol.29 , pp. 2972-2977
    • Yatabe, Y.1    Matsuo, K.2    Mitsudomi, T.3
  • 13
    • 84864042630 scopus 로고    scopus 로고
    • BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma
    • Colombino M, Capone M, Lissia A, Cossu A, Rubino C, De Giorgi V, et al. BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma. J Clin Oncol 2012;30: 2522–9.
    • (2012) J Clin Oncol , vol.30 , pp. 2522-2529
    • Colombino, M.1    Capone, M.2    Lissia, A.3    Cossu, A.4    Rubino, C.5    De Giorgi, V.6
  • 14
    • 84882715124 scopus 로고    scopus 로고
    • Tumor homogeneity between primary and metastatic sites for BRAF status in metastatic melanoma determined by immunohisto-chemical and molecular testing
    • Boursault L, Haddad V, Vergier B, Cappellen D, Verdon S, Bellocq J-P, et al. Tumor homogeneity between primary and metastatic sites for BRAF status in metastatic melanoma determined by immunohisto-chemical and molecular testing. PLoS ONE 2013;8:e70826.
    • (2013) Plos ONE , vol.8
    • Boursault, L.1    Haddad, V.2    Vergier, B.3    Cappellen, D.4    Verdon, S.5    Bellocq, J.-P.6
  • 15
    • 84865186133 scopus 로고    scopus 로고
    • Comparative genomic analysis of primary versus metastatic colorectal carcinomas
    • Vakiani E, Janakiraman M, Shen R, Sinha R, Zeng Z, Shia J, et al. Comparative genomic analysis of primary versus metastatic colorectal carcinomas. J Clin Oncol 2012;30:2956–62.
    • (2012) J Clin Oncol , vol.30 , pp. 2956-2962
    • Vakiani, E.1    Janakiraman, M.2    Shen, R.3    Sinha, R.4    Zeng, Z.5    Shia, J.6
  • 16
    • 84920285505 scopus 로고    scopus 로고
    • Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions
    • Brannon AR, Vakiani E, Sylvester BE, Scott SN, McDermott G, Shah RH, et al. Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions. Genome Biol 2014;15:454.
    • (2014) Genome Biol , vol.15 , pp. 454
    • Brannon, A.R.1    Vakiani, E.2    Sylvester, B.E.3    Scott, S.N.4    McDermott, G.5    Shah, R.H.6
  • 17
    • 84923013251 scopus 로고    scopus 로고
    • Concordant analysis of KRAS, BRAF, PIK3CA mutations, and PTEN expression between primary colorectal cancer and matched metastases
    • Mao C, Wu X-Y, Yang Z-Y, Threapleton DE, Yuan J-Q, Yu Y-Y, et al. Concordant analysis of KRAS, BRAF, PIK3CA mutations, and PTEN expression between primary colorectal cancer and matched metastases. Sci Rep 2015;5:8065.
    • (2015) Sci Rep , vol.5 , pp. 8065
    • Mao, C.1    Wu, X.-Y.2    Yang, Z.-Y.3    Threapleton, D.E.4    Yuan, J.-Q.5    Yu, Y.-Y.6
  • 18
    • 0035990831 scopus 로고    scopus 로고
    • Comparison of HER-2 status between primary breast cancer and corresponding distant metastatic sites
    • Gancberg D, Di Leo A, Cardoso F, Rouas G, Pedrocchi M, Paesmans M, et al. Comparison of HER-2 status between primary breast cancer and corresponding distant metastatic sites. Ann Oncol 2002;13: 1036–43.
    • (2002) Ann Oncol , vol.13 , pp. 1036-1043
    • Gancberg, D.1    Di Leo, A.2    Cardoso, F.3    Rouas, G.4    Pedrocchi, M.5    Paesmans, M.6
  • 20
    • 84888810020 scopus 로고    scopus 로고
    • Discordance in ERα, PR and HER2 receptor status across different distant breast cancer metastases within the same patient
    • Hoefnagel LDC, van der Groep P, van de Vijver MJ, Boers JE, Wesseling P, Wesseling J, et al. Discordance in ERα, PR and HER2 receptor status across different distant breast cancer metastases within the same patient. Ann Oncol 2013;24:3017–23.
