메뉴 건너뛰기




Volumn 20, Issue 1, 2018, Pages 99-109

Folic acid in stroke prevention in countries without mandatory folic acid food fortification: A meta-analysis of randomized controlled trials

Author keywords

Folic acid; Food; Fortified; Meta analysis; Prevention; Stroke

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID;

EID: 85041733991     PISSN: 22876391     EISSN: 22876405     Source Type: Journal    
DOI: 10.5853/jos.2017.01522     Document Type: Article
Times cited : (48)

References (58)
  • 1
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
    • Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 2002;288:2015-2022.
    • (2002) JAMA , vol.288 , pp. 2015-2022
  • 2
    • 3042766490 scopus 로고    scopus 로고
    • Clinical use and rational management of homocysteine, folic acid, and B vitamins in cardiovascular and thrombotic diseases
    • Stanger O, Herrmann W, Pietrzik K, Fowler B, Geisel J, Dierkes J, et al. Clinical use and rational management of homocysteine, folic acid, and B vitamins in cardiovascular and thrombotic diseases. Z Kardiol 2004;93:439-453.
    • (2004) Z Kardiol , vol.93 , pp. 439-453
    • Stanger, O.1    Herrmann, W.2    Pietrzik, K.3    Fowler, B.4    Geisel, J.5    Dierkes, J.6
  • 3
    • 27744603884 scopus 로고    scopus 로고
    • Dose-dependent effects of folic acid on blood concentrations of homocysteine: A meta-analysis of the randomized trials
    • Homocysteine Lowering Trialists’ Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 2005;82:806-812.
    • (2005) Am J Clin Nutr , vol.82 , pp. 806-812
  • 5
    • 84996576830 scopus 로고    scopus 로고
    • Folic acid supplementation and the risk of cardiovascular diseases: A meta-analysis of randomized controlled trials
    • Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB. Folic acid supplementation and the risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. J Am Heart Assoc 2016;5:e003768.
    • (2016) J am Heart Assoc , vol.5
    • Li, Y.1    Huang, T.2    Zheng, Y.3    Muka, T.4    Troup, J.5    Hu, F.B.6
  • 6
    • 77953133802 scopus 로고    scopus 로고
    • Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: A meta-analysis
    • Lee M, Hong KS, Chang SC, Saver JL. Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: a meta-analysis. Stroke 2010;41:1205-1212.
    • (2010) Stroke , vol.41 , pp. 1205-1212
    • Lee, M.1    Hong, K.S.2    Chang, S.C.3    Saver, J.L.4
  • 7
    • 84861320670 scopus 로고    scopus 로고
    • Efficacy of folic acid supplementation in stroke prevention: New insight from a meta-analysis
    • Huo Y, Qin X, Wang J, Sun N, Zeng Q, Xu X, et al. Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis. Int J Clin Pract 2012;66:544-551.
    • (2012) Int J Clin Pract , vol.66 , pp. 544-551
    • Huo, Y.1    Qin, X.2    Wang, J.3    Sun, N.4    Zeng, Q.5    Xu, X.6
  • 8
    • 84888243249 scopus 로고    scopus 로고
    • Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: A meta-analysis
    • Ji Y, Tan S, Xu Y, Chandra A, Shi C, Song B, et al. Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: a meta-analysis. Neurology 2013;81:1298-1307.
    • (2013) Neurology , vol.81 , pp. 1298-1307
    • Ji, Y.1    Tan, S.2    Xu, Y.3    Chandra, A.4    Shi, C.5    Song, B.6
  • 9
  • 10
    • 84927534831 scopus 로고    scopus 로고
    • Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: The CSPPT randomized clinical trial
    • Huo Y, Li J, Qin X, Huang Y, Wang X, Gottesman RF, et al. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial. JAMA 2015;313:1325-1335.
    • (2015) JAMA , vol.313 , pp. 1325-1335
    • Huo, Y.1    Li, J.2    Qin, X.3    Huang, Y.4    Wang, X.5    Gottesman, R.F.6
  • 11
    • 84941874245 scopus 로고    scopus 로고
    • Effectiveness of homocysteine lowering vitamins in prevention of thrombotic tendency at high altitude area: A randomized field trial
    • Kotwal J, Kotwal A, Bhalla S, Singh PK, Nair V. Effectiveness of homocysteine lowering vitamins in prevention of thrombotic tendency at high altitude area: a randomized field trial. Thromb Res 2015;136:758-762.
