Natural antibody repertoires: Development and functional role in inhibiting allergic airway disease

Annual Review of Immunology

Volumn 33, Issue , 2015, Pages 475-504

  Kearney, John F ^a   Patel, Preeyam ^a   Stefanov, Emily K ^a   King, R Glenn ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

Allergy; Asthma; B cells; Chitin; Hygiene hypothesis; Neonatal immunity

Indexed keywords

ANTIBODY; BACTERIAL POLYSACCHARIDE; N ACETYLGLUCOSAMINE; ALLERGEN;

ALLERGIC AIRWAY INFLAMMATION; ALLERGIC ASTHMA; ANTIBODY BLOOD LEVEL; ANTIBODY SPECIFICITY; ASPERGILLUS FUMIGATUS; B LYMPHOCYTE; BACTERIAL CELL WALL; CELL CLONE; CLONAL VARIATION; CROSS REACTION; DERMATOPHAGOIDES; ENTEROBACTER; HUMAN; HYGIENE HYPOTHESIS; IMMUNIZATION; IMMUNOREGULATION; INNATE IMMUNITY; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; REVIEW; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; T LYMPHOCYTE; TH1 CELL; TH2 CELL; ANIMAL; BACTERIUM; BLOOD; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; RESPIRATORY TRACT ALLERGY;

ALLERGENS; ANIMALS; ANTIBODIES; B-LYMPHOCYTES; BACTERIA; HOST-PATHOGEN INTERACTIONS; HUMANS; RESPIRATORY HYPERSENSITIVITY;

EID: 84927668143     PISSN: 07320582     EISSN: 15453278     Source Type: Book Series    
DOI: 10.1146/annurev-immunol-032713-120140     Document Type: Review

References (122)

