Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus

PLoS Pathogens

Volumn 10, Issue 5, 2014, Pages

  Lundin, Anna ^a   Dijkman, Ronald ^b,c   Bergström, Tomas ^a   Kann, Nina ^d   Adamiak, Beata ^a,i   Hannoun, Charles ^a   Kindler, Eveline ^b,c   Jónsdóttir, Hulda R ^b,c   Muth, Doreen ^e   Kint, Joeri ^f,g   Forlenza, Maria ^f   Müller, Marcel A ^e   Drosten, Christian ^e   Thiel, Volker ^b,c,h   Trybala, Edward ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^c INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (Switzerland)

^d CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^e UNIVERSITY OF BONN   (Germany)

^f WAGENINGEN UNIVERSITY   (Netherlands)

^g Merck Animal Health Bioprocess Technology and Support   (Netherlands)

^h UNIVERSITY OF BERN   (Switzerland)

ⁱ INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; AUTOPHAGY; CELL CYCLE; CELL PROLIFERATION ASSAY; CELL VIABILITY; CONTROLLED STUDY; CORONAVIRUS; CYTOTOXICITY; ELECTRON MICROSCOPY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; RESPIRATORY DISTRESS SYNDROME; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SYNTHESIS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; VIRUS REPLICATION; ANIMAL; CELL LINE; CELL MEMBRANE; CORONAVIRUS INFECTIONS; DRUG EFFECTS; GENETICS; HUMAN RESPIRATORY SYNCYTIAL VIRUS; METABOLISM; VIROLOGY; VIRUS ENTRY;

ANTIVIRUS AGENT; VIRUS RNA;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CELL MEMBRANE; CORONAVIRUS; CORONAVIRUS INFECTIONS; HUMANS; RESPIRATORY SYNCYTIAL VIRUSES; RNA, VIRAL; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 84901649016     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004166     Document Type: Article

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