메뉴 건너뛰기




Volumn 8, Issue JAN, 2018, Pages

CD4+ T helper cells play a key role in maintaining diabetogenic CD8+ T cell function in the pancreas

Author keywords

Autoimmunity; CD4 help; Effector CD8+ T cells; Imaging; In vivo; Type 1 diabetes

Indexed keywords

CD8 ANTIGEN; HEMAGGLUTININ;

EID: 85040813021     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.02001     Document Type: Article
Times cited : (20)

References (40)
  • 1
    • 77951776390 scopus 로고    scopus 로고
    • Genetics, pathogenesis and clinical interventions in type 1 diabetes
    • Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature (2010) 464:1293-300. doi:10.1038/nature08933
    • (2010) Nature , vol.464 , pp. 1293-1300
    • Bluestone, J.A.1    Herold, K.2    Eisenbarth, G.3
  • 4
    • 0037025990 scopus 로고    scopus 로고
    • Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD mice
    • Gagnerault M-C, Luan JJ, Lotton C, Lepault F. Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD mice. J Exp Med (2002) 196:369-77. doi:10.1084/jem.20011353
    • (2002) J Exp Med , vol.196 , pp. 369-377
    • Gagnerault, M.-C.1    Luan, J.J.2    Lotton, C.3    Lepault, F.4
  • 5
    • 0029812040 scopus 로고    scopus 로고
    • Constitutive class I-restricted exogenous presentation of self antigens in vivo
    • Kurts C, Heath WR, Carbone FR, Allison J, Miller JF, Kosaka H. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J Exp Med (1996) 184:923-30. doi:10.1084/jem.184.3.923
    • (1996) J Exp Med , vol.184 , pp. 923-930
    • Kurts, C.1    Heath, W.R.2    Carbone, F.R.3    Allison, J.4    Miller, J.F.5    Kosaka, H.6
  • 6
    • 58049217366 scopus 로고    scopus 로고
    • Memory-like CD8+ and CD4+ T cells cooperate to break peripheral tolerance under lymphopenic conditions
    • Le Saout C, Mennechet S, Taylor N, Hernandez J. Memory-like CD8+ and CD4+ T cells cooperate to break peripheral tolerance under lymphopenic conditions. Proc Natl Acad Sci U S A (2008) 105:19414-9. doi:10.1073/pnas.0807743105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19414-19419
    • Le Saout, C.1    Mennechet, S.2    Taylor, N.3    Hernandez, J.4
  • 7
    • 1942451803 scopus 로고    scopus 로고
    • Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice
    • Makhlouf L, Grey ST, Dong V, Csizmadia E, Arvelo MB, Auchincloss H Jr, et al. Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice. Transplantation (2004) 77:990-7. doi:10.1097/01.TP.0000118410.61419.59
    • (2004) Transplantation , vol.77 , pp. 990-997
    • Makhlouf, L.1    Grey, S.T.2    Dong, V.3    Csizmadia, E.4    Arvelo, M.B.5    Auchincloss, H.6
  • 8
    • 0037025944 scopus 로고    scopus 로고
    • Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens
    • Hernández J, Aung S, Marquardt K, Sherman LA. Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens. J Exp Med (2002) 196:323-33. doi:10.1084/jem.20011612
    • (2002) J Exp Med , vol.196 , pp. 323-333
    • Hernández, J.1    Aung, S.2    Marquardt, K.3    Sherman, L.A.4
  • 9
    • 84855456086 scopus 로고    scopus 로고
    • Intravital imaging of CTLs killing islet cells in diabetic mice
    • Coppieters K, Amirian N, Von Herrath M. Intravital imaging of CTLs killing islet cells in diabetic mice. J Clin Invest (2012) 122:119-31. doi:10.1172/JCI59285
    • (2012) J Clin Invest , vol.122 , pp. 119-131
    • Coppieters, K.1    Amirian, N.2    Von Herrath, M.3
  • 10
    • 34548359992 scopus 로고    scopus 로고
    • In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet β-cell killing
    • Calderon B, Suri A, Unanue ER. In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet β-cell killing. Am J Pathol (2006) 169:2137-47. doi:10.2353/ajpath.2006.060539
    • (2006) Am J Pathol , vol.169 , pp. 2137-2147
    • Calderon, B.1    Suri, A.2    Unanue, E.R.3
  • 11
    • 84856825977 scopus 로고    scopus 로고
    • Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
