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Volumn 22, Issue 12, 2017, Pages

De novo RNA sequencing and expression analysis of Aconitum carmichaelii to analyze key genes involved in the biosynthesis of diterpene Alkaloids

Author keywords

Aconitine; Aconitum; Diterpene alkaloids; KEGG pathway enrichment analysis; RNA sequencing; Transcript abundance

Indexed keywords

ACONITINE; ALKALOID; DITERPENE; PLANT PROTEIN; TRANSCRIPTOME;

EID: 85040200197     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules22122155     Document Type: Article
Times cited : (45)

References (60)
  • 1
    • 84921472469 scopus 로고    scopus 로고
    • A review on phytochemistry, pharmacology and toxicology studies of aconitum
    • Nyirimigabo, E.; Xu, Y.; Li, Y.; Wang, Y.; Agyemang, K.; Zhang, Y. A review on phytochemistry, pharmacology and toxicology studies of aconitum. J. Pharm. Pharmacol. 2015, 67, 1–19. [CrossRef] [PubMed]
    • (2015) J. Pharm. Pharmacol. , vol.67 , pp. 1-19
    • Nyirimigabo, E.1    Xu, Y.2    Li, Y.3    Wang, Y.4    Agyemang, K.5    Zhang, Y.6
  • 2
    • 70349761212 scopus 로고    scopus 로고
    • Aconitum in traditional Chinese medicine: A valuable drug or an unpredictable risk?
    • Singhuber, J.; Zhu, M.; Prinz, S.; Kopp, B. Aconitum in traditional chinese medicine: A valuable drug or an unpredictable risk? J. Ethnopharmacol. 2009, 126, 18–30. [CrossRef] [PubMed]
    • (2009) J. Ethnopharmacol. , vol.126 , pp. 18-30
    • Singhuber, J.1    Zhu, M.2    Prinz, S.3    Kopp, B.4
  • 3
    • 84964253189 scopus 로고    scopus 로고
    • Aconitum carmichaelii debeaux, cultivated as a medicinal plant in Western China
    • Yu, M.; Yand, Y.-S.; Shu, X.-Y.; Huang, J.; Hou, D.-B. Aconitum carmichaelii debeaux, cultivated as a medicinal plant in Western China. Genet. Resour. Crop Evol. 2016, 63, 919–924. [CrossRef]
    • (2016) Genet. Resour. Crop Evol. , vol.63 , pp. 919-924
    • Yu, M.1    Yand, Y.-S.2    Shu, X.-Y.3    Huang, J.4    Hou, D.-B.5
  • 4
    • 82555193836 scopus 로고    scopus 로고
    • Metabolomics study on fuzi and its processed products using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition analysis
    • Sun, H.; Ni, B.; Zhang, A.; Wang, M.; Dong, H.; Wang, X. Metabolomics study on fuzi and its processed products using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition analysis. Analyst 2012, 137, 170–185. [CrossRef] [PubMed]
    • (2012) Analyst , vol.137 , pp. 170-185
    • Sun, H.1    Ni, B.2    Zhang, A.3    Wang, M.4    Dong, H.5    Wang, X.6
  • 5
    • 78651412370 scopus 로고    scopus 로고
    • The relationship between growth of the aerial part and alkaloid content variation in cultivated Aconitum carmichaeli Debeaux
    • Kawasaki, R.; Motoya, W.; Atsumi, T.; Mouri, C.; Kakiuchi, N.; Mikage, M. The relationship between growth of the aerial part and alkaloid content variation in cultivated Aconitum carmichaeli Debeaux. J. Nat. Med. 2011, 65, 111–115. [CrossRef] [PubMed]
    • (2011) J. Nat. Med. , vol.65 , pp. 111-115
    • Kawasaki, R.1    Motoya, W.2    Atsumi, T.3    Mouri, C.4    Kakiuchi, N.5    Mikage, M.6
  • 6
    • 84918568865 scopus 로고    scopus 로고
    • A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii debeaux
    • Zhou, G.; Tang, L.; Zhou, X.; Wang, T.; Kou, Z.; Wang, Z. A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii debeaux. J. Ethnopharmacol. 2015, 160, 173–193. [CrossRef] [PubMed]
