The putative tumor suppressor microrna-30a-5p modulates clear cell renal cell carcinoma aggressiveness through repression of zeb2

Cell Death and Disease

Volumn 8, Issue 6, 2017, Pages

  Chen, Zhenhua ^a   Zhang, Jiaxing ^a   Zhang, Zhiling ^b   Feng, Zihao ^a   Wei, Jinhuan ^a   Lu, Jun ^a   Fang, Yong ^a   Liang, Yanping ^a   Cen, Junjie ^a   Pan, Yihui ^a   Huang, Yong ^a   Zhou, Fangjian ^b   Chen, Wei ^a   Luo, Junhang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DLEU2 PROTEIN, HUMAN; LONG UNTRANSLATED RNA; MICRORNA; MIRN30 MICRORNA, HUMAN; TUMOR SUPPRESSOR PROTEIN; ZEB2 PROTEIN, HUMAN; ZINC FINGER E BOX BINDING HOMEOBOX 2;

3' UNTRANSLATED REGION; ANIMAL; BINDING SITE; CANCER TRANSPLANTATION; CELL PROLIFERATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KIDNEY TUMOR; METABOLISM; MORTALITY; MOUSE; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PATHOLOGY; RENAL CELL CARCINOMA; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TUMOR CELL LINE; TUMOR INVASION;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BINDING SITES; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KIDNEY NEOPLASMS; MICE; MICE, NUDE; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; RNA, LONG NONCODING; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEINS; ZINC FINGER E-BOX BINDING HOMEOBOX 2;

EID: 85039069555     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2017.252     Document Type: Article

References (45)

1. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004; 5: 522–531.
2. Kato M, Slack FJ. microRNAs: small molecules with big roles-C. elegans to human cancer. Biol Cell 2008; 100: 71–81.
3. Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 2006; 20: 515–524.
4. Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006; 11: 441–450.
5. Ventura A, Jacks T. MicroRNAs and cancer: short RNAs go a long way. Cell 2009; 136: 586–591.
6. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857–866.
7. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016; 66: 7–30.
8. Yan BC, Mackinnon AC, Al-Ahmadie HA. Recent developments in the pathology of renal tumors: morphology and molecular characteristics of select entities. Arch Pathol Lab Med 2009; 133: 1026–1032.
9. Linehan WM. Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics. Genome Res 2012; 22: 2089–2100.
10. Nakada C, Matsuura K, Tsukamoto Y, Tanigawa M, Yoshimoto T, Narimatsu T et al. Genome-wide microRNA expression profiling in renal cell carcinoma: significant down-regulation of miR-141 and miR-200c. J Pathol 2008; 216: 418–427.
11. Juan D, Alexe G, Antes T, Liu H, Madabhushi A, Delisi C et al. Identification of a microRNA panel for clear-cell kidney cancer. Urology 2010; 75: 835–841.
12. Weng L, Wu X, Gao H, Mu B, Li X, Wang JH et al. MicroRNA profiling of clear cell renal cell carcinoma by whole-genome small RNA deep sequencing of paired frozen and formalin-fixed, paraffin-embedded tissue specimens. J Pathol 2010; 222: 41–51.
13. White NM, Khella HW, Grigull J, Adzovic S, Youssef YM, Honey RJ et al. miRNA profiling in metastatic renal cell carcinoma reveals a tumour-suppressor effect for miR-215. Br J Cancer 2011; 105: 1741–1749.
14. Yoshino H, Enokida H, Itesako T, Tatarano S, Kinoshita T, Fuse M et al. Epithelial-mesenchymal transition-related microRNA-200 s regulate molecular targets and pathways in renal cell carcinoma. J Hum Genet 2013; 58: 508–516.
15. Saini S, Yamamura S, Majid S, Shahryari V, Hirata H, Tanaka Y et al. MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells. Cancer Res 2011; 71: 6208–6219.
16. Majid S, Saini S, Dar AA, Hirata H, Shahryari V, Tanaka Y et al. MicroRNA-205 inhibits Src-mediated oncogenic pathways in renal cancer. Cancer Res 2011; 71: 2611–2621.
17. Mikhaylova O, Stratton Y, Hall D, Kellner E, Ehmer B, Drew AF et al. VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. Cancer Cell 2012; 21: 532–546.
18. Tsukigi M, Bilim V, Yuuki K, Ugolkov A, Naito S, Nagaoka A et al. Re-expression of miR-199a suppresses renal cancer cell proliferation and survival by targeting GSK-3beta. Cancer Lett 2012; 315: 189–197.
19. Chen X, Wang X, Ruan A, Han W, Zhao Y, Lu X et al. miR-141 is a key regulator of renal cell carcinoma proliferation and metastasis by controlling EphA2 expression. Clin Cancer Res 2014; 20: 2617–2630.
20. buting to clear cell renal cell carcinoma aggressive behaviour by targeting CAV1 and FLOT1. Oncotarget 2015; 6: 12543–12557.
21. Baraniskin A, Birkenkamp-Demtroder K, Maghnouj A, Zollner H, Munding J, Klein-Scory S et al. MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL. Carcinogenesis 2012; 33: 732–739.
22. Franzetti GA, Laud-Duval K, Bellanger D, Stern MH, Sastre-Garau X, Delattre O. MiR-30a-5p connects EWS-FLI1 and CD99, two major therapeutic targets in Ewing tumor. Oncogene 2013; 32: 3915–3921.
23. Li WF, Dai H, Ou Q, Zuo GQ, Liu CA. Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway. Tumour Biol 2016; 37: 5885–5895.
24. Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 2001; 7: 1267–1278.
25. Bindels S, Mestdagt M, Vandewalle C, Jacobs N, Volders L, Noel A et al. Regulation of vimentin by SIP1 in human epithelial breast tumor cells. Oncogene 2006; 25: 4975–4985.
26. Fang Y, Wei J, Cao J, Zhao H, Liao B, Qiu S et al. Protein expression of ZEB2 in renal cell carcinoma and its prognostic significance in patient survival. PLoS ONE 2013; 8: e62558.
27. Du Y, Kong G, You X, Zhang S, Zhang T, Gao Y et al. Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem 2012; 287: 26302–26311.
28. Xiao H, Tang K, Liu P, Chen K, Hu J, Zeng J et al. LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200 s in clear cell kidney carcinoma. Oncotarget 2015; 6: 38005–38015.
29. Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M et al. Along noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell 2011; 147: 358–369.
30. Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L et al. The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell 2013; 52: 101–112.
31. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D et al. MicroRNA expression profiles classify human cancers. Nature 2005; 435: 834–838.
32. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006; 103: 2257–2261.
33. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442–454.
34. Kang Y, Massague J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 2004; 118: 277–279.
35. Rosivatz E, Becker I, Specht K, Fricke E, Luber B, Busch R et al. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol 2002; 161: 1881–1891.
36. Miyoshi A, Kitajima Y, Sumi K, Sato K, Hagiwara A, Koga Y et al. Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer 2004; 90: 1265–1273.
37. Elloul S, Elstrand MB, Nesland JM, Trope CG, Kvalheim G, Goldberg I et al. Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Cancer 2005; 103: 1631–1643.
38. Maeda G, Chiba T, Okazaki M, Satoh T, Taya Y, Aoba T et al. Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression. Int J Oncol 2005; 27: 1535–1541.
39. Klein U, Lia M, Crespo M, Siegel R, Shen Q, Mo T et al. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 2010; 17: 28–40.
40. Hsu SD, Chu CH, Tsou AP, Chen SJ, Chen HC, Hsu PW et al. miRNAMap 2.0: genomic maps of microRNAs in metazoan genomes. Nucleic Acids Res 2008; 36(Database issue): D165–D169.
41. Dweep H, Gretz N. miRWalk2.0: a comprehensive atlas of microRNA-target interactions. Nat Methods 2015; 12: 697.
42. Betel D, Wilson M, Gabow A, Marks DS, Sander C. The microRNA.org resource: targets and expression. Nucleic Acids Res 2008; 36(Database issue): D149–D153.
43. Li JH, Liu S, Zhou H, Qu LH, Yang JH. starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res 2014; 42(Database issue): D92–D97.
44. Li J, Han L, Roebuck P, Diao L, Liu L, Yuan Y et al. TANRIC: an interactive open platform to explore the function of lncRNAs in Cancer. Cancer Res 2015; 75: 3728–3737.
45. Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 2004; 10: 7252–7259.