Plasma levels of microRNA-21,-126 and-423-5p alter During clinical improvement and are associated with the prognosis of acute heart failure

Molecular Medicine Reports

Volumn 17, Issue 3, 2018, Pages 4736-4746

  Dos Reis Schneider, Stéfanie Ingrid ^a,d   Silvello, Daiane ^a   Martinelli, Nidiane Carla ^a   Garbin, Arthur ^a   Biolo, Andréia ^a,b   Clausell, Nadine ^a,b   Andrades, Michael ^a   Dos Santos, Kátia Gonçalves ^a,c   Rohde, Luís Eduardo ^a,b  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

^d School of Law   (Brazil)

Author keywords

Biomarker; Cardiovascular disease; Heart failure; MiR; Prognosis; Survival

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAIN NATRIURETIC PEPTIDE; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MICRORNA; MICRORNA 126; MICRORNA 21; MICRORNA 423 5P; UNCLASSIFIED DRUG; VASODILATOR AGENT; MIRN126 MICRORNA, HUMAN; MIRN21 MICRORNA, HUMAN; MIRN423 MICRORNA, HUMAN;

ACUTE HEART FAILURE; ADULT; ALL CAUSE MORTALITY; ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR MORTALITY; COHORT ANALYSIS; COMPENSATION; CONTROLLED STUDY; DISEASE ASSOCIATION; EMERGENCY WARD; FEMALE; FOLLOW UP; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITAL READMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; ACUTE DISEASE; AGED; BLOOD; HEART FAILURE; HOSPITALIZATION; KAPLAN MEIER METHOD; MORTALITY;

ACUTE DISEASE; AGED; FEMALE; HEART FAILURE; HOSPITALIZATION; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MICRORNAS; MIDDLE AGED; NATRIURETIC PEPTIDE, BRAIN; PROGNOSIS;

EID: 85041224124     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2018.8428     Document Type: Article

References (36)

