Do the microbiota influence vaccines and protective immunity to pathogens?: Issues of sovereignty, federalism, and points-testing in the prokaryotic and eukaryotic spaces of the host-microbial superorganism

Cold Spring Harbor Perspectives in Biology

Volumn 10, Issue 2, 2018, Pages

  Macpherson, Andrew J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

VACCINE;

ANIMAL; EUKARYOTIC CELL; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; INFECTION; MICROFLORA; PROKARYOTIC CELL;

ANIMALS; EUKARYOTIC CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; INFECTION; MICROBIOTA; PROKARYOTIC CELLS; VACCINES;

EID: 85041406438     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a029363     Document Type: Article

References (43)

1. Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, Suda W, Imaoka A, Setoyama H, Nagamori T, et al. 2015. Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Cell 163: 367–380.
2. Balmer ML, Schurch CM, Saito Y, Geuking MB, Li H, Cuen-ca M, Kovtonyuk LV, McCoy KD, Hapfelmeier S, Och-senbein AF, et al. 2014. Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling. J Immunol 193: 5273–5283.
3. Bunker JJ, Flynn TM, Koval JC, Shaw DG, Meisel M, McDonald BD, Ishizuka IE, Dent AL, Wilson PC, Jabri B, et al. 2015. Innate and adaptive humoral responses coat distinct commensal bacteria with immunoglobulin A. Immunity 43: 541–553.
4. Cahenzli J, Koller Y, Wyss M, Geuking MB, McCoy KD. 2013. Intestinal microbial diversity during early-life colonization shapes long-term IgE levels. Cell Host Microße 14: 559–570.
5. Chatfield SN, Strugnell RA, Dougan G. 1989. Live Salmonella as vaccines and carriers of foreign antigenic determinants. Vaccine 7: 495–498.
6. Diard M, Garcia V, Maier L, Remus-Emsermann MN, Re-goes RR, Ackermann M, Hardt WD. 2013. Stabilization of cooperative virulence by the expression of an avirulent phenotype. Nature 494: 353–356.
7. Endt K, Stecher B, Chaffron S, Slack E, Tchitchek N, Benecke A, Van Maele L, Sirard JC, Mueller AJ, Heikenwalder M, et al. 2010. The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea. PLoS Pathog 6: e1001097.
8. Gensollen T, Iyer SS, Kasper DL, Blumberg RS. 2016. How colonization by microbiota in early life shapes the immune system. Science 352: 539–544.
9. Gomez de Aguero M, Ganal-Vonarburg SC, Fuhrer T, Rupp S, Uchimura Y, Li H, Steinert A, Heikenwalder M, Hapfelmeier S, Sauer U, et al. 2016. The maternal microbiota drives early postnatal innate immune development. Science 351: 1296–1302.
10. Harris NL, Spoerri I, Schopfer JF, Nembrini C, Merky P, Massacand J, Urban JF Jr., Lamarre A, Burki K, Odermatt B, et al. 2006. Mechanisms of neonatal mucosal antibody protection. J Immunol 177: 6256–6262.
11. Holmes E, Li JV, Athanasiou T, Ashrafian H, Nicholson JK. 2011. Understanding the role of gut microbiome-host metabolic signal disruption in health and disease. Trends Microßiol 19: 349–359.
12. Hooper LV, Littman DR, Macpherson AJ. 2012. Interactions between the microbiota and the immune system. Science 336: 1268–1273.
13. Imhann F, Bonder MJ, Vich Vila A, Fu J, Mujagic Z, Vork L, Tigchelaar EF, Jankipersadsing SA, Cenit MC, Harmsen HJ, et al. 2016. Proton pump inhibitors affect the gut microbiome. Gut 65: 740–748.
14. Kearney JF, Patel P, Stefanov EK, King RG. 2015. Natural antibody repertoires: Development and functional role in inhibiting allergic airway disease. Annu Rev Immunol 33: 475–504.
15. Kieper WC, Troy A, Burghardt JT, Ramsey C, Lee JY, Jiang HQ, Dummer W, Shen H, Cebra JJ, Surh CD. 2005. Recent immune status determines the source of antigens that drive homeostatic T cell expansion. J Immunol 174: 3158–3163.
16. Koch MA, Reiner GL, Lugo KA, Kreuk LS, Stanbery AG, Ansaldo E, Seher TD, Ludington WB, Barton GM. 2016. Maternal IgG and IgA antibodies dampen mucosal T helper cell responses in early life. Cell 165: 827–841.
17. Konrad A, Cong Y, Duck W, Borlaza R, Elson CO. 2006. Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota. Gastroenterology 130: 2050–2059.
18. Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS, Cua DJ, Powrie F, Cheever AW, Maloy KJ, et al. 2006. IL-23 plays a key role in Helicoßacter hepati-cus–induced T cell-dependent colitis. J Exp Med 203: 2485–2494.
