Platelet-derived microvesicles: A potential therapy for trauma-induced coagulopathy

Shock

Volumn 49, Issue 3, 2018, Pages 243-248

  Lopez, Ernesto ^a   Srivastava, Amit K ^a   Pati, Shibani ^b   Holcomb, John B ^a   Wade, Charles E ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Coagulopathy; Extracellular vesicles; Microparticles; Therapy; Transfusions; Trauma

Indexed keywords

PROCOAGULANT;

BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD VESSEL TONE; CELL THERAPY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIOPATHY OF TRAUMA; ENDOTHELIUM; EXOSOME; HEMOSTASIS; HUMAN; INFLAMMATION; INJURY; PERMEABILITY BARRIER; PLATELET MICROPARTICLE; REVIEW; THROMBOSIS; TRAUMA INDUCED COAGULOPATHY; BLOOD; COMPLICATION; FEMALE; MALE; MEMBRANE MICROPARTICLE; METABOLISM; THROMBOCYTE; THROMBOCYTE TRANSFUSION; TRANSPLANTATION;

BLOOD COAGULATION DISORDERS; BLOOD PLATELETS; CELL-DERIVED MICROPARTICLES; FEMALE; HUMANS; MALE; PLATELET TRANSFUSION; WOUNDS AND INJURIES;

EID: 85042432922     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000974     Document Type: Review

References (60)