    • (2015) J. Ethnopharmacol. , vol.160 , pp. 173-193
    • Zhou, G.1    Tang, L.2    Zhou, X.3    Wang, T.4    Kou, Z.5    Wang, Z.6
  • 8
    • 0033065612 scopus 로고    scopus 로고
    • Antinociceptive effect of Gosha-jinki-gan, a Kampo medicine, in streptozotocin-induced diabetic mice
    • Suzuki, Y.; Goto, K.; Ishige, A.; Komatsu, Y.; Kamei, J. Antinociceptive effect of Gosha-jinki-gan, a Kampo medicine, in streptozotocin-induced diabetic mice. Jpn. J. Pharmacol. 1999, 79, 169–175. [CrossRef] [PubMed]
    • (1999) Jpn. J. Pharmacol. , vol.79 , pp. 169-175
    • Suzuki, Y.1    Goto, K.2    Ishige, A.3    Komatsu, Y.4    Kamei, J.5
  • 10
    • 84859126293 scopus 로고    scopus 로고
    • Structure and dynamics of the isoprenoid pathway network
    • Vranova, E.; Coman, D.; Gruissem, W. Structure and dynamics of the isoprenoid pathway network. Mol. Plant 2012, 5, 318–333. [CrossRef] [PubMed]
    • (2012) Mol. Plant , vol.5 , pp. 318-333
    • Vranova, E.1    Coman, D.2    Gruissem, W.3
  • 11
    • 84899764072 scopus 로고    scopus 로고
    • To gibberellins and beyond! Surveying the evolution of (di)terpenoid metabolism
    • Zi, J.; Mafu, S.; Peters, R.J. To gibberellins and beyond! Surveying the evolution of (di)terpenoid metabolism. Ann. Rev. Plant Biol. 2014, 65, 259–286. [CrossRef] [PubMed]
    • (2014) Ann. Rev. Plant Biol. , vol.65 , pp. 259-286
    • Zi, J.1    Mafu, S.2    Peters, R.J.3
  • 12
    • 79953905118 scopus 로고    scopus 로고
    • Terpenoid-alkaloids: Their biosynthetic twist of fate and total synthesis
    • Cherney, E.C.; Baran, P.S. Terpenoid-alkaloids: Their biosynthetic twist of fate and total synthesis. Isr. J. Chem. 2011, 51, 391–405. [CrossRef] [PubMed]
    • (2011) Isr. J. Chem. , vol.51 , pp. 391-405
    • Cherney, E.C.1    Baran, P.S.2
  • 14
    • 60349087777 scopus 로고    scopus 로고
    • Qualitative and quantitative analysis of aconitine-type and lipo-alkaloids of Aconitum carmichaelii roots
    • Csupor, D.; Wenzig, E.M.; Zupko, I.; Wolkart, K.; Hohmann, J.; Bauer, R. Qualitative and quantitative analysis of aconitine-type and lipo-alkaloids of Aconitum carmichaelii roots. J. Chromatogr. A 2009, 1216, 2079–2086. [CrossRef] [PubMed]
    • (2009) J. Chromatogr. A , vol.1216 , pp. 2079-2086
    • Csupor, D.1    Wenzig, E.M.2    Zupko, I.3    Wolkart, K.4    Hohmann, J.5    Bauer, R.6
  • 15
    • 40249093007 scopus 로고    scopus 로고
    • Metabonomic study on the toxicity of hei-shun-pian, the processed lateral root of Aconitum carmichaelii debx (ranunculaceae)
    • Li, L.; Sun, B.; Zhang, Q.; Fang, J.; Ma, K.; Li, Y.; Chen, H.; Dong, F.; Gao, Y.; Li, F.; et al. Metabonomic study on the toxicity of hei-shun-pian, the processed lateral root of Aconitum carmichaelii debx (ranunculaceae). J. Ethnopharmacol. 2008, 116, 561–568. [CrossRef] [PubMed]
    • (2008) J. Ethnopharmacol. , vol.116 , pp. 561-568
    • Li, L.1    Sun, B.2    Zhang, Q.3    Fang, J.4    Ma, K.5    Li, Y.6    Chen, H.7    Dong, F.8    Gao, Y.9    Li, F.10
  • 16
    • 84876417195 scopus 로고    scopus 로고
    • UPLC-Q-TOF-HDMS analysis of constituents in the root of two kinds of Aconitum using a metabolomics approach
    • Sun, H.; Wang, M.; Zhang, A.; Ni, B.; Dong, H.; Wang, X. UPLC-Q-TOF-HDMS analysis of constituents in the root of two kinds of Aconitum using a metabolomics approach. Phytochem. Anal. PCA 2013, 24, 263–276. [CrossRef] [PubMed]