19. Kuwahara T, Ogura Y, Oshima K, Kurokawa K, Ooka T, Hirakawa H, Itoh T, Nakayama-Imaohji H, Ichimura M, Itoh K, et al. 2011. The lifestyle of the segmented filamentous bacterium: A non-culturable gut-associated immunostimulating microbe inferred by whole-genome sequencing. DNA Res 18: 291–303.
20. Lecuyer E, Rakotobe S, Lengline-Garnier H, Lebreton C, Picard M, Juste C, Fritzen R, Eberl G, McCoy KD, Macpherson AJ, et al. 2014. Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses. Immunity 40: 608–620.
21. Macpherson AJ, McCoy KD. 2015. Standardised animal models of host microbial mutualism. Mucosal Immunol 8: 476–486.
22. Macpherson AJ, Gatto D, Sainsbury E, Harriman GR, Hengartner H, Zinkernagel RM. 2000. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288: 2222–2226.
23. Maloy KJ, Powrie F. 2011. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474: 298–306.
24. R cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 197: 111–119.
25. McDonald EG, Milligan J, Frenette C, Lee TC. 2015. Continuous proton pump inhibitor therapy and the associated risk of recurrent Clostridium difficile infection. JAMA Intern Med 175: 784–791.
26. Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, et al. 2014. Immunoglobulin a coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158: 1000–1010.
27. Peterson DA, McNulty NP, Guruge JL, Gordon JI. 2007. IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microße 2: 328–339.
28. Pinna D, Corti D, Jarrossay D, Sallusto F, Lanzavecchia A. 2009. Clonal dissection of the human memory B-cell repertoire following infection and vaccination. Eur J Immunol 39: 1260–1270.
29. Rogier EW, Frantz AL, Bruno ME, Wedlund L, Cohen DA, Stromberg AJ, Kaetzel CS. 2014. Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression. Proc Natl Acad Sci 111: 3074–3079.
30. Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK. 2011. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 332: 974–977.
31. þ T cells against microbes. Annu Rev Immunol 34: 317–334.
32. Sano T, Huang W, Hall JA, Yang Y, Chen A, Gavzy SJ, Lee JY, Ziel JW, Miraldi ER, Domingos AI, et al. 2015. An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses. Cell 163: 381–393.
33. Sczesnak A, Segata N, Qin X, Gevers D, Petrosino JF, Hut-tenhower C, Littman DR, Ivanov II. 2011. The genome of Th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microße 10: 260–272.
34. Smith K, McCoy KD, Macpherson AJ. 2007. Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin Immunol 19: 59–69.
35. Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hut-nick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, et al. 2012. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 336: 1321–1325.
36. Teng F, Klinger CN, Felix KM, Bradley CP, Wu E, Tran NL, Umesaki Y, Wu HJ. 2016. Gut microbiota drive autoimmune arthritis by promoting differentiation and migration of Peyer’s Patch T follicular helper cells. Immunity 44: 875–888.
37. Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV. 2011. The antibacterial lectin RegIIIg promotes the spatial segregation of microbiota and host in the intestine. Science 334: 255–258.
38. van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JF, Tijssen JG, et al. 2013. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 368: 407– 415.
39. Wei M, Shinkura R, Doi Y, Maruya M, Fagarasan S, Honjo T. 2011. Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. Nat Immunol 12: 264–270.
40. Wu HJ, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, Littman DR, Benoist C, Mathis D. 2010. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32: 815–827.
41. H17 cells towards commensal bacterial antigens. Nature 510: 152–156.
42. Yilmaz B, Portugal S, Tran TM, Gozzelino R, Ramos S, Gomes J, Regalado A, Cowan PJ, d’Apice AJ, Chong AS, et al. 2014. Gut microbiota elicits a protective immune response against malaria transmission. Cell 159: 1277– 1289.
43. Zeng MY, Cisalpino D, Varadarajan S, Hellman J, Warren HS, Cascalho M, Inohara N, Nunez G. 2016. Gut micro-biota-induced immunoglobulin G controls systemic infection by symbiotic bacteria and pathogens. Immunity 44: 647–658.