Complementary feeding with cowpea reduces growth faltering in rural Malawian infants: A blind, randomized controlled clinical trial

American Journal of Clinical Nutrition

Volumn 106, Issue 6, 2017, Pages 1500-1507

  Stephenson, Kevin B ^a   Agapova, Sophia E ^a   Divala, Oscar ^b   Kaimila, Yankho ^b   Maleta, Kenneth M ^b   Thakwalakwa, Chrissie ^b   Ordiz, M Isabel ^a   Trehan, Indi ^a,c   Manary, Mark J ^a,b,d  

^a WASHINGTON UNIVERSITY   (United States)

^b UNIVERSITY OF MALAWI   (Malawi)

^c Queen Elizabeth Central Hospital campus   (Malawi)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Common bean; Complementary feeding; Cowpea; Environmental enteric dysfunction; Legumes; Malawi; Stunting

Indexed keywords

ANTHROPOMETRY; ARTICLE; BEAN FLOUR; BREAST FEEDING; CALORIC INTAKE; COMPLEMENTARY FEEDING; CONTROLLED STUDY; COWPEA; DIET THERAPY; ENTEROPATHY; ENVIRONMENTAL ENTERIC DYSFUNCTION; FEMALE; GROWTH RETARDATION; HUMAN; INFANT; MAIZE; MAJOR CLINICAL STUDY; MALAWIAN; MALE; RANDOMIZED CONTROLLED TRIAL; RURAL POPULATION; SOYBEAN; STUDENT T TEST; ADMINISTRATION AND DOSAGE; BODY HEIGHT; DIET; DIETARY FIBER; DOUBLE BLIND PROCEDURE; FEEDING BEHAVIOR; GASTROINTESTINAL TRACT; GROWTH DISORDER; INFANT NUTRITION; MALAWI; METABOLISM; PHASEOLUS; PHYSIOLOGY; PLANT SEED; PROSPECTIVE STUDY; PROTEIN INTAKE; VIGNA;

LACTULOSE;

BODY HEIGHT; DIET; DIETARY FIBER; DIETARY PROTEINS; DOUBLE-BLIND METHOD; FEEDING BEHAVIOR; FEMALE; GASTROINTESTINAL TRACT; GROWTH DISORDERS; HUMANS; INFANT; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; LACTULOSE; MALAWI; MALE; PHASEOLUS; PROSPECTIVE STUDIES; RURAL POPULATION; SEEDS; VIGNA;

EID: 85038129834     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.117.160986     Document Type: Article

References (30)