    • (2013) Phytochem. Anal. PCA , vol.24 , pp. 263-276
    • Sun, H.1    Wang, M.2    Zhang, A.3    Ni, B.4    Dong, H.5    Wang, X.6
  • 17
    • 84959345650 scopus 로고    scopus 로고
    • Dynamic variation patterns of Aconitum alkaloids in daughter root of Aconitum carmichaelii (fuzi) in the decoction process based on the content changes of nine Aconitum alkaloids by HPLC- MS- MS
    • Luo, H.; Huang, Z.; Tang, X.; Yi, J.; Chen, S.; Yang, A.; Yang, J. Dynamic variation patterns of Aconitum alkaloids in daughter root of Aconitum carmichaelii (fuzi) in the decoction process based on the content changes of nine Aconitum alkaloids by HPLC- MS- MS. Iran. J. Pharm. Res. IJPR 2016, 15, 263–273. [PubMed]
    • (2016) Iran. J. Pharm. Res. IJPR , vol.15 , pp. 263-273
    • Luo, H.1    Huang, Z.2    Tang, X.3    Yi, J.4    Chen, S.5    Yang, A.6    Yang, J.7
  • 18
    • 84938053772 scopus 로고    scopus 로고
    • Next-generation sequencing (NGS) transcriptomes reveal association of multiple genes and pathways contributing to secondary metabolites accumulation in tuberous roots of Aconitum heterophyllum wall
    • Pal, T.; Malhotra, N.; Chanumolu, S.K.; Chauhan, R.S. Next-generation sequencing (NGS) transcriptomes reveal association of multiple genes and pathways contributing to secondary metabolites accumulation in tuberous roots of Aconitum heterophyllum wall. Planta 2015, 242, 239–258. [CrossRef] [PubMed]
    • (2015) Planta , vol.242 , pp. 239-258
    • Pal, T.1    Malhotra, N.2    Chanumolu, S.K.3    Chauhan, R.S.4
  • 19
    • 84922502881 scopus 로고    scopus 로고
    • Distribution of toxic alkaloids in tissues from three herbal medicine Aconitum species using laser micro-dissection, UHPLC-QTOF MS and LC-MS/MS techniques
    • Jaiswal, Y.; Liang, Z.; Ho, A.; Wong, L.; Yong, P.; Chen, H.; Zhao, Z. Distribution of toxic alkaloids in tissues from three herbal medicine Aconitum species using laser micro-dissection, UHPLC-QTOF MS and LC-MS/MS techniques. Phytochemistry 2014, 107, 155–174. [CrossRef] [PubMed]
    • (2014) Phytochemistry , vol.107 , pp. 155-174
    • Jaiswal, Y.1    Liang, Z.2    Ho, A.3    Wong, L.4    Yong, P.5    Chen, H.6    Zhao, Z.7
  • 20
    • 0031955518 scopus 로고    scopus 로고
    • Base-calling of automated sequencer traces using phred. I. Accuracy assessment
    • Ewing, B.; Hillier, L.; Wendl, M.C.; Green, P. Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res. 1998, 8, 175–185. [CrossRef] [PubMed]
    • (1998) Genome Res. , vol.8 , pp. 175-185
    • Ewing, B.1    Hillier, L.2    Wendl, M.C.3    Green, P.4
  • 24
    • 84902474663 scopus 로고    scopus 로고
    • Soapdenovo-trans: De novo transcriptome assembly with short RNA-seq reads
    • Xie, Y.; Wu, G.; Tang, J.; Luo, R.; Patterson, J.; Liu, S.; Huang, W.; He, G.; Gu, S.; Li, S.; et al. Soapdenovo-trans: De novo transcriptome assembly with short RNA-seq reads. Bioinformatics 2014, 30, 1660–1666. [CrossRef] [PubMed]
    • (2014) Bioinformatics , vol.30 , pp. 1660-1666
    • Xie, Y.1    Wu, G.2    Tang, J.3    Luo, R.4    Patterson, J.5    Liu, S.6    Huang, W.7    He, G.8    Gu, S.9    Li, S.10
  • 26
    • 33745634395 scopus 로고    scopus 로고
    • Cd-hit: A fast program for clustering and comparing large sets of protein or nucleotide sequences
