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Volumn 1, Issue 4, 2016, Pages

A high-content, phenotypic screen identifies fluorouridine as an inhibitor of pyoverdine biosynthesis and Pseudomonas aeruginosa virulence

Author keywords

5 fluorouracil; 5 fluorouridine; Caenorhabditis elegans; High throughput screening; Pseudomonas aeruginosa; Pyoverdine; Siderophores; Virulence determinants

Indexed keywords


EID: 85041547188     PISSN: None     EISSN: 23795042     Source Type: Journal    
DOI: 10.1128/mSphere.00217-16     Document Type: Article
Times cited : (46)

References (43)
  • 1
    • 33644865799 scopus 로고    scopus 로고
    • Pandrug-resistant Pseudomonas aeruginosa among hospitalised patients: clinical features, risk-factors and outcomes
    • Wang CY, Jerng JS, Chen KY, Cheng KY, Lee LN, Yu CJ, Hsueh PR, Yang PC. 2006. Pandrug-resistant Pseudomonas aeruginosa among hospitalised patients: clinical features, risk-factors and outcomes. Clin Microbiol Infect 12:63-68. http://dx.doi.org/10.1111/j.1469-0691.2005.01305.x
    • (2006) Clin Microbiol Infect , vol.12 , pp. 63-68
    • Wang, C.Y.1    Jerng, J.S.2    Chen, K.Y.3    Cheng, K.Y.4    Lee, L.N.5    Yu, C.J.6    Hsueh, P.R.7    Yang, P.C.8
  • 2
    • 84907586950 scopus 로고    scopus 로고
    • Discovery and development of new antibacterial agents targeting gram-negative bacteria in the era of pandrug resistance: is the future promising?
    • Page MG, Bush K. 2014. Discovery and development of new antibacterial agents targeting gram-negative bacteria in the era of pandrug resistance: is the future promising? Curr Opin Pharmacol 18:91-97. http://dx.doi.org/10.1016/j.coph.2014.09.008
    • (2014) Curr Opin Pharmacol , vol.18 , pp. 91-97
    • Page, M.G.1    Bush, K.2
  • 3
    • 84902275303 scopus 로고    scopus 로고
    • Multidrug-resistant and extensively drug-resistant gram-negative pathogens: current and emerging therapeutic approaches
    • Karaiskos I, Giamarellou H. 2014. Multidrug-resistant and extensively drug-resistant gram-negative pathogens: current and emerging therapeutic approaches. Expert Opin Pharmacother 15:1351-1370. http:// dx.doi.org/10.1517/14656566.2014.914172
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 1351-1370
    • Karaiskos, I.1    Giamarellou, H.2
  • 4
    • 55049136420 scopus 로고    scopus 로고
    • Has nature already identified all useful antibacterial targets?
    • Bumann D. 2008. Has nature already identified all useful antibacterial targets? Curr Opin Microbiol 11:387-392. http://dx.doi.org/10.1016/ j.mib.2008.08.002
    • (2008) Curr Opin Microbiol , vol.11 , pp. 387-392
    • Bumann, D.1
  • 5
    • 15544384259 scopus 로고    scopus 로고
    • Antibacterial drug discovery: is it all downhill from here?