1. Hoddinott J, Maluccio JA, Behrman JR, Flores R, Martorell R. Effect of a nutrition intervention during early childhood on economic productivity in Guatemalan adults. Lancet 2008;371:411–6.
2. Korpe PS, Petri WA. Environmental enteropathy: critical implications of a poorly understood condition. Trends Mol Med 2012;18:328–36.
3. Bhutta ZA, Ahmed T, Black RE, Cousens S, Dewey K, Giugliani E, Haider BA, Kirkwood B, Morris SS, Sachdev HP, et al.; Maternal and Child Undernutrition Study Group. What works? Interventions for maternal and child undernutrition and survival. Lancet 2008;371:417–40.
4. Stephenson K, Amthor R, Mallowa S, Nungo R, Maziya-Dixon B, Gichuki S, Mbanaso A, Manary M. Consuming cassava as a staple food places children 2–5 years old at risk for inadequate protein intake, an observational study in Kenya and Nigeria. Nutr J 2010;9:9.
5. Blanton LV, Charbonneau MR, Salih T, Barratt MJ, Venkatesh S, Ilkaveya O, Subramanian S, Manary MJ, Trehan I, Jorgensen JM, et al. Gut bacteria that rescue growth impairments transmitted by immature microbiota from undernourished children. Science 2016;351:aad3311.
6. Duranti M. Grain legume proteins and nutraceutical properties. Fito-terapia 2006;77:67–82.
7. Sandoval M, Ronzio RA, Muanza DN, Clark DA, Miller MJ. Peroxynitrite-induced apoptosis in epithelial (T84) and macrophage (RAW 264.7) cell lines, effect of legume-derived polyphenols (phy-tolens). Nitric Oxide 1997;1:476–83.
8. Daniell EL, Ryan EP, Brick MA, Thompson HJ. Dietary dry bean effects on hepatic expression of stress and toxicity-related genes in rats. Br J Nutr 2012;108(Suppl 1):S37–45.
9. Trehan I, Kelly P, Shaikh N, Manary MJ. New insights into environmental enteric dysfunction. Arch Dis Child 2016;101:741–4.
10. Denno DM, Vanbuskirk K, Nelson ZC, Musser CA, Hay burgess DC, Tarr PI. Use of the lactulose to mannitol ratio to evaluate childhood environmental enteric dysfunction: a systematic review. Clin Infect Dis 2014;59(Suppl 4):S213–9.
11. Trehan I, Benzoni NS, Wang AZ, Bollinger LB, Ngoma TN, Chimimba UK, Stephenson KB, Agapova SE, Maleta KM, Manary MJ. Common beans and cowpeas as complementary foods to reduce environmental enteric dysfunction and stunting in Malawian children: study protocol for two randomized controlled trials. Trials 2015;16:520.
12. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009;41:1149–60.
13. PAHO. Guiding principles for complementary feeding of the breastfed child. Washington (DC): Pan American Health Organization; 2003.
14. Gibson RS, Ferguson EL. An interactive 24-hour recall for assessing the adequacy of iron and zinc intakes in developing countries. Washington (DC) and Cali (Colombia): International Food Policy Research Institute (IFPRI) and International Center for Tropical Agriculture (CIAT); 2008.
15. Galpin L, Manary MJ, Fleming K, Ou CN, Ashorn P, Shulman RJ. Effect of Lactobacillus GG on intestinal integrity in Malawian children at risk of tropical enteropathy. Am J Clin Nutr 2005;82:1040–5.
16. Trehan I, Shulman RJ, Ou CN, Maleta K, Manary MJ. A randomized, double-blind, placebo-controlled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathy. Am J Gastroenterol 2009;104:2326–33.
17. Ordiz MI, Shaikh N, Trehan I, Maleta K, Stauber J, Shulman R, Devaraj S, Tarr PI, Manary MJ. Environmental enteric dysfunction is associated with poor linear growth and can be identified by host fecal mRNAs. J Pediatr Gastroenterol Nutr 2016;63:453–9.
18. Shulman RJ, Schanler RJ, Lau C, Heitkemper M, Ou CN, Smith EO. Early feeding, antenatal glucocorticoids, and human milk decrease intestinal permeability in preterm infants. Pediatr Res 1998;44:519–23.
19. Yu J, Ordiz MI, Stauber J, Shaikh N, Trehan I, Barnell E, Head RD, Maleta K, Tarr PI, Manary MJ. Environmental enteric dysfunction includes a broad spectrum of inflammatory responses and epithelial repair processes. Cell Mol Gastroenterol Hepatol. 2015;2:158–74.e1.
20. Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ 2010;340:c869.
21. Willett WC. Nutritional epidemiology. Oxford (United Kingdom): Oxford Scholarship Online; 2009.
22. Vereecken CA, De Bourdeaudhuij I, Maes L. The HELENA online food frequency questionnaire: reproducibility and comparison with four 24-hour recalls in Belgian-Flemish adolescents. Eur J Clin Nutr 2010;64:541–8.
23. DeBoer MD, Scharf RJ, Leite AM, Ferrer A, Havt A, Pinkerton R, Lima AA, Guerrant RL. Systemic inflammation, growth factors, and linear growth in the setting of infection and malnutrition. Nutrition 2017;33:248–53.
24. van Zanten GC, Knudsen A, Roytio H, Forssten S, Lawther M, Blennow A, Lahtinen SJ, Jakobsen M, Svensson B, Jespersen L. The effect of selected synbiotics on microbial composition and short-chain fatty acid production in a model system of the human colon. PLoS One 2012;7:e47212.
25. de Punder K, Pruimboom L. The dietary intake of wheat and other cereal grains and their role in inflammation. Nutrients 2013;5:771–87.
26. Dinoto A, Suksomcheep A, Ishizuka S, Kimura H, Hanada S, Kamagata Y, Asano K, Tomita F, Yokota A. Modulation of rat cecal microbiota by administration of raffinose and encapsulated Bifido-bacterium breve. Appl Environ Microbiol 2006;72:784–92.
27. Kim HS, Cha E, Kim YH, Jeon YH, Olson BH, Byun Y, Park HD. Raffinose, a plant galactoside, inhibits Pseudomonas aeruginosa bio-film formation via binding to LecA and decreasing cellular cyclic diguanylate levels. Sci Rep 2016;6:25318.
28. Weisz AJ, Manary MJ, Stephenson K, Agapova S, Manary FG, Thakwalakwa C, Shulman RJ, Manary MJ. Abnormal gut integrity is associated with reduced linear growth in rural Malawian children. J Pediatr Gastroenterol Nutr 2012;55:747–50.
29. Garcia-Perez I, Pasma JM, Gibson R, Chambers ES, Hansen TH, Vestergaard H, Hansen T, Beckmann M, Pederson O, Elliot P, et al. Objective assessment of dietary patterns by use of metabolic pheno-typing: a randomised, controlled, crossover trial. Lancet Diabetes En-docrinol 2017;5:184–95.
30. de Onis M, Branca F. Childhood stunting: a global perspective. Matern Child Nutr 2016;12(Suppl 1):12–6.