    • Li, W.; Godzik, A. Cd-hit: A fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics 2006, 22, 1658–1659. [CrossRef] [PubMed]
    • (2006) Bioinformatics , vol.22 , pp. 1658-1659
    • Li, W.1    Godzik, A.2
  • 28
    • 84946041548 scopus 로고    scopus 로고
    • Biochemical functional predictions for protein structures of unknown or uncertain function
    • Mills, C.L.; Beuning, P.J.; Ondrechen, M.J. Biochemical functional predictions for protein structures of unknown or uncertain function. Comput. Struct. Biotechnol. J. 2015, 13, 182–191. [CrossRef] [PubMed]
    • (2015) Comput. Struct. Biotechnol. J. , vol.13 , pp. 182-191
    • Mills, C.L.1    Beuning, P.J.2    Ondrechen, M.J.3
  • 30
    • 43949138227 scopus 로고    scopus 로고
    • Blast2go: A comprehensive suite for functional analysis in plant genomics
    • Conesa, A.; Gotz, S. Blast2go: A comprehensive suite for functional analysis in plant genomics. Int. J. Plant Genom. 2008, 2008, 619832. [CrossRef] [PubMed]
    • (2008) Int. J. Plant Genom. , vol.2008 , pp. 619832
    • Conesa, A.1    Gotz, S.2
  • 34
    • 60349120513 scopus 로고    scopus 로고
    • Development and mapping of simple sequence repeat markers for pearl millet from data mining of expressed sequence tags
    • Senthilvel, S.; Jayashree, B.; Mahalakshmi, V.; Kumar, P.S.; Nakka, S.; Nepolean, T.; Hash, C. Development and mapping of simple sequence repeat markers for pearl millet from data mining of expressed sequence tags. BMC Plant Biol. 2008, 8, 119. [CrossRef] [PubMed]
    • (2008) BMC Plant Biol. , vol.8 , pp. 119
    • Senthilvel, S.1    Jayashree, B.2    Mahalakshmi, V.3    Kumar, P.S.4    Nakka, S.5    Nepolean, T.6    Hash, C.7
  • 35
    • 0036428541 scopus 로고    scopus 로고
    • In silico analysis on frequency and distribution of microsatellites in ests of some cereal species
    • Varshney, R.K.; Thiel, T.; Stein, N.; Langridge, P.; Graner, A. In silico analysis on frequency and distribution of microsatellites in ests of some cereal species. Cell. Mol. Biol. Lett. 2002, 7, 537–546. [PubMed]
    • (2002) Cell. Mol. Biol. Lett. , vol.7 , pp. 537-546
    • Varshney, R.K.1    Thiel, T.2    Stein, N.3    Langridge, P.4    Graner, A.5
  • 36
    • 0038682598 scopus 로고    scopus 로고
    • Mcgill ingestive skills assessment (MISA): Development and first field test of an evaluation of functional ingestive skills of elderly persons
    • Lambert, H.C.; Gisel, E.G.; Groher, M.E.; Wood-Dauphinee, S. Mcgill ingestive skills assessment (MISA): Development and first field test of an evaluation of functional ingestive skills of elderly persons. Dysphagia 2003, 18, 101–113. [CrossRef] [PubMed]
    • (2003) Dysphagia , vol.18 , pp. 101-113
    • Lambert, H.C.1    Gisel, E.G.2    Groher, M.E.3    Wood-Dauphinee, S.4
  • 37
    • 0342833336 scopus 로고
    • Transport and accumulation of secondary metabolites
    • Amsterdam, The Netherlands, 24–29 June 1990; Nijkamp, H.J.J., Van Der Plas, L.H.W., Van Aartrijk, J., Eds.; Springer: Dordrecht, The Netherlands
    • Brodelius, P.E. Transport and accumulation of secondary metabolites. In Progress in Plant Cellular and Molecular Biology: Proceedings of the Viith International Congress on Plant Tissue and Cell Culture, Amsterdam, The Netherlands, 24–29 June 1990; Nijkamp, H.J.J., Van Der Plas, L.H.W., Van Aartrijk, J., Eds.; Springer: Dordrecht, The Netherlands, 1990; pp. 567–576.