    • (2013) Ann Oncol , vol.24 , pp. 3017-3023
    • Hoefnagel, L.D.C.1    Van Der Groep, P.2    Van De Vijver, M.J.3    Boers, J.E.4    Wesseling, P.5    Wesseling, J.6
  • 21
    • 84915803539 scopus 로고    scopus 로고
    • Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2-amplified gastroesophageal adenocarcinoma
    • Kim J, Fox C, Peng S, Pusung M, Pectasides E, Matthee E, et al. Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2-amplified gastroesophageal adenocarcinoma. J Clin Invest 2014;124:5145–58.
    • (2014) J Clin Invest , vol.124 , pp. 5145-5158
    • Kim, J.1    Fox, C.2    Peng, S.3    Pusung, M.4    Pectasides, E.5    Matthee, E.6
  • 22
    • 84907270779 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of gastric adenocarcinoma
    • Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 2014;513:202–9.
    • (2014) Nature , vol.513 , pp. 202-209
  • 23
    • 84940612958 scopus 로고    scopus 로고
    • Whole-genome sequencing provides new insights into the clonal architecture of Barrett’s esophagus and esophageal adenocarcinoma
    • Ross-Innes CS, Becq J, Warren A, Cheetham RK, Northen H, O’Donovan M, et al. Whole-genome sequencing provides new insights into the clonal architecture of Barrett’s esophagus and esophageal adenocarcinoma. Nat Genet 2015;47:1038–46.
    • (2015) Nat Genet , vol.47 , pp. 1038-1046
    • Ross-Innes, C.S.1    Becq, J.2    Warren, A.3    Cheetham, R.K.4    Northen, H.5    O’Donovan, M.6
  • 25
    • 84957991275 scopus 로고    scopus 로고
    • Intra-Tumoral Heterogeneity of HER2, FGFR2, cMET and ATM in Gastric Cancer: Optimizing Personalized Healthcare through Innovative Pathological and Statistical Analysis
    • Ye P, Zhang M, Fan S, Zhang T, Fu H, Su X, et al. Intra-Tumoral Heterogeneity of HER2, FGFR2, cMET and ATM in Gastric Cancer: Optimizing Personalized Healthcare through Innovative Pathological and Statistical Analysis. PLoS ONE 2015;10:e0143207.
    • (2015) Plos ONE , vol.10
    • Ye, P.1    Zhang, M.2    Fan, S.3    Zhang, T.4    Fu, H.5    Su, X.6
  • 26
    • 85042557058 scopus 로고    scopus 로고
    • Frequent coamplification of receptor tyrosine kinase and downstream signaling genes in japanese primary gastric cancer and conversion in matched lymph node metastasis
    • Published Ahead of Print:1
    • Silva ANS, Coffa J, Menon V, Hewitt LC, Das K, Miyagi Y, et al. Frequent coamplification of receptor tyrosine kinase and downstream signaling genes in japanese primary gastric cancer and conversion in matched lymph node metastasis. Ann Surg 2016; Published Ahead of Print:1.
    • (2016) Ann Surg
    • Silva, A.N.S.1    Coffa, J.2    Menon, V.3    Hewitt, L.C.4    Das, K.5    Miyagi, Y.6
  • 27
    • 84947781075 scopus 로고    scopus 로고
    • Ideal number of biopsy tumor fragments for predicting HER2 status in gastric carcinoma resection specimens
    • Ahn S, Ahn S, Van Vrancken M, Lee M, Ha SY, Lee H, et al. Ideal number of biopsy tumor fragments for predicting HER2 status in gastric carcinoma resection specimens. Oncotarget 2015;6:38372–80.
    • (2015) Oncotarget , vol.6 , pp. 38372-38380
    • Ahn, S.1    Ahn, S.2    Van Vrancken, M.3    Lee, M.4    Ha, S.Y.5    Lee, H.6
  • 28
    • 84982084091 scopus 로고    scopus 로고
    • Assessment of HER2 status in patients with gastroesophageal adenocarcinoma treated with epirubicin-based chemotherapy: Heterogeneity-related issues and prognostic implications
    • Personeni N, Baretti M, Bozzarelli S, Spaggiari P, Rubino L, Tronconi MC, et al. Assessment of HER2 status in patients with gastroesophageal adenocarcinoma treated with epirubicin-based chemotherapy: heterogeneity-related issues and prognostic implications. Gastric Cancer 2017;20:428–37.
