When inflammation and depression go together: The longitudinal effects of parent-child relationships

Development and Psychopathology

Volumn 29, Issue 5, 2017, Pages 1969-1986

  Beach, Steven R H ^a   Lei, Man Kit ^a   Simons, Ronald L ^a   Barr, Ashley B ^b   Simons, Leslie G ^a   Ehrlich, Katherine ^a   Brody, Gene H ^a   Philibert, Robert A ^c  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AFRICAN AMERICAN; CHILD; CHILD PARENT RELATION; DEPRESSION; FEMALE; HUMAN; HUMAN RELATION; IMMUNOLOGY; INFLAMMATION; LONGITUDINAL STUDY; MALE; MENTAL STRESS; PROSPECTIVE STUDY; PSYCHOLOGY; SEXUALITY; YOUNG ADULT;

ADOLESCENT; ADULT; AFRICAN AMERICANS; CHILD; DEPRESSION; FEMALE; HUMANS; INFLAMMATION; INTERPERSONAL RELATIONS; LONGITUDINAL STUDIES; MALE; PARENT-CHILD RELATIONS; PARENTING; PROSPECTIVE STUDIES; SEXUAL PARTNERS; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 85042221348     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S0954579417001523     Document Type: Article

References (89)

1. Barr, A. B., Culatta, E., & Simons, R. L. (2013). Romantic relationships and health among African American young adults: Linking patterns of relationship quality over time to changes in physical and mental health. Journal of Health and Social Behavior, 54, 369-385. doi:10.1177/0022146513486652
2. Barr, A. B., Sutton, T. E., Simons, L. G., Wickrama, K. A. S., & Lorenz, F. O. (2016). Romantic relationship transitions and changes in health among rural, White young adults. Journal of Family Psychology, 30, 832-842. doi:10.1037/fam0000207
3. Beach, S. R. H. (2014). The couple and family discord model of depression: Updates and future directions. In C. R. Agnew & S. C. South (Eds.), Interpersonal relationships and health: Social and clinical psychological mechanisms (pp. 133-155). New York: Oxford University Press.
4. Beach, S. R. H., Lei, M. K., Brody, G. H., Dogan, M. V., & Philibert, R. A. (2015). Higher levels of protective parenting are associated with better young adult health: Exploration of mediation through epigenetic influences on pro-inflammatory processes. Frontiers in Psychology, 6, 676. doi:10.3389/fpsyg.2015.00676
5. Beach, S. R. H., Lei, M. K., Brody, G. H., Kim, S., Barton, A.W., Dogan, M. V., & Philibert, R. A. (2016). Parenting, SES-risk, and later young adult health: Exploration of opposing indirect effects via DNA methylation. Child Development, 87, 111-121. doi:10.1111/cdev.12486
6. Beach, S. R. H., Lei, M. K., Brody, G. H., Miller, G. E., Chen, E., Mandara, J., & Philibert, R. A. (2016). Smoking in young adulthood among African Americans: Interconnected effects of supportive parenting in early adolescence, pro-inflammatory epitype, and young adult stress. Development and Psychopathology. Advance online publication. doi:10.1017/S0954579416000961
7. Beach, S. R. H., Sandeen, E. E., & O'Leary, K. D. (1990). Depression in marriage: A model for etiology and treatment. New York: Guilford Press.
8. Bentler, P. M. (1990). Comparative fit indexes in structural models. Psychological Bulletin, 107, 238-246.
9. Blatt, S. J., & Homann, E. (1992). Parent-child interaction in the etiology of dependent and self-critical depression. Clinical Psychology Review, 12, 47-91.
10. Brody, G. H., Chen, Y.-F., Murry, V. M., Simons, R. L., Ge, X., Gibbons, F. X., ⋯ Cutrona, C. E. (2006). Perceived discrimination and the adjustment of African American youths: A five-year longitudinal analysis with contextual moderation effects. Child Development, 77, 1170-1189.
11. Brody, G. H., Miller, G. E., Yu, T., Beach, S. R. H., & Chen, E. (2016). Supportive family environments ameliorate the link between racial discrimination and epigenetic aging: A replication across two longitudinal cohorts. Psychological Science, 27, 530-541. doi:10.1177/095679761562 6703
12. Brody, G. H., Yu, T., & Beach, S. R. H. (2016). Resilience to adversity and the early origins of disease. Development and Psychopathology, 28, 1347-1365. doi:10.1017/S0954579416000894
13. Brody, G. H., Yu, T., Beach, S. R. H., Kogan, S. M., Windle, M., & Philibert, R. A. (2014). Harsh parenting and adolescent health: A longitudinal analysis with genetic moderation. Health Psychology, 33, 401-409. doi:10.1037/a0032686
14. Brody, G. H., Yu, T., Miller, G. E., & Chen, C. (2015). Discrimination, racial identity, and cytokine levels among African-American adolescents. Journal of Adolescent Health, 56, 496-501.