    • (1990) Progress in Plant Cellular and Molecular Biology: Proceedings of The Viith International Congress on Plant Tissue and Cell Culture , pp. 567-576
    • Brodelius, P.E.1
  • 38
    • 62349130698 scopus 로고    scopus 로고
    • Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
    • Langmead, B.; Trapnell, C.; Pop, M.; Salzberg, S.L. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 2009, 10, R25. [CrossRef] [PubMed]
    • (2009) Genome Biol. , vol.10 , pp. R25
    • Langmead, B.1    Trapnell, C.2    Pop, M.3    Salzberg, S.L.4
  • 39
    • 79961123152 scopus 로고    scopus 로고
    • Rsem: Accurate transcript quantification from RNA-Seq data with or without a reference genome
    • Li, B.; Dewey, C.N. Rsem: Accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinform. 2011, 12, 323. [CrossRef] [PubMed]
    • (2011) BMC Bioinform , vol.12 , pp. 323
    • Li, B.1    Dewey, C.N.2
  • 40
    • 84964211427 scopus 로고    scopus 로고
    • RNA-seq transcriptome analysis of panax japonicus, and its comparison with other panax species to identify potential genes involved in the saponins biosynthesis
    • Rai, A.; Yamazaki, M.; Takahashi, H.; Nakamura, M.; Kojoma, M.; Suzuki, H.; Saito, K. RNA-seq transcriptome analysis of panax japonicus, and its comparison with other panax species to identify potential genes involved in the saponins biosynthesis. Front. Plant Sci. 2016, 7, 481. [CrossRef] [PubMed]
    • (2016) Front. Plant Sci. , vol.7 , pp. 481
    • Rai, A.1    Yamazaki, M.2    Takahashi, H.3    Nakamura, M.4    Kojoma, M.5    Suzuki, H.6    Saito, K.7
  • 41
    • 84938582898 scopus 로고    scopus 로고
    • Orthofinder: Solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy
    • Emms, D.M.; Kelly, S. Orthofinder: Solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy. Genome Biol. 2015, 16, 157. [CrossRef] [PubMed]
    • (2015) Genome Biol. , vol.16 , pp. 157
    • Emms, D.M.1    Kelly, S.2
  • 43
    • 70350366897 scopus 로고    scopus 로고
    • OsTGAP1, a bZIP transcription factor, coordinately regulates the inductive production of diterpenoid phytoalexins in rice
    • Okada, A.; Okada, K.; Miyamoto, K.; Koga, J.; Shibuya, N.; Nojiri, H.; Yamane, H. OsTGAP1, a bZIP transcription factor, coordinately regulates the inductive production of diterpenoid phytoalexins in rice. J. Biol. Chem. 2009, 284, 26510–26518. [CrossRef] [PubMed]
    • (2009) J. Biol. Chem. , vol.284 , pp. 26510-26518
    • Okada, A.1    Okada, K.2    Miyamoto, K.3    Koga, J.4    Shibuya, N.5    Nojiri, H.6    Yamane, H.7
  • 44
    • 0033180217 scopus 로고    scopus 로고
    • Diterpene synthesis in stevia rebaudiana: Recruitment and up-regulation of key enzymes from the gibberellin biosynthetic pathway
    • Richman, A.S.; Gijzen, M.; Starratt, A.N.; Yang, Z.; Brandle, J.E. Diterpene synthesis in stevia rebaudiana: Recruitment and up-regulation of key enzymes from the gibberellin biosynthetic pathway. Plant J. Cell Mol. Biol. 1999, 19, 411–421. [CrossRef]
    • (1999) Plant J. Cell Mol. Biol. , vol.19 , pp. 411-421
    • Richman, A.S.1    Gijzen, M.2    Starratt, A.N.3    Yang, Z.4    Brandle, J.E.5
  • 45
    • 18044391639 scopus 로고    scopus 로고
    • Two sesquiterpene synthases are responsible for the complex mixture of sesquiterpenes emitted from arabidopsis flowers
    • Tholl, D.; Chen, F.; Petri, J.; Gershenzon, J.; Pichersky, E. Two sesquiterpene synthases are responsible for the complex mixture of sesquiterpenes emitted from arabidopsis flowers. Plant J. Cell Mol. Biol. 2005, 42, 757–771. [CrossRef] [PubMed]
    • (2005) Plant J. Cell Mol. Biol. , vol.42 , pp. 757-771
    • Tholl, D.1    Chen, F.2    Petri, J.3    Gershenzon, J.4    Pichersky, E.5
  • 46
  • 47
    • 80053596961 scopus 로고    scopus 로고
    • Terpene specialized metabolism in arabidopsis thaliana
    • American Society of Plant Biologists: Rockville, MD, USA
    • Tholl, D.; Lee, S. Terpene specialized metabolism in arabidopsis thaliana. In Arabidopsis Book; American Society of Plant Biologists: Rockville, MD, USA, 2011; Volume 9, p. e0143.
