Safety assessment of standardized aqueous Brucea javanica extract in rats

Journal of Ethnopharmacology

Volumn 215, Issue , 2018, Pages 21-26

  Man, Farahdina ^a   Choo, Chee Yan ^a  

^a UNIVERSITI TEKNOLOGI MARA   (Malaysia)

Author keywords

Aqueous extract; Brucea javanica; Hypoglycemia; Seeds; Toxicity

Indexed keywords

ALKALINE PHOSPHATASE; BILIRUBIN; BRUCEA JAVANICA EXTRACT; BRUCEINE D; BRUCEINE E; CREATININE; DEIONIZED WATER; GLIBENCLAMIDE; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; UREA; PLANT EXTRACT;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOGLYCEMIA; LIMIT OF QUANTITATION; MALE; NONHUMAN; PLANT SEED; RAT; RISK ASSESSMENT; STANDARDIZATION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BRUCEA; CHEMISTRY; SPRAGUE DAWLEY RAT; TOXICITY TESTING;

ANIMALS; BRUCEA; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TOXICITY TESTS;

EID: 85039805286     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2017.12.040     Document Type: Article

References (37)

1. Anderson, M.M., O'Neill, M.J., Phillipson, J.D., Warhurst, D.C., In vitro cytotoxicity of a series of quassinoids from Brucea javanica fruits against KB cells. Planta Med. 57 (1991), 62–64.
2. Atsamo, A.D., Nguelefack, T.B., Datté J.Y., Kamanyi, A., Acute and subchronic oral toxicity assessment of the aqueous extract from the stem bark of Erythrina senegalensis DC (Fabaceae) in rodents. J. Ethnopharmacol. 134 (2011), 697–702.
3. Buckley, L.A., Dorato, M.A., High dose selection in general toxicity studies for drug development: a pharmaceutical industry perspective. Regul. Toxicol. Pharmacol. 54 (2009), 301–307.
4. Cassady, J.M., Suffness, M., Terpenoid antitumour agents. Cassady, J.M., Douros, J.D., (eds.) Anticancer Agents Based on Natural Product Molecules, 1980, Academic Press, New York, 201–269.
5. Chen, K.L., Bi, K.S., Han, F., Zhu, H.Y., Zhang, X.S., Mao, X.J., Yin, R., Evaluation of the protective effect of Zhi-Zi-da-Huang decoction on acute liver injury with cholestasis induced by α-naphthylisothiocyanate in rats. J. Ethnopharmacol. 172 (2015), 402–409.
6. Chu, I., Villeneuve, D.C., Yagminas, A., LeCavalier, P., Poon, R., Feeley, M., Kennedy, S.W., Seegal, R.F., Häkansson, H., Ahlborg, U.G., Valli, V.E., Subchronic toxicity of 3,3’,4,4’,5-penta-chlorobiphenyl in the rat. I. Clinical, biochemical, hematological, and histopathological changes. Fundam. Appl. Toxicol. 11 (1994), 457–468.
7. Cuendet, M., Gills, J.J., Pezzuto, J.M., Brusatol-induced HL-60 cell differentiation involves NF-κB activation. Cancer Lett. 206 (2004), 43–50.
8. Ezeja, M.I., Anaga, A.O., Asuzu, I.U., Acute and sub-chronic toxicity pro fi le of methanol leaf extract of Gouania longipetala in rats. J. Ethnopharmacol. 151 (2014), 1155–1164.
9. Fukumiya, N., Okano, M., Miyamoto, M., Antitumour agents 127. Bruceoside C new cytotoxic quassinoid glucoside and related compounds from Brucea javanica. J. Nat. Prod. 55 (1992), 468–475.
10. Giordani, M.A., Collicchio, T.C.M., Donizeti Ascêncio, S.D., de Oliveira Martins, D.T., Balogun, S.O., Bieski, I.G.C., da Silva, L.A., Colodel, E.M., de Souza, R.L., de Souza, D.L.P., de França, S.A., Andrade, C.M.B., Kawashita, N.H., Hydroethanolic extract of the inner stem bark of Cedrela odorata has low toxicity and reduces hyperglycemia induced by an overload of sucrose and glucose. J. Ethnopharmacol. 162 (2015), 352–361.
11. Hall, I.H., Liou, Y.F., Lee, K.H., Chaney, S., Willingham, J.W., Antitumour agents LIX: effects of quassinoids on protein synthesis of a number of murine tumours and normal cells. J. Pharm. Sci. 72 (1983), 626–630.
12. ICH, 2005. International Conference on Harmonisation (ICH) Harmonised Tripartite Guideline: Validation of Analytical Procedures: Text And Methodology Q2(R1).
13. Jahn, A.I., Günzel, P.K.H., The value of spermatology in male reproductive toxicology: do spermatologic examinations in fertility studies provide new and additional information relevant for safety assessment?. Reprod. Toxicol. 11 (1997), 171–178.
14. Kamperdick, C., Sung, T.V., Thuy, T.T., Tri, M.V., Adam, G., (20R)-O-(3)-α-L-arabinopyranosylpregn-5-ene-3β,20-diol from Brucea javanica. Phytochemistry 38 (1995), 699–701.
15. Kim, L.H., Suzuki, R., Hitotsuyanagi, Y., Takeya, K., Three novel quassinoids, javanicolides A and B and javanicoside A, from seeds of Brucea javanica. Tetrahedron 59 (2003), 9985–9989.
16. Kociba, R.J., Keeler, P.A., Park, C.N., Gehring, P.J., 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): results of a 13-week oral toxicity study in rats. Toxicol. Appl. Pharmacol. 35 (1976), 553–574.
