PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma

Neuropsychopharmacology

Volumn 43, Issue 3, 2018, Pages 469-481

  Breen, Michael S ^a   Tylee, Daniel S ^b   Maihofer, Adam X ^c   Neylan, Thomas C ^d,e   Mehta, Divya ^f   Binder, Elisabeth B ^g,h   Chandler, Sharon D ^c   Hess, Jonathan L ^b   Kremen, William S ^c,i   Risbrough, Victoria B ^c,i   Woelk, Christopher H ^j,k   Baker, Dewleen G ^c,i   Nievergelt, Caroline M ^c,i   Tsuang, Ming T ^c,i   Buxbaum, Joseph D ^a   Glatt, Stephen J ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^g MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^h EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ VETERANS AFFAIRS MEDICAL CENTER   (United States)

^j UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^k MERCK RESEARCH LABORATORIES   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; TRANSCRIPTOME;

ARTICLE; BLOOD ANALYSIS; DOWN REGULATION; GENE EXPRESSION; HUMAN; INJURY; LIPID METABOLISM; OVERLAPPING GENE; PATHOPHYSIOLOGY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTEIN INTERACTION; SEX DIFFERENCE; TETRATRICOPEPTIDE REPEAT; BLOOD; FEMALE; IMMUNOLOGY; MALE; META ANALYSIS; SEXUAL CHARACTERISTICS;

FEMALE; HUMANS; MALE; SEX CHARACTERISTICS; STRESS DISORDERS, POST-TRAUMATIC; TRANSCRIPTOME;

EID: 85040451639     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2017.220     Document Type: Article

References (44)

