Fluid resuscitation with lactated Ringer’s solution vs normal saline in acute pancreatitis: A triple-blind, randomized, controlled trial

United European Gastroenterology Journal

Volumn 6, Issue 1, 2018, Pages 63-72

  de Madaria, Enrique ^a   Herrera Marante, Iván ^a   González Camacho, Verónica ^a   Bonjoch, Laia ^b   Quesada Vázquez, Noé ^a   Almenta Saavedra, Isabel ^a   Miralles Maciá, Cayetano ^a   Acevedo Piedra, Nelly G ^a   Roger Ibáñez, Manuela ^a   Sánchez Marin, Claudia ^a   Osuna Ligero, Rosa ^a   Gracia, Ángel ^a   Llorens, Pere ^a   Zapater, Pedro ^a   Singh, Vikesh K ^c   Moreu Martín, Rocío ^a   Closa, Daniel ^b  

^a HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^b INST D INVESTIGACIONS B   (Spain)

^c DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Acute pancreatitis; fluid resuscitation; lactated Ringer s solution; randomized controlled trial; systemic inflammatory response syndrome prevention and control

Indexed keywords

C REACTIVE PROTEIN; MANNOSE RECEPTOR; RINGER LACTATE SOLUTION; SODIUM CHLORIDE;

ABDOMINAL PAIN; ACUTE CHOLECYSTITIS; ACUTE PANCREATITIS; ADULT; AMYLASE BLOOD LEVEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY MASS; CONTROLLED STUDY; DEHYDRATION; DIAGNOSTIC ERROR; DOUBLE BLIND PROCEDURE; FEMALE; FLUID RESUSCITATION; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HEMATOCRIT; HOSPITAL MORTALITY; HOSPITALIZATION; HUMAN; HYPOVOLEMIA; IMMUNOFLUORESCENCE TEST; INFLAMMATION; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NUTRITIONAL SUPPORT; OUTCOME ASSESSMENT; PANCREAS NECROSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TRIACYLGLYCEROL LIPASE BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL;

EID: 85041122603     PISSN: 20506406     EISSN: 20506414     Source Type: Journal    
DOI: 10.1177/2050640617707864     Document Type: Article

References (34)

