Epidemiological and serological investigation into the role of gestational maternal influenza virus infection and autism spectrum disorders

mSphere

Volumn 2, Issue 3, 2017, Pages

  Mahic, Milada ^a,b   Che, Xiaoyu ^a   Susser, Ezra ^a,c   Levin, Bruce ^a   Reichborn Kjennerud, Ted ^b   Magnus, Per ^b   Stoltenberg, Camilla ^b,d   Chauhan, Lokendrasingh ^a   Briese, Thomas ^a   Bresnahan, Michaeline ^a,c   Surén, Pål ^b   Hornig, Mady ^a   Mjaaland, Siri ^a,b,e   Lipkin, W Ian ^a  

^a Columbia University ^*  (United States)

^b NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^d UNIVERSITY OF BERGEN   (Norway)

^e KG Jebsen Centre for Research on Influenza Vaccines   (Norway)

Author keywords

Autism; Birth cohort; Infection; Influenza virus; Prenatal; Serology

Indexed keywords

EID: 85041534436     PISSN: None     EISSN: 23795042     Source Type: Journal    
DOI: 10.1128/mSphere.00159-17     Document Type: Article

References (34)

1. Elsabbagh M, Divan G, Koh YJ, Kim YS, Kauchali S, Marcín C, Montiel-Nava C, Patel V, Paula CS, Wang C, Yasamy MT, Fombonne E. 2012. Global prevalence of autism and other pervasive developmental disorders. Autism Res 5:160-179. https://doi.org/10.1002/aur.239
2. Buescher AV, Cidav Z, Knapp M, Mandell DS. 2014. Costs of autism spectrum disorders in the United Kingdom and the United States. JAMA Pediatr 168:721-728. https://doi.org/10.1001/jamapediatrics.2014.210
3. Hallmayer J, Cleveland S, Torres A, Phillips J, Cohen B, Torigoe T, Miller J, Fedele A, Collins J, Smith K, Lotspeich L, Croen LA, Ozonoff S, Lajonchere C, Grether JK, Risch N. 2011. Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry 68:1095-1102. https://doi.org/10.1001/archgenpsychiatry.2011.76
4. Lyall K, Ashwood P, Van de Water J, Hertz-Picciotto I. 2014. Maternal immune-mediated conditions, autism spectrum disorders, and developmental delay. J Autism Dev Disord 44:1546-1555. https://doi.org/10 .1007/s10803-013-2017-2
5. Lyall K, Schmidt RJ, Hertz-Picciotto I. 2014. Maternal lifestyle and environmental risk factors for autism spectrum disorders. Int J Epidemiol 43:443-464. https://doi.org/10.1093/ije/dyt282
6. Mahic M, Mjaaland S, Bovelstad HM, Gunnes N, Susser E, Bresnahan M, Oyen AS, Levin B, Che X, Hirtz D, Reichborn-Kjennerud T, Schjolberg S, Roth C, Magnus P, Stoltenberg C, Suren P, Hornig M, Lipkin WI. 2017. Maternal immunoreactivity to herpes simplex virus 2 and risk of autism spectrum disorder in male offspring. mSphere 2:e00016-17. https://doi .org/10.1128/mSphere.00016-17
7. WHO Regional Office for Europe. 2016. Influenza data and statistics. WHO Regional Office for Europe, Copenhagen, Denmark
8. Thompson WW, Shay DK, Weintraub E, Brammer L, Bridges CB, Cox NJ, Fukuda K. 2004. Influenza-associated hospitalizations in the United States. JAMA 292:1333-1340. https://doi.org/10.1001/jama.292.11.1333
9. Thompson WW, Weintraub E, Dhankhar P, Cheng PY, Brammer L, Meltzer MI, Bresee JS, Shay DK. 2009. Estimates of US influenza-associated deaths made using four different methods. Influenza Other Respir Viruses 3:37-49. https://doi.org/10.1111/j.1750-2659.2009.00073.x
10. Raj RS, Bonney EA, Phillippe M. 2014. Influenza, immune system, and pregnancy. Reprod Sci 21:1434-1451. https://doi.org/10.1177/ 1933719114537720
11. Shi L, Fatemi SH, Sidwell RW, Patterson PH. 2003. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci 23:297-302
12. Brown AS, Begg MD, Gravenstein S, Schaefer CA, Wyatt RJ, Bresnahan M, Babulas VP, Susser ES. 2004. Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry 61:774-780. https:// doi.org/10.1001/archpsyc.61.8.774
13. Atladóttir Hó, Henriksen TB, Schendel DE, Parner ET. 2012. Autism after infection, febrile episodes, and antibiotic use during pregnancy: an exploratory study. Pediatrics 130:e1447-e1454. https://doi.org/10.1542/ peds.2012-1107
14. Zerbo O, Iosif AM, Walker C, Ozonoff S, Hansen RL, Hertz-Picciotto I. 2013. Is maternal influenza or fever during pregnancy associated with autism or developmental delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) study. J Autism Dev Disord 43:25-33. https://doi.org/10.1007/s10803-012-1540-x