    • (2017) Gastric Cancer , vol.20 , pp. 428-437
    • Personeni, N.1    Baretti, M.2    Bozzarelli, S.3    Spaggiari, P.4    Rubino, L.5    Tronconi, M.C.6
  • 29
    • 84949575492 scopus 로고    scopus 로고
    • Extra-gain of HER2-positive cases through HER2 reassessment in primary and metastatic sites in advanced gastric cancer with initially HER2-negative primary tumours: Results of GASTric cancer HER2 reassessment study 1 (GASTHER1)
    • Park SR, Park YS, Ryu M-H, Ryoo B-Y, Woo CG, Jung H-Y, et al. Extra-gain of HER2-positive cases through HER2 reassessment in primary and metastatic sites in advanced gastric cancer with initially HER2-negative primary tumours: results of GASTric cancer HER2 reassessment study 1 (GASTHER1). Eur J Cancer 2016;53: 42–50.
    • (2016) Eur J Cancer , vol.53 , pp. 42-50
    • Park, S.R.1    Park, Y.S.2    Ryu, M.-H.3    Ryoo, B.-Y.4    Woo, C.G.5    Jung, H.-Y.6
  • 30
    • 84942101777 scopus 로고    scopus 로고
    • Preferential HER2 expression in liver metastases and EGFR expression in peritoneal metastases in patients with advanced gastric cancer
    • Saito T, Nakanishi H, Mochizuki Y, Ito S, Ito Y, Misawa K, et al. Preferential HER2 expression in liver metastases and EGFR expression in peritoneal metastases in patients with advanced gastric cancer. Gastric Cancer 2015;18:711–9.
    • (2015) Gastric Cancer , vol.18 , pp. 711-719
    • Saito, T.1    Nakanishi, H.2    Mochizuki, Y.3    Ito, S.4    Ito, Y.5    Misawa, K.6
  • 31
    • 79955468866 scopus 로고    scopus 로고
    • Comparison of HER2 status in primary and paired metastatic sites of gastric carcinoma
    • Bozzetti C, Negri FV, Lagrasta CA, Crafa P, Bassano C, Tamagnini I, et al. Comparison of HER2 status in primary and paired metastatic sites of gastric carcinoma. Br J Cancer 2011;104:1372–6.
    • (2011) Br J Cancer , vol.104 , pp. 1372-1376
    • Bozzetti, C.1    Negri, F.V.2    Lagrasta, C.A.3    Crafa, P.4    Bassano, C.5    Tamagnini, I.6
  • 32
    • 85020682540 scopus 로고    scopus 로고
    • HER2 testing and clinical decision making in gastroesophageal adenocarcinoma: Guideline from the college of American pathologists, American Society for Clinical Pathology, and the American Society of Clinical Oncology
    • Bartley AN, Washington MK, Colasacco C, Ventura CB, Ismaila N, Benson AB, et al. HER2 testing and clinical decision making in gastroesophageal adenocarcinoma: guideline from the college of American pathologists, American Society for Clinical Pathology, and the American Society of Clinical Oncology. J Clin Oncol 2017;35:446–64.
    • (2017) J Clin Oncol , vol.35 , pp. 446-464
    • Bartley, A.N.1    Washington, M.K.2    Colasacco, C.3    Ventura, C.B.4    Ismaila, N.5    Benson, A.B.6
  • 33
    • 85042565464 scopus 로고    scopus 로고
    • Pertuzumab (P) + trastuzumab (H) + chemotherapy (CT) for HER2-positive metastatic gastric or gastro-oesophageal junction cancer (mGC/GEJC): Final analysis of a Phase III study (JACOB
    • Tabernero J, Hoff PM, Shen L, Ohtsu A, Shah MA, Cheng K, et al. Pertuzumab (P) + trastuzumab (H) + chemotherapy (CT) for HER2-positive metastatic gastric or gastro-oesophageal junction cancer (mGC/GEJC): final analysis of a Phase III study (JACOB). Ann Oncol 2017;28(Suppl 5):v209–68.