1. Strachan DP. 1989. Hay fever, hygiene, and household size. BMJ 299:1259-60
2. Bach JF. 2002. The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 347:911-20
3. Rook GA, Raison CL, Lowry CA. 2014. Microbial 'Old Friends', immunoregulation and socioeconomic status. Clin. Exp. Immunol. 177:1-12
4. Boyden SV. 1966. Natural antibodies and the immune response. Adv. Immunol. 5:1-28
5. Bos NA, Kimura H, Meeuwsen CG, De Visser H, Hazenberg MP, et al. 1989. Serum immunoglobulin levels and naturally occurring antibodies against carbohydrate antigens in germ-free BALB/c mice fed chemically defined ultrafiltered diet. Eur. J. Immunol. 19:2335-39
6. Choi YS, Baumgarth N. 2008. Dual role for B-1a cells in immunity to influenza virus infection. J. Exp. Med. 205:3053-64
7. Briles DE, Nahm M, Schroer K, Davie J, Baker P, et al. 1981. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae. J. Exp. Med. 153:694-705
8. Ballot DE, Nana T, Sriruttan C, Cooper PA. 2012. Bacterial bloodstream infections in neonates in a developing country. ISRN Pediatr. 2012:508512
9. O'Brien KL, Wolfson LJ, Watt JP, Henkle E, Deloria-Knoll M, et al. 2009. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 374:893-902
10. World Health Organ. 2005. Group A streptococcal vaccine development: current status and issues of relevance to less developed countries.WHO/FCH/CAH/05.09 Geneva, Switz. http://whqlibdoc.who.int/hq/ 2005/WHO-IVB-05.14-eng.pdf
11. Phares CR,Lynfield R, FarleyMM,Mohle-Boetani J,HarrisonLH, et al. 2008. Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005. JAMA 299:2056-65
12. Kearney JF, McCarthy MT, Stohrer R, BenjaminWH Jr, Briles DE. 1985. Induction of germ-line antialpha 1-3 dextran antibody responses in mice by members of the Enterobacteriaceae family. J. Immunol. 135:3468-72
13. Foote JB, Kearney JF. 2009. Generation of B cell memory to the bacterial polysaccharide alpha-1,3 dextran. J. Immunol. 183:6359-68
14. Stohrer R, Lee MC, Kearney JF. 1983. Analysis of the anti-alpha 1 leads to 3 dextran response with monoclonal anti-idiotype antibodies. J. Immunol. 131:1375-79
15. Masmoudi H, Motasantos T, Huetz F, Coutinho A, Cazenave PA. 1990. All T15 Id-positive antibodies (but not the majority of VHT15+ antibodies) are produced by peritoneal CD5+ B lymphocytes. Int. Immunol. 2:515-20
16. Sigal NH, Pickard AR, Metcalf ES, Gearhart PJ, Klinman NR. 1977. Expression of phosphorylcholinespecific B cells during murine development. J. Exp. Med. 146:933-48
17. Pritchard DG, Gray BM, Egan ML. 1992. Murine monoclonal antibodies to type Ib polysaccharide of group B streptococci bind to human milk oligosaccharides. Infect. Immun. 60:1598-602
18. Martin F, Kearney JF. 2000. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity 12:39-49
19. Foote JB, Mahmoud TI, Vale AM, Kearney JF. 2012. Long-term maintenance of polysaccharide-specific antibodies by IgM-secreting cells. J. Immunol. 188:57-67
20. Hayakawa K, Hardy RR, HondaM,Herzenberg LA, Steinberg AD, Herzenberg LA. 1984. Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. PNAS 81:2494-98
21. Wardemann H, Boehm T, Dear N, Carsetti R. 2002. B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleen. J. Exp. Med. 195:771-80
22. Kroese FG, Butcher EC, Stall AM,Lalor PA, Adams S,HerzenbergLA. 1989. Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity. Int. Immunol. 1:75-84
23. Lalor PA, Stall AM, Adams S, Herzenberg LA. 1989. Permanent alteration of the murine Ly-1 B repertoire due to selective depletion of Ly-1 B cells in neonatal animals. Eur. J. Immunol. 19:501-6
24. JiangHQ, ThurnheerMC,ZuercherAW,BoikoNV, BosNA, Cebra JJ. 2004. Interactions of commensal gut microbes with subsets of B-and T-cells in the murine host. Vaccine 22:805-11
25. Choi YS, Dieter JA, Rothaeusler K, Luo Z, Baumgarth N. 2012. B-1 cells in the bone marrow are a significant source of natural IgM. Eur. J. Immunol. 42:120-29
26. Reynolds AE, KuraokaM, Kelsoe G. 2015. Natural IgM is produced by CD5-plasma cells that occupy a distinct survival niche in bone marrow. J. Immunol. 194:231-42
