Mutations in ppe38 block PE-PGRS secretion and increase virulence of Mycobacterium tuberculosis

Nature Microbiology

Volumn 3, Issue 2, 2018, Pages 181-188

  Ates, Louis S ^a,b   Dippenaar, Anzaan ^c   Ummels, Roy ^a   Piersma, Sander R ^a   Van Der Woude, Aniek D ^a   Van Der Kuij, Kim ^a   Le Chevalier, Fabien ^b   Mata Espinosa, Dulce ^d   Barrios Payán, Jorge ^d   Marquina Castillo, Brenda ^d   Guapillo, Carolina ^d   Jiménez, Connie R ^a   Pain, Arnab ^e   Houben, Edith N G ^f   Warren, Robin M ^c   Brosch, Roland ^b   Hernández Pando, Rogelio ^d   Bitter, Wilbert ^a,f  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITY OF STELLENBOSCH   (South Africa)

^d INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^e KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Saudi Arabia)

^f AMSTERDAM INSTITUTE FOR MOLECULES   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; PROTEIN PE PGRS; PROTEIN PPE MPTR; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; BACTERIAL DNA; ESX-5 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; MEMBRANE PROTEIN; PE-PGRS PROTEIN, MYCOBACTERIUM; VIRULENCE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CONTROLLED STUDY; GENE DELETION; GENE LOCUS; GENE MUTATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG TUBERCULOSIS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPE; PHYLOGENY; PPE38 GENE; PRIORITY JOURNAL; PROTEIN SECRETION; ANIMAL; BAGG ALBINO MOUSE; CHINA; DISEASE MODEL; GENETICS; METABOLISM; MICROBIOLOGY; MUTATION; PATHOGENICITY; TYPE VII SECRETION SYSTEM; VIRULENCE;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BEIJING; DISEASE MODELS, ANIMAL; DNA, BACTERIAL; GENE DELETION; HUMANS; MEMBRANE PROTEINS; MICE, INBRED BALB C; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PHENOTYPE; PHYLOGENY; TUBERCULOSIS, PULMONARY; TYPE VII SECRETION SYSTEMS; VIRULENCE; VIRULENCE FACTORS;

EID: 85040652026     PISSN: None     EISSN: 20585276     Source Type: Journal    
DOI: 10.1038/s41564-017-0090-6     Document Type: Article

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