High-speed MALDI-TOF imaging mass spectrometry: Rapid ion image acquisition and considerations for next generation instrumentation

Journal of the American Society for Mass Spectrometry

Volumn 22, Issue 6, 2011, Pages 1022-1031

  Spraggins, Jeffrey M ^a   Caprioli, Richard M ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Continuous laser raster; Imaging; Lipids; MALDI; Mass spectrometry; Microprobe; TOF

Indexed keywords

CONTINUOUS LASERS; IMAGING; MALDI; MICRO-PROBES; TOF;

DESORPTION; IMAGE ACQUISITION; INSTRUMENTS; IONS; PULSE REPETITION RATE; SECONDARY ION MASS SPECTROMETRY; SOLID STATE LASERS; SPECTROMETRY; TISSUE;

YLF LASERS;

LIPID;

ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; FLOW RATE; HIGH THROUGHPUT SCREENING; IMAGE ACQUISITION; IMAGE ANALYSIS; LASER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR IMAGING; NONHUMAN; RAT; SIGNAL TRANSDUCTION;

ANGIOTENSIN II; ANIMALS; BRAIN CHEMISTRY; IMAGE PROCESSING, COMPUTER-ASSISTED; LASERS; LIPIDS; RATS; SIGNAL PROCESSING, COMPUTER-ASSISTED; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

RATTUS;

EID: 79955806756     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-011-0121-0     Document Type: Article

References (26)

