메뉴 건너뛰기




Volumn 11, Issue 5, 2008, Pages 387-392

Has nature already identified all useful antibacterial targets?

Author keywords

[No Author keywords available]

Indexed keywords

16S RIBOSOME RNA; 23S RIBOSOME RNA; ALANINE RACEMASE; ANTIBACTERIAL TARGET PROTEIN; ANTIBIOTIC AGENT; BACITRACIN; BACTERIAL ENZYME; BETA LACTAM ANTIBIOTIC; CYCLOSERINE; DELTA9 STEAROYL DESATURASE; DEXTRO ALANINE DEXTRO ALANINE LIGASE; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; DNA GYRASE COMPLEX; DNA TOPOISOMERASE COMPLEX; FOSFOMYCIN; GAMMA GLUTAMYLTRANSFERASE; GYRASE; ISOLEUCINE TRANSFER RNA; LIPID; NOVOBIOCIN; PROTEIN; PSEUDOMONIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RAMOPLANIN; RIFAMPICIN; RNA POLYMERASE; UNCLASSIFIED DRUG; UNDECAPRENYL PYROPHOSPHATE LIPID CARRIER; UNINDEXED DRUG; VANCOMYCIN;

EID: 55049136420     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mib.2008.08.002     Document Type: Review
Times cited : (40)

