Preclinical modeling of myelodysplastic syndromes

Leukemia

Volumn 31, Issue 12, 2017, Pages 2702-2708

  Rouault Pierre, K ^a   Mian, S A ^a,b   Goulard, M ^c   Abarrategi, A ^a   Di Tulio, A ^a   Smith, A E ^b,d   Mohamedali, A ^b   Best, S ^b   Nloga, A M ^e   Kulasekararaj, A G ^d   Ades, L ^e   Chomienne, C ^c,e   Fenaux, P ^c,e   Dosquet, C ^c,e   Mufti, G J ^b,d   Bonnet, D ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d KING S COLLEGE HOSPITAL   (United Kingdom)

^e SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; BIOLOGICAL MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL EXPANSION; CLONAL EVOLUTION; COCULTURE; CONTROLLED STUDY; DISEASE MODEL; FEMALE; GENE STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MESENCHYMAL STROMA CELL; MOUSE; MYELODYSPLASTIC SYNDROME; NEXT GENERATION SEQUENCING; NONHUMAN; PRECLINICAL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; BONE MARROW TRANSPLANTATION; CHROMOSOME ABERRATION; GENE EXPRESSION; GENETICS; IMMUNOPHENOTYPING; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; REPORTER GENE; XENOGRAFT;

ANIMALS; BIOMARKERS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CHROMOSOME ABERRATIONS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; GENES, REPORTER; HETEROGRAFTS; HUMANS; IMMUNOPHENOTYPING; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, KNOCKOUT; MYELODYSPLASTIC SYNDROMES;

EID: 85038255780     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2017.172     Document Type: Article

References (16)

1. Mufti GJ, Bennett JM, Goasguen J, Bain BJ, Baumann I, Brunning R et al. Diagnosis and classification of myelodysplastic syndrome: International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts. Haematologica 2008; 93: 1712-1717.
2. Greenberg PL, Tuechler H, Schanz J, Sanz G, Garcia-Manero G, Sole F et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood 2012; 120: 2454-2465.
3. Gangat N, Patnaik MM, Tefferi A. Myelodysplastic syndromes: contemporary review and how we treat. Am J Hematol 2016; 91: 76-89.
4. Mian SA, Smith AE, Kulasekararaj AG, Kizilors A, Mohamedali AM, Lea NC et al. Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome. Haematologica 2013; 98: 1058-1066.
5. Papaemmanuil E, Cazzola M, Boultwood J, Malcovati L, Vyas P, Bowen D et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med 2011; 365: 1384-1395.
6. Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 2011; 478: 64-69.
7. Haferlach T, Nagata Y, Grossmann V, Okuno Y, Bacher U, Nagae G et al. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia 2014; 28: 241-247.
8. Woll PS, Kjallquist U, Chowdhury O, Doolittle H, Wedge DC, Thongjuea S et al. Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo. Cancer Cell 2014; 25: 794-808.
9. Mian SA, Rouault-Pierre K, Smith AE, Seidl T, Pizzitola I, Kizilors A et al. SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment. Nat Commun 2015; 6: 10004.
10. Rouault-Pierre K, Smith AE, Mian SA, Pizzitola I, Kulasekararaj AG, Mufti GJ et al. Myelodysplastic syndrome can propagate from the multipotent progenitor compartment. Haematologica 2017; 102: E7-e10.
11. Medyouf H, Mossner M, Jann JC, Nolte F, Raffel S, Herrmann C et al. Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit. Cell Stem Cell 2014; 14: 824-837.
12. Wunderlich M, Brooks RA, Panchal R, Rhyasen GW, Danet-Desnoyers G, Mulloy JC. OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues. Blood 2014; 123: E134-e144.
13. Li X, Deeg HJ. Murine xenogeneic models of myelodysplastic syndrome: An essential role for stroma cells. Exp Hematol 2014; 42: 4-10.
14. Geyh S, Oz S, Cadeddu RP, Frobel J, Bruckner B, Kundgen A et al. Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells. Leukemia 2013; 27: 1841-1851.
15. Abarrategi A, Foster K, Hamilton A, Mian SA, Passaro D, Gribben J et al. Versatile humanized niche model enables study of normal and malignant human hematopoiesis. J Clin Invest 2017; 127: 543-548.
16. Reinisch A, Thomas D, Corces MR, Zhang X, Gratzinger D, Hong WJ et al. A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells. Nat Med 2016; 22: 812-821.