    • Projan SJ, Shlaes DM. 2004. Antibacterial drug discovery: is it all downhill from here? Clin Microbiol Infect 10(Suppl 4):18-22. http:// dx.doi.org/10.1111/j.1465-0691.2004.1006.x
    • (2004) Clin Microbiol Infect , vol.10 , pp. 18-22
    • Projan, S.J.1    Shlaes, D.M.2
  • 6
    • 23244458270 scopus 로고    scopus 로고
    • A retrospective on the failures and successes of antibacterial drug discovery
    • Silver LL. 2005. A retrospective on the failures and successes of antibacterial drug discovery. IDrugs 8:651-655
    • (2005) IDrugs , vol.8 , pp. 651-655
    • Silver, L.L.1
  • 9
    • 84906354624 scopus 로고    scopus 로고
    • Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways
    • O'Reilly LP, Benson JA, Cummings EE, Perlmutter DH, Silverman GA, Pak SC. 2014. Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways. Expert Opin Drug Discov 9:1021-1032. http://dx.doi.org/10.1517/17460441.2014.930125
    • (2014) Expert Opin Drug Discov , vol.9 , pp. 1021-1032
    • O'Reilly, L.P.1    Benson, J.A.2    Cummings, E.E.3    Perlmutter, D.H.4    Silverman, G.A.5    Pak, S.C.6
  • 10
    • 84876377610 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death
    • Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM. 2013. Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host Microbe 13:406-416. http://dx.doi.org/10.1016/ j.chom.2013.03.003
    • (2013) Cell Host Microbe , vol.13 , pp. 406-416
    • Kirienko, N.V.1    Kirienko, D.R.2    Larkins-Ford, J.3    Wählby, C.4    Ruvkun, G.5    Ausubel, F.M.6
  • 11
    • 33845951124 scopus 로고    scopus 로고
    • Pyoverdine siderophores: from biogenesis to biosignificance
    • Visca P, Imperi F, Lamont IL. 2007. Pyoverdine siderophores: from biogenesis to biosignificance. Trends Microbiol 15:22-30. http:// dx.doi.org/10.1016/j.tim.2006.11.004
    • (2007) Trends Microbiol , vol.15 , pp. 22-30
    • Visca, P.1    Imperi, F.2    Lamont, I.L.3
  • 12
    • 34248669844 scopus 로고    scopus 로고
    • How we learnt about iron acquisition in Pseudomonas aeruginosa: a series of very fortunate events
    • Vasil ML. 2007. How we learnt about iron acquisition in Pseudomonas aeruginosa: a series of very fortunate events. Biometals 20:587-601. http://dx.doi.org/10.1007/s10534-006-9067-2
    • (2007) Biometals , vol.20 , pp. 587-601
    • Vasil, M.L.1
  • 13
    • 0034873465 scopus 로고    scopus 로고
    • Characterization of an endoprotease (PrpL) encoded by a PvdS-regulated gene in Pseudomonas aeruginosa
    • Wilderman PJ, Vasil AI, Johnson Z, Wilson MJ, Cunliffe HE, Lamont IL, Vasil ML. 2001. Characterization of an endoprotease (PrpL) encoded by a PvdS-regulated gene in Pseudomonas aeruginosa. Infect Immun 69:5385-5394. http://dx.doi.org/10.1128/IAI.69.9.5385-5394.2001
    • (2001) Infect Immun , vol.69 , pp. 5385-5394
    • Wilderman, P.J.1    Vasil, A.I.2    Johnson, Z.3    Wilson, M.J.4    Cunliffe, H.E.5    Lamont, I.L.6    Vasil, M.L.7
  • 16
    • 0034127711 scopus 로고    scopus 로고
    • The oxygen-and iron-dependent sigma factor pvdS of Pseudomonas aeruginosa is an important virulence factor in experimental infective endocarditis
    • Xiong YQ, Vasil ML, Johnson Z, Ochsner UA, Bayer AS. 2000. The oxygen-and iron-dependent sigma factor pvdS of Pseudomonas aeruginosa is an important virulence factor in experimental infective endocarditis. J Infect Dis 181:1020-1026. http://dx.doi.org/10.1086/315338
    • (2000) J Infect Dis , vol.181 , pp. 1020-1026
    • Xiong, Y.Q.1    Vasil, M.L.2    Johnson, Z.3    Ochsner, U.A.4    Bayer, A.S.5
  • 17
    • 84871087295 scopus 로고    scopus 로고
    • The two-component sensor KinB acts as a phosphatase to regulate Pseudomonas aeruginosa virulence
    • Chand NS, Clatworthy AE, Hung DT. 2012. The two-component sensor KinB acts as a phosphatase to regulate Pseudomonas aeruginosa virulence. J Bacteriol 194:6537-6547 http://dx.doi.org/10.1128/JB.01168-12
    • (2012) J Bacteriol , vol.194 , pp. 6537-6547
    • Chand, N.S.1    Clatworthy, A.E.2    Hung, D.T.3
  • 18
    • 84922666062 scopus 로고    scopus 로고
    • Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