    • Coppieters KT, Dotta F, Amirian N, Campbell PD, Kay TWH, Atkinson MA, et al. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med (2012) 209:51-60. doi:10.1084/jem.20111187
    • (2012) J Exp Med , vol.209 , pp. 51-60
    • Coppieters, K.T.1    Dotta, F.2    Amirian, N.3    Campbell, P.D.4    Kay, T.W.H.5    Atkinson, M.A.6
  • 12
    • 84869110419 scopus 로고    scopus 로고
    • Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/SCID/IL2RG null mice
    • Unger WW, Pearson T, Abreu JR, Laban S, van der Slik AR, Mulder-van der Kracht S, et al. Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/SCID/IL2RG null mice. PLoS One (2012) 7:e49213. doi:10.1371/journal.pone.0049213
    • (2012) PLoS One , vol.7
    • Unger, W.W.1    Pearson, T.2    Abreu, J.R.3    Laban, S.4    van der Slik, A.R.5    Mulder-van der Kracht, S.6
  • 13
    • 84903458886 scopus 로고    scopus 로고
    • An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function
    • Friedman RS, Lindsay RS, Lilly JK, Nguyen V, Sorensen CM, Jacobelli J, et al. An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function. Proc Natl Acad Sci U S A (2014) 111:9223-8. doi:10.1073/pnas.1322193111
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 9223-9228
    • Friedman, R.S.1    Lindsay, R.S.2    Lilly, J.K.3    Nguyen, V.4    Sorensen, C.M.5    Jacobelli, J.6
  • 14
    • 84920446851 scopus 로고    scopus 로고
    • Antigen recognition in the islets changes with progression of autoimmune islet infiltration
    • Lindsay RS, Corbin K, Mahne A, Levitt BE, Gebert MJ, Wigton EJ, et al. Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J Immunol (2015) 194:522-30. doi:10.4049/jimmunol.1400626
    • (2015) J Immunol , vol.194 , pp. 522-530
    • Lindsay, R.S.1    Corbin, K.2    Mahne, A.3    Levitt, B.E.4    Gebert, M.J.5    Wigton, E.J.6
  • 15
    • 84862893004 scopus 로고    scopus 로고
    • Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung
    • Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, et al. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med (2012) 209:1183-99. doi:10.1084/jem.20112667
    • (2012) J Exp Med , vol.209 , pp. 1183-1199
    • Thornton, E.E.1    Looney, M.R.2    Bose, O.3    Sen, D.4    Sheppard, D.5    Locksley, R.6
  • 16
    • 78449290135 scopus 로고    scopus 로고
    • CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes
    • Bos R, Sherman LA. CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes. Cancer Res (2010) 70:8368-77. doi:10.1158/0008-5472.CAN-10-1322
    • (2010) Cancer Res , vol.70 , pp. 8368-8377
    • Bos, R.1    Sherman, L.A.2
  • 17
    • 29244482759 scopus 로고    scopus 로고
    • Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
    • Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, et al. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol (2006) 7:83-92. doi:10.1038/ni1289
    • (2006) Nat Immunol , vol.7 , pp. 83-92
    • Tang, Q.1    Adams, J.Y.2    Tooley, A.J.3    Bi, M.4    Fife, B.T.5    Serra, P.6
  • 18
    • 84862976472 scopus 로고    scopus 로고
    • A decade of imaging cellular motility and interaction dynamics in the immune system
    • Germain RN, Robey EA, Cahalan MD. A decade of imaging cellular motility and interaction dynamics in the immune system. Science (2012) 336:1676-81. doi:10.1126/science.1221063
    • (2012) Science , vol.336 , pp. 1676-1681
    • Germain, R.N.1    Robey, E.A.2    Cahalan, M.D.3
  • 19
    • 84941356605 scopus 로고    scopus 로고
    • Robust anti-viral immunity requires multiple distinct T cell-dendritic cell interactions
    • EickhoffS, Brewitz A, Gerner MY, Klauschen F, Komander K, Hemmi H, et al. Robust anti-viral immunity requires multiple distinct T cell-dendritic cell interactions. Cell (2015) 162:1322-37. doi:10.1016/j.cell.2015.08.004
    • (2015) Cell , vol.162 , pp. 1322-1337
