Mixed signature of activation and dysfunction allows human decidual CD8+ T cells to provide both tolerance and immunity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 2, 2017, Pages 385-390

  Van Der Zwan, Anita ^a,b   Bi, Kevin ^c   Norwitz, Errol R ^d   Crespo, Ângela C ^a,c   Claas, Frans H J ^b   Strominger, Jack L ^a   Tilburgs, Tamara ^a  

^a Harvard University   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d TUFTS MEDICAL CENTER   (United States)

Author keywords

Cytotoxicity; Placenta; Pregnancy; T cell exhaustion; Trophoblast

Indexed keywords

GAMMA INTERFERON; GRANZYME; PERFORIN; TUMOR NECROSIS FACTOR;

ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONGENITAL INFECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME SYNTHESIS; FEMALE; FETUS DEVELOPMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOLOGY; IMMUNOREGULATION; IN VITRO STUDY; INFECTION; LYMPHOCYTE PROLIFERATION; PLACENTA DEVELOPMENT; PREGNANCY COMPLICATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DECIDUA; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; PROCEDURES; TIME FACTOR; VIROLOGY;

CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DECIDUA; FEMALE; GENE EXPRESSION PROFILING; GRANZYMES; HUMANS; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; PERFORIN; TIME FACTORS;

EID: 85040231467     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1713957115     Document Type: Article

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