15. Zerbo O, Qian Y, Yoshida C, Fireman BH, Klein NP, Croen LA. 2017. Association between influenza infection and vaccination during pregnancy and risk of autism spectrum disorder. JAMA Pediatr 171:e163609. https://doi.org/10.1001/jamapediatrics.2016.3609
16. Wutzler P, Schmidt-Ott R, Hoyer H, Sauerbrei A. 2009. Prevalence of influenza A and B antibodies in pregnant women and their offspring. J Clin Virol 46:161-164. https://doi.org/10.1016/j.jcv.2009.06.024
17. Kash JC, Tumpey TM, Proll SC, Carter V, Perwitasari O, Thomas MJ, Basler CF, Palese P, Taubenberger JK, García-Sastre A, Swayne DE, Katze MG. 2006. Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature 443:578-581. https:// doi.org/10.1038/nature05181
18. Perrone LA, Plowden JK, García-Sastre A, Katz JM, Tumpey TM. 2008. H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog 4:e1000115. https://doi.org/10.1371/journal.ppat .1000115
19. Moretti ME, Bar-Oz B, Fried S, Koren G. 2005. Maternal hyperthermia and the risk for neural tube defects in offspring: systematic review and meta-analysis. Epidemiology 16:216-219. https://doi.org/10.1097/01 .ede.0000152903.55579.15
20. McClain MT, Henao R, Williams J, Nicholson B, Veldman T, Hudson L, Tsalik EL, Lambkin-Williams R, Gilbert A, Mann A, Ginsburg GS, Woods CW. 2016. Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge. Clin Exp Immunol 183:441-451. https://doi.org/10.1111/cei .12736
21. Atladóttir HO, Thorsen P, Østergaard L, Schendel DE, Lemcke S, Abdallah M, Parner ET. 2010. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. J Autism Dev Disord 40: 1423-1430. https://doi.org/10.1007/s10803-010-1006-y
22. Zerbo O, Qian Y, Yoshida C, Grether JK, Van de Water J, Croen LA. 2015. Maternal infection during pregnancy and autism spectrum disorders. J Autism Dev Disord 45:4015-4025. https://doi.org/10.1007/s10803-013-2016-3
23. Jones KL, Croen LA, Yoshida CK, Heuer L, Hansen R, Zerbo O, DeLorenze GN, Kharrazi M, Yolken R, Ashwood P, Van de Water J. 2017. Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation. Mol Psychiatry 22:273-279. https://doi.org/10.1038/mp.2016.77
24. Magnus P, Birke C, Vejrup K, Haugan A, Alsaker E, Daltveit AK, Handal M, Haugen M, Høiseth G, Knudsen GP, Paltiel L, Schreuder P, Tambs K, Vold L, Stoltenberg C. 2016. Cohort profile update: the Norwegian Mother and Child Cohort Study (MoBa). Int J Epidemiol 45:382-388. https://doi .org/10.1093/ije/dyw029
25. Burbelo PD, Ching KH, Mattson TL, Light JS, Bishop LR, Kovacs JA. 2007. Rapid antibody quantification and generation of whole proteome antibody response profiles using LIPS (luciferase immunoprecipitation systems). Biochem Biophys Res Commun 352:889-895. https://doi.org/10 .1016/j.bbrc.2006.11.140
26. Hale BG, Randall RE, Ortín J, Jackson D. 2008. The multifunctional NS1 protein of influenza A viruses. J Gen Virol 89:2359-2376. https://doi.org/ 10.1099/vir.0.2008/004606-0
27. Burbelo PD, Goldman R, Mattson TL. 2005. A simplified immunoprecipitation method for quantitatively measuring antibody responses in clinical sera samples by using mammalian-produced Renilla luciferaseantigen fusion proteins. BMC Biotechnol 5:22. https://doi.org/10.1186/ 1472-6750-5-22
28. WHO. 2011. Manual for the laboratory diagnosis and virological surveillance of influenza. WHO Global Influenza Surveillance Network, Geneva, Switzerland
29. Balish AL, Katz JM, Klimov AI. 2013. Influenza: propagation, quantification, and storage. Curr Protoc Microbiol Chapter 15:Unit15G.11. https:// doi.org/10.1002/9780471729259.mc15g01s29
30. Monto AS, Maassab HF. 1981. Ether treatment of type B influenza virus antigen for the hemagglutination inhibition test. J Clin Microbiol 13: 54-57
31. Norwegian Institute of Public Health. 2016. Norwegian Mother and Child Cohort Study (MoBa). NIPH, Oslo, Norway. https://www.fhi.no/en/studies/ moba/
32. Hosmer DW, Lemeshow S. 1992. Confidence interval estimation of interaction. Epidemiology 3:452-456. https://doi.org/10.1097/00001648-199209000-00012
33. Schafer JL. 1997. Analysis of incomplete multivariate data, 1st ed. Chapman & Hall, London, United Kingdom
34. Rubin DB. 1987. Multiple imputation for nonresponse in surveys. Wiley, New York, NY