27. Yang Y, Tung JW, Ghosn EE, Herzenberg LA, Herzenberg LA. 2007. Division and differentiation of natural antibody-producing cells in mouse spleen. PNAS 104:4542-46
28. Kawahara T, Ohdan H, Zhao G, Yang YG, Sykes M. 2003. Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells. J. Immunol. 171:5406-14
29. Pihlgren M, Friedli M, Tougne C, Rochat AF, Lambert PH, Siegrist CA. 2006. Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survival. J. Immunol. 176:165-72
30. Belnoue E, Pihlgren M, McGaha TL,TougneC,Rochat AF, et al. 2008. APRIL is critical for plasmablast survival in the bonemarrow and poorly expressed by early-life bonemarrow stromal cells. Blood 111:2755-64
31. Vakil M, Kearney JF. 1991. Functional relationship between T15 and J558 idiotypes in BALB/c mice. Dev. Immunol. 1:213-24
32. Tarlinton D. 2011. Memory B cell and plasma cell differentiation. Presented at Keyst. Symp., Apr. 12-17, Whistler, Can.
33. BrilesDE, Nahm M, Marion TN, Perlmutter RM, Davie JM. 1982. Streptococcal group A carbohydrate has properties of both a thymus-independent (TI-2) and a thymus-dependent antigen. J. Immunol. 128:2032-35
34. Rijkers GT, Sanders EA, Breukels MA, Zegers BJ. 1998. Infant B cell responses to polysaccharide determinants. Vaccine 16:1396-400
35. Gray BM, Dillon HC Jr, Briles DE. 1983. Epidemiological studies of Streptococcus pneumoniae in infants: development of antibody to phosphocholine. J. Clin. Microbiol. 18:1102-7
36. Carlsson L, Holmberg D. 1990. Genetic basis of the neonatal antibody repertoire: germline V-gene expression and limited N-region diversity. Int. Immunol. 2:639-43
37. Feeney AJ. 1990. Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences. J. Exp. Med. 172:1377-90
38. Schroeder HW Jr, Mortari F, Shiokawa S, Kirkham PM, Elgavish RA, Bertrand FE 3rd. 1995. Developmental regulation of the human antibody repertoire. Ann. N.Y. Acad. Sci. 764:242-60
39. SchroederHWJr, Zhang L, Philips JB 3rd. 2001. Slow, programmedmaturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life. Blood 98:2745-51
40. Martin F, Chen X, Shu F, Kearney JF. 1995. Development of the mouse B-cell repertoire. Ann. N.Y. Acad. Sci. 764:207-21
41. Timens W, Boes A, Poppema S. 1989. Human marginal zone B cells are not an activated B cell subset: strong expression of CD21 as a putativemediator for rapid B cell activation. Eur. J. Immunol. 19:2163-66
42. Siegrist CA, Aspinall R. 2009. B-cell responses to vaccination at the extremes of age. Nat. Rev. Immunol. 9:185-94
43. Zinkernagel RM. 2003. On natural and artificial vaccinations. Annu. Rev. Immunol. 21:515-46
44. Zinkernagel RM. 2001. Maternal antibodies, childhood infections, and autoimmune diseases. N. Engl. J. Med. 345:1331-35
45. Sigal NH, Gearhart PJ, Press JL, Klinman NR. 1976. Late acquisition of a germ line antibody specificity. Nature 259:51-52
46. Snape MD, Kelly DF, Green B, Moxon ER, Borrow R, Pollard AJ. 2005. Lack of serum bactericidal activity in preschool children two years after a single dose of serogroupCmeningococcal polysaccharideprotein conjugate vaccine. Pediatr. Infect. Dis. J. 24:128-31
47. Kelly DF, SnapeMD,ClutterbuckEA, Green S, Snowden C, et al. 2006. CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigenspecific memory B cells. Blood 108:2642-47
48. Snape MD, Kelly DF, Salt P, Green S, Snowden C, et al. 2006. Serogroup C meningococcal glycoconjugate vaccine in adolescents: persistence of bactericidal antibodies and kinetics of the immune response to a booster vaccine more than 3 years after immunization. Clin. Infect. Dis. 43:1387-94
49. Harris NL, Spoerri I, Schopfer JF, Nembrini C, Merky P, et al. 2006. Mechanisms of neonatal mucosal antibody protection. J. Immunol. 177:6256-62
50. Benedict CL,Kearney JF. 1999. Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice. Immunity 10:607-17
51. Benedict CL,Gilfillan S, Thai TH, Kearney JF. 2000. Terminal deoxynucleotidyl transferase and repertoire development. Immunol. Rev. 175:150-57
52. Mahmoud TI, Kearney JF. 2010. Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide α-1,3 dextran. J. Immunol. 184:851-58