    • (2015) Thromb Res , vol.136 , pp. 758-762
    • Kotwal, J.1    Kotwal, A.2    Bhalla, S.3    Singh, P.K.4    Nair, V.5
  • 12
    • 69449100622 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
    • Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009;339:b2535.
    • (2009) BMJ , vol.339
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 14
    • 0034823867 scopus 로고    scopus 로고
    • Funnel plots for detecting bias in meta-analysis: Guidelines on choice of axis
    • Sterne JA, Egger M. Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 2001; 54:1046-1055.
    • (2001) J Clin Epidemiol , vol.54 , pp. 1046-1055
    • Sterne, J.A.1    Egger, M.2
  • 15
    • 37049035730 scopus 로고    scopus 로고
    • Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis
    • Wetterslev J, Thorlund K, Brok J, Gluud C. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol 2008;61:64-75.
    • (2008) J Clin Epidemiol , vol.61 , pp. 64-75
    • Wetterslev, J.1    Thorlund, K.2    Brok, J.3    Gluud, C.4
  • 16
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (visp) randomized controlled trial
    • Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (visp) randomized controlled trial. JAMA 2004;291:565-575.
    • (2004) JAMA , vol.291 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Chambless, L.E.3    Spence, J.D.4    Pettigrew, L.C.5    Howard, V.J.6
  • 18
    • 33645753544 scopus 로고    scopus 로고
    • Homocysteine lowering with folic acid and B vitamins in vascular disease
    • Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006;354:1567-1577.
    • (2006) N Engl J Med , vol.354 , pp. 1567-1577
    • Lonn, E.1    Yusuf, S.2    Arnold, M.J.3    Sheridan, P.4    Pogue, J.5    Micks, M.6
  • 19
    • 34249979299 scopus 로고    scopus 로고
    • Folic acid for the prevention of colorectal adenomas: A randomized clinical trial
    • Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007;297:2351-2359.
    • (2007) JAMA , vol.297 , pp. 2351-2359
    • Cole, B.F.1    Baron, J.A.2    Sandler, R.S.3    Haile, R.W.4    Ahnen, D.J.5    Bresalier, R.S.6
  • 20
    • 34548566329 scopus 로고    scopus 로고
    • Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: A randomized controlled trial
    • Jamison RL, Hartigan P, Kaufman JS, Goldfarb DS, Warren SR, Guarino PD, et al. Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial. JAMA 2007;298:1163-1170.
    • (2007) JAMA , vol.298 , pp. 1163-1170
    • Jamison, R.L.1    Hartigan, P.2    Kaufman, J.S.3    Goldfarb, D.S.4    Warren, S.R.5    Guarino, P.D.6
  • 21
    • 43049176549 scopus 로고    scopus 로고
    • Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: A randomized trial
    • Albert CM, Cook NR, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, et al. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA 2008;299:2027-2036.
    • (2008) JAMA , vol.299 , pp. 2027-2036
    • Albert, C.M.1    Cook, N.R.2    Gaziano, J.M.3    Zaharris, E.4    Macfadyen, J.5    Danielson, E.6
  • 22
    • 77951645401 scopus 로고    scopus 로고
    • Effect of B-vitamin therapy on progression of diabetic nephropathy: A randomized controlled trial
    • House AA, Eliasziw M, Cattran DC, Churchill DN, Oliver MJ, Fine A, et al. Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial. JAMA 2010;303:1603-1609.
    • (2010) JAMA , vol.303 , pp. 1603-1609
    • House, A.A.1    Eliasziw, M.2    Cattran, D.C.3    Churchill, D.N.4    Oliver, M.J.5    Fine, A.6
  • 23
    • 79955565728 scopus 로고    scopus 로고
    • Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: Primary results from the folic acid for vascular outcome reduction in transplantation trial
    • Bostom AG, Carpenter MA, Kusek JW, Levey AS, Hunsicker L, Pfeffer MA, et al. Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the folic acid for vascular outcome reduction in transplantation trial. Circulation 2011;123:1763-1770.
    • (2011) Circulation , vol.123 , pp. 1763-1770
    • Bostom, A.G.1    Carpenter, M.A.2    Kusek, J.W.3    Levey, A.S.4    Hunsicker, L.5    Pfeffer, M.A.6
  • 24
    • 84891441646 scopus 로고    scopus 로고
    • Oral high-dose multivitamins and minerals after myocardial infarction: A randomized trial
    • Lamas GA, Boineau R, Goertz C, Mark DB, Rosenberg Y, Stylianou M, et al. Oral high-dose multivitamins and minerals after myocardial infarction: a randomized trial. Ann Intern Med 2013;159:797-805.