    • Eickhoff, S.1    Brewitz, A.2    Gerner, M.Y.3    Klauschen, F.4    Komander, K.5    Hemmi, H.6
  • 20
    • 84941739187 scopus 로고    scopus 로고
    • Spatiotemporally distinct interactions with dendritic cell subsets facilitates CD4+ and CD8+ T cell activation to localized viral infection
    • Hor JL, Whitney PG, Zaid A, Brooks AG, Heath WR, Mueller SN. Spatiotemporally distinct interactions with dendritic cell subsets facilitates CD4+ and CD8+ T cell activation to localized viral infection. Immunity (2015) 43:554-65. doi:10.1016/j.immuni.2015.07.020
    • (2015) Immunity , vol.43 , pp. 554-565
    • Hor, J.L.1    Whitney, P.G.2    Zaid, A.3    Brooks, A.G.4    Heath, W.R.5    Mueller, S.N.6
  • 22
    • 0026571924 scopus 로고
    • Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells
    • Lo D, Freedman J, Hesse S, Palmiter RD, Brinster RL, Sherman LA. Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells. Eur J Immunol (1992) 22:1013-22. doi:10.1002/eji.1830220421
    • (1992) Eur J Immunol , vol.22 , pp. 1013-1022
    • Lo, D.1    Freedman, J.2    Hesse, S.3    Palmiter, R.D.4    Brinster, R.L.5    Sherman, L.A.6
  • 24
    • 0028409436 scopus 로고
    • A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity
    • Scott B, Liblau R, Degermann S, Marconi LA, Ogata L, Caton AJ, et al. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity (1994) 1:73-82. doi:10.1016/1074-7613(94)90011-6
    • (1994) Immunity , vol.1 , pp. 73-82
    • Scott, B.1    Liblau, R.2    Degermann, S.3    Marconi, L.A.4    Ogata, L.5    Caton, A.J.6
  • 25
    • 84962407388 scopus 로고    scopus 로고
    • Metabolism regulates exposure of pancreatic islets to circulating molecules in vivo
    • Michau A, Hodson DJ, Fontanaud P, Guillou A, Espinosa-Carrasco G, Molino F, et al. Metabolism regulates exposure of pancreatic islets to circulating molecules in vivo. Diabetes (2016) 65:463-75. doi:10.2337/db15-1168
    • (2016) Diabetes , vol.65 , pp. 463-475
    • Michau, A.1    Hodson, D.J.2    Fontanaud, P.3    Guillou, A.4    Espinosa-Carrasco, G.5    Molino, F.6
  • 26
    • 67651104326 scopus 로고    scopus 로고
    • Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii
    • Schaeffer M, Han S-J, Chtanova T, van Dooren GG, Herzmark P, Chen Y, et al. Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii. J Immunol (2009) 182:6379-93. doi:10.4049/jimmunol.0804307
    • (2009) J Immunol , vol.182 , pp. 6379-6393
    • Schaeffer, M.1    Han, S.-J.2    Chtanova, T.3    van Dooren, G.G.4    Herzmark, P.5    Chen, Y.6
  • 27
    • 84872869824 scopus 로고    scopus 로고
    • Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons
    • Schaeffer M, Langlet F, Lafont C, Molino F, Hodson DJ, Roux T, et al. Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons. Proc Natl Acad Sci U S A (2013) 110:1512-7. doi:10.1073/pnas.1212137110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 1512-1517
    • Schaeffer, M.1    Langlet, F.2    Lafont, C.3    Molino, F.4    Hodson, D.J.5    Roux, T.6
  • 28
    • 70249143637 scopus 로고    scopus 로고
    • Homeostatic proliferation and survival of naive and memory T cells
    • Boyman O, Letourneau S, Krieg C, Sprent J. Homeostatic proliferation and survival of naive and memory T cells. Eur J Immunol (2009) 39:2088-94. doi:10.1002/eji.200939444
    • (2009) Eur J Immunol , vol.39 , pp. 2088-2094
    • Boyman, O.1    Letourneau, S.2    Krieg, C.3    Sprent, J.4
  • 31
    • 84888141725 scopus 로고    scopus 로고
    • Visualizing how T cells collect activation signals in vivo
    • Moreau HD, Bousso P. Visualizing how T cells collect activation signals in vivo. Curr Opin Immunol (2014) 26:56-62. doi:10.1016/j.coi.2013.10.013
    • (2014) Curr Opin Immunol , vol.26 , pp. 56-62
    • Moreau, H.D.1    Bousso, P.2
  • 32
    • 79952143765 scopus 로고    scopus 로고
    • Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans
    • Calderon B, Carrero JA, Miller MJ, Unanue ER. Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans. Proc Natl Acad Sci U S A (2011) 108:1561-6. doi:10.1073/pnas.1018973108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 1561-1566
    • Calderon, B.1    Carrero, J.A.2    Miller, M.J.3    Unanue, E.R.4
  • 33
    • 84907901062 scopus 로고    scopus 로고
    • Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes
    • Yang J, Chow I-T, Sosinowski T, Torres-Chinn N, Greenbaum CJ, James EA, et al. Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes. Proc Natl Acad Sci U S A (2014) 111:14840-5. doi:10.1073/pnas.1416864111
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 14840-14845
    • Yang, J.1    Chow, I.-T.2    Sosinowski, T.3    Torres-Chinn, N.4    Greenbaum, C.J.5    James, E.A.6
  • 34
    • 33847137354 scopus 로고    scopus 로고
    • In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor
    • Boissonnas A, Fetler L, Zeelenberg IS, Hugues S, Amigorena S. In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor. J Exp Med (2007) 204:345-56. doi:10.1084/jem.20061890
    • (2007) J Exp Med , vol.204 , pp. 345-356
    • Boissonnas, A.1    Fetler, L.2    Zeelenberg, I.S.3    Hugues, S.4    Amigorena, S.5
  • 35
    • 38449092560 scopus 로고    scopus 로고
    • Recruitment and activation of macrophages by pathogenic CD4 T cells in type 1 diabetes: evidence for involvement of CCR8 and CCL1
    • Cantor J, Haskins K. Recruitment and activation of macrophages by pathogenic CD4 T cells in type 1 diabetes: evidence for involvement of CCR8 and CCL1. J Immunol (2007) 179:5760-7. doi:10.4049/jimmunol.179.9.5760
    • (2007) J Immunol , vol.179 , pp. 5760-5767
    • Cantor, J.1    Haskins, K.2
  • 36
    • 58149352396 scopus 로고    scopus 로고
    • Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
    • Kim JV, Kang SS, Dustin ML, McGavern DB. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature (2008) 457:191-5. doi:10.1038/nature07591
    • (2008) Nature , vol.457 , pp. 191-195
    • Kim, J.V.1    Kang, S.S.2    Dustin, M.L.3    McGavern, D.B.4
  • 37
    • 84894082425 scopus 로고    scopus 로고
    • Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues
    • Honda T, Egen JG, Lämmermann T, Kastenmüller W, Torabi-Parizi P, Germain RN. Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues. Immunity (2014) 40:235-47. doi:10.1016/j.immuni.2013.11.017
    • (2014) Immunity , vol.40 , pp. 235-247
    • Honda, T.1    Egen, J.G.2    Lämmermann, T.3    Kastenmüller, W.4    Torabi-Parizi, P.5    Germain, R.N.6
  • 38
    • 84857826936 scopus 로고    scopus 로고
    • CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis
    • Phares TW, Stohlman SA, Hwang M, Min B, Hinton DR, Bergmann CC. CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis. J Virol (2012) 86:2416-27. doi:10.1128/JVI.06797-11
    • (2012) J Virol , vol.86 , pp. 2416-2427
    • Phares, T.W.1    Stohlman, S.A.2    Hwang, M.3    Min, B.4    Hinton, D.R.5    Bergmann, C.C.6
  • 39
    • 33645866471 scopus 로고    scopus 로고
    • Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction
    • Castellino F, Huang AY, Altan-Bonnet G, Stoll S, Scheinecker C, Germain RN. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature (2006) 440:890-5. doi:10.1038/nature04651
    • (2006) Nature , vol.440 , pp. 890-895
    • Castellino, F.1    Huang, A.Y.2    Altan-Bonnet, G.3    Stoll, S.4    Scheinecker, C.5    Germain, R.N.6
  • 40
    • 84975480271 scopus 로고    scopus 로고
    • CD4+ T-cell help amplifies innate signals for primary CD8+ T-cell immunity
    • Bedoui S, Heath WR, Mueller SN. CD4+ T-cell help amplifies innate signals for primary CD8+ T-cell immunity. Immunol Rev (2016) 272:52-64. doi:10.1111/imr.12426
    • (2016) Immunol Rev , vol.272 , pp. 52-64
    • Bedoui, S.1    Heath, W.R.2    Mueller, S.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.