17. Liou, Y.F., Hall, I.H., Okano, M., Lee, K.H., Chaney, S.G., Antitumor agents XLVIII: structure-activity relationships of quassinoids as in vitro protein synthesis inhibitors of P-388 lymphocytic leukemia tumor cell metabolism. J. Pharm. Sci. 71 (1982), 430–435.
18. Mukinda, J.T., Eagles, F.K., Acute and sub-chronic oral toxicity profile of the aqueous extract of Pohygala fruticosa in female mice and rats. J. Ethnopharmacol. 128 (2010), 236–240.
19. Murakami, C., Fukamiya, N., Tamura, S., Okano, M., Bastow, K.F., Tokuda, H., Mukainaka, T., Nishino, H., Lee, K.-H., Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids. Bioorg. Med. Chem. 12 (2004), 4963–4968.
20. NoorShahida, A., Wong, T.W., Choo, C.Y., Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr. (Simaroubaceae) seeds. J. Ethnopharmacol. 124 (2009), 586–591.
21. NoorShahida, A., Choo, C.Y., Wong, T.W., Acute/subacute oral toxicity of Brucea javanica seeds with hypoglycemic activity. J. Nat. Rem. 11 (2011), 60–68.
22. O'Neill, M.J., Bray, D.H., Boardman, P., Chan, K.L., Phillipson, J.D., Warhurst, D.C., Peters, W., Plants as sources of antimalarial drugs, Part 4: activity of Brucea javanica fruits against chloroquine-resistant Plasmodium falciparum in vitro and against Plasmodium berghei in vivo. J. Nat. Prod. 50 (1987), 41–48.
23. O'Neill, M.J., Bray, D.H., Boardman, P., Phillipson, J.D., Warhurst, D.C., Peters, W., Suffness, M., Plants as sources of antimalarial drugs: In vitro antimalarial activities of some quassinoids. Antimicrob. Agents Chemother. 30 (1986), 101–104.
24. OECD, 2001. Organisation for Economic Co-operation and Development (OECD) Guidelines for Testing of Chemicals: Acute Oral Toxicity (423).
25. OECD, 2008. Organisation for Economic Co-operation and Development (OECD) Guidelines for Testing of Chemicals: Repeated Dose Oral Toxicity Study in Rodents (407).
26. Okano, M., Fukamiya, N., Tagahara, K., Cosentino, M., Lee, T.-Y., Morris, S.-N., Lee, K.-H., Anti-HIV activity of quassinoids. Bioorg. Med. Chem. Lett. 6 (1996), 701–706.
27. Okano, M., Fukamiya, N., Tagahara, K., Tokuda, H., Iwashima, A., Nishino, H., Lee, K.-H., Inhibitory effects of quassinoids on Epstein-Barr-virus activation. Cancer Lett. 94 (1995), 139–149.
28. Olson, H., Betton, G., Robinson, D., Thomas, K., Monro, A., Kolaja, G., Lilly, P., Sanders, J., Sipes, G., Bracken, W., Dorato, M., Van Deun, K., Smith, P., Berger, B., Heller, A., Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharmacol. 32 (2000), 56–67.
29. Ozer, J., Ratweb, M., Shawc, M., Baileya, W., Schomaker, S., The current state of serum biomarker of hepatoxicity. Toxicity 245 (2008), 194–205.
30. Polonsky, J., Varenne, J., Prange, T., Pascard, C., Antileukaemic quassinoids: structure (X-ray analysis) of bruceine C and revised structure of bruceantinol. Tetrahedron Lett. 21 (1980), 1853–1856.
31. Su, B.-N., Chang, L.C., Park, E.J., Cuendet, M., Santarsiero, B.D., Mesecar, A.D., Mehta, R.G., Fong, H.S., Pezzuto, J.M., Kinghorn, A.D., Bioactive Constituents of the Seeds of Brucea javanica. Planta Med. 68 (2002), 730–733.
32. Tang, W., Eisandbrand, G., Chemistry, Pharmacology and Use in Traditional Modern Medicine: Brucea javanica (L.) Merr. 1992, Springer-Verlag Publisher, USA, 207–222.
33. Turpaev, K., Welsh, N., Brusatol inhibits the response of cultured beta-cells to pro-inflammatory cytokines in vitro. Biochem. Biophys. Res. Commun. 460 (2015), 868–872.
34. Weingand, K., Brown, G., Hall, R., Davies, D., Gossett, K., Neptun, D., Waner, T., Matsuzawa, T., Salemink, P., Froelke, W., Provost, J.P., Negro, G.D., Batchelor, J., Nomura, M., Groetsch, H., Boink, A., Kimball, J., Woodman, D., York, M., Johnson, E.F., Lupart, M., Melloni, E., Harmonization of animal clinical pathology testing in toxicity and safety studies. Fundam. Appl. Toxicol. 29 (1996), 198–201.
35. Wright, C.W., O'Neill, M.J., Phillipson, J.D., Warhurst, D.C., Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem and a number of quassinoids. Antimicrob. Agents Chemother. 32 (1988), 1725–1729.
36. Ye, Q.M., Bai, L.L., Hu, S.Z., Tian, H.Y., Ruan, L.J., Tan, Y.F., Hu, L.P., Ye, W.C., Zhang, D.M., Jian, R.W., Isolation, chemotaxonomic significance and cytotoxic effects of quassinoids from Brucea javanica. Fitoterapia 105 (2015), 66–72.
37. Zhao, L., Wen, Q., Yang, G., Huang, Z., Shen, T., Li, H., Ren, D., Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway. Phytomedicine 23 (2016), 114–122.