    • (2013) Ann Intern Med , vol.159 , pp. 797-805
    • Lamas, G.A.1    Boineau, R.2    Goertz, C.3    Mark, D.B.4    Rosenberg, Y.5    Stylianou, M.6
  • 25
    • 13344269001 scopus 로고    scopus 로고
    • Lowered risks of hypertension and cerebrovascular disease after vitamin/mineral supplementation: The Linxian Nutrition Intervention Trial
    • Mark SD, Wang WFraumeni JF Jr, Li JY, Taylor PR, Wang GQ, et al. Lowered risks of hypertension and cerebrovascular disease after vitamin/mineral supplementation: the Linxian Nutrition Intervention Trial. Am J Epidemiol 1996;143:658-664.
    • (1996) Am J Epidemiol , vol.143 , pp. 658-664
    • Mark, S.D.1    Wang, W.2    Fraumeni, J.F.3    Li, J.Y.4    Taylor, P.R.5    Wang, G.Q.6
  • 26
    • 1242339767 scopus 로고    scopus 로고
    • Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: A randomised pilot trial
    • Liem AH, van Boven AJ, Veeger NJ, Withagen AJ, Robles de Medina RM, Tijssen JG, et al. Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial. Int J Cardiol 2004;93:175-179.
    • (2004) Int J Cardiol , vol.93 , pp. 175-179
    • Liem, A.H.1    Van Boven, A.J.2    Veeger, N.J.3    Withagen, A.J.4    Robles De Medina, R.M.5    Tijssen, J.G.6
  • 29
    • 33747068232 scopus 로고    scopus 로고
    • Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients
    • Righetti M, Serbelloni P, Milani S, Ferrario G. Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients. Blood Purif 2006;24:379-386.
    • (2006) Blood Purif , vol.24 , pp. 379-386
    • Righetti, M.1    Serbelloni, P.2    Milani, S.3    Ferrario, G.4
  • 30
    • 33644908006 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (Asfast) in chronic renal failure: A multicenter, randomized, controlled trial
    • Zoungas S, McGrath BP, Branley P, Kerr PG, Muske C, Wolfe R, et al. Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (asfast) in chronic renal failure: a multicenter, randomized, controlled trial. J Am Coll Cardiol 2006;47:1108-1116.
    • (2006) J am Coll Cardiol , vol.47 , pp. 1108-1116
    • Zoungas, S.1    McGrath, B.P.2    Branley, P.3    Kerr, P.G.4    Muske, C.5    Wolfe, R.6
  • 31
    • 49949101867 scopus 로고    scopus 로고
    • Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: A randomized controlled trial
    • Ebbing M, Bleie Ø, Ueland PM, Nordrehaug JE, Nilsen DW, Vollset SE, et al. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. JAMA 2008;300:795-804.
    • (2008) JAMA , vol.300 , pp. 795-804
    • Ebbing, M.1    Bleie, Ø.2    Ueland, P.M.3    Nordrehaug, J.E.4    Nilsen, D.W.5    Vollset, S.E.6
  • 32
    • 79551499975 scopus 로고    scopus 로고
    • Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: A randomised placebo controlled trial
    • Galan P, Kesse-Guyot E, Czernichow S, Briancon S, Blacher J, Hercberg S, et al. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. BMJ 2010;341:c6273.
    • (2010) BMJ , vol.341
    • Galan, P.1    Kesse-Guyot, E.2    Czernichow, S.3    Briancon, S.4    Blacher, J.5    Hercberg, S.6
  • 33
    • 77955656519 scopus 로고    scopus 로고
    • B vitamins in patients with recent transient ischaemic attack or stroke in the vitamins to Prevent Stroke (Vitatops) trial: A randomised, double-blind, parallel, placebo-controlled trial
    • VITATOPS Trial Study Group. B vitamins in patients with recent transient ischaemic attack or stroke in the vitamins to Prevent Stroke (vitatops) trial: a randomised, double-blind, parallel, placebo-controlled trial. Lancet Neurol 2010;9:855-865.
    • (2010) Lancet Neurol , vol.9 , pp. 855-865
  • 34
    • 77950246384 scopus 로고    scopus 로고
    • B vitamins and the risk of total mortality and cardiovascular disease in end-stage renal disease: Results of a randomized controlled trial
    • Heinz J, Kropf S, Domröse U, Westphal S, Borucki K, Luley C, et al. B vitamins and the risk of total mortality and cardiovascular disease in end-stage renal disease: results of a randomized controlled trial. Circulation 2010;121:1432-1438.