    • (2011) Arabidopsis Book , vol.9 , pp. e0143
    • Tholl, D.1    Lee, S.2
  • 48
    • 84940846285 scopus 로고    scopus 로고
    • Involvement of an ent-copalyl diphosphate synthase in tissue-specific accumulation of specialized diterpenes in Andrographis paniculata
    • Misra, R.C.; Garg, A.; Roy, S.; Chanotiya, C.S.; Vasudev, P.G.; Ghosh, S. Involvement of an ent-copalyl diphosphate synthase in tissue-specific accumulation of specialized diterpenes in Andrographis paniculata. Plant Sci. 2015, 240, 50–64. [CrossRef] [PubMed]
    • (2015) Plant Sci. , vol.240 , pp. 50-64
    • Misra, R.C.1    Garg, A.2    Roy, S.3    Chanotiya, C.S.4    Vasudev, P.G.5    Ghosh, S.6
  • 49
    • 84940547876 scopus 로고    scopus 로고
    • Andrographis paniculata transcriptome provides molecular insights into tissue-specific accumulation of medicinal diterpenes
    • Garg, A.; Agrawal, L.; Misra, R.C.; Sharma, S.; Ghosh, S. Andrographis paniculata transcriptome provides molecular insights into tissue-specific accumulation of medicinal diterpenes. BMC Genom. 2015, 16, 659. [CrossRef] [PubMed]
    • (2015) BMC Genom , vol.16 , pp. 659
    • Garg, A.1    Agrawal, L.2    Misra, R.C.3    Sharma, S.4    Ghosh, S.5
  • 50
    • 84922565326 scopus 로고    scopus 로고
    • Transcripts of two ent-copalyl diphosphate synthase genes differentially localize in rice plants according to their distinct biological roles
    • Toyomasu, T.; Usui, M.; Sugawara, C.; Kanno, Y.; Sakai, A.; Takahashi, H.; Nakazono, M.; Kuroda, M.; Miyamoto, K.; Morimoto, Y.; et al. Transcripts of two ent-copalyl diphosphate synthase genes differentially localize in rice plants according to their distinct biological roles. J. Exp. Bot. 2015, 66, 369–376. [CrossRef] [PubMed]
    • (2015) J. Exp. Bot. , vol.66 , pp. 369-376
    • Toyomasu, T.1    Usui, M.2    Sugawara, C.3    Kanno, Y.4    Sakai, A.5    Takahashi, H.6    Nakazono, M.7    Kuroda, M.8    Miyamoto, K.9    Morimoto, Y.10
  • 51
    • 85006215777 scopus 로고    scopus 로고
    • Molecular dissection of pathway components unravel atisine biosynthesis in a non-toxic Aconitum species, A. Heterophyllum wall
    • Kumar, V.; Malhotra, N.; Pal, T.; Chauhan, R.S. Molecular dissection of pathway components unravel atisine biosynthesis in a non-toxic Aconitum species, A. heterophyllum wall. 3 Biotech 2016, 6, 106. [CrossRef] [PubMed]
    • (2016) 3 Biotech , vol.6 , pp. 106
    • Kumar, V.1    Malhotra, N.2    Pal, T.3    Chauhan, R.S.4
  • 53
    • 3242655621 scopus 로고    scopus 로고
    • Metabolic channeling in plants
    • Winkel, B.S. Metabolic channeling in plants. Ann. Rev. Plant Biol. 2004, 55, 85–107. [CrossRef] [PubMed]
    • (2004) Ann. Rev. Plant Biol. , vol.55 , pp. 85-107
    • Winkel, B.S.1
  • 54
    • 84930203622 scopus 로고    scopus 로고
    • Cytochromes p450 for terpene functionalisation and metabolic engineering
    • Pateraki, I.; Heskes, A.M.; Hamberger, B. Cytochromes p450 for terpene functionalisation and metabolic engineering. Adv. Biochem. Eng. Biotechnol. 2015, 148, 107–139. [PubMed]