    • (2017) Ann Oncol , vol.28 , pp. v209-v268
    • Tabernero, J.1    Hoff, P.M.2    Shen, L.3    Ohtsu, A.4    Shah, M.A.5    Cheng, K.6
  • 35
    • 84960109778 scopus 로고    scopus 로고
    • Molecular heterogeneity and receptor co-amplification drive resistance to targeted therapy in MET-amplified esophagogastric cancer
    • Kwak EL, Ahronian LG, Siravegna G, Mussolin B, Godfrey JT, Clark JW, et al. Molecular heterogeneity and receptor co-amplification drive resistance to targeted therapy in MET-amplified esophagogastric cancer. Cancer Discov 2015;5:1271–81.
    • (2015) Cancer Discov , vol.5 , pp. 1271-1281
    • Kwak, E.L.1    Ahronian, L.G.2    Siravegna, G.3    Mussolin, B.4    Godfrey, J.T.5    Clark, J.W.6
  • 36
    • 84982958036 scopus 로고    scopus 로고
    • High-level clonal FGFR amplification and response to FGFR inhibition in a translational clinical trial
    • Pearson A, Smyth E, Babina IS, Herrera-Abreu MT, Tarazona N, Peckitt C, et al. High-level clonal FGFR amplification and response to FGFR inhibition in a translational clinical trial. Cancer Discov 2016;6:838–51.
    • (2016) Cancer Discov , vol.6 , pp. 838-851
    • Pearson, A.1    Smyth, E.2    Babina, I.S.3    Herrera-Abreu, M.T.4    Tarazona, N.5    Peckitt, C.6
  • 37
    • 84940485164 scopus 로고    scopus 로고
    • Use of biomarkers to guide decisions on systemic therapy for women with metastatic breast cancer: American Society of Clinical Oncology Clinical Practice Guideline
    • Van Poznak C, Somerfield MR, Bast RC, Cristofanilli M, Goetz MP, Gonzalez-Angulo AM, et al. Use of biomarkers to guide decisions on systemic therapy for women with metastatic breast cancer: American Society of Clinical Oncology Clinical Practice Guideline. J. Clin. Oncol 2015:2695–704.
    • (2015) J. Clin. Oncol , pp. 2695-2704
    • Van Poznak, C.1    Somerfield, M.R.2    Bast, R.C.3    Cristofanilli, M.4    Goetz, M.P.5    Gonzalez-Angulo, A.M.6
  • 38
    • 84863136284 scopus 로고    scopus 로고
    • Quantitative analysis of cell-free DNA in the plasma of gastric cancer patients
    • Park J-L, Kim HJ, Choi BY, Lee H-C, Jang H-R, Song KS, et al. Quantitative analysis of cell-free DNA in the plasma of gastric cancer patients. Oncol Lett 2012;3:921–6.
    • (2012) Oncol Lett , vol.3 , pp. 921-926
    • Park, J.-L.1    Kim, H.J.2    Choi, B.Y.3    Lee, H.-C.4    Jang, H.-R.5    Song, K.S.6
  • 39
    • 84863045726 scopus 로고    scopus 로고
    • Genome-wide DNA Methylation profiling of cell-free serum DNA in esophageal adenocarcinoma and barrett esophagus
    • Zhai R, Zhao Y, Su L, Cassidy L, Liu G, Christiani DC. Genome-wide DNA Methylation profiling of cell-free serum DNA in esophageal adenocarcinoma and barrett esophagus. Neoplasia 2012;14:29–33.
    • (2012) Neoplasia , vol.14 , pp. 29-33
    • Zhai, R.1    Zhao, Y.2    Su, L.3    Cassidy, L.4    Liu, G.5    Christiani, D.C.6
  • 40
    • 84896539307 scopus 로고    scopus 로고
    • Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA
    • Oxnard GR, Paweletz CP, Kuang Y, Mach SL, O’Connell A, Messineo MM, et al. Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA. Clin Cancer Res 2014;20:1698–705.
    • (2014) Clin Cancer Res , vol.20 , pp. 1698-1705
    • Oxnard, G.R.1    Paweletz, C.P.2    Kuang, Y.3    Mach, S.L.4    O’Connell, A.5    Messineo, M.M.6
  • 41
    • 84870312106 scopus 로고    scopus 로고
    • Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing
    • Leary RJ, Sausen M, Kinde I, Papadopoulos N, Carpten JD, Craig D, et al. Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Sci Transl Med 2012; 4:162ra154–4.