1. Haydock MD, Mittal A, Wilms HR, Fluid therapy in acute pancreatitis: Anybody’s guess. Ann Surg 2013; 257: 182–188.
2. Wu BU, Hwang JQ, Gardner TH, Lactated Ringer's solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin Gastroenterol Hepatol 2011; 9: 710–717.
3. Tenner S, Baillie J, DeWitt J, American College of Gastroenterology guideline: Management of acute pancreatitis. Am J Gastroenterol 2013; 108: 1400–1415. 1416.
4. Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology 2013; 13(4 Suppl 2): e1–e15.
5. Chan AW, Tetzlaff JM, Gøtzsche PC, SPIRIT 2013 explanation and elaboration: Guidance for protocols of clinical trials. BMJ 2013; 346: e7586–e7586.
6. Kahan BC, Cro S, Doré CJ, Reducing bias in open-label trials where blinded outcome assessment is not feasible: Strategies from two randomised trials. Trials 2014; 15: 456–456.
7. Banks PA, Bollen TL, Dervenis C, Classification of acute pancreatitis—2012: Revision of the Atlanta classification and definitions by international consensus. Gut 2013; 62: 102–111.
8. Papachristou GI, Clermont G, Sharma A, Risk and markers of severe acute pancreatitis. Gastroenterol Clin North Am 2007; 36: 277–296. viii.
9. Acevedo-Piedra NG, Moya-Hoyo N, Rey-Riveiro M, Validation of the determinant-based classification and revision of the Atlanta classification systems for acute pancreatitis. Clin Gastroenterol Hepatol 2014; 12: 311–316.
10. Chanput W, Mes JJ, Wichers HJ. THP-1 cell line: An in vitro cell model for immune modulation approach. Int Immunopharmacol 2014; 23: 37–45.
11. Myburgh JA. Fluid resuscitation in acute medicine: What is the current situation? J Intern Med 2015; 277: 58–68.
12. Scheingraber S, Rehm M, Sehmisch C, Rapid saline infusion produces hyperchloremic acidosis in patients undergoing gynecologic surgery. Anesthesiology 1999; 90: 1265–1270.
13. Williams EL, Hildebrand KL, McCormick SA, The effect of intravenous lactated Ringer’s solution versus 0.9% sodium chloride solution on serum osmolality in human volunteers. Anesth Analg 1999; 88: 999–1003.
14. Wilkes NJ, Woolf R, Mutch M, The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patients. Anesth Analg 2001; 93: 811–816.
15. Reid F, Lobo DN, Williams RN, Ab normal saline and physiological Hartmann’s solution: A randomized double-blind crossover study. Clin Sci (Lond) 2003; 104: 17–24.
16. Hadimioglu N, Saadawy I, Saglam T, The effect of different crystalloid solutions on acid-base balance and early kidney function after kidney transplantation. Anesth Analg 2008; 107: 264–269.
17. Kellum JA, Song M, Li J. Science review: Extracellular acidosis and the immune response: Clinical and physiologic implications. Crit Care 2004; 8: 331–336.
18. Raghunathan K, Shaw A, Nathanson B, Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis*. Crit Care Med 2014; 42: 1585–1591.
19. Yunos NM, Bellomo R, Hegarty C, Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA 2012; 308: 1566–1572.
20. Shaw AD, Bagshaw SM, Goldstein SL, Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte. Ann Surg 2012; 255: 821–829.
21. Noble MD, Romac J, Vigna SR, A pH-sensitive, neurogenic pathway mediates disease severity in a model of post-ERCP pancreatitis. Gut 2008; 57: 1566–1571.
22. Bhoomagoud M, Jung T, Atladottir J, Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats. Gastroenterology 2009; 137: 1083–1092.
23. Rajamäki K, Nordström T, Nurmi K, Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome. J Biol Chem 2013; 288: 13410–13419.
24. Iraporda C, Errea A, Romanin DE, Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells. Immunobiology 2015; 220: 1161–1169.
25. Colegio OR, Chu NQ, Szabo AL, Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 2014; 513: 559–563.
26. Hoque R, Farooq A, Ghani A, Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Gastroenterology 2014; 146: 1763–1774.
27. de-Madaria E, Banks PA, Moya-Hoyo N, Early factors associated with fluid sequestration and outcomes of patients with acute pancreatitis. Clin Gastroenterol Hepatol 2014; 12: 997–1002.
28. Lipinski M, Rydzewska-Rosolowska A, Rydzewski A, Fluid resuscitation in acute pancreatitis: Normal saline or lactated Ringer’s solution? World J Gastroenterol 2015; 21: 9367–9372.
29. Mao EQ, Tang YQ, Fei J, Fluid therapy for severe acute pancreatitis in acute response stage. Chin Med J (Engl) 2009; 122: 169–173.
30. Buxbaum J, Yan A, Yeh K, Aggressive hydration with lactated Ringer’s solution reduces pancreatitis after endoscopic retrograde cholangiopancreatography. Clin Gastroenterol Hepatol 2014; 12: 303–307. e1.
31. Mayer AD, McMahon MJ, Bowen M, C reactive protein: An aid to assessment and monitoring of acute pancreatitis. J Clin Pathol 1984; 37: 207–211.
32. Puolakkainen P, Valtonen V, Paananen A, C-reactive protein (CRP) and serum phospholipase A2 in the assessment of the severity of acute pancreatitis. Gut 1987; 28: 764–771.
33. Rau B, Steinbach G, Baumgart K, Serum amyloid A versus C-reactive protein in acute pancreatitis: Clinical value of an alternative acute-phase reactant. Crit Care Med 2000; 28: 736–742.
34. Mäkelä JT, Eila H, Kiviniemi H, Computed tomography severity index and C-reactive protein values predicting mortality in emergency and intensive care units for patients with severe acute pancreatitis. Am J Surg 2007; 194: 30–34.