53. Veenhoven R, Bogaert D, Uiterwaal C, Brouwer C, Kiezebrink H, et al. 2003. Effect of conjugate pneumococcal vaccine followed by polysaccharide pneumococcal vaccine on recurrent acute otitis media: a randomised study. Lancet 361:2189-95
54. Blanchard Rohner G, Snape MD, Kelly DF, John T, Morant A, et al. 2008. The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster response. J. Immunol. 180:2165-73
55. Kelly DF, Snape MD, Perrett KP, Clutterbuck EA, Lewis S, et al. 2009. Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal polysaccharide vaccine. Immunology 127:134-43
56. McVernon J, MacLennan J, Pollard AJ, Oster P, Wakefield MJ, et al. 2003. Immunologic memory with no detectable bactericidal antibody response to a first dose of meningococcal serogroup C conjugate vaccine at four years. Pediatr. Infect. Dis. J. 22:659-61
57. Siegrist CA. 2008. Blame vaccine interference, not neonatal immunization, for suboptimal responses after neonatal diphtheria, tetanus, and acellular pertussis immunization. J. Pediatr. 153:305-7
58. Dagan R, Kayhty H, Wuorimaa T, Yaich M, Bailleux F, et al. 2004. Tolerability and immunogenicity of an eleven valent mixed carrier Streptococcus pneumoniae capsular polysaccharide-diphtheria toxoid or tetanus protein conjugate vaccine in Finnish and Israeli infants. Pediatr. Infect. Dis. J. 23:91-98
59. Hamilton AM, Kearney JF. 1994. Effects of IgM allotype suppression on serum IgM levels, B-1 and B-2 cells, and antibody responses in allotype heterozygous F1 mice. Dev. Immunol. 4:27-41
60. Hamilton AM, Lehuen A, Kearney JF. 1994. Immunofluorescence analysis of B-1 cell ontogeny in the mouse. Int. Immunol. 6:355-61
61. Gronwall C, Silverman GJ. 2014. Natural IgM: beneficial autoantibodies for the control of inflammatory and autoimmune disease. J. Clin. Immunol. 34(Suppl. 1):S12-21
62. Mahmoud TI, SchroederHWJr, Kearney JF. 2011. Limiting CDR-H3 diversity abrogates the antibody response to the bacterial polysaccharide α1→3 dextran. J. Immunol. 187:879-86
63. Barbar E, Martin TM, Brown M, RittenbergMB, PeytonDH. 1996. Binding of phenylphosphocholinecarrier conjugates to the combining site of antibodies maintains a conformation of the hapten. Biochemistry 35:2958-67
64. Chang SP, Brown M, Rittenberg MB. 1982. Immunologic memory to phosphorylcholine. II. PC-KLH induces two antibody populations that dominate different isotypes. J. Immunol. 128:702-6
65. Robbins JB, Schneerson R, Szu SC. 1995. Perspective: hypothesis: serum IgG antibody is sufficient to confer protection against infectious diseases by inactivating the inoculum. J. Infect. Dis. 171:1387-98
66. GranoffDM, Holmes SJ, Osterholm MT,McHugh JE, Lucas AH, et al. 1993. Induction of immunologic memory in infants primedwith Haemophilus influenzae type b conjugate vaccines. J. Infect. Dis. 168:663-71
67. Granoff DM, RathoreMH, Holmes SJ, Granoff PD, Lucas AH. 1993. Effect of immunity to the carrier protein on antibody responses to Haemophilus influenzae type b conjugate vaccines. Vaccine 11(Suppl. 1):S46-51
68. Granoff DM, Shackelford PG, Holmes SJ, Lucas AH. 1993. Variable region expression in the antibody responses of infants vaccinated with Haemophilus influenzae type b polysaccharide-protein conjugates: description of a new lambda light chain-associated idiotype and the relation between idiotype expression, avidity, and vaccine formulation. The Collaborative Vaccine Study Group. J. Clin. Invest. 91:788-96
69. Lucas AH, Azmi FH, Mink CM, Granoff DM. 1993. Age-dependent V region expression in the human antibody response to the Haemophilus influenzae type b polysaccharide. J. Immunol. 150:2056-61
70. Reason DC, Lucas AH. 1993. Content and dynamics of the human antibody variable region repertoire to the Haemophilus influenzae type b polysaccharide. Springer Semin. Immunopathol. 15:119-37
71. Chung GH, Scott MG, Kim KH, Kearney J, Siber GR, et al. 1993. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. V. In vivo expression of individual antibody clones is dependent on Ig CH haplotypes and the categories of antigen. J. Immunol. 151:4352-61