    • (2010) Circulation , vol.121 , pp. 1432-1438
    • Heinz, J.1    Kropf, S.2    Domröse, U.3    Westphal, S.4    Borucki, K.5    Luley, C.6
  • 35
    • 77953867844 scopus 로고    scopus 로고
    • Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: A randomized trial
    • Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group, Armitage JM, Bowman L, Clarke RJ, Wallendszus K, Bulbulia R, et al. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA 2010;303:2486-2494.
    • (2010) JAMA , vol.303 , pp. 2486-2494
    • Armitage, J.M.1    Bowman, L.2    Clarke, R.J.3    Wallendszus, K.4    Bulbulia, R.5
  • 36
    • 77955350748 scopus 로고    scopus 로고
    • B-vitamin therapy for diabetic nephropathy: Reply
    • Spence JD, House AA, Eliasziw M. B-vitamin therapy for diabetic nephropathy: reply. JAMA 2010;304:636-637.
    • (2010) JAMA , vol.304 , pp. 636-637
    • Spence, J.D.1    House, A.A.2    Eliasziw, M.3
  • 37
    • 27644521579 scopus 로고    scopus 로고
    • Vitamin intervention for stroke prevention trial: An efficacy analysis
    • Spence JD, Bang H, Chambless LE, Stampfer MJ. Vitamin intervention for stroke prevention trial: an efficacy analysis. Stroke 2005;36:2404-2409.
    • (2005) Stroke , vol.36 , pp. 2404-2409
    • Spence, J.D.1    Bang, H.2    Chambless, L.E.3    Stampfer, M.J.4
  • 38
    • 85026910830 scopus 로고    scopus 로고
    • B vitamins in stroke prevention: Time to reconsider
    • Spence JD, Yi Q, Hankey GJ. B vitamins in stroke prevention: time to reconsider. Lancet Neurol 2017;16:750-760.
    • (2017) Lancet Neurol , vol.16 , pp. 750-760
    • Spence, J.D.1    Yi, Q.2    Hankey, G.J.3
  • 39
    • 84255183716 scopus 로고    scopus 로고
    • Understanding the complexity of homocysteine lowering with vitamins: The potential role of subgroup analyses
    • Spence JD, Stampfer MJ. Understanding the complexity of homocysteine lowering with vitamins: the potential role of subgroup analyses. JAMA 2011;306:2610-2611.
    • (2011) JAMA , vol.306 , pp. 2610-2611
    • Spence, J.D.1    Stampfer, M.J.2
  • 40
    • 84997078143 scopus 로고    scopus 로고
    • Efficacy of folic acid therapy on the progression of chronic kidney disease: The renal substudy of the China stroke primary prevention trial
    • Xu X, Qin X, Li Y, Sun D, Wang J, Liang M, et al. Efficacy of folic acid therapy on the progression of chronic kidney disease: the renal substudy of the China stroke primary prevention trial. JAMA Intern Med 2016;176:1443-1450.
    • (2016) JAMA Intern Med , vol.176 , pp. 1443-1450
    • Xu, X.1    Qin, X.2    Li, Y.3    Sun, D.4    Wang, J.5    Liang, M.6
  • 41
    • 20544474458 scopus 로고    scopus 로고
    • Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products
    • Robertson J, Iemolo F, Stabler SP, Allen RH, Spence JD. Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products. CMAJ 2005;172:1569-1573.
    • (2005) CMAJ , vol.172 , pp. 1569-1573
    • Robertson, J.1    Iemolo, F.2    Stabler, S.P.3    Allen, R.H.4    Spence, J.D.5
  • 42
    • 84958033799 scopus 로고    scopus 로고
    • Metabolic vitamin B12 deficiency: A missed oppor tunity to prevent dementia and stroke
    • Spence JD. Metabolic vitamin B12 deficiency: a missed oppor tunity to prevent dementia and stroke. Nutr Res 2016;36:109-116.
    • (2016) Nutr Res , vol.36 , pp. 109-116
    • Spence, J.D.1
  • 43
    • 2942548943 scopus 로고    scopus 로고
    • Serum total homocysteine concentrations and risk of stroke and its subtypes in Japanese
    • Iso H, Moriyama Y, Sato S, Kitamura A, Tanigawa T, Yamagi-shi K, et al. Serum total homocysteine concentrations and risk of stroke and its subtypes in Japanese. Circulation 2004;109:2766-2772.
