The value of spermatology in male reproductive toxicology: Do spermatologic examinations in fertility studies provide new and additional information relevant for safety assessment?

Reproductive Toxicology

Volumn 11, Issue 2-3, 1997, Pages 171-178

  Jahn, A I ^a   Gunzel, P K H ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISPERMATOGENIC AGENT; XENOBIOTIC AGENT;

ANIMAL; DIAGNOSTIC VALUE; DRUG EFFECT; FERTILITY; FUNCTIONAL ASSESSMENT; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NOTE; ORGAN WEIGHT; PATHOLOGY; PRACTICE GUIDELINE; RAT; REPRODUCTIVE TOXICITY; RISK ASSESSMENT; SEMEN ANALYSIS; SPERMATOGENESIS; TESTIS; TOXICITY TESTING;

ANIMALIA;

EID: 0031105941     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(97)00003-8     Document Type: Editorial

References (34)

1. A Giwercman Declining semen quality and increasing incidence of abnormalities in male reproductive organs—fact or fiction? Hum Reprod 10 Suppl 1 1995 158 164
2. H Fisch ET Goluboff JH Olson F Feldshuh SJ Broder DH Barad Semen analysis in 1,283 men from the United States over a 25-year period: no decline in quality Fertil Steril 65 1996 1009 1014
3. CA Paulsen NG Berman C Wang Data from men in greater Seattle area reveals no downward trend in semen quality: further evidence that deterioration of semen quality is not geographically uniform Fertil Steril 65 1996 1015 1020
4. Commission of the European Communities, III/3387/93 Final, CPMP note for guidance; detection of toxicity to reproduction for medicinal products [guideline prepared within the International Conference on Harmonisation (ICH) process].
5. B Ulbrich AK Palmer Detection of effects on male reproduction—a literature survey J Am Coll Toxicol 14 1995 293 327
6. S Takayama M Akaike K Kawashima M Takahashi Y Kurokawa A collaborative study in Japan on optimal treatment period and parameters for detection of male fertility disorders induced by drugs in rats J Am Coll Toxicol 14 1995 266 292
7. T Kamataki Testicular toxicity J Toxicol Sci. 1995 20
8. Detection of toxicity to reproduction for medicinal products guideline prepared within the International Conference on Harmonisation (ICH) process March 1996 Addendum: S5B: toxicity to male fertility
9. OECD guideline for testing of chemicals 415; one-generation reproduction toxicity study 26 May 1983
10. OECD guideline for testing of chemicals 416; two-generation reproduction toxicity study 26 May 1983
11. OECD guideline for testing of chemicals 421; reproduction/ developmental toxicity screening test 27 July 1995
12. OECD guideline for testing of chemicals 422; combined repeated dose toxicity study with the reproduction/developmental toxicity screening test 22 March 1996
13. Environmental Protection Agency, pesticide assessment guidelines subdivision F, hazard evaluation: human and domestic animals, revised edition of November 1984; Section 83-4: reproduction and fertility effects.
14. Environmental Protection Agency health effects test guidelines OPPTS 870.3800, reproduction and fertility effects, public draft 6 October 1995 published February 1996
15. OECD draft guidelines for the testing of chemicals 416; twogeneration reproduction toxicity study, draft April 1996
16. H Zenick ED Clegg SD Perreault GR Klinefelter LE Gray Assessment of male reproductive toxicity. A risk assessment approach AW Hayes Principles and methods of toxicology 3rd ed. 1994 Raven Press New York 937 988
17. LD Russell RA Ettlin AP Sinha Hikim ED Clegg Histological and histopathological evaluation of the testis 1990 Cache River Press Clearwater
18. BP Setchell Male reproductive organs and semen HH Cole PT Cupps Reproduction in domestic animals 3rd ed. 1977 Academic Press New York 229 256
19. BP Setchell DE Brooks Anatomy, vasculature, innervation, and fluids of the male reproductive tract 2nd ed. E Knobil JD Neill The physiology of reproduction vol. 1 1988 Raven Press New York 753 836
20. Leidl W. co-workers. Vorlesungs- und Kursunterlagen für Studenten der Veterinärmedizin; Lehrstuhl für Physiologie und Pathologie der Fortpflanzung, insbesondere Andrologie und künstliche Besamung. Tiermedizinische Fakultät der LMU München.
21. H Hildebrandt Pschyrembel, Klinisches Wötterbuch 1994 Walter de Gruyter Berlin 1438 1439
22. F Vogel W Bee U Zühlke R Korte Investigation of fertility and maturity in the male cynomolgus monkey ( Macaca fascicularis ) Lecture during the Annual Meeting of the Society of Toxicology Baltimore 1995
23. RP Amann A critical review of methods for evaluation of spermatogenesis from seminal characteristics J Androl 2 1981 37 58
24. WF Blazak TL Ernst BE Stewart Potential indicators of reproductive toxicity: testicular sperm production and epididymal sperm number, transit time, and motility in Fischer 344 rats Fundam Appl Toxicol. 5 1985 1097
25. U Kvist Clinical assessment of toxic effects on male reproduction Lecture during the Eurotox '93, Continuing Education Course: Male reproductive toxicology Uppsala 1993
26. D Newall Male fertility evaluation. What should be required and when should it be conducted? Lecture during the IBC UK Conference: ICH Guidelines on reprotoxicity and toxicokinetics London 1996
27. Re Linder Lf Strader Vl Slott Jd Suarez Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants Reprod Toxicol 6 1992 491 505
28. Male reproductive toxicology 2nd ed. RE Chapin JJ Heindel Methods in toxicology vol. 3A 1993 Academic Press San Diego
29. J Seed Re Chapin Ed Clegg Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report Reprod Toxicol 10 1996 237 244
30. DS Irvine Computer assisted semen analysis systems: sperm motility assessment Hum Reprod 10 Suppl 1 1995 53 59
31. VL Slott JD Suarez SD Perreault Rat sperm motility analysis: methodologic considerations Reprod Toxicol 5 1991 449 458
32. VR Burruel R Yanagimachi WK Whitten Normal mice develop from oocytes injected with spermatozoa with grossly misshapen heads Biol Reprod 55 1996 709 714
33. JL Yovich PL Matson Male subfertility: concepts in 1995 Hum Reprod. 10 Suppl 1 1995 3 9
34. J Woods DA Garside An in vivo and in vitro investigation into the effects of α-chlorohydrin on sperm motility and correlation with fertility in the HAN Wistar rat Reprod Toxicol 10 1996 199 207