72. Vakil M, Briles DE, Kearney JF. 1991. Antigen-independent selection of T15 idiotype during B-cell ontogeny in mice. Dev. Immunol. 1:203-12
73. Vakil M, Kearney JF. 1986. Functional characterization of monoclonal auto-anti-idiotype antibodies isolated from the early B cell repertoire of BALB/c mice. Eur. J. Immunol. 16:1151-58
74. Greenspan NS, Fulton RJ,Davie JM. 1986. Analysis of anti-streptococcal group A carbohydrate idiotope levels in sera: correlation ofmagnitude of expression with idiotope position andVKhaplotype. J. Immunol. 137:228-33
75. Stohrer R, Kearney J. 1984. Ontogeny of B cell precursors responding to alpha 1-greater than 3 dextran in BALB/c mice. J. Immunol. 133:2323-26
76. Huflejt ME, Vuskovic M, Vasiliu D, Xu H, Obukhova P, et al. 2009. Anti-carbohydrate antibodies of normal sera: findings, surprises and challenges. Mol. Immunol. 46:3037-49
77. Scott MG, Briles DE, Shackelford PG, Smith DS, Nahm MH. 1987. Human antibodies to phosphocholine: IgG anti-PC antibodies express restricted numbers of VandCregions. J. Immunol. 138:3325-31
78. Emmrich F, Schilling B, Eichmann K. 1985. Human immune response to group A streptococcal carbohydrate (A-CHO). I. Quantitative and qualitative analysis of the A-CHO-specific B cell population responding in vitro to polyclonal and specific activation. J. Exp. Med. 161:547-62
79. Shackelford PG, Nelson SJ, Palma AT, Nahm MH. 1988. Human antibodies to group A streptococcal carbohydrate: ontogeny, subclass restriction, and clonal diversity. J. Immunol. 140:3200-5
80. Newacheck PW, Taylor WR. 1992. Childhood chronic illness: prevalence, severity, and impact. Am. J. Public Health 82:364-71
81. Hansen G, Berry G, DeKruyff RH, UmetsuDT. 1999. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J. Clin. Invest. 103:175-83
82. Yamaya M. 2012. Virus infection-induced bronchial asthma exacerbation. Pulm. Med. 2012:834826
83. AcevedoN, Erler A, Briza P, Puccio F, Ferreira F, Caraballo L. 2011. Allergenicity of Ascaris lumbricoides tropomyosin and IgE sensitization among asthmatic patients in a tropical environment. Int. Arch. Allergy Immunol. 154:195-206
84. Lechner CJ, Komander K, Hegewald J, Huang X, Gantin RG, et al. 2013. Cytokine and chemokine responses to helminth and protozoan parasites and to fungus and mite allergens in neonates, children, adults, and the elderly. Immun. Ageing 10:29
85. Mizoguchi E, Mizoguchi A, Preffer FI, Bhan AK. 2000. Regulatory role of mature B cells in a murine model of inflammatory bowel disease. Int. Immunol. 12:597-605
86. Vargas MH. 2006. Ecological association between scarlet fever and asthma. Respir. Med. 100:363-66
87. Schaub B, Liu J,Hoppler S, Schleich I, Huehn J, et al. 2009. Maternal farm exposuremodulates neonatal immune mechanisms through regulatory T cells. J. Allergy Clin. Immunol. 123:774-82.e5
88. Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, et al. 2004. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 363:608-15
89. AkdisM, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, et al. 2004. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J. Exp. Med. 199:1567-75
90. Bellinghausen I, Klostermann B, Knop J, Saloga J. 2003. Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production. J. Allergy Clin. Immunol. 111:862-68
91. McGuirk P, Mills KH. 2002. Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases. Trends Immunol. 23:450-55
92. Dimov VV, Stokes JR, Casale TB. 2009. Immunomodulators in asthma therapy. Curr. Allergy Asthma Rep. 9:475-83
93. Schwarze J, Cieslewicz G, Joetham A, Sun LK, Sun WN, et al. 1998. Antigen-specific immunoglobulin-A prevents increased airway responsiveness and lung eosinophilia after airway challenge in sensitized mice. Am. J. Respir. Crit. Care Med. 158:519-25
94. Moerch U, Haahr Hansen M, Vest Hansen NJ, Rasmussen LK, Oleksiewicz MB, et al. 2006. Allergenspecific polyclonal antibodies reduce allergic disease in a mouse model of allergic asthma. Int. Arch. Allergy Immunol. 140:261-69
95. Murali PS, Kelly KJ, Fink JN, Kurup VP. 1994. Investigations into the cellular immune responses in latex allergy. J. Lab Clin. Med. 124:638-43
