Versatile humanized niche model enables study of normal and malignant human hematopoiesis

Journal of Clinical Investigation

Volumn 127, Issue 2, 2017, Pages 543-548

  Abarrategi, Ander ^a   Foster, Katie ^a   Hamilton, Ashley ^a   Mian, Syed A ^a,b   Passaro, Diana ^a   Gribben, John ^c   Mufti, Ghulam ^b   Bonnet, Dominique ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE MYELOID LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE TISSUE; ENGRAFTMENT; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR ENGRAFTMENT; ANIMAL; BIOLOGICAL MODEL; IMMUNOLOGY; MESENCHYMAL STROMA CELL; PATHOLOGY; STEM CELL NICHE; TUMOR MICROENVIRONMENT;

ANIMALS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MESENCHYMAL STROMAL CELLS; MICE; MODELS, BIOLOGICAL; STEM CELL NICHE; TUMOR MICROENVIRONMENT;

EID: 85014123770     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI89364     Document Type: Article

References (19)

1. Pearce DJ, et al. AML engraftment in the NOD/SCID assay reflects the outcome ofAML: implications for our understanding of the heterogeneity of AML. Blood. 2006;107(3):1166-1173.
2. Vargaftig J, et al. Frequency of leukemic initiating cells does not depend on the xenotransplantation model used. Leukemia. 2012;26(4):858-860.
3. Sanchez PV, et al. A robust xenotransplantation model for acute myeloid leukemia. Leukemia. 2009;23(11):2109-2117.
4. Theocharides AP, Rongvaux A, Fritsch K, Flavell RA, Manz MG. Humanized hemato-lymphoid system mice. Haematologica. 2016;101(1):5-19.
5. Lee J, et al. Implantable microenvironments to attract hematopoietic stem/cancer cells. Proc Natl Acad Sci USA. 2012;109(48):19638-19643.
6. Song J, et al. An in vivo model to study and manipulate the hematopoietic stem cell niche. Blood. 2010;115(13):2592-2600.
7. Holzapfel BM, et al. Tissue engineered humanized bone supports human hematopoiesis in vivo. Biomaterials. 2015;61:103-114.
8. Reinisch A, et al. Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation. Blood. 2015;125(2):249-260.
9. Torisawa YS, et al. Bone marrow-on-A-chip replicates hematopoietic niche physiology in vitro. Nat Methods. 2014;11(6):663-669.
10. Abarrategi A, et al. In vivo ectopic implantation model to assess human mesenchymal progenitor cell potential. Stem Cell Rev. 2013;9(6):833-846.
11. Vaiselbuh SR, Edelman M, Lipton JM, Liu JM. Ectopic human mesenchymal stem cell-coated scaffolds in NOD/SCID mice: an in vivo model of the leukemia niche. Tissue Eng Part C Methods. 2010;16(6):1523-1531.
12. Groen RW, et al. Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma. Blood. 2012;120(3):e9-e16.
13. Chen Y, et al. Human extramedullary bone marrow in mice: A novel in vivo model of genetically controlled hematopoietic microenvironment. Blood. 2012;119(21):4971-4980.
14. Reinisch A, et al. A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells. Nat Med. 2016;22(7):812-821.
15. Sontakke P, et al. Modeling BCR-ABL and MLLAF9 leukemia in a human bone marrow-like scaffold-based xenograft model. Leukemia. 2016;30(10):2064-2073.
16. Antonelli A, et al. Establishing human leukemia xenograft mouse models by implanting human bone marrow-like scaffold-based niches. Blood. 2016;128(25):2949-2959.
17. Robert-Richard E, et al. Human cell engraftment after busulfan or irradiation conditioning of NOD/SCID mice. Haematologica. 2006;91(10):1384.
18. Chan CK, et al. Endochondral ossification is required for haematopoietic stem-cell niche formation. Nature. 2009;457(7228):490-494.
19. Scotti C, et al. Engineering of a functional bone organ through endochondral ossification. Proc Natl Acad Sci USA. 2013;110(10):3997-4002.