    • (2015) Adv. Biochem. Eng. Biotechnol. , vol.148 , pp. 107-139
    • Pateraki, I.1    Heskes, A.M.2    Hamberger, B.3
  • 55
    • 84872171321 scopus 로고    scopus 로고
    • Plant P450s as versatile drivers for evolution of species-specific chemical diversity
    • Hamberger, B.; Bak, S. Plant P450s as versatile drivers for evolution of species-specific chemical diversity. Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 2013, 368, 20120426. [CrossRef] [PubMed]
    • (2013) Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. , vol.368 , pp. 20120426
    • Hamberger, B.1    Bak, S.2
  • 56
    • 79953234390 scopus 로고    scopus 로고
    • A p450-centric view of plant evolution
    • Nelson, D.; Werck-Reichhart, D. A p450-centric view of plant evolution. Plant J. Cell Mol. Biol. 2011, 66, 194–211. [CrossRef] [PubMed]
    • (2011) Plant J. Cell Mol. Biol. , vol.66 , pp. 194-211
    • Nelson, D.1    Werck-Reichhart, D.2
  • 57
    • 84863143888 scopus 로고    scopus 로고
    • Characterization of CYP76M5–8 indicates metabolic plasticity within a plant biosynthetic gene cluster
    • Wang, Q.; Hillwig, M.L.; Okada, K.; Yamazaki, K.; Wu, Y.; Swaminathan, S.; Yamane, H.; Peters, R.J. Characterization of CYP76M5–8 indicates metabolic plasticity within a plant biosynthetic gene cluster. J. Biol. Chem. 2012, 287, 6159–6168. [CrossRef] [PubMed]
    • (2012) J. Biol. Chem. , vol.287 , pp. 6159-6168
    • Wang, Q.1    Hillwig, M.L.2    Okada, K.3    Yamazaki, K.4    Wu, Y.5    Swaminathan, S.6    Yamane, H.7    Peters, R.J.8
  • 58
    • 84924629414 scopus 로고    scopus 로고
    • Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
    • Love, M.I.; Huber, W.; Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014, 15, 550. [CrossRef] [PubMed]
    • (2014) Genome Biol. , vol.15 , pp. 550
    • Love, M.I.1    Huber, W.2    Anders, S.3
  • 59
    • 0037854629 scopus 로고    scopus 로고
    • Exploiting est databases for the development and characterization of gene-derived ssr-markers in barley (Hordeum vulgare L.)
    • Thiel, T.; Michalek, W.; Varshney, R.K.; Graner, A. Exploiting est databases for the development and characterization of gene-derived ssr-markers in barley (Hordeum vulgare L.). Theor. Appl. Genet. Theor. Angew. Genet. 2003, 106, 411–422. [CrossRef] [PubMed]
    • (2003) Theor. Appl. Genet. Theor. Angew. Genet. , vol.106 , pp. 411-422
    • Thiel, T.1    Michalek, W.2    Varshney, R.K.3    Graner, A.4
  • 60
    • 84890330527 scopus 로고    scopus 로고
    • MEGA6: Molecular evolutionary genetics analysis version 6.0
    • Tamura, K.; Stecher, G.; Peterson, D.; Filipski, A.; Kumar, S. MEGA6: Molecular evolutionary genetics analysis version 6.0. Mol. Biol. Evol. 2013, 30, 2725–2729. [CrossRef] [PubMed]
    • (2013) Mol. Biol. Evol. , vol.30 , pp. 2725-2729
    • Tamura, K.1    Stecher, G.2    Peterson, D.3    Filipski, A.4    Kumar, S.5


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