15. Brown, G.W., & Harris, T. O. (1989). Social origins of depression: A study of psychiatric disorder in women. London: Routledge.
16. Browne, M. W., & Cudeck, R. (1992). Alternative ways of assessing model fit. Sociological Methods and Research, 21, 230-258.
17. Bryant, C. M. (2006). Pathways linking early experiences and later relationship functioning. In A. C. Crouter & A. Booth (Eds.), Romance and sex in adolescence and emerging adulthood: Risks and opportunities (pp. 103-111). Mahwah, NJ: Erlbaum.
18. Chen, E., & Miller, G. E. (2013). Socioeconomic status and health: Mediating and moderating factors. Annual Review of Clinical Psychology, 9, 723-749.
19. Chou, T., Asnaani, A., & Hofmann, S. G. (2012). Perception of racial discrimination and psychopathology across three U.S. ethnic minority groups. Cultural Diversity and Ethnic Minority Psychology, 18, 74-81. doi:10.1037/a0025432
20. Cicchetti, D., & Toth, S. L. (2005). Child maltreatment. Annual Review of Clinical Psychology, 1, 409-438.
21. Cole, S.W. (2013). Social regulation of human gene expression: Mechanisms and implications for public health. American Journal of Public Health, 103(Suppl. 1), S84-S92. doi:10.2105/AJPH.2012.301183
22. Cole, S.W., Conti, G., Arevalo, J. M. G., Ruggiero, A. M., Heckman, J. J., & Suomi, S. J. (2012). Transcriptional modulation of the developing immune system by early life social adversity. Proceedings of the National Academy of Sciences, 109, 20578-20583. doi:10.1073/pnas.1218253109
23. Conger, R. D., Conger, K. J., Elder, G. H., Lorenz, F. O., Simons, R. L., & Whitbeck, L. B. (1992). A family process model of economic hardship and adjustment of early adolescent boys. Child Development, 63, 526-541.
24. Conger, R. D., Conger, K. J., & Marin, M. J. (2010). Socioeconomic status, family processes, and individual development. Journal of Marriage and Family, 72, 685-704.
25. Conger, R. D., Cui, M., Bryant, G. M., & Elder, G. H. (2000). Competence in early adult romantic relationships. Journal of Personality and Social Psychology, 79, 224-237. doi:10.1037/0022-3514.79.2.224
26. Conger, R. D., & Elder, G. H., Jr. (1994). Families in troubled times: The Iowa Youth and Families Project. In R. D. Conger & G. H. Elder Jr., (Eds.), Families in troubled times: Adapting to change in rural America (pp. 57-78). Hawthorne, NY: Aldine de Gruyter.
27. Conraads, V. M., Denollet, J., De Clerck, L. S., Stevens, W. J., Bridts, C., & Vrints, C. J. (2006). Type D personality is associated with increased levels of tumour necrosis factor (TNF)-α and TNF-α receptors in chronic heart failure. International Journal of Cardiology, 113, 34-38.
28. Cui, M., Lorenz, F., Conger, R., Melby, J., & Bryant, C. (2005). Observer, self-, and partner reports of hostile behaviors in romantic relationships. Journal of Marriage and Family, 67, 1169-1181. doi:10.1111/j.1741-3737.2005.00208.x
29. Cutrona, C. E., Abraham, W. T., Russel, D.W., Beach, S. R. H., Burzette, R., Gibbons, F. X., ⋯ Philibert, R. A. (2015). Financial strain, inflammatory factors, and hemoglobin A1C levels in African-American women. British Journal of Health Psychology, 20, 662-679. doi:10.1111/bjhp.12120
30. Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A., Poulton, R., & Caspi, A. (2008). Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of General Psychiatry, 65, 409-415.
31. Dube, S. R., Fairweather, D., Pearson, W. S., Felitti, V. J., Anda, R. F., & Croft, J. B. (2009). Cumulative childhood stress and autoimmune diseases in adults. Psychosomatic Medicine, 71, 243-250.
32. Eberhart, N., & Hammen, C. (2006). Interpersonal predictors of onset of depression during the transition to adulthood. Personal Relationships, 13, 195-206.