1. National-Center-for-Health-Statistics. Leading causes of death reports, national and regional, 1999-2015: Center for Disease Control and Prevention; 2014 [cited 2017 January].
2. Morton AP,Moore EE,Wohlauer MV, Lo K, Silliman CC, Burlew CC, Banerjee A, Revisiting early postinjury mortality. Are they bleeding because they are dying or dying because they are bleeding? J Surg Res 179(1): 5-9, 2013.
3. Gunter OL Jr, Au BK, Isbell JM, Mowery NT, Young PP, Cotton BA: Optimizing outcomes in damage control resuscitation: Identifying blood product ratios associated with improved survival. J Trauma 65(3): 527-534, 2008.
4. Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, et al.: Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 248(3): 447-458, 2008.
5. Spinella PC, Pidcoke HF, Strandenes G, Hervig T, Fisher A, Jenkins D, Yazer M, Stubbs J, Murdock A, Sailliol A, et al.: Whole blood for hemostatic resuscitation of major bleeding. Transfusion 56(suppl 2): S190-202, 2016.
6. Cardenas JC, Wade CE, Holcomb JB: Mechanisms of trauma-induced coagulopathy. Curr Opin Hematol 21(5): 404-409, 2014.
7. Etchill EW, Myers SP, Raval JS, Hassoune A, SenGupta A, Neal MD: Platelet transfusion in critical care and surgery: Evidence-based review of contemporary practice and future directions. Shock 47(5): 537-549, 2017.
8. Pidcoke HF, Spinella PC, Ramasubramanian AK, Strandenes G, Hervig T, Ness PM, Cap AP: Refrigerated platelets for the treatment of acute bleeding: A review of the literature and reexamination of current standards. Shock 41(suppl 1): 51-53, 2014.
9. Schmidt AE, Refaai MA, Blumberg N: Platelet transfusion and thrombosis: More questions than answers. Semin Thromb Hemost 42(2): 118-124, 2016.
10. Nomura S: Microparticle and atherothrombotic diseases. J Atheroscler Thromb 23(1): 1-9, 2016.
11. Boilard E, Duchez AC, Brisson A: The diversity of platelet microparticles. Curr Opin Hematol 22(5): 437-444, 2015.
12. Maegele M, Schochl H, Cohen MJ: An update on the coagulopathy of trauma. Shock 41(suppl 1): 21-25, 2014.
13. Johansson P, Stensballe J, Ostrowski S: Shock induced endotheliopathy (SHINE) in acute critical illness-A unifying pathophysiologic mechanism. Crit Care 21(1): 25, 2017.
14. Chang R, Cardenas JC, Wade CE, Holcomb JB: Advances in the understanding of trauma-induced coagulopathy. Blood 128(8): 1043-1049, 2016.
15. Chargaff E,West R: The biological significance of the thromboplastic protein of blood. J Biol Chem 166(1): 189-197, 1946.
16. Wolf P: The nature and significance of platelet products in human plasma. Br J Haematol 13(3): 269-288, 1967.
17. Yanez-Mo M, Siljander PR, Andreu Z, Zavec AB, Borras FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, et al.: Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles 4(1): 27066, 2015.
18. Colombo M, Raposo G, Thery C: Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol 30(1): 255-289, 2014.
19. Koniusz S, Andrzejewska A, Muraca M, Srivastava AK, Janowski M, Lukomska B: Extracellular vesicles in physiology, pathology, and therapy of the immune and central nervous system, with focus on extracellular vesicles derived from mesenchymal stem cells as therapeutic tools. Front Cell Neurosci 10: 109, 2016.
20. Flamant S, Tamarat R: Extracellular vesicles and vascular injury: New insights for radiation exposure. Radiat Res 186(2): 203-218, 2016.
21. Lynch SF, Ludlam CA: Plasma microparticles and vascular disorders. Br J Haematol 137(1): 36-48, 2007.
22. Matijevic N, Wang YW, Kostousov V, Wade CE, Vijayan KV, Holcomb JB: Decline in platelet microparticles contributes to reduced hemostatic potential of stored plasma. Thromb Res 128(1): 35-41, 2011.
23. Hargett LA, Bauer NN: On the origin of microparticles: From "platelet dust" to mediators of intercellular communication. Pulm Circ 3(2): 329-340, 2013.
24. Hugel B, Martinez MC, Kunzelmann C, Freyssinet JM: Membrane microparticles: Two sides of the coin. Physiology 20: 22-27, 2005.
25. Sinauridze EI, Kireev DA, Popenko NY, Pichugin AV, Panteleev MA, Krymskaya OV, Ataullakhanov FI: Platelet microparticle membranes have 50-to 100-fold higher specific procoagulant activity than activated platelets. Thromb Haemost 97: 425-432, 2007.
26. Mooberry MJ, Key NS: Microparticle analysis in disorders of hemostasis and thrombosis. Cytometry A 89(2): 111-122, 2016.
27. Tempo JA, Englyst NA, Holloway JA, Smith DC: Platelet microvesicles (microparticles) in cardiac surgery. J Cardiothorac Vasc Anesth 30(1): 222-228, 2016.
28. Owens AP 3rd, Mackman N: Microparticles in hemostasis and thrombosis. Circ Res 108(10): 1284-1297, 2011.
29. Piccin A, Murphy WG, Smith OP: Circulating microparticles: Pathophysiology and clinical implications. Blood Rev 21(3): 157-171, 2007.
30. Berckmans RJ, Nieuwland R, Boing AN, Romijn FP, Hack CE, Sturk A: Cellderived microparticles circulate in healthy humans and support low grade thrombin generation. Thromb Haemost 85(4): 639-646, 2001.
31. Matijevic N, Wang YW, Wade CE, Holcomb JB, Cotton BA, Schreiber MA, Muskat P, Fox EE, Del Junco DJ, Cardenas JC, et al.: Cellular microparticle and thrombogram phenotypes in the prospective observational multicenter major trauma transfusion (PROMMTT) study: Correlation with coagulopathy. Thromb Res 134(3): 652-658, 2014.
32. Balvers K, Curry N, Kleinveld DJ, Boing AN, Nieuwland R, Goslings JC, Juffermans NP: Endogenous microparticles drive the proinflammatory host immune response in severely injured trauma patients. Shock 43(4): 317-321, 2015.
33. Park MS, Xue A, Spears GM, Halling TM, Ferrara MJ, Kuntz MM, Dhillon SK, Jenkins DH, Harmsen WS, Ballman KV, et al.: Thrombin generation and procoagulant microparticle profiles after acute trauma: A prospective cohort study. J Trauma Acute Care Surg 79(5): 726-731, 2015.