1. Breen MS, Maihofer AX, Glatt SJ, Tylee DS, Chandler SD, Tsuang MT et al (2015). Gene networks specific for innate immunity define post-traumatic stress disorder. Mol Psychiatry 20: 1538-1545.
2. Breen MS, Stein DS, Baldwin D (2016). Systematic review of blood transcriptome profiling in neuropsychiatric disorders: guidelines for biomarker discovery. Hum Psychopharmacol 31: 373-381.
3. Chen J, Bardes E, Aronow B, Jegga A (2015). ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res 37: W305-W311.
4. Cohen S, Janicki-Deverts D, Doyle WJ, Miller GE, Frank E, Rabin BS et al (2016). Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA 109: 5995-5999.
5. Daskalakis N, Cohen H, Nievergelt CM, Baker DG, Buxbaum JD, Russo SJ et al (2016). New translational perspectives for bloodbased biomarkers of PTSD: from glucocorticoid to immune mediators of stress susceptibility. Exp Neurol 284: 133-140.
6. Diaz-Beltran L, Esteban F, Wall D (2016). A common molecular signature in ASD gene expression: following Root 66 to autism. Transl Psychiatry 6: e705.
7. DiGangi J, Gomez D, Mendoza L, Jason LA, Keys CB, Koenen KC (2013). Pretrauma risk factors for posttraumatic stress disorder: a systematic review of the literature. Clin Psychol Rev 33: 728-744.
8. Elenkov I, Wilder R, Chrousos G, Vizi E (2000). The sympathetic nerve-an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 52: 595-638.
9. Felger J, Lotrich F (2013). Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 246: 199-229.
10. Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A et al (2012). STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res 41: D808-D815.
11. Freidenberg B, Gusmano R, Hickling EJ, Blanchard EB, Bremner JD, Frye C (2010). Women with PTSD have lower basal salivary cortisol levels later in the day than do men with PTSD: a preliminary study. Physiol Behav 99: 234-236.
12. Galliher-Beckley A, Williams J, Cidlowski J (2011). Ligandindependent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signaling. Mol Cell Biol 31: 4663-4675.
13. Gill J, Saligan L, Woods S, Page G (2009). PTSD is associated with an excess of inflammatory immune activities. Perspect Psychiatr Care 45: 262-277.
14. Glatt SJ, Tylee DS, Chandler SD, Pazol J, Nievergelt CM, Woelk CH et al (2015). Blood-based gene-expression predictors of PTSD risk and resilience among deployed marines: a pilot study. Am J Med Genet B Neuropsychiatr Genet 162: 313-326.
15. Hess J, Tylee DS, Barve R, de Jong S, Ophoff RA, Kumarasinghe N et al (2016). Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia. Schizophr Res 176: 114-124.
16. Kayala M, Baldi P (2012). Cyber-T web server: differential analysis of high-throughput data. Nucleic Acids Res 40: W553-W559.
17. Kessler R (1995). Posttraumatic stress disorder in the national comorbidity survey. Arch Gen Psychiatry 52: 1048.
18. Langfelder P, Horvath S (2008). WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9: 559.
19. Langfelder P, Luo R, Oldham M, Horvath S (2011). Is my network module preserved and reproducible? PLoS Comput Biol 7: e1001057.
20. Leek J, Johnson W, Parker H, Jaffe A, Storey J (2015). The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28: 882-883.
21. Mehta D, Klengel T, Conneely KN, Smith AK, Altmann A, Pace TW et al (2013). Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proc Natl Acad Sci USA 110: 8302-8307.
22. Michopoulos V, Norrholm S, Jovanovic T (2015). Diagnostic biomarkers for posttraumatic stress disorder: promising horizons from translational neuroscience research. Biol Psychiatry 78: 344-353.
23. Newman A, Long Liu A, Green MR, Gentles AJ, Feng W, Xu Y et al (2015). Robust enumeration of cell subsets from tissue expression profiles. Nat Methods 12: 453-457.
24. Neylan T, Sun B, Rempel H, Ross J, Lenoci M, O'Donovan A et al (2011). Suppressed monocyte gene expression profile in men versus women with PTSD. Brain Behav Immun 25: 524-553.
25. Pacák K, Palkovits M (2001). Stressor specificity of central neuroendocrine responses: implications for stress-related disorders. Endocr Rev 22: 502-548.
26. PageGP, Edwards JW, GadburyGL, Yelisetti P,Wang J, Trivedi P et al (2006). The PowerAtlas: a power and sample size atlas formicroarray experimental design and research. BMC Bioinformatics 7: 84.
27. Passos IC, Vasconcelos-Moreno MP, Costa LG, Kunz M, Brietzke E, Quevedo J et al (2015). Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and metaregression. Lancet Psychiatry 2: 1002-1012.
28. Pinero J, Queralt-Rosinach N, Bravo A, Deu-Pons J, Bauer-Mehren A, Baron M et al (2015). DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes. Database 2015: bav028.
29. Posma E, Moes H, Heineman M, Faas M (2014). The effect of testosterone on cytokine production in the specific and non-specific immune response. Am J Reprod Immunol 52: 237-243.
30. Ramchand R, Schell TL, Karney BR, Osilla KC, Bruns RM, Caldarone LB (2010). Disparate prevalence estimates of PTSD among service members who served in Iraq and Afghanistan: possible explanations. J Trauma Stress 23: 59-68.
31. Reul J (2014). Making memories of stressful events: a journey along epigenetic, gene transcription, and signaling pathways. Front Psychiatry 5: 5.
32. Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W et al (2015). limma powers differential expression analyses for RNAsequencing and microarray studies. Nucleic Acids Res 43: e47-e47.
33. Sarapas C, Cai G, Bierer LM, Golier JA, Galea S, Ising M et al (2011). Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks. Dis Markers 30: 101-110.
34. Segman R, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, Shalev AY (2005). Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol Psychiatry 10: 425-425.
35. Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D et al (2003). Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13: 2498-2504.
36. Silverman M, Pearce B, Biron C, Miller A (2013). Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection. Viral Immunol 18: 41-78.
37. Silverman M, Sternberg E (2012). Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann N Y Acad Sci 1261: 55-63.
38. Simon R, Lam A, Li MC, Ngan M, Menenzes S, Zhao Y (2007). Analysis of gene expression data using BRB-Array tools. Cancer Inform 2: 11-17.
39. Söndergaard H, Hansson L, Theorell T (2004). The inflammatory markers C-reactive protein and serum amyloid A in refugees with and without posttraumatic stress disorder. Clin Chim Acta 342: 93-98.
40. Tylee DS, Chandler SD, Nievergelt CM, Liu X, Pazol J, Woelk CH et al (2015). Blood-based gene-expression biomarkers of posttraumatic stress disorder among deployed marines: a pilot study. Psychoneuroendocrinology 51: 472-494.
41. Tylee DS, Jess JL, Quinn TP, Barve R, Huang H, Zhang-James Y et al (2016). Blood transcriptomic comparison of individuals with and without autism spectrum disorder: a combined-samples mega-analysis. Am J Med Genet B Neuropsychiatr Genet 9999: 1-21.
42. Whitaker A, Gilpin N, Edwards S (2014). Animal models of posttraumatic stress disorder and recent neurobiological insights. Behav Pharmacol 25: 398-409.
43. Yehuda R, Halligan S, Grossman R, Golier J, Wong C (2002). The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder. Biol Psychiatry 52: 393-403.
44. Yu G, Li F, Qin Y, Bo X, Wu Y, Wang S (2015). GOSemSim: an R package for measuring semantic similarity among GO terms and gene products. Bioinformatics 26: 976-978.