33. Ehrlich, K. B., Miller, G. E., Rohleder, N., & Adam, E. K. (2015). Trajectories of relationship stress and inflammatory processes in adolescence. Development and Psychopathology, 28, 127-138. doi:10.1017/S0954579415000334
34. Elenkov, I. J., & Chrousos, G. P. (2002). Stress hormones, proinflammatory and anti-inflammatory cytokines, and autoimmunity. Annals of the New York Academy of Sciences, 966, 290-303.
35. Espejo, E., Hammen, C., Connolly, N., Brennan, P., Najman, J., & Bor, W. (2007). Stress sensitization and adolescent depressive severity as a function of childhood adversity: A link to anxiety disorders. Journal of Abnormal Child Psychology, 35, 287-299.
36. Flinn, M. V., & England, B. G. (1995). Childhood stress and family environment. Current Anthropology, 36, 854-866. doi:10.1086/204444
37. Furstenberg, F. F. (2008). The intersections of social class and the transition to adulthood. New Directions for Child and Adolescent Development, 2008, 1-10.
38. Geronimus, A. T., Hicken, M., Keene, D., & Bound, J. (2006). "Weathering" and age patterns of allostatic load scores among Blacks and Whites in the United States. American Journal of Public Health, 96, 826-833. doi:10.2105/ajph.2004.060749
39. Geronimus, A. T., Hicken, M. T., Pearson, J. A., Seashols, S. J., Brown, K. L., & Cruz, T. D. (2010). Do US Black women experience stress-related accelerated biological aging? A novel theory and first population-based test of Black-White differences in telomere length. Human Nature, 21, 19-38. doi:10.1007/s12110-010-9078-0
40. Gibbons, F. X., Gerrard, M., Cleveland, M. J., Wills, T. A., & Brody, G. (2004). Perceived discrimination and substance use in African American parents and their children: A panel study. Journal of Personality and Social Psychology, 86, 517-529. doi:10.1037/0022-3514.86. 4.517
41. Gibbons, F. X., Kingsbury, J. H., Weng, C., Gerrard, M., Cutrona, C., Willa, T. A., & Stock, M. (2014). Effects of perceived racial discrimination on health status and health behavior: A differential mediation hypothesis. Health Psychology, 33, 11-19. doi:10.1037/a0033857
42. Glassman, A. H., & Miller, G. E. (2007). Where there is depression, there is inflammation. Sometimes! Biological Psychiatry, 62, 280-281.
43. Gluckman, P. D., Hanson, M. A., & Spencer, H. G. (2005). Predictive adaptive responses and human evolution. Trends in Ecology and Evolution, 20, 537-533.
44. Hammen, C. (2006). Stress generation in depression: Reflections on origins, research, and future directions. Journal of Clinical Psychology, 62, 1065-1082. doi:10.1002/JCLP.20293
45. Hepgul, N., Cattaneo, A., Agarwal, K., Baraldi, S., Borsini, A., Bufalino, C., ⋯ Pariante, C. M. (2016). Transcriptomics in interferon-α-treated patients identifies inflammation-, neuroplasticity- and oxidative stressrelated signatures as predictors and correlates of depression. Neuropsychopharmacology, 41, 2502-2511. doi:10.1038/npp.2016.50
46. Hertzman, C. (2012). Putting the concept of biological embedding in historical perspective. Proceedings of the National Academy of Sciences, 109(Suppl. 2), 17160-17167. doi:10.1073/pnas.1202203109
47. Irwin, M. R., & Cole, S. W. (2011). Reciprocal regulation of the neural and innate immune systems. Nature Reviews Immunology, 11, 625-632.
48. Kessler, R. C., & Mroczek, D. (1994). Scoring of the UM CIDI short forms. Ann Arbor, MI: University of Michigan, Institute for Social Research.
49. Kiecolt-Glaser, J. K., Gouin, J., & Hantsoo, L. (2010). Close relationships, inflammation, and health. Neuroscience & Biobehavioral Reviews, 35, 33-38. doi:10.1016/j.neubiorev.2009.09.003
50. Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., Malarkey, W. B., Lemeshow, S., Dickinson, S. L., & Glaser, R. (2005). Hostile marital interactions, proinflammatory cytokine production, and wound healing. Archives of General Psychiatry, 62, 1377-1384. doi:10.1001/archpsyc.62.12.1377
51. Kohen, D. E., Brooks-Gunn, J., Leventhal, T., & Hertzman, C. (2002). Neighborhood income and physical and social disorder in Canada: Associations with young children's competencies. Child Development, 73, 1844-1860.