1. RM Caprioli TB Farmer J Gile 1997 Molecular Imaging of Biological Samples: Localization of Peptides and Proteins using MALDI-TOF MS Anal. Chem. 69 4751 4760 10.1021/ac970888i 1:CAS:528:DyaK2sXntVagtLc%3D
2. ER Amstalden van Hove DF Smith RMA Heeren 2010 A Concise Review of Mass Spectrometry Imaging J. Chromatogr. A 1217 3946 3954 10.1016/j.chroma.2010.01. 033 1:CAS:528:DC%2BC3cXmvVWjtbc%3D
3. LA McDonnell GL Corthals SM Willems A van Remoortere RJM van Zeijl AM Deelder 2010 Peptide and Protein Imaging Mass Spectrometry in Cancer Research Journal of Proteomics 73 1921 1944 10.1016/j.jprot.2010.05.007 1:CAS:528:DC%2BC3cXhtFGjtr%2FK
4. A Svatos 2010 Mass Spectrometric Imaging of Small Molecules Trends Biotechnol. 28 425 434 10.1016/j.tibtech.2010.05.005 1:CAS:528: DC%2BC3cXptVags74%3D
5. DS Cornett ML Reyzer P Chaurand RM Caprioli 2007 MALDI Imaging Mass Spectrometry: Molecular Snapshots of Biochemical Systems Nat. Methods 4 828 833 10.1038/nmeth1094 1:CAS:528:DC%2BD2sXhtV2mtr7F (Pubitemid 350055580)
6. LA McDonnell RMA Heeren 2007 Imaging Mass Spectrometry Mass Spectrom. Rev. 26 606 643 10.1002/mas.20124 1:CAS:528:DC%2BD2sXot1KltLk%3D (Pubitemid 47169781)
7. S Guenther M Koestler O Schulz B Spengler 2010 Laser Spot Size and Laser Power Dependence of Ion Formation in High Resolution MALDI Imaging Int. J. Mass Spectrom. 294 7 15 10.1016/j.ijms.2010.03.014 1:CAS:528:DC%2BC3cXntlCqsLo%3D
8. JH Jun Z Song Z Liu BJ Nikolau ES Yeung YJ Lee 2010 High-Spatial and High-Mass Resolution Imaging of Surface Metabolites of Arabidopsis Thaliana by Laser Desorption-Ionization Mass Spectrometry using Colloidal Silver Anal. Chem. 82 3255 3265 10.1021/ac902990p 1:CAS:528:DC%2BC3cXjtlajsbw%3D
9. P Chaurand KE Schriver RM Caprioli 2007 Instrument Design and Characterization for High Resolution MALDI-MS Imaging of Tissue Sections J. Mass Spectrom. 42 476 489 10.1002/jms.1180 1:CAS:528:DC%2BD2sXkvVehtr8%3D (Pubitemid 46649084)
10. ML Reyzer P Chaurand PM Angel RM Caprioli 2010 Direct Molecular Analysis of Whole-Body Animal Tissue Sections by MALDI Imaging Mass Spectrometry Methods Mol. Biol. 656 285 301 10.1007/978-1-60761-746-4-17 1:CAS:528:DC%2BC3cXhtFKqsLnO
11. EG Solon A Schweitzer M Stoeckli B Prideaux 2010 Autoradiography, MALDI-MS, and SIMS-MS Imaging in Pharmaceutical Discovery and Development AAPS J. 12 11 26 10.1208/s12248-009-9158-4 1:CAS:528:DC%2BC3cXisVGrtr0%3D
12. PJ Trim CM Henson JL Avery A McEwen MF Snel E Claude PS Marshall A West AP Princivalle MR Clench 2008 Matrix-Assisted Laser Desorption/Ionization-Ion Mobility Separation-Mass Spectrometry Imaging of Vinblastine in Whole Body Tissue Sections Anal. Chem. 80 8628 8634 10.1021/ac8015467 1:CAS:528: DC%2BD1cXht1ehsb%2FL
13. M Stoeckli D Staab A Schweitzer J Gardiner D Seebach 2007 Imaging of a Î2-Peptide Distribution in Whole-Body Mice Sections by MALDI Mass Spectrometry J. Am. Soc. Mass Spectrom. 18 1921 1924 10.1016/j.jasms.2007.08.005 1:CAS:528:DC%2BD2sXht1Orur%2FJ (Pubitemid 350011150)
14. M Djidja E Claude MF Snel S Francese P Scriven V Carolan MR Clench 2010 Novel Molecular Tumor Classification using MALDI-Mass Spectrometry Imaging of Tissue Micro-Array Anal. Bioanal. Chem. 397 587 601 10.1007/s00216-010-3554-6 1:CAS:528:DC%2BC3cXislOmtrY%3D
15. Y Morita K Ikegami N Goto-Inoue T Hayasaka N Zaima H Tanaka T Uehara T Setoguchi T Sakaguchi H Igarashi H Sugimura M Setou H Konno 2010 Imaging Mass Spectrometry of Gastric Carcinoma in Formalin-Fixed Paraffin-Embedded Tissue Microarray Cancer Sci. 101 267 273 10.1111/j.1349-7006.2009.01384.x 1:CAS:528:DC%2BC3cXnvVOiuw%3D%3D
16. MR Groseclose PP Massion P Chaurand RM Caprioli 2008 High-Throughput Proteomic Analysis of Formalin-Fixed Paraffin-Embedded Tissue Microarrays using MALDI Imaging Mass Spectrometry Proteomics. 8 3715 3724 10.1002/pmic.200800495 1:CAS:528:DC%2BD1cXht1Sgu7%2FI
17. M Karas F Hillenkamp 1988 Laser Desorption Ionization of Proteins with Molecular Masses Exceeding 10,000 Daltons Anal. Chem. 60 2299 2301 10.1021/ac00171a028 1:CAS:528:DyaL1cXlsVGmu7g%3D
18. A Holle A Haase M Kayser J Hoehndorf 2006 Optimizing UV Laser Focus Profiles for Improved MALDI Performance J. Mass Spectrom. 41 705 716 10.1002/jms.1041 1:CAS:528:DC%2BD28XntVCnu74%3D (Pubitemid 44023098)
19. PJ Trim M Djidja SJ Atkinson K Oakes LM Cole DMG Anderson PJ Hart S Francese MR Clench 2010 Introduction of a 20 kHz Nd:YVO4 Laser into a Hybrid Quadrupole Time-of-Flight Mass Spectrometer for MALDI-MS Imaging Anal. Bioanal. Chem. 397 3409 3419 10.1007/s00216-010-3874-6 1:CAS:528:DC%2BC3cXovVGntLo%3D
20. Simmons, D. A. Improved MALDI-MS Imaging Performance using Continuous Laser Rastering. Applied Biosystems Technical Note. 2008.
21. JA Hankin RM Barkley RC Murphy 2007 Sublimation as a Method of Matrix Application for Mass Spectrometric Imaging J. Am. Soc. Mass Spectrom. 18 1646 1652 10.1016/j.jasms.2007.06.010 1:CAS:528:DC%2BD2sXps1Gksr8%3D (Pubitemid 47302327)
22. ML Vestal 2009 Modern MALDI Time-of-Flight Mass Spectrometry J. Mass Spectrom. 44 303 317 10.1002/jms.1537 1:CAS:528:DC%2BD1MXktVSqsbg%3D
23. M Vestal K Hayden 2007 High Performance MALDI-TOF Mass Spectrometry for Proteomics Int. J. Mass Spectrom. 268 83 92 10.1016/j.ijms.2007.06.021 1:CAS:528:DC%2BD2sXht1ymsr3O
24. Vestal, M. L.; Hayden, K. M. High-Performance MALDI-TOF Mass Spectrometry. Proceedings of the ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, USA, June (2007)
25. SN Jackson HJ Wang AS Woods 2005 In Situ Structural Characterization of Phosphatidylcholines in Brain Tissue using MALDI-MS/MS J. Am. Soc. Mass Spectrom. 16 2052 2056 10.1016/j.jasms.2005.08.014 1:CAS:528:DC%2BD2MXht1CmsbrO (Pubitemid 41642968)
26. JA Hankin RC Murphy 2010 Relationship between MALDI IMS Intensity and Measured Quantity of Selected Phospholipids in Rat Brain Sections Anal. Chem. 82 8476 8484 10.1021/ac101079v 1:CAS:528:DC%2BC3cXhtFygsb3M