Tissue protein imaging at 1 µm laser spot diameter for high spatial resolution and high imaging speed using transmission geometry MALDI TOF MS

Analytical and Bioanalytical Chemistry

Volumn 407, Issue 8, 2015, Pages 2337-2342

  Zavalin, Andre ^a   Yang, Junhai ^a   Hayden, Kevin ^b   Vestal, Marvin ^b   Caprioli, Richard M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SimulTOF Systems   (United States)

Author keywords

High spatial resolution; MALDI; MS imaging; Protein imaging; Transmission geometry

Indexed keywords

PROTEIN;

ANIMAL; CEREBELLUM; CHEMISTRY; EVALUATION STUDY; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; MOLECULAR IMAGING; MOUSE; PROCEDURES; TANDEM MASS SPECTROMETRY;

ANIMALS; CEREBELLUM; MICE; MOLECULAR IMAGING; PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 85039706375     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-015-8532-6     Document Type: Note

References (20)

1. Caprioli RM, Farmer TB, Gile J (1997) Molecular imaging of biological samples: localization of peptides and proteins using MALDITOF MS. Anal Chem 69(23):4751-4760
2. Fenner NC, Daly NR (1966) Laser used for mass analysis. Rev Sci Instrum 37(8):1068-1070. doi:10.1063/1.1720410
3. Hillenkamp F, Unsöld E, Kaufmann R, Nitsche R (1975) A highsensitivity laser microprobe mass analyzer. Appl Phys 8(4):341-348. doi:10.1007/BF00898368
4. Vogt H, Heinen HJ, Meier S, Wechsung R (1981) LAMMA 500 principle and technical description of the instrument. Z Anal Chem 308(3):195-200. doi:10.1007/BF00479623
5. Dingle T, Griffiths BW, Ruckman JC (1981) LIMA-a laser induced ion mass analyser. Vacuum 31(10-12):571-577. doi:10.1016/0042-207X(81)90069-5
6. Van Vaeck L, Struyf H, Van Roy W, Adams F (1994) Organic and inorganic analysis with laser microprobe mass spectrometry. Part I:Instrumentation and methodology. Mass Spectrom Rev 13(3):189-208. doi:10.1002/mas.1280130302
7. Zavalin A, Todd EM, Rawhouser PD, Yang JH, Norris JL, Caprioli RM (2012) Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS. J Mass Spectrom 47(11):1473-1481. doi:10.1002/Jms.3108
8. Thiery-Lavenant G, Zavalin AI, Caprioli RM (2013) Targeted multiplex imaging mass spectrometry in transmission geometry for subcellular spatial resolution. J Am Soc Mass Spectrom 24(4):609-614. doi:10.1007/s13361-012-0563-z
9. Spraggins JM, Caprioli R (2011) High-speed MALDI-TOF imaging mass spectrometry: rapid ion image acquisition and considerations for next generation instrumentation. J Am SocMass Spectrom 22(6):1022-1031. doi:10.1007/s13361-011-0121-0
10. SimulTOF 200 Combo | SimulTOF Systems. http://www.simultof. com/content/simultof-200-combo.
11. Ritzau S, Hayden K, Vestal M (2012) Improved MALDI-TOF performance with practical implementation of very high post-acceleration. In: 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada
12. Trim P, Djidja M-C, Atkinson S, Oakes K, Cole L, Anderson DG, Hart P, Francese S, Clench M (2010) Introduction of a 20 kHz Nd:YVO4 laser into a hybrid quadrupole time-of-flight mass spectrometer for MALDI-MS imaging. Anal Bioanal Chem 397(8):3409-3419. doi:10.1007/s00216-010-3874-6
13. Zavalin A, Yang J, Caprioli R (2013) Laser beam filtration for high spatial resolution MALDI imaging mass spectrometry. J Am Soc Mass Spectrom 24(7):1153-1156. doi:10.1007/s13361-013-0638-5
14. Fernández-Pradas JM, Colina M, Serra P,Domı J,Morenza JL (2004) Laser-induced forward transfer of biomolecules. Thin Solid Films 453-454:27-30. doi:10.1016/j.tsf.2003.11.154
15. Yang J, Zavalin A, Caprioli R (2014) Highly robust sample preparation with 2,5-dihydroxyacetophenone for MALDI imaging of proteins (2 -70 kDa) at high spatial resolution (5 µm). In: 62th ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore,MD
16. Wenzel T, Sparbier K, Mieruch T, Kostrzewa M (2006) 2,5-Dihydroxyacetophenone: a matrix for highly sensitive matrixassisted laser desorption/ionization time-of-flight mass spectrometric analysis of proteins using manual and automated preparation techniques. Rapid Commun Mass Spectrom 20(5):785-789. doi:10.1002/ rcm.2378
17. Anderson DM, Ablonczy Z, Koutalos Y, Spraggins J, Crouch RK, Caprioli RM, Schey KL (2014) High resolution MALDI imaging mass spectrometry of retinal tissue lipids. J Am Soc Mass Spectrom 25(8):1394-1403. doi: 10.1007/s13361-014-0883-2
18. Prophet EB, Armed Forces Institute of Pathology et al (1992) Laboratory methods in histotechnology. American Registry of Pathology, Washington
19. Burnum KE, Tranguch S, Mi D, Daikoku T, Dey SK, Caprioli RM (2008) Imaging mass spectrometry reveals unique protein profiles during embryo implantation. Endocrinology 149(7):3274-3278. doi:10.1210/en.2008-0309
20. Crecelius AC, Cornett DS, Caprioli RM, Williams B, Dawant BM, Bodenheimer B (2005) Three-dimensional visualization of protein expression in mouse brain structures using imaging mass spectrometry. J Am Soc Mass Spectrom 16(7):1093-1099. doi:10.1016/j. jasms.2005.02.026