    • (2004) Circulation , vol.109 , pp. 2766-2772
    • Iso, H.1    Moriyama, Y.2    Sato, S.3    Kitamura, A.4    Tanigawa, T.5    Yamagi-Shi, K.6
  • 44
    • 30744464594 scopus 로고    scopus 로고
    • Elevated plasma homocysteine in acute stroke was not associated with severity and outcome: Stronger association with small artery disease
    • Perini F, Galloni E, Bolgan I, Bader G, Ruffini R, Arzenton E, et al. Elevated plasma homocysteine in acute stroke was not associated with severity and outcome: stronger association with small artery disease. Neurol Sci 2005;26:310-318.
    • (2005) Neurol Sci , vol.26 , pp. 310-318
    • Perini, F.1    Galloni, E.2    Bolgan, I.3    Bader, G.4    Ruffini, R.5    Arzenton, E.6
  • 45
    • 55749102084 scopus 로고    scopus 로고
    • Homocysteine and its relationship to stroke subtypes in a uk black population: The south London ethnicity and stroke study
    • Khan U, Crossley C, Kalra L, Rudd A, Wolfe CD, Collinson P, et al. Homocysteine and its relationship to stroke subtypes in a uk black population: the south London ethnicity and stroke study. Stroke 2008;39:2943-2949.
    • (2008) Stroke , vol.39 , pp. 2943-2949
    • Khan, U.1    Crossley, C.2    Kalra, L.3    Rudd, A.4    Wolfe, C.D.5    Collinson, P.6
  • 46
    • 77953829432 scopus 로고    scopus 로고
    • Homocysteine and ischemic stroke subtype: A relationship study in Chinese patients
    • Ma Y, Zhao X, Zhang W, Liu L, Wang Y, Fang R, et al. Homocysteine and ischemic stroke subtype: a relationship study in Chinese patients. Neurol Res 2010;32:636-641.
    • (2010) Neurol Res , vol.32 , pp. 636-641
    • Ma, Y.1    Zhao, X.2    Zhang, W.3    Liu, L.4    Wang, Y.5    Fang, R.6
  • 48
    • 43549091613 scopus 로고    scopus 로고
    • Association of plasma total homocysteine levels with subclinical brain injury: Cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study
    • Seshadri S, Wolf PA, Beiser AS, Selhub J, Au R, Jacques PF, et al. Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study. Arch Neurol 2008;65:642-649.
    • (2008) Arch Neurol , vol.65 , pp. 642-649
    • Seshadri, S.1    Wolf, P.A.2    Beiser, A.S.3    Selhub, J.4    Au, R.5    Jacques, P.F.6
  • 49
    • 67949094319 scopus 로고    scopus 로고
    • Association of plasma homocysteine concentration with cerebral white matter hyperintensity on magnetic resonance images in stroke patients
    • Tseng YL, Chang YY, Liu JS, Su CS, Lai SL, Lan MY. Association of plasma homocysteine concentration with cerebral white matter hyperintensity on magnetic resonance images in stroke patients. J Neurol Sci 2009;284:36-39.
    • (2009) J Neurol Sci , vol.284 , pp. 36-39
    • Tseng, Y.L.1    Chang, Y.Y.2    Liu, J.S.3    Su, C.S.4    Lai, S.L.5    Lan, M.Y.6
  • 50
    • 79958012936 scopus 로고    scopus 로고
    • Homocysteine and cerebral small vessel disease in patients with symptomatic atherosclerotic disease. The SMART-MR study
    • Kloppenborg RP, Nederkoorn PJ, van der Graaf Y, Geerlings MI. Homocysteine and cerebral small vessel disease in patients with symptomatic atherosclerotic disease. The SMART-MR study. Atherosclerosis 2011;216:461-466.
    • (2011) Atherosclerosis , vol.216 , pp. 461-466
    • Kloppenborg, R.P.1    Nederkoorn, P.J.2    Van Der Graaf, Y.3    Geerlings, M.I.4
  • 51
    • 84965089107 scopus 로고    scopus 로고
    • Relationship between homocysteine level and diabetic retinopathy: A systematic review and meta-analysis
    • Xu C, Wu Y, Liu G, Liu X, Wang F, Yu J. Relationship between homocysteine level and diabetic retinopathy: a systematic review and meta-analysis. Diagn Pathol 2014;9:167.