References (27)
  • 1
    • 12944302098 scopus 로고    scopus 로고
    • Lack of development of new antimicrobial drugs: a potential serious threat to public health
    • Norrby S.R., Nord C.E., and Finch R. Lack of development of new antimicrobial drugs: a potential serious threat to public health. Lancet Infect Dis 5 (2005) 115-119
    • (2005) Lancet Infect Dis , vol.5 , pp. 115-119
    • Norrby, S.R.1    Nord, C.E.2    Finch, R.3
  • 2
    • 35748958975 scopus 로고    scopus 로고
    • Late stage antibacterial drugs in the clinical pipeline
    • Projan S.J., and Bradford P.A. Late stage antibacterial drugs in the clinical pipeline. Curr Opin Microbiol 10 (2007) 441-446
    • (2007) Curr Opin Microbiol , vol.10 , pp. 441-446
    • Projan, S.J.1    Bradford, P.A.2
  • 4
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: confronting the challenges of antibacterial discovery
    • Comprehensive review of difficulties in antimicrobial R&D from an industrial perspective.
    • Payne D.J., Gwynn M.N., Holmes D.J., and Pompliano D.L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 6 (2007) 29-40. Comprehensive review of difficulties in antimicrobial R&D from an industrial perspective.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3    Pompliano, D.L.4
  • 5
    • 36248994803 scopus 로고    scopus 로고
    • The targets of currently used antibacterial agents: lessons for drug discovery
    • Detailed analysis of targets of currently used antibiotics. Interestingly, most antibiotics appear to interact with multiple, often unrelated targets.
    • Lange R.P., Locher H.H., Wyss P.C., and Then R.L. The targets of currently used antibacterial agents: lessons for drug discovery. Curr Pharm Des 13 (2007) 3140-3154. Detailed analysis of targets of currently used antibiotics. Interestingly, most antibiotics appear to interact with multiple, often unrelated targets.
    • (2007) Curr Pharm Des , vol.13 , pp. 3140-3154
    • Lange, R.P.1    Locher, H.H.2    Wyss, P.C.3    Then, R.L.4
  • 6
    • 31544450286 scopus 로고    scopus 로고
    • Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection
    • 2006.0008. This publication defines the set of essential in the prime model microbe Escherichia coli under two experimental conditions. Comparison with other bacteria revealed only 42 essential and broadly conserved genes.
    • Baba T., Ara T., Hasegawa M., Takai Y., Okumura Y., Baba M., Datsenko K.A., Tomita M., Wanner B.L., and Mori H. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol 2 (2006) 2006.0008. This publication defines the set of essential in the prime model microbe Escherichia coli under two experimental conditions. Comparison with other bacteria revealed only 42 essential and broadly conserved genes.
    • (2006) Mol Syst Biol , vol.2
    • Baba, T.1    Ara, T.2    Hasegawa, M.3    Takai, Y.4    Okumura, Y.5    Baba, M.6    Datsenko, K.A.7    Tomita, M.8    Wanner, B.L.9    Mori, H.10
  • 7
    • 22144455317 scopus 로고    scopus 로고
    • Novel target sites in bacteria for overcoming antibiotic resistance
    • Black M.T., and Hodgson J. Novel target sites in bacteria for overcoming antibiotic resistance. Adv Drug Deliv Rev 57 (2005) 1528-1538
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 1528-1538
    • Black, M.T.1    Hodgson, J.2
  • 8
    • 55049093781 scopus 로고    scopus 로고
    • Renaissance in antibacterial discovery from actinomycetes
    • Overview of challenges and opportunities for discovering natural products with novel antimicrobial mechanisms.
    • Baltz R.H. Renaissance in antibacterial discovery from actinomycetes. Curr Opin Pharmacol 3 (2008) 3. Overview of challenges and opportunities for discovering natural products with novel antimicrobial mechanisms.
    • (2008) Curr Opin Pharmacol , vol.3 , pp. 3
    • Baltz, R.H.1
  • 9
    • 28144441826 scopus 로고    scopus 로고
    • The bacterial ribosome as a target for antibiotics
    • Poehlsgaard J., and Douthwaite S. The bacterial ribosome as a target for antibiotics. Nat Rev Microbiol 3 (2005) 870-881
    • (2005) Nat Rev Microbiol , vol.3 , pp. 870-881
    • Poehlsgaard, J.1    Douthwaite, S.2
  • 10
    • 0038101420 scopus 로고    scopus 로고
    • Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening
    • Wyss P.C., Gerber P., Hartman P.G., Hubschwerlen C., Locher H., Marty H.P., and Stahl M. Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening. J Med Chem 46 (2003) 2304-2312
    • (2003) J Med Chem , vol.46 , pp. 2304-2312
    • Wyss, P.C.1    Gerber, P.2    Hartman, P.G.3    Hubschwerlen, C.4    Locher, H.5    Marty, H.P.6    Stahl, M.7
  • 11
    • 0033668153 scopus 로고    scopus 로고
    • Mining bacterial genomes for antimicrobial targets
    • Loferer H. Mining bacterial genomes for antimicrobial targets. Mol Med Today 6 (2000) 470-474
    • (2000) Mol Med Today , vol.6 , pp. 470-474
    • Loferer, H.1
  • 13
    • 34249042613 scopus 로고    scopus 로고
    • The pan-genome: towards a knowledge-based discovery of novel targets for vaccines and antibacterials
    • Genetic diversity of pathogen clinical isolates complicates the development of control strategies. Comprehensive analysis of the corresponding 'pan-genome' could provide a more reliable picture of gene essentiality.