96. Reisinger J, Horak F, Pauli G, van Hage M, Cromwell O, et al. 2005. Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity. J. Allergy Clin. Immunol. 116:347-54
97. Kurup VP, Choi H, Murali PS, Resnick A, Fink JN, Coffman RL. 1997. Role of particulate antigens of Aspergillus in murine eosinophilia. Int. Arch. Allergy Immunol. 112:270-78
98. Hamelmann E, Oshiba A, Schwarze J, Bradley K, Loader J, et al. 1997. Allergen-specific IgE and IL-5 are essential for the development of airway hyperresponsiveness. Am. J. Respir. Cell Mol. Biol. 16:674-82
99. Tsitoura DC, Yeung VP, DeKruyff RH, Umetsu DT. 2002. Critical role of B cells in the development of T cell tolerance to aeroallergens. Int. Immunol. 14:659-67
100. Wills-Karp M, Nathan A, Page K, Karp CL. 2010. New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol. 3:104-10
101. HarnettW, Harnett MM. 2008. Parasitic nematode modulation of allergic disease. Curr. Allergy Asthma Rep. 8:392-97
102. Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, et al. 2013. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. PNAS 110:E2209-18
103. Kung TT, Jones H, Adams GK 3rd, Umland SP, Kreutner W, et al. 1994. Characterization of a murine model of allergic pulmonary inflammation. Int. Arch. Allergy Immunol. 105:83-90
104. Shah A, Panjabi C. 2002. Allergic bronchopulmonary aspergillosis: a review of a disease with a worldwide distribution. J. Asthma 39:273-89
105. ShahabuddinM, Toyoshima T, Aikawa M, Kaslow DC. 1993. Transmission-blocking activity of a chitinase inhibitor and activation of malarial parasite chitinase by mosquito protease. PNAS 90:4266-70
106. Shibata Y, MetzgerWJ, Myrvik QN. 1997. Chitin particle-induced cell-mediated immunity is inhibited by soluble mannan: mannose receptor-mediated phagocytosis initiates IL-12 production. J. Immunol. 159:2462-67
107. Kin NW, Stefanov EK, Dizon BL, Kearney JF. 2012. Antibodies generated against conserved antigens expressed by bacteria and allergen-bearing fungi suppress airway disease. J. Immunol. 189:2246-56
108. Quest Diagn. 2011. The largest study of allergy testing in the United States. Quest Diagn. Health Trends, QuestDiagn., Madison, NJ. http://www.questdiagnostics.com/dms/Documents/Other/2011-QD-AllergyReport.pdf
109. Baldo BA, Krilis S, Fletcher TC. 1979. Phosphorylcholine-containing allergens. Naturwissenschaften 66:623-25
110. Baldo BA, Fletcher TC, Uhlenbeuck G. 1977. Reaction of house dust mite extracts with mouse antiphosphorylcholine and anti-galactan myeloma proteins. Naturwissenschaften 64:594-95
111. Holt PG, Sly PD. 2007. Prevention of allergic respiratory disease in infants: current aspects and future perspectives. Curr. Opin. Allergy Clin. Immunol. 7:547-55
112. Yazdanbakhsh M, Kremsner PG, van Ree R. 2002. Allergy, parasites, and the hygiene hypothesis. Science 296:490-94
113. Kalliomaki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. 2001. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J. Allergy Clin. Immunol. 107:129-34
114. Baumgarth N. 2011. The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat. Rev. Immunol. 11:34-46
115. Bell WJ,Roth LM, Nalepa CA. 2007. Cockroaches: Ecology, Behavior, and Natural History. Baltimore, MD: Johns Hopkins Univ. Press
116. Kato A, Hulse KE, Tan BK, Schleimer RP. 2013. B-lymphocyte lineage cells and the respiratory system. J. Allergy Clin. Immunol. 131:933-57
117. Lutz HU, ed. 2012. Naturally Occurring Antibodies (NAbs). New York: Springer Sci. + Bus. Media
118. Martin F, Kearney JF. 2002. Marginal-zone B cells. Nat. Rev. Immunol. 2:323-35
119. Racine R, Winslow GM. 2009. IgM in microbial infections: taken for granted? Immunol. Lett. 125:79-85
120. Vas J, Grönwall C, Silverman GJ. 2013. Fundamental roles of the innate-like repertoire of natural antibodies in immune homeostasis. Front. Immunol. 4:4
121. Colloff MJ. 2009. Dust Mites. Collingwood, Aust.: CSIRO
122. West CE, Jenmalm MC, Prescott SL. 2015. The gut microbiota and its role in the development of allergic disease: a wider perspective. Clin. Exp. Allergy. 45:43-53