    • (2012) Sci Transl Med , vol.4
    • Leary, R.J.1    Sausen, M.2    Kinde, I.3    Papadopoulos, N.4    Carpten, J.D.5    Craig, D.6
  • 42
    • 84990050278 scopus 로고    scopus 로고
    • Association between plasma genotyping and outcomes of treatment with osimertinib (AZD9291) in advanced non-small-cell lung cancer
    • Oxnard GR, Thress KS, Alden RS, Lawrance R, Paweletz CP, Cantarini M, et al. Association between plasma genotyping and outcomes of treatment with osimertinib (AZD9291) in advanced non-small-cell lung cancer. J Clin Oncol 2016;34:3375–82.
    • (2016) J Clin Oncol , vol.34 , pp. 3375-3382
    • Oxnard, G.R.1    Thress, K.S.2    Alden, R.S.3    Lawrance, R.4    Paweletz, C.P.5    Cantarini, M.6
  • 43
    • 78650762588 scopus 로고    scopus 로고
    • A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries
    • Fisher S, Barry A, Abreu J, Minie B, Nolan J, Delorey TM, et al. A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries. Genome Biol 2011;12:R1.
    • (2011) Genome Biol , vol.12 , pp. R1
    • Fisher, S.1    Barry, A.2    Abreu, J.3    Minie, B.4    Nolan, J.5    Delorey, T.M.6
  • 45
    • 80052707308 scopus 로고    scopus 로고
    • ContEst: Estimating cross-contamination of human samples in next-generation sequencing data
    • Cibulskis K, McKenna A, Fennell T, Banks E, DePristo M, Getz G. ContEst: estimating cross-contamination of human samples in next-generation sequencing data. Bioinformatics 2011;27:2601–2.
    • (2011) Bioinformatics , vol.27 , pp. 2601-2602
    • Cibulskis, K.1    McKenna, A.2    Fennell, T.3    Banks, E.4    Depristo, M.5    Getz, G.6
  • 46
    • 34147104969 scopus 로고    scopus 로고
    • A faster circular binary segmentation algorithm for the analysis of array CGH data
    • Venkatraman ES, Olshen AB. A faster circular binary segmentation algorithm for the analysis of array CGH data. Bioinformatics 2007; 23:657–63.
    • (2007) Bioinformatics , vol.23 , pp. 657-663
    • Venkatraman, E.S.1    Olshen, A.B.2
  • 51
    • 77955405475 scopus 로고    scopus 로고
    • Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor
    • McLaren W, Pritchard B, Rios D, Chen Y, Flicek P, Cunningham F. Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor. Bioinformatics 2010;26:2069–70.
    • (2010) Bioinformatics , vol.26 , pp. 2069-2070
    • McLaren, W.1    Pritchard, B.2    Rios, D.3    Chen, Y.4    Flicek, P.5    Cunningham, F.6
  • 52
    • 84936114621 scopus 로고    scopus 로고
    • BreaKmer: Detection of structural variation in targeted massively parallel sequencing data using kmers
    • Abo RP, Ducar M, Garcia EP, Thorner AR, Rojas-Rudilla V, Lin L, et al. BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers. Nucleic Acids Res 2015; 43: e19–9.
    • (2015) Nucleic Acids Res , vol.43 , pp. e19-e19
    • Abo, R.P.1    Ducar, M.2    Garcia, E.P.3    Thorner, A.R.4    Rojas-Rudilla, V.5    Lin, L.6
  • 53
    • 84928582479 scopus 로고    scopus 로고
    • Next-generation clinical trials: Novel strategies to address the challenge of tumor molecular heterogeneity
    • Catenacci DVT. Next-generation clinical trials: Novel strategies to address the challenge of tumor molecular heterogeneity. Mol Oncol 2015;9:967–96.
    • (2015) Mol Oncol , vol.9 , pp. 967-996
    • Catenacci, D.V.T.1
  • 54
    • 84954025664 scopus 로고    scopus 로고
    • Expansion platform type II: Testing a treatment strategy
    • Catenacci DVT. Expansion platform type II: testing a treatment strategy. Lancet Oncol 2015;16:1276–8.
    • (2015) Lancet Oncol , vol.16 , pp. 1276-1278
    • Catenacci, D.V.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.