    • Kirienko NV, Ausubel FM, Ruvkun G. 2015. Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 112:1821-1826. http://dx.doi.org/10.1073/ pnas.1424954112
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 1821-1826
    • Kirienko, N.V.1    Ausubel, F.M.2    Ruvkun, G.3
  • 19
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang JH, Chung TD, Oldenburg KR. 1999. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 4:67-73. http://dx.doi.org/10.1177/ 108705719900400206
    • (1999) J Biomol Screen , vol.4 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3
  • 21
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: Kyoto encyclopedia of genes and genomes
    • Kanehisa M, Goto S. 2000. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28:27-30. http://dx.doi.org/10.1093/nar/ 28.1.27
    • (2000) Nucleic Acids Res , vol.28 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 22
    • 0020643556 scopus 로고
    • Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes
    • El Sayed YM, Sadée W. 1983. Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes. Cancer Res 43:4039-4044
    • (1983) Cancer Res , vol.43 , pp. 4039-4044
    • El Sayed, Y.M.1    Sadée, W.2
  • 23
    • 0031715937 scopus 로고    scopus 로고
    • Capecitabine: a new oral fluoropyrimidine
    • Ignoffo RJ. 1998. Capecitabine: a new oral fluoropyrimidine. Cancer Pract 6:302-304. http://dx.doi.org/10.1046/j.1523-5394.1998.00028.x
    • (1998) Cancer Pract , vol.6 , pp. 302-304
    • Ignoffo, R.J.1
  • 24
    • 0037257321 scopus 로고    scopus 로고
    • The importance of efflux pumps in bacterial antibiotic resistance
    • Webber MA, Piddock LJ. 2003. The importance of efflux pumps in bacterial antibiotic resistance. J Antimicrob Chemother 51:9-11. http:// dx.doi.org/10.1093/jac/dkg050
    • (2003) J Antimicrob Chemother , vol.51 , pp. 9-11
    • Webber, M.A.1    Piddock, L.J.2
  • 25
    • 0035352919 scopus 로고    scopus 로고
    • Siderotyping-a powerful tool for the characterization of pyoverdines
    • Fuchs R, Schäfer M, Geoffroy V, Meyer JM. 2001. Siderotyping-a powerful tool for the characterization of pyoverdines. Curr Top Med Chem 1:31-57. http://dx.doi.org/10.2174/1568026013395542
    • (2001) Curr Top Med Chem , vol.1 , pp. 31-57
    • Fuchs, R.1    Schäfer, M.2    Geoffroy, V.3    Meyer, J.M.4
  • 27
    • 0031794801 scopus 로고    scopus 로고
    • Siderotyping of fluorescent pseudomonads: characterization of pyoverdines of Pseudomonas fluorescens and Pseudomonas putida strains from Antarctica
    • Meyer JM, Stintzi A, Coulanges V, Shivaji S, Voss JA, Taraz K, Budzikiewicz H. 1998. Siderotyping of fluorescent pseudomonads: characterization of pyoverdines of Pseudomonas fluorescens and Pseudomonas putida strains from Antarctica. Microbiology 144:3119-3126. http://dx.doi.org/10.1099/00221287-144-11-3119
    • (1998) Microbiology , vol.144 , pp. 3119-3126
    • Meyer, J.M.1    Stintzi, A.2    Coulanges, V.3    Shivaji, S.4    Voss, J.A.5    Taraz, K.6    Budzikiewicz, H.7
  • 29
    • 0017369396 scopus 로고
    • Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells
    • Wilkinson DS, Crumley J. 1977. Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells. J Biol Chem 252:1051-1056
    • (1977) J Biol Chem , vol.252 , pp. 1051-1056
    • Wilkinson, D.S.1    Crumley, J.2
  • 30
    • 0015918811 scopus 로고
    • Inhibition of ribosomal ribonucleic acid maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluorouridine
    • Wilkinson DS, Pitot HC. 1973. Inhibition of ribosomal ribonucleic acid maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluorouridine. J Biol Chem 248:63-68
    • (1973) J Biol Chem , vol.248 , pp. 63-68
    • Wilkinson, D.S.1    Pitot, H.C.2
  • 31
    • 0015102073 scopus 로고
    • Effects of fluorouracil on RNA synthesis in Bacillus cereus
    • Hahn GA, Mandel HG. 1971. Effects of fluorouracil on RNA synthesis in Bacillus cereus. Biochem Pharmacol 20:1973-1990. http://dx.doi.org/ 10.1016/0006-2952(71)90397-2
    • (1971) Biochem Pharmacol , vol.20 , pp. 1973-1990
    • Hahn, G.A.1    Mandel, H.G.2
  • 32
    • 0018180606 scopus 로고