34. Lacroix R, Robert S, Poncelet P, Kasthuri RS, Key NS, Dignat-George F, Workshop IS: Standardization of platelet-derived microparticle enumeration by flow cytometry with calibrated beads: Results of the international society on thrombosis and haemostasis SSC collaborative workshop. J Thromb Haemost 8(11): 2571-2574, 2010.
35. Cointe S, Judicone C, Robert S, Mooberry MJ, Poncelet P, Wauben M, Nieuwland R, Key NS, Dignat-George F, Lacroix R: Standardization of microparticle enumeration across different flow cytometry platforms: Results of a multicenter collaborative workshop. J Thromb Haemost 15(1): 187-193, 2017.
36. Mezouar S, Mege D, Darbousset R, Farge D, Debourdeau P, Dignat-George F, Panicot-Dubois L, Dubois C: Involvement of platelet-derived microparticles in tumor progression and thrombosis. Semin Oncol 41(3): 346-358, 2014.
37. Hron G, Kollars M, Weber H, Sagaster V, Quehenberger P, Eichinger S, Kyrle PA, Weltermann A: Tissue factor-positive microparticles: Cellular origin and association with coagulation activation in patients with colorectal cancer. Thromb Haemost 97: 119-123, 2006.
38. Badimon L, Suades R, Fuentes E, Palomo I, Padro T: Role of platelet-derived microvesicles as crosstalk mediators in atherothrombosis and future pharmacology targets: A link between inflammation, atherosclerosis, and thrombosis. Front Pharmacol 7: 293, 2016.
39. Brohi K, Singh J, Heron M, Coats T: Acute traumatic coagulopathy. J Trauma 54(6): 1127-1130, 2003.
40. Johansson PI, Henriksen HH, Stensballe J, Gybel-Brask M, Cardenas JC, Baer LA, Cotton BA, Holcomb JB, Wade CE, Ostrowski SR: Traumatic endotheliopathy: A prospective observational study of 424 severely injured patients. Ann Surg 265(3): 597-603, 2017.
41. Tuma M, Canestrini S, Alwahab Z, Marshall J, Trauma and endothelial glycocalyx. The microcirculation helmet? Shock 46(4): 352-357, 2016.
42. Matijevic N, Wang YW, Holcomb JB, Kozar R, Cardenas JC, Wade CE: Microvesicle phenotypes are associated with transfusion requirements and mortality in subjects with severe injuries. J Extracell Vesicles 4: 29338, 2015.
43. Windelov NA, Johansson PI, Sorensen AM, Perner A, Wanscher M, Larsen CF, Ostrowski SR, Rasmussen LS: Low level of procoagulant platelet microparticles is associated with impaired coagulation and transfusion requirements in trauma patients. J Trauma Acute Care Surg 77(5): 692-700, 2014.
44. Midura EF, Jernigan PL, Kuethe JW, Friend LA, Veile R, Makley AT, Caldwell CC, Goodman MD: Microparticles impact coagulation after traumatic brain injury. J Surg Res 197(1): 25-31, 2015.
45. Nekludov M, Mobarrez F, Gryth D, Bellander BM, Wallen H: Formation of microparticles in the injured brain of patients with severe isolated traumatic brain injury. J Neurotrauma 31(23): 1927-1933, 2014.
46. Chao FC, Kim BK, Houranieh AM, Liang FH, Konrad MW, Swisher SN, Tullis JL, Infusible platelet membrane microvesicles. A potential transfusion substitute for platelets. Transfusion 36(6): 536-542, 1996.
47. Nasiri S, Rivandi S, Gholizadeh S: Infusible platelet membranes improve hemostasis in thrombocytopenic rabbits: Studies with two different injection doses. Int J Pharm Sci Res 3(12): 4895-4898, 2012.
48. Jenkins DH, Rappold JF, Badloe JF, Berseus O, Blackbourne L, Brohi KH, Butler FK, Cap AP, Cohen MJ, Davenport R, et al.: Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: Definitions, current practice, and knowledge gaps. Shock 41(suppl 1): 3-12, 2014.
49. Pati S, Pilia M, Grimsley JM, Karanikas AT, Oyeniyi B, Holcomb JB, Cap AP, Rasmussen TE: Cellular therapies in trauma and critical care medicine: Forging new frontiers. Shock 44(6): 505-523, 2015.
50. Merten M, Pakala R, Thiagarajan P, Benedict CR: Platelet microparticles promote platelet interaction with subendothelial matrix in a glycoprotein iib/iiia dependent mechanism. Circulation 99(19): 2577-2582, 1999.
51. Hietbrink F, Koenderman L, Althuizen M, Pillay J, Kamp V, Leenen LP: Kinetics of the innate immune response after trauma: Implications for the development of late onset sepsis. Shock 40(1): 21-27, 2013.
52. Ceroi A, Delettre FA, Marotel C, Gauthier T, Asgarova A, Biichle S, Duperrier A, Mourey G, Perruche S, Lagrost L, et al.: The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver x receptor activation. Haematologica 101(3): E72-e76, 2016.
53. Peng Z, Pati S, Potter D, Brown R, Holcomb JB, Grill R, Wataha K, Park PW, Xue H, Kozar RA: Fresh frozen plasma lessens pulmonary endothelial inflammation and hyperpermeability after hemorrhagic shock and is associated with loss of syndecan 1. Shock 40(3): 195-202, 2013.
54. Gulati A: Vascular endothelium and hypovolemic shock. Curr Vasc Pharmacol 14(2): 187-195, 2016.
55. Mause SF, Ritzel E, Liehn EA, Hristov M, Bidzhekov K, Muller-Newen G, Soehnlein O, Weber C: Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury. Circulation 122(5): 495-506, 2010.
56. Lovren F, Verma S: Evolving role of microparticles in the pathophysiology of endothelial dysfunction. Clin Chem 59(8): 1166-1174, 2013.
57. Versteeg HH, Heemskerk JW, Levi M, Reitsma PH: New fundamentals in hemostasis. Physiol Rev 93(1): 327-358, 2013.
58. Fu L, Hu XX, Lin ZB, Chang FJ, Ou ZJ, Wang ZP, Ou JS: Circulating microparticles from patients with valvular heart disease and cardiac surgery inhibit endothelium-dependent vasodilation. J Thorac Cardiovasc Surg 150(3): 666-672, 2015.
59. Nasiri S: Infusible platelet membrane as a platelet substitute for transfusion: An overview. Blood Transfus 11(3): 337-342, 2013.
60. Zhao Z, Muth DC, Mahairaki V, Cheng L, Witwer KW: Isolation and characterization of extracellular vesicles in stem cell-related studies. In: Srivastava AK, Snyder EY, Teng YD, editors. Stem Cell Technologies in Neuroscience. New York, NY: Springer New York. p. 205-223, 2017.