52. Landrine, H., & Klonoff, E. A. (1996). The Schedule of Racist Events: A measure of racial discrimination and a study of its negative physical and mental health consequences. Journal of Black Psychology, 22, 144-168. doi:10.1177/00957984960222002
53. Luthar, S. S. (2006). Resilience in development: A synthesis of research across five decades. In D. Cicchetti & D. J. Cohen (Eds.), Developmental psychopathology: Risk, disorder, and adaptation (pp. 740-795). Hoboken, NJ: Wiley.
54. Marques, A. H., Silverman, M. N., & Sternberg, E. M. (2009). Glucocorticoid dysregulations and their clinical correlates: From receptors to therapeutics. Annals of the New York Academy of Sciences, 1179, 1-18. doi:10.1111/j.1749-6632.2009.04987.x
55. McEwen, B. S. (1998). Protective and damaging effects of stress mediators. New England Journal of Medicine, 338, 171-179.
56. McLoyd, V. C. (1990). The impact of economic hardship on Black families and children: Psychological distress, parenting, and socioemotional development. Child Development, 61, 311-346. doi:10.1111/j.1467-8624.1990.tb02781.x
57. Miller, A. H., Maletic, V., & Raison, C. L. (2009). Inflammation and its discontents: The role of cytokines in the pathophysiology ofmajor depression. Biological Psychiatry, 65, 732-741. doi:10.1016/j.biopsych.2008.11.029
58. Miller, G. E., & Chen, E. (2010). Harsh family climate in early life presages the emergence of pro-inflammatory phenotype in adolescence. Psychological Science, 21, 848-856.
59. Miller, G. E., Chen, E., & Parker, K. J. (2011). Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychological Bulletin, 137, 959-997.
60. Miller, G. E., Chen, E., Sze, J., Marin, T., Arevalo, J. M. G., Doll, R., ⋯ Cole, S. W. (2008). A genomic fingerprint of chronic stress in humans: Blunted glucocorticoid and increased NF-kB signaling. Biological Psychiatry, 64, 266-272 doi:10.1016/j.biopsych.2008.03.017
61. Miller, G. E., & Cole, S. W. (2012). Clustering of depression and inflammation in adolescents previously exposed to childhood adversity. Biological Psychiatry, 72, 34-40. doi:10.1016/j.biopsych.2012.02.034
62. Miller, G. E., Lachman, M. E., Chen, E., Gruenewald, T. L., Karlamangla, A. S., & Seeman, T. E. (2011). Pathways to resilience: Maternal nurturance as a buffer against the effects of childhood poverty on metabolic syndrome at midlife. Psychological Science, 22, 1591-1599.
63. Mirowsky, J. (1999). Analyzing associations between mental health and social circumstances. In C. S. Aneshensel & J. C. Phelan (Eds.), Handbook of the sociology of mental health (pp. 105-123). New York: Plenum Press.
64. Moffitt, T. E., & Klaus-Grawe 2012 Think Tank (2013). Childhood exposure to violence and lifelong health: Clinical intervention science and stress biology research join forces. Development and Psychopathology, 25, 1619-1634. doi:10.1017/S0954579413000801
65. Muthen, L. K., & Muthen, B. O. (2015). Mplus version 7/04: Base program and combination add-on. Los Angeles: Authors.
66. Nunnally, J. C. (1978). Psychometric theory. New York: McGraw-Hill.
67. Osgood, D.W., Foster, E. M., Flanagan, C., & Ruth, G. R. (Eds.). (2005). On your own without a net: The transition to adulthood for vulnerable populations. Chicago: University of Chicago Press.
68. Overbeek, G., Vollebergh, W., de Graaf, R., Scholte, R., de Kemp, R., & Engels, R. (2006). Longitudinal associations of marital quality and marital dissolution with the incidence of DSM-III-R disorders. Journal of Family Psychology, 20, 284-291. doi:10.1037/0893-3200.20.2.284
69. Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., & Maes, M. (2013). So depression is an inflammatory disease, but where does the inflammation come from? BMC Medicine, 11, 200. doi:10.1186/1741-7015-11-200
70. Pendry, P., & Adam, E. K. (2007). Associations between parents' marital functioning, maternal parenting quality, maternal emotion and child cortisol levels. International Journal of Behavioral Development, 31, 218-231.
71. Phelan, J. C., & Link, B. G. (2015). Is racism a fundamental cause of inequalities in health? Annual Review of Sociology, 41, 311-330. doi:10.1146/annurev-soc-073014-112305
72. Raison, C. L., Capuron, L., & Miller, A. H. (2006). Cytokines sing the blues: Inflammation and the pathogenesis of depression. Trends in Immunology, 27, 24-31.