    • Inhibition of transfer RNA function by replacement of uridine and uridine-derived nucleosides with 5-fluorouridine
    • Ramberg ES, Ishaq M, Rulf S, Moeller B, Horowitz J. 1978. Inhibition of transfer RNA function by replacement of uridine and uridine-derived nucleosides with 5-fluorouridine. Biochemistry 17:3978-3985. http:// dx.doi.org/10.1021/bi00612a016
    • (1978) Biochemistry , vol.17 , pp. 3978-3985
    • Ramberg, E.S.1    Ishaq, M.2    Rulf, S.3    Moeller, B.4    Horowitz, J.5
  • 33
    • 0017179676 scopus 로고
    • Biological consequences of incorporation of 5-fluorocytidine in the RNA of 5-fluorouracil-treated eukaryotic cells
    • Gleason MK, Fraenkel-Conrat H. 1976. Biological consequences of incorporation of 5-fluorocytidine in the RNA of 5-fluorouracil-treated eukaryotic cells. Proc Natl Acad Sci U S A 73:1528-1531. http:// dx.doi.org/10.1073/pnas.73.5.1528
    • (1976) Proc Natl Acad Sci U S A , vol.73 , pp. 1528-1531
    • Gleason, M.K.1    Fraenkel-Conrat, H.2
  • 35
    • 60549093122 scopus 로고    scopus 로고
    • Uracil influences quorum sensing and biofilm formation in Pseudomonas aeruginosa and fluorouracil is an antagonist
    • Ueda A, Attila C, Whiteley M, Wood TK. 2009. Uracil influences quorum sensing and biofilm formation in Pseudomonas aeruginosa and fluorouracil is an antagonist. Microb Biotechnol 2:62-74. http:// dx.doi.org/10.1111/j.1751-7915.2008.00060.x
    • (2009) Microb Biotechnol , vol.2 , pp. 62-74
    • Ueda, A.1    Attila, C.2    Whiteley, M.3    Wood, T.K.4
  • 36
    • 0018744377 scopus 로고
    • Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2=-deoxyuridine
    • Houghton JA, Houghton PJ, Wooten RS. 1979. Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2=-deoxyuridine. Cancer Res 39: 2406-2413
    • (1979) Cancer Res , vol.39 , pp. 2406-2413
    • Houghton, J.A.1    Houghton, P.J.2    Wooten, R.S.3
  • 37
    • 38449085292 scopus 로고    scopus 로고
    • Maintenance of C. elegans
    • WormBook (ed), Wormbook. 11 February
    • Stiernagle T. 11 February 2006. Maintenance of C. elegans. In The C. elegans Research Community, WormBook (ed), Wormbook. http:// dx.doi.org/10.1895/wormbook.1.101.1
    • (2006) The C. elegans Research Community
    • Stiernagle, T.1
  • 38
    • 0029035765 scopus 로고
    • Common virulence factors for bacterial pathogenicity in plants and animals
    • Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG, Ausubel FM. 1995. Common virulence factors for bacterial pathogenicity in plants and animals. Science 268:1899-1902. http://dx.doi.org/10.1126/ science.7604262
    • (1995) Science , vol.268 , pp. 1899-1902
    • Rahme, L.G.1    Stevens, E.J.2    Wolfort, S.F.3    Shao, J.4    Tompkins, R.G.5    Ausubel, F.M.6
  • 39
    • 84912068019 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa PA14 pathogenesis in Caenorhabditis elegans
    • Kirienko NV, Cezairliyan BO, Ausubel FM, Powell JR. 2014. Pseudomonas aeruginosa PA14 pathogenesis in Caenorhabditis elegans. Methods Mol Biol 1149:653-669. http://dx.doi.org/10.1007/978-1-4939-0473-0_50
    • (2014) Methods Mol Biol , vol.1149 , pp. 653-669
    • Kirienko, N.V.1    Cezairliyan, B.O.2    Ausubel, F.M.3    Powell, J.R.4
  • 40
    • 84990008231 scopus 로고    scopus 로고
    • Highthroughput screening for novel anti-infectives using a C. elegans pathogenesis model
    • Conery AL, Larkins-Ford J, Ausubel FM, Kirienko NV. 2014. Highthroughput screening for novel anti-infectives using a C. elegans pathogenesis model. Curr Protoc Chem Biol 6:25-37
    • (2014) Curr Protoc Chem Biol , vol.6 , pp. 25-37
    • Conery, A.L.1    Larkins-Ford, J.2    Ausubel, F.M.3    Kirienko, N.V.4
  • 41
  • 43
    • 34247563433 scopus 로고    scopus 로고
    • Transcriptome profiling of the C. elegans Rb ortholog reveals diverse developmental roles
    • Kirienko NV, Fay DS. 2007. Transcriptome profiling of the C. elegans Rb ortholog reveals diverse developmental roles. Dev Biol 305:674-684. http://dx.doi.org/10.1016/j.ydbio.2007.02.021
    • (2007) Dev Biol , vol.305 , pp. 674-684
    • Kirienko, N.V.1    Fay, D.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.