1. Fang YC and Yeh CH: Role of microRNAs in vascular remodeling. Curr Mol Med 15:684-696, 2015.
2. Small EM and Olson EN: Pervasive roles of microRNAs in cardiovascular biology. Nature 469:336-342, 2011.
3. Zhou J, Dong X, Zhou Q, Wang H, Qian Y, Tian W, Ma D and Li X: MicroRNA expression profiling of heart tissue during fetal development. Int J Mol Med 33:1250-1260, 2014
4. Papageorgiou N, Tslamandris S, Giolis A and Tousoulis D: MicroRNAs in cardiovascular disease: Perspectives and reality. Cardiol Rev 24 110-118, 2016.
5. Navickas R, Gal D, Laucevicius A, Taparauskaite A, Zdanyte M and Holvoet P: Identifying circulating microRNAs as biomarkers of cardiovascular disease: A systematic review. Cardiovasc Res 111:322-337, 2016.
6. Romaine SP, Tomaszewski M, Condorelli G and Samani NJ: MicroRNAs in cardiovascular disease: An introduction for clinicians. Heart 101:921-928, 2015
7. Cakmak HA, Coskunpinar E, Ikitimur B, Barman HA, Karadag B, Tiryakioglu NO, Kahraman K and Vural VA: The prognostic value of circulating microRNAs in heart failure: Preliminary results from a genome-wide expression study. J Cardiovasc Med (Hagestown) 16:431-437, 2015
8. Qiang L, Hong L, Ningfu W, Huaihong C and Jing W: Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients. Int J Cardiol 168:2082-2088, 2013.
9. Fukushima Y, Nakanishi M, Nonogi H, Goto Y and Iwai N: Assessment of plasma miRNAs in congestive heart failure. Circ J 75:336-340, 2011.
10. Bruno N, ter Maaten JM, Ovchinnikova ES, Vegter EL, Valente MA, van der Meer P, de Boer RA, van der Harst P, Schmitter D, Metra M, et al: MicroRNAs relate to early worsening of renal function in patients with acute heart failure. Int J Cardiol 203:564-569, 2016.
11. Ovchinnikova ES, Schmitter D, Vegter EL, Ter Maaten JM, Valente MA, Liu LC, van der Harst P, Pinto YM, de Boer RA, Meyer S, et al: Signature of circulating microRNAs in patients with acute heart failure. Eur J Heart Fail 18:414-423, 2016.
12. Seronde MF, Vausort M, Gayat E, Goretti E, Ng LL, Squire IB, Vodovar N, Sadoune M, Samuel JL, Thum T, et al: Circulating microRNAs and outcome in patients with acute heart failure. PLoS One 10:e0142237, 2015.
13. Xiao J, Gao R, Bei Y, Zhou Q, Zhou Y, Zhang H, Jin M, Wei S, Wang K, Xu X, et al: Circulating miR-30d predicts survival in patients with acute heart failure. Cell Physiol Biochem 41:865-874, 2017.
14. Fan KL, Zhang HF, Shen J, Zhang Q and Li XL: Circulating microRNAs levels in Chinese heart failure patients caused by dilated cardiomyopathy. Indian Heart J 65:12-16, 2013.
15. Goren Y, Kushnir M, Zafrir B, Tabak S, Lewis BS and Amir O: Serum levels of microRNAs in patients with heart failure. Eur J Heart Fail 14:147-154, 2012.
16. Tijsen AJ, Creemers EE, Moerland PD, de Windt LJ, van der Wal AC, Kok WE and Pinto YM: MiR423-5p as a circulating biomarker for heart failure. Circ Res 106:1035-1039, 2010.
17. Biolo A, Fisch M, Balog J, Chao T, Schulze PC, Ooi H, Siwik D and Colucci WS: Episodes of acute heart failure syndrome are associated with increased levels of troponin and extracellular matrix markers. Circ Heart Fail 3:44-50, 2010.
18. Sato Y, Yamada T, Taniguchi R, Nagai K, Makiyama T, Okada H, Kataoka K, Ito H, Matsumori A, Sasayama S and Takatsu Y: Persistently increased serum concentrations of cardiac troponin T in patients with idiopathic dilated cardiomyopathy are predictive of adverse outcomes. Circulation 103:369-374, 2001.
19. Schulze PC, Biolo A, Gopal D, Shahzad K, Balog J, Fish M, Siwik D and Colucci WS: Dynamics in insulin resistance and plasma levels of adipokines in patients with acute decompensated and chronic stable heart failure. J Cardiac Fail 17:1004-1011, 2011.
20. DeAguero JL, McKown EN, Zhang L, Keirsey J, Fischer EG, Samedi VG, Canan BD, Kilic A, Janssen PM and Delfín DA: Altered protein levels in the isolated extracellular matrix of failing human hearts with dilated cardiomyopathy. Cardiovasc Pathol 26:12-20, 2017.
21. Thomé JG, Mendoza MR, Cheuiche A V, La Porta VL, Silvello D, Dos Santos KG, Andrades ME, Clausell N, Rohde LE and Biolo A: Circulating microRNAs in obese and lean heart failure patients: A case-control study with computational target prediction analysis. Gene 574:1-10, 2015.
22. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) method. Methods 25:402-408, 2001.
23. Endo K, Naito Y, Ji X, Nakanishi M, Noguchi T, Goto Y, Nonogi H, Ma X, Weng H, Hirokawa G, et al: MicroRNA 210 as a biomarker for congestive heart failure. Biol Pharm Bull 36:48-54, 2013.
24. Wang J, Liew OW, Richards AM and Chen YT: Overview of microRNAs in cardiac hypertrophy, fibrosis, and apoptosis. Int J Mol Sci 17:E749, 2016.
25. Liu R.-H, Ning B, Ma X.-E, Gong WM and Jia TH: Regulatory roles of microRNA-21 in fibrosis through interaction with diverse pathways (Review). Mol Med Rep 13:2359-2366, 2016.
26. Abdellatif M: Differential expression of microRNAs in different disease states. Circ Res 110:638-650, 2012.
27. Topkara VK and Mann DL: Clinical applications of miRNAs in cardiac remodeling and heart failure. Per Med 7:531-548, 2010.
28. McManus DD, Tanriverdi K, Lin H, Esa N, Kinno M, Mandapati D, Tam S, Okike ON, Ellinor PT, Keaney JF Jr, et al: Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study). Heart Rhythm 12:3-10, 2015.
29. Dickinson BA, Semus HM, Montgomery RL, Stack C, Latimer PA, Lewton SM, Lynch JM, Hullinger TG, Seto AG and van Rooij E: Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure. Eur J Heart Fail 15:650-659, 2013.
30. Li Q, Yu Q, Na R and Liu B: MiR-423-5p inhibits human cardiomyoblast proliferation and induces cell apoptosis by targeting Gab 1. Int J Clin Exp Pathol 9:8953-8962, 2016.
31. Luo P, He T, Jiang R and Li G: MicroRNA-423-5p targets O-GlcNAc transferase to induce apoptosis in cardiomyocytes. Mol Med Rep 12:1163-1168, 2015.
32. Olivieri F, Antonicelli R, Lorenzi M, D'Alessandra Y, Lazzarini R, Santini G, Spazzafumo L, Lisa R, La Sala L, Galeazzi R, et al: Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction. Int J Cardiol 167:531-536, 2013.
33. Goldraich LA, Martinelli NC, Matte U, Cohen C, Andrades M, Pimentel M, Biolo A, Clausell N and Rohde LE: Transcoronary gradient of plasma microRNA 423-5p in heart failure: Evidence of altered myocardial expression. Biomarkers 19:135-141, 2014.
34. Vegter EL, van der Meer P, de Windt LJ, Pinto YM and Voors AA: MicroRNAs in heart failure: From biomarker to target for therapy. Eur J Heart Fail 18:457-468, 2016.
35. Viereck J, Bang C, Foinquinos A and Thum T: Regulatory RNAs and paracrine networks in the heart. Cardiovasc Res 102:290-301, 2014.
36. Caroli A, Cardillo MT, Galea R and Biasucci L M L: Potential therapeutic role of microRNAs in ischemic heart disease. J Cardiol 61:315-320, 2013.