73. Raison, C. L., & Miller, A. H. (2003). When not enough is too much: The role of insufficient glucocorticoid signaling in the pathophysiology of stressrelated disorders. American Journal of Psychiatry, 160, 1554-1565. doi:10.1176/appi.ajp.160.9.1554
74. Rickard, I. J., & Lummaa, V. (2007). The predictive adaptive response and metabolic syndrome: Challenges for the hypothesis. Trends in Endocrinology and Metabolism, 18, 94-99. doi:10.1016/j.tem.2007. 02.004
75. Rohleder, N., Marin, T. J., Ma, R., & Miller, G. E. (2009). Biologic cost of caring for a cancer patient: Dysregulation of pro- and anti-inflammatory signaling pathways. Journal of Clinical Oncology, 27, 2909-2915. doi:10.1200/JCO.2008.18.7435
76. Schofield, T. J., Conger, R. D., Gonzales, J. E., & Merrick, M. T. (2016). Harsh parenting, physical health, and the protective role of positive parent-adolescent relationships. Social Science & Medicine, 157, 18-26. doi:10.1016/j.socscimed.2016.03.027
77. Simons, L. G., Simons, R. L., Landor, A. M., Bryant, C. M., & Beach, S. R. H. (2014). Factors linking childhood experiences to adult romantic relationships among African Americans. Journal of Family Psychology, 28, 368-379. doi:10.1037/a0036393
78. Simons, R. L., Lei, M. K., Beach, S. R. H., Barr, A. B., Simons, L. G., Gibbons, F. X., Philibert, R. A. (2016). Discrimination, segregation, and chronic inflammation: Testing the weathering explanation for the poor health of Black Americans. Unpublished manuscript, University of Georgia.
79. Simons, R. L., Lei, M. K., Beach, S. R. H., Philibert, R. A., Cutrona, C. E., Gibbons, F. X., & Barr, A. (2016). Economic hardship and biological weathering: The epigenetics of aging in a U.S. sample of black women. Social Science and Medicine, 150, 192-200.
80. Simons, R. L., Simons, L. G., & Wallace, L. E. (2004). Families, delinquency and crime: Linking society's most basic institution to antisocial behavior. New York: Oxford University Press.
81. Slopen, N., Lewis, T. T., Gruenewald, T. L., Mujahid, M. S., Ryff, C. D., Albert, M. A., & Williams, D. R. (2010). Early life adversity and inflammation in African Americans and Whites in the midlife in the United States survey. Psychosomatic Medicine, 72, 694-701. doi:10.1097/PSY.0b013e3181e9c16f
82. Steinberg, S. J., & Davila, J. (2008). Adolescent romantic functioning and depression: The moderating role of parental emotional availability. Journal of Clinical Child and Adolescent Psychology, 37, 350-362.
83. Stock, M. L., Gibbons, F. X., Peterson, L. M., & Gerrard, M. (2013). The effects of racial discrimination on the HIV-risk cognitions and behaviors of Black adolescents and young adults. Health Psychology, 32, 543.
84. Surjadi, F. F., Lorenz, F. O., Wickrama, K. A. S., & Conger, R. D. (2011). Parental support, partner support, and the trajectories of mastery from adolescence to early adulthood. Journal of Adolescence, 34, 619-628.
85. Taylor, B. D., Holzman, C. B., Fichorova, R. N., Tian, Y., Jones, N. M., Fu, W., & Senagore, P. K. (2013). Inflammation biomarkers in vaginal fluid and preterm delivery. Human Reproduction, 28, 942-952.
86. van Kammen, D. P., McAllister-Sistilli, C. G., Kelley, M. E., Gurklis, J. A., & Yao, J. K. (1999). Elevated interleukin-6 in schizophrenia. Psychiatry Research, 87, 129-136.
87. Waldinger, R. J., & Schulz, M. S. (2016). The long reach of nurturing family environments: Links with midlife emotion-regulatory styles and late-life security in intimate relationships. Psychological Science, 27, 1443-1450. doi:10.1177/0956797616661556
88. Whisman, M. A., & Bruce, M. L. (1999). Marital distress and incidence of major depressive episode in a community sample. Journal of Abnormal Psychology, 108, 674-678. doi:10.1037/021-843X.108.4.674
89. Young, J. R. (2012). Underemployment in urban and rural America, 2005-2012. Durham, NH: University of New Hampshire, Carsey Institute.