    • (2014) Diagn Pathol , vol.9 , pp. 167
    • Xu, C.1    Wu, Y.2    Liu, G.3    Liu, X.4    Wang, F.5    Yu, J.6
  • 52
    • 84947288762 scopus 로고    scopus 로고
    • Hyperhomocysteinemia predicts renal function decline: A prospective study in hypertensive adults
    • Xie D, Yuan Y, Guo J, Yang S, Xu X, Wang Q, et al. Hyperhomocysteinemia predicts renal function decline: a prospective study in hypertensive adults. Sci Rep 2015;5:16268.
    • (2015) Sci Rep , vol.5
    • Xie, D.1    Yuan, Y.2    Guo, J.3    Yang, S.4    Xu, X.5    Wang, Q.6
  • 53
    • 84870882890 scopus 로고    scopus 로고
    • B vitamins and magnetic resonance imaging-detected ischemic brain lesions in patients with recent transient ischemic attack or stroke: The vitamins to Prevent Stroke (VITATOPS) MRI-substudy
    • Cavalieri M, Schmidt R, Chen C, Mok V, de Freitas GR, Song S, et al. B vitamins and magnetic resonance imaging-detected ischemic brain lesions in patients with recent transient ischemic attack or stroke: the vitamins to Prevent Stroke (VITATOPS) MRI-substudy. Stroke 2012;43:3266-3270.
    • (2012) Stroke , vol.43 , pp. 3266-3270
    • Cavalieri, M.1    Schmidt, R.2    Chen, C.3    Mok, V.4    De Freitas, G.R.5    Song, S.6
  • 54
    • 2142757272 scopus 로고    scopus 로고
    • Effect of homocysteine-lowering treatment with folic acid plus vitamin B on cerebrovascular atherosclerosis and white matter abnormalities as determined by MRA and MRI: A placebo-controlled, randomized trial
    • Vermeulen EG, Stehouwer CD, Valk J, van der Knaap M, van den Berg M, Twisk JW, et al. Effect of homocysteine-lowering treatment with folic acid plus vitamin B on cerebrovascular atherosclerosis and white matter abnormalities as determined by MRA and MRI: a placebo-controlled, randomized trial. Eur J Clin Invest 2004;34:256-261.
    • (2004) Eur J Clin Invest , vol.34 , pp. 256-261
    • Vermeulen, E.G.1    Stehouwer, C.D.2    Valk, J.3    Van Der Knaap, M.4    Van Den Berg, M.5    Twisk, J.W.6
  • 55
    • 79953718498 scopus 로고    scopus 로고
    • Folic acid food fortification—its history, effect, concerns, and future directions
    • Crider KS, Bailey LB, Berry RJ. Folic acid food fortification—its history, effect, concerns, and future directions. Nutrients 2011;3:370-384.
    • (2011) Nutrients , vol.3 , pp. 370-384
    • Crider, K.S.1    Bailey, L.B.2    Berry, R.J.3
  • 56
    • 0033551352 scopus 로고    scopus 로고
    • The effect of folic acid fortification on plasma folate and total homocysteine concentrations
    • Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999;340:1449- 1454.
    • (1999) N Engl J Med , vol.340 , pp. 1449-1454
    • Jacques, P.F.1    Selhub, J.2    Bostom, A.G.3    Wilson, P.W.4    Rosenberg, I.H.5
  • 57
    • 78651295457 scopus 로고    scopus 로고
    • A dose-finding trial of the effect of long-term folic acid intervention: Implications for food fortification policy
    • Tighe P, Ward M, McNulty H, Finnegan O, Dunne A, Strain J, et al. A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy. Am J Clin Nutr 2011;93:11-18.
    • (2011) Am J Clin Nutr , vol.93 , pp. 11-18
    • Tighe, P.1    Ward, M.2    McNulty, H.3    Finnegan, O.4    Dunne, A.5    Strain, J.6
  • 58
    • 0038680324 scopus 로고    scopus 로고
    • Low vitamin B6 but not homocyst(E)ine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification
    • Kelly PJ, Shih VE, Kistler JP, Barron M, Lee H, Mandell R, et al. Low vitamin B6 but not homocyst(e)ine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification. Stroke 2003;34:e51-e54.
    • (2003) Stroke , vol.34 , pp. e51-e54
    • Kelly, P.J.1    Shih, V.E.2    Kistler, J.P.3    Barron, M.4    Lee, H.5    Mandell, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.