    • Muzzi A., Masignani V., and Rappuoli R. The pan-genome: towards a knowledge-based discovery of novel targets for vaccines and antibacterials. Drug Discov Today 12 (2007) 429-439. Genetic diversity of pathogen clinical isolates complicates the development of control strategies. Comprehensive analysis of the corresponding 'pan-genome' could provide a more reliable picture of gene essentiality.
    • (2007) Drug Discov Today , vol.12 , pp. 429-439
    • Muzzi, A.1    Masignani, V.2    Rappuoli, R.3
  • 15
    • 4644242447 scopus 로고    scopus 로고
    • Antibacterial research and development in the 21(st) Century - an industry perspective of the challenges
    • Thomson C.J., Power E., Ruebsamen-Waigmann H., and Labischinski H. Antibacterial research and development in the 21(st) Century - an industry perspective of the challenges. Curr Opin Microbiol 7 (2004) 445-450
    • (2004) Curr Opin Microbiol , vol.7 , pp. 445-450
    • Thomson, C.J.1    Power, E.2    Ruebsamen-Waigmann, H.3    Labischinski, H.4
  • 16
    • 33745912507 scopus 로고    scopus 로고
    • Identification of novel antimicrobials using a live-animal infection model
    • Screening approach utilizing an invertebrate model host. The data suggest more stringent requirements in infected host animals compared to in vitro cultures.
    • Moy T.I., Ball A.R., Anklesaria Z., Casadei G., Lewis K., and Ausubel F.M. Identification of novel antimicrobials using a live-animal infection model. Proc Natl Acad Sci U S A 103 (2006) 10414-10419. Screening approach utilizing an invertebrate model host. The data suggest more stringent requirements in infected host animals compared to in vitro cultures.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10414-10419
    • Moy, T.I.1    Ball, A.R.2    Anklesaria, Z.3    Casadei, G.4    Lewis, K.5    Ausubel, F.M.6
  • 17
    • 33845311869 scopus 로고    scopus 로고
    • Signature-tagged mutagenesis: barcoding mutants for genome-wide screens
    • Mazurkiewicz P., Tang C.M., Boone C., and Holden D.W. Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nat Rev Genet 7 (2006) 929-939
    • (2006) Nat Rev Genet , vol.7 , pp. 929-939
    • Mazurkiewicz, P.1    Tang, C.M.2    Boone, C.3    Holden, D.W.4
  • 21
    • 33645030241 scopus 로고    scopus 로고
    • Robust Salmonella metabolism limits possibilities for new antimicrobials
    • Extensive in vivo screen of metabolic targets in a Gram-negative pathogen. The data suggest unexpected rich host microenvironments even for this intracellular pathogen as one primary reason for the small number of suitable targets.
    • Becker D., Selbach M., Rollenhagen C., Ballmaier M., Meyer T.F., Mann M., and Bumann D. Robust Salmonella metabolism limits possibilities for new antimicrobials. Nature 440 (2006) 303-307. Extensive in vivo screen of metabolic targets in a Gram-negative pathogen. The data suggest unexpected rich host microenvironments even for this intracellular pathogen as one primary reason for the small number of suitable targets.
    • (2006) Nature , vol.440 , pp. 303-307
    • Becker, D.1    Selbach, M.2    Rollenhagen, C.3    Ballmaier, M.4    Meyer, T.F.5    Mann, M.6    Bumann, D.7
  • 22
    • 33645733997 scopus 로고    scopus 로고
    • Do targets limit antibiotic discovery?
    • Questions some of the selection criteria for targets in the preceding study and stresses the fact that a few targets might be actually sufficient for developing clinically useful antimicrobials.
    • Schmid M.B. Do targets limit antibiotic discovery?. Nat Biotechnol 24 (2006) 419-420. Questions some of the selection criteria for targets in the preceding study and stresses the fact that a few targets might be actually sufficient for developing clinically useful antimicrobials.
    • (2006) Nat Biotechnol , vol.24 , pp. 419-420
    • Schmid, M.B.1
  • 25
    • 27144443099 scopus 로고    scopus 로고
    • Drug discovery: playing dirty
    • Frantz S. Drug discovery: playing dirty. Nature 437 (2005) 942-943
    • (2005) Nature , vol.437 , pp. 942-943
    • Frantz, S.1
  • 26
    • 33644522058 scopus 로고    scopus 로고
    • Understanding the longevity of the beta-lactam antibiotics and of antibiotic/beta-lactamase inhibitor combinations
    • Buynak J.D. Understanding the longevity of the beta-lactam antibiotics and of antibiotic/beta-lactamase inhibitor combinations. Biochem Pharmacol 71 (2006) 930-940
    • (2006) Biochem Pharmacol , vol.71 , pp. 930-940
    • Buynak, J.D.1
  • 27
    • 34347258175 scopus 로고    scopus 로고
    • Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox
    • Open-source tools for computational prediction of essential genes and synthetically lethal defects.
    • Becker S.A., Feist A.M., Mo M.L., Hannum G., Palsson B.O., and Herrgard M.J. Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox. Nat Protoc 2 (2007) 727-738. Open-source tools for computational prediction of essential genes and synthetically lethal defects.
    • (2007) Nat Protoc , vol.2 , pp. 727-738
    • Becker, S.A.1    Feist, A.M.2    Mo, M.L.3    Hannum, G.4    Palsson, B.O.5    Herrgard, M.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.