Interleukin-10-Overexpressing Mesenchymal Stromal Cells Induce a Series of Regulatory Effects in the Inflammatory System and Promote the Survival of Endotoxin-Induced Acute Lung Injury in Mice Model

DNA and Cell Biology

Volumn 37, Issue 1, 2018, Pages 53-61

  Wang, Chenfei ^a   Lv, Dan ^a   Zhang, Xiaobin ^a   Ni, Zhu Ang ^a   Sun, Xiaofan ^a   Zhu, Changqing ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Acute lung injury; interleukin 10; mesenchymal stromal cell

Indexed keywords

ENDOTOXIN; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; RETROVIRUS VECTOR; TUMOR NECROSIS FACTOR; IL10 PROTEIN, MOUSE;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BODY WEIGHT LOSS; CELL THERAPY; CONTROLLED STUDY; LUNG LAVAGE; LYMPHOCYTIC INFILTRATION; MALE; MESENCHYMAL STROMA CELL; MOUSE; MOUSE MODEL; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS INFECTION; SPLEEN LYMPHOCYTE; SURVIVAL RATE; T LYMPHOCYTE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; INFLAMMATION; LUNG; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLISM; PROCEDURES;

ACUTE LUNG INJURY; ANIMALS; DISEASE MODELS, ANIMAL; ENDOTOXINS; INFLAMMATION; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; LUNG; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL;

EID: 85040574394     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.2017.3735     Document Type: Article

References (29)

1. Bellani, G., Laffey, J.G., Pham, T., Fan, E., Brochard, L., Esteban, A., et al. (2016). Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315, 788-800.
2. Choi, J.J., Yoo, S.A., Park, S.J., Kang, Y.J., Kim, W.U., Oh, I.H., et al. (2008). Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice. Clin Exp Immunol 153, 269-276.
3. D'Alessio, F.R., Tsushima, K., Aggarwal, N.R., West, E.E., Willett, M.H., Britos, M.F., et al. (2009). CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest 119, 2898-2913.
4. Garibaldi, B.T., D'Alessio, F.R., Mock, J.R., Files, D.C., Chau, E., Eto, Y., et al. (2013). Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment. Am J Respir Cell Mol Biol 48, 35-43.
5. Gupta, N., Su, X., Popov, B., Lee, J.W., Serikov, V., and Matthay, M.A. (2007). Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 179, 1855-1863.
6. Hiroshima, Y., Hsu, K., Tedla, N., Chung, Y.M., Chow, S., Herbert, C., et al. (2014). S100A8 induces IL-10 and protects against acute lung injury. J Immunol 192, 2800-2811.
7. Inoue, G. (2000). Effect of interleukin-10 (IL-10) on experi-mental LPS-induced acute lung injury. J Infect Chemother 6, 51-60.
8. Kapur, R., Kim, M., Aslam, R., McVey, M.J., Tabuchi, A., Luo, A., et al. (2017). T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10. Blood 129, 2557-2569.
9. Krasnodembskaya, A., Song, Y., Fang, X., Gupta, N., Serikov, V., Lee, J.W., et al. (2010). Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cell 28, 2229-2238.
10. Kratchmarova, I., Blagoev, B., Haack-Sorensen, M., Kassem, M., and Mann, M. (2005). Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science 308, 1472-1477.
11. Lee, J.W., Fang, X., Gupta, N., Serikov, V., and Matthay, M.A. (2009). Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci USA 106, 16357-16362.
12. Li, G., Cao, Y., Sun, Y., Xu, R., Zheng, Z., and Song, H. (2016). Ultrafine particles in the airway aggravated experimental lung injury through impairment in Treg function. Biochem Bio-phys Res Commun 478, 494-500.
13. Li, H.D., Zhang, Q.X., Mao, Z., Xu, X.J., Li, N.Y., and Zhang, H. (2015). Exogenous interleukin-10 attenuates hyperoxia-induced acute lung injury in mice. Exp Physiol 100, 331-340.
14. Martinez, F.O., and Gordon, S. (2014). The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 6, 13.
15. Matthay, M.A., and Zimmerman, G.A. (2005). Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol 33, 319-327.
16. Mei, S.H., Haitsma, J.J., Dos Santos, C.C., Deng, Y., Lai, P.F., Slutsky, A.S., et al. (2010). Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and im-proving survival in sepsis. Am J Respir Crit Care Med 182, 1047-1057.
17. Min, C.K., Kim, B.G., Park, G., Cho, B., and Oh, I.H. (2007). IL-10-transduced bone marrow mesenchymal stem cells can attenuate the severity of acute graft-versus-host disease after experimental allogeneic stem cell transplantation. Bone Marrow Transpl 39, 637-645.
18. Oh, I.H., and Eaves, C.J. (2002). Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity. Oncogene 21, 4778-4787.
19. Parekkadan, B., and Milwid, J.M. (2010). Mesenchymal stem cells as therapeutics. Annu Rev Biomed Eng 12, 87-117.
20. Patel, B.V., Wilson, M.R., O'Dea, K.P., and Takata, M. (2013). TNF-induced death signaling triggers alveolar epithelial dysfunction in acute lung injury. J Immunol 190, 4274-4282.
21. Perl, M., Lomas-Neira, J., Venet, F., Chung, C.S., and Ayala, A. (2011). Pathogenesis of indirect (secondary) acute lung injury. Expert Rev Respir Med 5, 115-126.
22. Rojas, M., Xu, J., Woods, C.R., Mora, A.L., Spears, W., Roman, J., et al. (2005). Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 33, 145-152.
23. Singer, B.D., Mock, J.R., Aggarwal, N.R., Garibaldi, B.T., Sidhaye, V.K., Florez, M.A., et al. (2015). Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation. Am J Respir Cell Mol Biol 52, 641-652.
24. Walter, J., Ware, L.B., and Matthay, M.A. (2014). Mesenchy-mal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis. Lancet Respir Med 2, 1016-1026.
25. Wheeler, A.P., and Bernard, G.R. (2007). Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet 369, 1553-1564.
26. Wilson, J.G., Liu, K.D., Zhuo, H., Caballero, L., McMillan, M., Fang, X., et al. (2015). Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med 3, 24-32.
27. Wu, C.L., Lin, L.Y., Yang, J.S., Chan, M.C., and Hsueh, C.M. (2009). Attenuation of lipopolysaccharide-induced acute lung injury by treatment with IL-10. Respirology 14, 511-521.
28. Xu, S., Xu, M., Li, G.G., Wang, C., Song, H., and Bai, J. (2016). Early recruitment of IL-10-producing B cells into alveoli improved the resolution of acute lung injury. Cell Physiol Biochem 38, 1752-1760.
29. Zheng, G., Huang, L., Tong, H., Shu, Q., Hu, Y., Ge, M., et al. (2014). Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study. Respir Res 15, 39.